전신성 홍반성 낭창의 임상적 고찰

신영태,이정호,신승훈,이강욱 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

To elucidate the clinical feature and clinicopathologic correlation of systemic lupus erythematosus(SLE), the authors analized symptoms and signs, laboratory findings and kidney pathology in 25 patients with SLE who were admitted to the Department of Internal Medicine, Chungnam National University Hospital from My 1985 to October 1989. Kidny biopsy was performed in 15 patients out of 19 patients who showed lupus nephritis. The results were as follows: 1. The ratio of male of females was 1:11.5. They were 14 to 53 years old and mean age was 30.2 years old. The peak age incidence was 3rd and 4th decades. 2. The most frequent chief complaint on admission was fever and chills. Most patients had two or more symptoms such as arthralgia, malar rash, generalized edema or weakness. 3. In 84% of the patients, duration from onset of the disease to diagnosis of SLE was longer than 1 month, which suggested that diagnosis of SLE is not easy in early stage of SLE. 4. The positive anti -DNA was the most frequently observed ARA criteria of SLE. And positive ANA, malar rash, persistent proteinuria, leukopenia, positive LE cell preparation, arthritis and oral ulcer were observed in order of frequency. 5. The frequent and pertinent general symptoms, not included in ARA criteria were fever and chills, arthralgia and abdominal pain which were observed in more than half of the patients. 6. On immunologic test, serum concentrations of C3 and C4 were decreased in 96% of the patients, serum concentration of Ig G, Ig A were increased in 65%, 36.8% and 26.3% of the patients respectively. The RA test was positive in 25% of the patients. 7. Lupus nephritis represented 76% of all SLE patients and pathological classification on 15 patients with lupus nephritis revealed class IV lupus nephritis in 9 patients(60%), class II n 3 patients (21%), class V in 2 patients(13.3%) and class III in 1 patient. 8. 7 out of 9 patients with class IV lupus nephritis and 1 out of 2 patients with class V lupus nephritis showed nephrotic syndrome. Progressive azotemia were observed in 3 out of 9 patient with class IV lupus nephritis and in 1 out of 2 patients with class V lupus nephritis. There were no nephrotic syndroms or azotemia in class II and class III lupus nephritis. 9. Of 17 patients who can be followed up, 9 patients were improved, 5 patients became progressive azotemia and 3 patients resulted in death. The causes of death were myocarditis with pericarditis in 1 patients, pneumonia with acute respiratory failure in 1 patient and CNS involvement of SLE in 1 patient.

農巖文學 硏究序說

신승훈 翰林大學校 泰東古典硏究所 1999 泰東古典硏究 Vol.16 No.-

위선암에서 E-cadherin, a-catenin 및 p53의 표출

신영훈,양승하 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Gastric adenocarcinoma is the most common malignant tumor in Korea. There is many reports many oncogens related to progression and metastasis of tumor. Among these oncogene, E-cadhering and a-catenin are important to maintain normal structure by cellular adhesion, The changed expression of of these genes affect to invasion and metastasis of the tumor and relate to prognosis of patients. p53 regulate cellular porliferation and over expression of p53 relates to malignant trasformation and poor prognosis of patients. To evaluate The expressing of E-cadherin, a-catenin, and p53 according to histopathologic features and the relation between these antigens and prognosis in gastric adenocarcinoma, we have performed immune staining for 91 cases. The results were as follows; 1) E-cadherin and a-catenin showed loss or reduction of expression in 50.5% and 87.9% of gastric adenocarcinoma, respectively, and the expression rates of p53 was 49.5%. 2) The frequency of the loss or reduction of E-cadherin expression in diffuse type of gastric adenocarcinoma was more high than intestinal type. 3) The frequency of the loss or reduction of a-catenin expression in cases invaded to serosa and sourrounding tissue in gastric adenocarcinoma was more high than cases to muscle layer. 4) The frequency of the loss or reduction of both E-cadherin and a-catenin was more high in diffuse type than intestinal type of gastric adenocarcinoma, and in cases invaded to serosa and surrounding tissue and in cases showing metastasis to lymph node than suscle layer and non-metastasis in advaced carcinoma 5) The expression of p53 in advanced carcinoma was more high in cases invaded to serosa and surrounding tissue and in cases showing metastasis to lymph node than muscle layer and non-metastasis. 6) The loss or reduction of both E-cadherin and a-catenin in cases showing p53 expression showed more high frequency than in p53 non expression. Abov results indicated that the loss or reduction of E-cadherin expression in gastric adenocarcinoma may be related to diffuse type, and a-catenin in advanced carcinoma to invasion depth. The expression of p53 may be related to metastatic cancer to lymph nodes and depth of depth in advanced carcinoma.

