http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
기계적 자극이 치주인대 세포의 osteoprotegerin과 receptor activator of nuclear factor κB ligand mRNA 발현에 미치는 영향
이기주,이승일,황충주,,옥승호,전옥순 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.4
본 연구는 치주인대 세포에 지속적이고 점진적 인장력을 가하여 치아 이동 시 형성되는 인장부위의 기계적 자극에 대한 생화학적 전달과 치조골 흡수와 생성 조절 기전을 이해하고자 하였다. 치주인대 세포가 배양된 유연한 성장 표면을 가진 배지에 지속적이고 점진적인 인장력을 가하고 골흡수 인자인 PGE_(2)와 골형성 인자인 ALP의 생성량을 1, 3, 6, 12시간 후에 측정하여 정량비교하였고 파골세포 분화기전을 조절하는 OPG, RANKL의 인자들과 matrix metalloproteinase (MMP)-1, -8, -9, -13, tissue inhlbitor of matrix metalloproteinase (TIMP)-1의 인자들을 역전사 중합효소 연쇄반응 검사하여 m-RNA 발현을 비교한 결과, 치주인대 세포에 인장력을 가한 경우 대조군보다 PGE_(2)의 농도가 적었고 (p<0.05) ALP의 농도 변화는 없었으며 OPG의 mRNA 발현이 증가하였으나, RANKL의 mRNA 발현은 감소하였다. 그리고 TIMP-1과 MMP-1, -8, -9, -13의 mRNA 발현이 대조군과 차이가 없었다. 이상의 연구에서 사람의 치주인대 세포는 점진적이고 지속적인 인장력에 대한 반응으로 PGE_(2)의 생성과 RANKL의 mRNA 발현은 감소하고 OPG의 mRNA 발현은 증가하여 골흡수를 억제하는 효과를 보이는 것으로 나타났다. