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류승렬(Seung Rel Ryu),김혜진(Hye Jin Kim),홍진태(Jin Tae Hong),이종권(Jong Kwon Lee),이선희(Sun Hee Lee),이병무(Byung Mu Lee),김부영(Pu Young Kim) 대한약학회 1999 약학회지 Vol.43 No.5
Abuse liability of ephedrine was investigated by measurement of locomotor activity and self-administration in Sprague-Dawley rats. Locomotor activity was determined in rats treated with 3, 10 and 30mg/kg ephedrine for 14 days. Self-administration by ephedrine (0.23, 1 and 2.3mg/kg) was examined in food-trained rats. We also examined effect of dopamine receptor antagonist (spiperone, 30mcg/kg) on the ephedrine-induced response of self-administration. Body weight was not statistically difference between control and ephedrine treatment group, but locomotor activity was dose-dependently increased. Self-administration for ephedrine was decreased in the early response (day 1 and 2) but the response was increased by higher dose of ephedrine. Self-administration was decreased by dopamine receptor antagonist (spiperone). These data showed that ephedrine increased locomotor activity and induced response of self-administration, and the effects of ephedrine were partially related to the dopaminergic system, which suggest that ephedrine may have abuse liability.
Involvement of Cortical Damage in the Ischemia/Reperfusion-Induced Memory Impairment of Wistar Rats
Hong, Jin-Tae,Ryu, Seung-Rel,Kim, Hye-Jin,Lee, Sun-Hee,Lee, Byung-Moo,Kim, Pu-Young The Pharmaceutical Society of Korea 2000 Archives of Pharmacal Research Vol.23 No.4
The effect of ischemia/reperfusion-induced neuronal damage on the memory impairment were investigated using active avoidance and Morris water maze tasks in Wistar rats. Focal ischemia was induced by 1 h occlusion of the right middle cerebral artery (MCA) of Wistar male rats. Reperfusion was induced by releasing the occlusion and restoring the blood circulation for 24 h. The acquisition and preservation memory tested by active avoidance showed a significant difference between the sham and ischemia/reperfusion group. The water maze acquisition performance was also significant difference between sham and ischemia/repefusion groups in both latency and moving distance. The infarction volume was increased by the ischemia/reperfusion. Furthermore, the cresyl violet staining of the ischemia/reperfusion brain showed severe neuronal damage (pyramidal cell loss) in the cortex in addition to the striatum lesion of brain. This study shows that pyramidal cell damage in the cortex lesion may be partially related to memorial disturbance in the ischemia/reperfusion brain injury.
In vitro Alternatives to Skin Irritation Test
Kim, Dai Byung,Ryu, Seung Rel,Kim, Pu Young,Shin, Dae Sup,Lee, Sun Hee,Koh, Jae Sook,Park, Won Sae 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.3
In vitro cell culture system has been proposed as a promising alternative model to in vivo skin irritation test. These studies were performed to screen the cytotoxicity effects of surfactants using normal human skin fibroblasts. Cell membrane integrity assessed by the leakage of lactate dehydrogenase (LDH) and mitochondrial integrity by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] reduction test were affected in a dose dependent manner. The irritation potential of surfactants to human skin patch test, and the changes of capillary permeability by rabbit intradermal safety test were assessed as in vivo methods. Our results suggest that LDH leakage assay and MTT reduction test using cultured human fibroblasts could be predictive for the irritancy of various surfactants in human, and LDH assay is superior correlated with in vivo test (r=0.886) to MTT test with in vivo test (r=0.757).
이종권,김대병,이은희,이선희,류승렬,최기환,김윤정,김부영 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-
신제형개발시 기초자료제공비 목적으로 5종의 소염진통제 약물에 대한 피부자극시험을 id oifroassay로 실시하여 비교하고자 하였파. 시험물질로는 경근 및 주사꾹로 시판중인 소염진통제 diclofenac, naproxen, meclofenamicacid, ibuprofen, fenoprofen등 5종을 선정하여 in oifro cytotoxicity를 비교분석하였다. 사람의 foreskin으로부터 fibroblast를 배양하고 투여딸물의 노출시간을 24, 48시간으로 하여 노출시간에 대한 차이를 비교하였으며 세포독성은 비교적 많이 쓰이는 neutr,al red uptake assay 및 최근게 소개된 .a.lamar Blueassay를 실시하여 microplatereader로 측정하였으며 시험방법에 따른 cytotoxicity결과를 비교하였다. ,111포의 성장을 50% 감소시키는 TCiL느로비교해 볼 때 meclofenamic acid)diclofenac>fenoprofen>ibuprefen>naproxen순으로 나타났으며 5종의 소염진통제틀 대한 세포독성시험방법으로 alamarblue방법이 MTT나 고RV방법보다 세포독성이 민감하게 나타났다. This study vras carried out to investigate the cytotoricitf was assayed with human skin fibroblasts on 5 anti-infl.ammatorr drugs(Oiclofenac, Naprexen, Merlefenamic acid, rbuprofen andFenoprofen) which are commercially used as oral preparations cr injections. The cytotoxicity of 5 chem-icals was evaluated by using MTT assay, neutral red uptake assay and Atamar Blue assay after theCells had beeu exposed tO Chemicals fOr 24 hours Of 48 hours. The CDmPartiVe Cytotoxicity followed thegeneral order of nleclofenamic acid>diclofenae>fenoprefen>ibuprofen>naproxen as results of Icso de-termined by Alamar Blue assar were lower than those of MTT and NRU assay. These data providealarnar blue assay can be useful method for the assessment of in vitro skin irritation test for anti- in-flammatory drugs.