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Park, Un-Chul,Cho, Myung-Soo,Park, Jung-Hyun,Kim, Sang-Jin,Ku, Seung-Yup,Choi, Young-Min,Moon, Shin-Yong,Yu, Hyeong-Gon The Korean Society for Reproductive Medicine 2011 Clinical and Experimental Reproductive Medicine Vol.38 No.4
Objective: To differentiate the human embryonic stem cells (hESCs) into the retinal pigment epithelium (RPE) in the defined culture condition and determine its therapeutic potential for the treatment of retinal degenerative diseases. Methods: The embryoid bodies were formed from hESCs and attached on the matrigel coated culture dishes. The neural structures consisting neural precursors were selected and expanded to form rosette structures. The mechanically isolated neural rosettes were differentiated into pigmented cells in the media comprised of N2 and B27. Expression profiles of markers related to RPE development were analyzed by reverse transcription-polymerase chain reaction and immunostaining. Dissociated putative RPE cells ($10^5$ cells/5 ${\mu}L$) were transplanted into the subretinal space of rat retinal degeneration model induced by intravenous sodium iodate injection. Animals were sacrificed at 1, 2, and 4 weeks after transplantation, and immnohistochemistry study was performed to verify the survival of the transplanted cells. Results: The putative RPE cells derived from hESC showed characteristics of the human RPE cells morphologically and expressed molecular markers and associated with RPE fate. Grafted RPE cells were found to survive in the subretinal space up to 4 weeks after transplantation, and the expression of RPE markers was confirmed with immunohistochemistry. Conclusion: Transplanted RPE cells derived from hESC in the defined culture condition successfully survived and migrated within subretinal space of rat retinal degeneration model. These results support the feasibility of the hESC derived RPE cells for cell-based therapies for retinal degenerative disease.
Degradation Evaluation of 2.25Cr-1Mo Steel Using Nondestructive Method
Park, Jong Seo,Baek, Un Bong,Kim, Jeong Min,Nahm, Seung Hoon,Ahn, Bong Young Trans Tech Publications, Ltd. 2005 Key Engineering Materials Vol.297 No.-
<P>Several nondestructive evaluation methods were attempted for the estimation of the creep damage of degraded 2.25Cr-1Mo steel. The specimens of three different aging periods were prepared by an isothermal heat treatment at 430°C, 482°C, and 515°C. The effect of probe configuration on the electrical resistivity was studied. Single configuration method and dual-configuration method were utilized for measuring electrical resistivity. The electrical resistivity was determined by a standard DC four-point probe method at 24±0.5°C. Indentation test, magnetic characteristics test and ultrasonic test were carried out to investigate the correlation between the major characteristics and aging parameter. Unlike the electrical resistivity characteristics, ultrasonic attenuation coefficient and indentation characteristics did not show a relation to Larson-Miller parameter. However, a correlation between the electrical resistivity and aging parameter was identified, which allows one to estimate the extent of material degradation.</P>
Validity of Diagnostic Codes for Identification of Psoriasis Patients in Korea
( Seung Pil Ham ),( Jae Hong Oh ),( Hee Jae Park ),( Jong Uk Kim ),( Ho Young Kim ),( So Young Jung ),( Sun Young Choi ),( Jung Eun Seol ),( Hyojin Kim ),( Myoung Shin Kim ),( Un Ha Lee ),( Mira Choi 대한피부과학회 2020 Annals of Dermatology Vol.32 No.2
Background: Recently, the number of nationwide medical researches on psoriasis using the National Health Insurance Service database has been on the rise. However, identification of psoriasis using diagnostic codes alone can lead to misclassification. Accuracy of the diagnostic codes and their concordance with medical records should be validated first to identify psoriasis patients correctly. Objective: To validate the diagnostic codes of psoriasis (International Classification of Diseases, 10th Revision L40) and to find the algorithm for the identification of psoriasis. Methods: We collected medical records of patients who received their first diagnostic codes of psoriasis during 5 years from five hospitals. Fifteen percent of psoriasis patients