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여운철,조광현,이유신,허대석,이승철 ( Un Cheol Yeo,Kwang Hyun Cho,Yoo Shin Lee,Dae Seog Heo,Seung Chul Lee ) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.5
A Case of Erythema Multiforme A ssociated with Malignant Lymphoma Un Cheol Yeo, M.D., Kwang Hyun Cho, M.D., Yoo Shin Lee, M.D., Dae Seog Heo*, M.D., Seoung Chul Lee**, M.D Department of Dermatology and Internal Medicine*, College of Medicine, Seoul National University, Seoul, Korea, Department of Dermatology**, College of Medicine, Inha University, Kyung Gi Do, Korea We report a case of erythema multiforme associated with malignant lymphoma. Fifty-six-year-old male patient visited our clinic complaining generalized skin lesions which were compatible with erythema multiforme clinically and histopathologically. The skin lesions were treatment-resistant, recurrent and persistent for 3 years. In consideration of old age, atypical features of erythema multiforme and no other demonstrable etiology of erythema multiforme, we studied for internal malignancy. Malignant lymphoma at the duodenum was revealed by UGI series, abdominal CT, and endoscopic biopsy. After chemotherapy, the tumor mass and active skin lesions were cleared simultaneously. Erythema multiforme may be regarded as one of the paraneoplastic syndromes.
Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression
Seung-Hoon Lee(Seung-Hoon Lee),Cheolmin Shin(Cheolmin Shin),Young-Hoon Ko(Young-Hoon Ko),Moon-Soo Lee(Moon-Soo Lee),Moon Ho Park(Moon Ho Park),Chi-Un Pae(Chi-Un Pae),Ho-Kyoung Yoon(Ho-Kyoung Yoon),Cha 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Although several previous studies have examined the association between late-life depression and blood adipokine levels, a marker of chronic inflammation, no studies have comprehensively considered the effects of metabolic syndrome, which is known to affect blood adipokine levels. This study examined blood adipokine levels in geriatric depression after adjusting for the effects of metabolic syndrome. Methods: Participants were selected from the Ansan Geriatric Study (depression group [n = 76] and control group [n = 76]). Blood concentrations of four adipokines (adiponectin, resistin, neutrophil-gelatinase-associated lipocalin [NGAL], and plasminogen activator inhibitor-1 [PAI-1]) were measured using immunoassays. The effects of blood adipokine concentration on the diagnosis of depression were analyzed using multivariate logistic regression to adjust for the effects of metabolic syndrome and potential confounding factors. Results: When the effects of metabolic syndrome and potential confounding factors were adjusted, only PAI-1 could explain the diagnosis of depression among all the adipokines. The depression group showed a lower blood PAI-1 level than the control group. Adiponectin, resistin, and NGAL could not explain the diagnosis of depression when the effects of metabolic syndrome and potential confounding factors were adjusted. Conclusion: This study suggests the possibility that the blood PAI-1 levels in clinically pathological late-life depression may show contrasting results to those with subclinical depressive symptoms. Additionally, considering that most previous studies have been conducted with pre-geriatric populations, the study suggests the possibility that geriatric depression may show inflammatory changes with patterns that are different from those of depression in the pre-geriatric population.
A New Phenylpropane Glycoside from the Rhizome of Sparganium stoloniferum
Lee, Seung-Young,Choi, Sang-Un,Lee, Jei-Hyun,Lee, Dong-Ung,Lee, Kang-Ro 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
The purification of the MeOH extract from the rhizome of Sparganium stoloniferum Buch.-Hamil. (Sparganiaceae) using column chromatography furnished one new phenylpropanoid glycoside (7) and known phenolic compounds (1-6, and 8-13). The structural elucidation of 7 was based on 1D- and 2D-NMR spectroscopic data analysis to be ${\beta}$-D-(6-O-trans-feruloyl) fructofuranosyl-${\alpha}$-D-O-glucopyranoside. Compounds 1-6, and 8-13 were elucidated by spectroscopy and confirmed by comparison with reported data; 24-methylenecycloartanol (1), phydroxybenzaldehyde (2), ferulic acid (3), p-coumaric acid (4), vanillic acid (5), ${\beta}$-D-(1-O-acetyl- 3-O-trans-feruloyl)fructofuranosy-${\alpha}$-D-2',4',6'.-O-triacetyglucopyranoisde (6), ${\beta}$-D-(1-O-acetyl-3,6-O-trans-diferuloyl)fructofuranosyl-${\alpha}$-D-2',4',6'.-O-triacetylglucopyranoisde (8), hydroxytyrosol acetate (9), hydroxytyrosol (10), isorhamnetin-3-O-rutinoside (11), n-butyl-${\alpha}$-D-fructofuranoside (12), and n-butyl-${\beta}$-D-fructopyranoside (13). Compounds 3 and 9-13 were isolated for the first time from this plant. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay.
Lee Seung-Hoon,Jeon Sang Won,Shin Cheolmin,Pae Chi-Un,Ashwin A. Patkar,Prakash S. Masand,An Hyonggin,Han Changsu 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.4
Objective This study aimed to compare the efficacy and safety of escitalopram, vortioxetine, and desvenlafaxine for acute treatment of major depressive disorder (MDD) with cognitive complaint (CC).Methods A total of 129 patients with MDD who also complained of CC were randomized evenly to either escitalopram, vortioxetine, or desvenlafaxine group and underwent a multi-center, six-week, rater-blinded, and head-to-head comparative trial. Differences in depressive symptoms following treatment were measured using the Hamilton Depression Rating Scale (HAMD) and the Montgomery-Åsberg Depression Rating Scale (MADRS). Subjective cognitive function and the presence of adverse events were assessed.Results The three antidepressant treatment groups did not show significant differences in the improvement of depressive symptoms as measured by HAMD and MADRS. Desvenlafaxine treatment was associated with a superior treatment response rate in depressive symptoms compared to vortioxetine or escitalopram treatment. However, no significant differences were found in the remission rate of depressive symptoms. The three antidepressant treatment groups did not show significant differences in the improvement of CC. Adverse profiles of each treatment group were tolerable, with no significant differences.Conclusion In acute antidepressant treatment for MDD with CC, escitalopram, vortioxetine, and desvenlafaxine presented similar efficacy in relief of depressive symptoms; however, desvenlafaxine was associated with a superior treatment. Further studies are needed to confirm these results by investigating the therapeutic efficacy and safety profile of long-term antidepressant treatment of MDD with CC (Clinical Trial Registry, http://cris.nih.go.kr/cris/en/: KCT0002173).
A New Flavonol Glycoside from Hylomecon vernalis
Seung Young Lee,이강노,김기현,이일균,Kyu Ha Lee,Sang Un Choi 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.3
Purification of a MeOH extract from the aerial parts of Hylomecon vernalis Maxim. (Papaveraceae) using column chromatography furnished a new acetylated flavonol glycoside (1), together with twenty known phenolic compounds (2-21). Structural elucidation of 1 was based on 1D- and 2D-NMR spectroscopy data analysis to be quercetin 3-O-[4'''-O-acetyl-α-L-arabinopyranosyl]-(1'''→6'')-β-D-galactopyranoside (1). The structures of compounds 2-21 were elucidated by spectroscopy and confirmed by comparison with reported data; quercetin 3-O-[2'''-O-acetyl-α-L-arabinopyranosyl]-(1'''→6'')-β-D-galactopyranoside (2), quercetin 3-O-α-L-arabinopyranosyl-(1'''→6'')-β-D-galactopyranoside (3), quercetin 3-O-β-D-galactopyranoside (4), kaempferol 3,7-O-α-L-dirhamnopyranoside (5), diosmetin 7-O-β-D-glucopyranoside (6), diosmetin 7-O-β-D-xylopyranosyl-(1'''→6'')-β-D-glucopyranoside (7), p-hydroxybenzoic acid (8), protocatechuic acid (9), caffeic acid (10), 6-hydroxy-3,4-dihydro-1-oxo-β-carboline (11), (Z)-3-hexenyl-β-D-glucopyranoside (12), (E)-2-hexenyl-β-D-glucopyranoside (13), (Z)-3-hexenyl-α-Larabinopyranosyl-(1''→6')-β-D-glucopyranoside (14), oct-1-en-3-yl-α-L-arabinopyranosyl-(1''→6')-β-D-glucopyranoside (15), benzyl-β-D-apiofuranosyl-(1''→6')-β-D-glucopyranoside (16), benzyl-α-L-arabinopyranosyl-(1''→6')-β-D-glucopyranoside (17), benzyl-β-D-xylopyranosyl-(1''→6')-β-D-glucopyranoside (18), 2-phenylethyl-α-L-arabinopyranosyl-(1''→6')-β-D-glucopyranoside (19), 2-phenylethyl-β-D-apiofuranosyl-(1''→6')-β-D-glucopyranoside (20), and aryl-β-D-glucopyranoside (21). Compounds 2-21 were isolated for the first time from this plant. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay.
Lee, Sang Hyung,Lee, Seung Mi,Lim, Nam Gu,Kim, Hyun Joo,Bae, Sung-Hee,Ock, Minsu,Kim, Un-Na,Lee, Jin Yong,Jo, Min-Woo Wolters Kluwer Health 2016 Medicine Vol.95 No.34
<P><B>Abstract</B></P><P>Teenage mothers are at high risk for maternal and neonatal complications. This study aimed to evaluate the socioeconomic circumstances of teenage pregnancy, and determine whether these increased risks remained after adjustment for socioeconomic circumstances in Korea. Using the National Health Insurance Corporation database, we selected women who terminated pregnancy, by delivery or abortion, from January 1, 2010 to December 31, 2010. Abortion, delivery type, and maternal complications were defined based on the International Classification of Diseases-10th Revision. We compared teenagers (13–19 years at the time of pregnancy termination) with other age groups and investigated differences based on socioeconomic status, reflected by Medical Aid (MA) and National Health Insurance (NHI) beneficiaries. We used multivariate analysis to define the factors associated with preterm delivery. Among 463,847 pregnancies, 2267 (0.49%) involved teenagers. Teenage mothers were more likely to have an abortion (33.4%) than deliver a baby when compared with other age groups (20.8%; <I>P</I> < 0.001). About 14.4% of teenage mothers had never received prenatal care throughout pregnancy. Among teenage mothers, 61.7% of MA recipients made fewer than 4 prenatal care visits (vs 38.8% of NHI beneficiaries) (<I>P</I> < 0.001). Teenage mothers more often experienced preterm delivery and perineal laceration (<I>P</I> < 0.001). Teenage mothers (<20 years) were 2.47 times more likely to have preterm delivery than older mothers (20–34 years; <I>P</I> < 0.001). Teenage mothers had higher risk of inadequate prenatal care and subsequently of preterm delivery, which remained significantly higher after adjusting for socioeconomic confounding variables and adequacy of prenatal care in Korean teenagers (<I>P</I> < 0.001).</P>