각화낭성치성종양의 재발과 연관된 p53, Ki-67, PCNA 및 cytokeratin 17, cytokeratin 18의 발현

신상훈,성화식,이승환 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.24

The keratocystic odontogenic tumor(OKC) represents approximately 11% of odontogenic cysts and is decided by microscopic and histopathologic determinant rather than by clinical apprearance. The OKC is noted for its capacity to recur after treatment. In this study, p53, Ki-67, PCNA and cytokeratin 17, cytokeratin 18 expression of OKC in relation to non-recurrenct lesion and recurrent lesion after cyst enucleation were examinated. The p53, Ki-67, PCNA and cytokeratin 17, cytokeratin 18 antibody staining were used. The obtained results were as follows. In proliferating rate of non-recurrent OKCs and recurrent OKCs using p53, Ki-67 and PCNA staing, there was not significant difference. In cytokeratin 17 staining, strong positive reaction was showed in all layers of recurrent OKCs rather than non-recurrent OKCs. In cytokeratin 18 staining, negative or weakly positive reaction was showed in recurrent OKCs rather than non-recurrent OKCs. In summary, it was suggested that the recurrence of OKCs was not related to proliferating rate of epithelium and the prognosis of the recurrence of OKCs is helped using cytokeratin 17 and cytokeratin 18.

하악과두에 발생하는 골연골종의 진단학적 방법

신상훈,차승만,황대석,김용덕,김욱규 부산대학교 병원 암연구소 2006 부산대병원학술지 Vol.- No.20

Pulpose : Osteeochondroma is a common benign tumor of the axial skeleton, especially the distal metaphysis of the femur and the proximal metaphysis of the tibia, however, is\ occured rarely on the facial skeleton. Tumors of the mandibular condyle are various and rare. so common interest is a little and its clinical symptoms are similar to the others. therefore, early diagnosis is very difficult. In this study, we will present our cases and review the literatures. Patients and Methods: We studied 17 patients(8 males, 9 females) who were diagnosed a osteochondroma of the mandibular condyle in the department of oral and maxillofacial surgery, Pusan National University Hospital. We reviewed the medical records. Results : Patients' mean age was 30.05 years. The sexual distribution is almost same. Twelve left condyles and five right condyles were involeved. The main symptoms was noise and facial asymmetry. Conclusion : Osteeochondroma is a rare benign tumor of the mandibular condyle. The differential diagnosis is difficult. However, using CT and MRI, we diagnosed early the osteochondroma and treated properly. Thus, we presented the cases of the osteochondroma with the literature reviews.

급성신우신염의 임상적 고찰

신영태,신승훈,이순구,이정호,이강욱 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

A clinical retrospective study was undertaken in 81 patients with acute pyelonephritis admitted to the Department of Internal Medicine, Chungnam National University Hospital from January 1983 to December 1989. The results were as follows : 1. Total number of patients studied was 81(M/F ratio, 1 : 4.4). The M/F ratio of 22 complicated patients (27.2%) was 1 : 2.7 2. The predisposing factors associated with complicated patients were as follows : 7 cases of urinary tract stone, 7 cases of pregnancy, 4 cases of neurogenic bladder and each one case of prostatic hypertrophy, ureter cancer, bladder diverticulum and polycystic kidney disease. 3. The common subjective symptoms on admission were fever and chills, frank pain, nausea and vomiting. High body temperature and CVA tenderness were noted in 61% and 95% of patients respectively. And 50.6% of patients revealed right CVA tenderness and 28.4% in left, 16% in both respectively. There was no difference in symptoms and signs between complicated and uncomplicated groups 4. In 50 patients(61.7%) microorganisms were isolated on the urine culture specimens. The most common organism was E. coli(80%), and followed by Staphylococcus aureus and Serratia odorifera. E coli was the most frequent pathogen in both female and male patients, and in complicated and uncomplicated groups. (In sensitivity test of complicated and uncomplicated groups). In sensitivity test of causative pathogens to antibiotics, E coli was sensitive to amikacin(93%), tobramycin(83.3%) and gentamycin(79.4%) and 88.9 percent of E coli were ressistant to ampicillin 5. In urinary examination on admission, pyuria was noted in 81% of patients, and proteinuria and microscopic hematuria were noted in 68% and 44% of patients respectively. 6. Within 3 days after antibiotics treatment deference was occured in 73.5% of total patients, and complicated patients revealed delayed defeverence compared to uncomplicated ones.