were randomly selected from each hospital. We performed a validation by reviewing medical records and compared 5 algorithms to identify the best algorithm. Results: Total of 538 cases were reviewed and classified as psoriasis (n=368), not psoriasis (n=159), and questionable (n=11). The most accurate algorithm was including patients with ≥1 visits with psoriasis as primary diagnostic codes and prescription of vitamin D derivatives. Its positive predictive value was 96.5% (95% confidence interval [CI], 93.9%~98.1%), which was significantly higher than those of the algorithm, including patients with ≥1 visits with psoriasis as primary diagnostic codes or including ≥1 visits with diagnostic codes of psoriasis (primary or additional) (91.0% and 69.8%). Sensitivity was 90.8% (95% CI, 87.2%~ 93.4%) and specificity was 92.5% (95% CI, 86.9%~ 95.9%). Conclusion: Our study demonstrates a validated algorithm to identify psoriasis, which will be useful for the nationwide population-based study of psoriasis in Korea. (Ann Dermatol 32(2) 115∼121, 2020)
Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression
Seung-Hoon Lee(Seung-Hoon Lee),Cheolmin Shin(Cheolmin Shin),Young-Hoon Ko(Young-Hoon Ko),Moon-Soo Lee(Moon-Soo Lee),Moon Ho Park(Moon Ho Park),Chi-Un Pae(Chi-Un Pae),Ho-Kyoung Yoon(Ho-Kyoung Yoon),Cha 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Although several previous studies have examined the association between late-life depression and blood adipokine levels, a marker of chronic inflammation, no studies have comprehensively considered the effects of metabolic syndrome, which is known to affect blood adipokine levels. This study examined blood adipokine levels in geriatric depression after adjusting for the effects of metabolic syndrome. Methods: Participants were selected from the Ansan Geriatric Study (depression group [n = 76] and control group [n = 76]). Blood concentrations of four adipokines (adiponectin, resistin, neutrophil-gelatinase-associated lipocalin [NGAL], and plasminogen activator inhibitor-1 [PAI-1]) were measured using immunoassays. The effects of blood adipokine concentration on the diagnosis of depression were analyzed using multivariate logistic regression to adjust for the effects of metabolic syndrome and potential confounding factors. Results: When the effects of metabolic syndrome and potential confounding factors were adjusted, only PAI-1 could explain the diagnosis of depression among all the adipokines. The depression group showed a lower blood PAI-1 level than the control group. Adiponectin, resistin, and NGAL could not explain the diagnosis of depression when the effects of metabolic syndrome and potential confounding factors were adjusted. Conclusion: This study suggests the possibility that the blood PAI-1 levels in clinically pathological late-life depression may show contrasting results to those with subclinical depressive symptoms. Additionally, considering that most previous studies have been conducted with pre-geriatric populations, the study suggests the possibility that geriatric depression may show inflammatory changes with patterns that are different from those of depression in the pre-geriatric population.
Un-Ki Hwang(황운기),Kyoung-Ho An(안경호),Hyoun-Kook Jin(진현국),Seung-Youn Park(박승윤),Pyoung-Joong Kim(김평중),Seung-Min Lee(이승민) 환경독성보건학회 2007 환경독성보건학회지 Vol.22 No.4
4-nonylphenol (4-NP)이 해산어류인 조피볼락, Sebastes schlegeli의 혈장 vitellogenin (VTO), alkaline-labile protein phosphorus (ALPP), calcium (Ca), glutamate pyruvate transaminase (GPT) 및 hepatosomatic index (HSI)에 미치는 영향을 조사하였다. 실험어에 3일간격으로 estradiol-17β (E₂, 5 ㎎/㎏ B.W.) 또는 4-NP (0, 10, 50, 100 및 200 ㎎/㎏ B.W.)을 복강에 2번 주사한 후, 7일째에 채혈과 적출을 통해 혈장과 간장을 수집해 분석이 실시되었다. 대조 실험어에는 용매로 사용된 70% 에탄올만이 투여되었다. E₂ 투여 실험어의 혈장 단백질을 전기 영동상으로 분석한 결과 약 l70kDa의 위치에서 짙은 VTG 밴드가 관찰되었으나, 용매만 투여한 대조 실험어의 혈장에서는 동일 밴드가 관찰되지 않았다. 4-NP 투여한 모든 실험어의 혈장 단백질에서는 E₂ 투여 실험어와 동일한 VTG 밴드가 관찰되었다. 혈장 ALPP와 Ca 농도도 4-NP 투여 실험어에서 E₂ 투여 실험어와 유사하게 증가하였으며, 이들 농도 변화는 VTG 합성과 더불어 증가하는 경향을 나타냈다. 혈장 전위효소인 GPT와 HSI도 E₂ 투여 실험어와 유사하게 4-NP가 투여된 모든 실험어에서 급격히 증가하였다. 이상의 결과로부터 연안생태계 내에서 서식하는 어류가 4-NP과 같은 내분비 장애물질(Endocrine Disrupting Compounds, EDCs)에 의해 영향을 받는지를 규명하기 위한 생물학적 지표로서 VTG와 더불어 혈장 ALPP와 Ca이 사용가능할 것으로 판단된다. 또한, 조피볼락과 같은 해산어가 EDCs에 노출되어 VTG가 합성될 때 간장 기능의 손상으로 혈장 전위효소인 GPT가 일시적으로 증가하고 간장도 비대해져 HSI가 높아지는 것으로 판단된다.
( Seung-yong Lee ),( Narayan Chandra Paul ),( Won Park ),( Gyeong-dan Yu ),( Jin-cheon Park ),( Mi-nam Chung ),( Sang-sik Nam ),( Seon-kyeong Han ),( Hyeong-un Lee ),( San Goh ),( Im Been Lee ),( Jung 한국균학회 2019 韓國菌學會誌 Vol.47 No.4
A common post-harvest disease of sweetpotato tuber is root rot caused by Fusarium solani in Korea as well as the other countries. Storage root rot disease was monitored earlier on sweetpotato (Ipomoea batatas) in storehouses of different locations in Korea. In the present study, an isolate SPL16124 was choosen and collected from Sweetpotato Research Lab., Bioenergy Crop Research Institute, NICS, Muan, Korea, and confirmed the identification as Fusarium solani by conidial and molecular phylogenetic analysis (internal transcribed spacer ITS and translation elongation factor EF 1-α gene sequences). The isolate was cultured on potato dextrose agar, and conidiation was induced. The fungus was screened for Fusarium root rot on tuber of 14 different varieties. Among the tested variety, Yenjami, Singeonmi, Daeyumi, and Sinjami showed resistant to root rot disease. Additionally, the pathogen was tested for pathogenicity on stalks of these varieties. No symptom was observed on the stalk, and it was confirmed that the disease is tissue specific.
Occurrence and Prevalence of Honeybee Disease in Apis mellifera and Apis cerana in Korea
Seung-Won Kang,Mi-Sun Yoo,Jin-Hyeong Noh,Hyo Seon Park,il Min,Dong-Min Jeon,Su Chin Park,Mi Seong Lee,Young Un Hong,Sang Young Bang,Eun Hee Jang,Min Kwon Lee,Jong Sik Park,Myeong-Ho Jeong,Kwang Jung,M 한국양봉학회 2012 韓國養蜂學會誌 Vol.27 No.3
The occurrence and distribution of twelve bee diseases was investigated in Apis mellifera (A. mellifera) and Apis cerana (A. cerana) in Korea: american foulbrood (AFB), european foulbrood (EFB), chalkbrood, stonebrood, Nosema, sacbrood virus (SBV), acute bee paralysis virus (ABPV), deformed wing virus (DWV), black queen cell virus (BQCV), kashmir bee virus (KBV), chronic bee paralysis virus (CBPV) and Varroa destructor (V. destructor). Samples were collected from Korean apiaries located in different regions of the country in Novemver 2010-October 2011. V. destructor was the most prevalent disease in A. mellifera (identified in 75% of samples), followed by Nosema (46%), chalkbrood (39%), stonebrood (37%), BQCV (24%), DWV (22%), SBV (15%), KBV (13%), AFB (12%), and EFB (0.6%). SBV was identified in 64% of A. cerana samples and was especially dominant during the winter, when it was identified in 70% of samples. The results indicate that disease prevalence is associated with both susceptibility and season. A. cerana was susceptible to SBV during hibernation but resistant to V. destructor, whereas A. mellifera was susceptible to V. destructor during the working period, which was associated with the spread of other viruses. This is the first paper reporting the detection of 12 distinct diseases in A. mellifera and A. cerana honeybees in Korea.
Seung Pil Lee,Sang Yun Min,Jin Sik Kim,Jong Un Park,Man Soo Kim 대한환경공학회 2014 Environmental Engineering Research Vol.19 No.1
In this study, the influence of the control and operational parameters within a sewage treatment plant were reviewed by performing multiple regression analysis on the effluent quality of the sewage treatment. The data used for this review are based on the actual data from a sewage treatment plant using the media process within the year 2012. The prediction models of chemical oxygen demand(CODMn) and total nitrogen (T-N) within the effluent of the 2nd settling tank based on the multiple regression analysis yielded the prediction accuracy measurements of 0.93 and 0.84, respectively; and it was concluded that the model was accurately predicting the variances of the actual observed values. If the data on the energy spent on each operating condition can be collected, then the operating parameter that conserves energy without violating the effluent quality standards of COD and T-N can be determined using the regression model and the standardized regression coefficients. These results can provide appropriate operation guidelines to conserve energy to the operators at sewage treatment plants that consume a lot of energy.