글로우 방전을 이용한 이산화탄소의 전환특성

신용섭,송승훈,곽동주 慶星大學校 1998 論文集 Vol.19 No.2

In this study, the characteristics of CO₂conversion and glow discharge were investigated using glow discharge plasma reactor with a parallel copper electrode system. A pure CO₂ gas was used for the carrier gas under gas pressure of 10∼80 torr in a glow discharge. For glow discharge, discharge current was increased with the increase of discharge voltage. In the case of constant discharge voltage, the discharge current tend to increase with the decreasing of gas pressure. Using pure CO₂only, the CO₂conversion was increased with the increase of discharge power and the decreased of gas pressure. The maximum CO₂ conversion was 28% at 10 torr, 598 W, 902.4V. Energy yield was decreased with the increase of discharge power and discharge voltage. Also, the concentrations of CO₂and O₂in the produced gas were slightly increased with the increase of CO₂ conversion.

하악골 전돌증 수술 후 하악골 이동량에 따른 발음 양상에 관한 비교 연구

신기영,이동근,오승환,성헌모,이숙향 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.1

After performing mandibular setback surgery, we found some changes in patterns and organs of speech. This investigation was undertaken to investigate the aspect and degree of speech patterns according to the amount of surgical setback in mandibular prognathic patients. Thirteen patients with skeletal Class Ⅲ malocclusion were studied preoperative and postoperative over 6 months. They had undergone the mandible setback operation via bilateral sagittal split ramus osteotomy(BSSRO). We split the patients into two groups. Group 1 included patients whose degree of mandibular setback was 6mm or less, and Group 2 above 6mm. Control group was two adults wish normal speech patterns. A phonetician performed narrow phonetic transcriptions of tape-recorded words and sen- tences produced by each of the patients and the acoustic characteristics of the plosives, fricatives, and flaps were analyzed with a phonetic computer program (Computerized Speech Lab(CSL) Model 4300B(USA) ). The results are as fallows : 1. Genera1ly, Patients showed longer closure duration of plosives, shorter VOT(voice onset time) and higher ratio of closure duration against VOT 2. Patients showed more frequent diffuse distribution than the control group in frication noise energy of fricatives. 3. In fricatives, frequency of compact from were higher in group 1 than in group 2. 4. Generally, a short duraction of closure for /ㄹ/ was not realized in the patient's flaps. Instead, it was realized as fricatives, sonorant with a vowel-like formant structure, or trill type consonant. 5. Abnormality of the patient's articulation was reduced, but adaptation of their articulation after surgery was not perfect and the degree of adaptation was different according to the degree of surgical setback.

다카야스 동맥염과 동반된 초점성 분절성 사구체경화증 1예

강신명,송영수,김주성,윤수영,이루다,최규헌,조승연,이호영,한대석,정현주' 대한신장학회 2000 대한신장학회잡지 Vol.19 No.5

톨루엔의 一回 및 反復吸入 露出이 白鼠에 미치는 影響 : 血中 濃度 및 細胞外性 아미노酸 神經傳達物質의 濃度變化 Blood concentration and extracellular amino acid neurotransmitter levels

백승경,신윤열,박용훈,이진훈,최태혁,이완구 內務部 國立科學搜査硏究所 1996 國立 科學 搜査 硏究所 年報 Vol.28 No.-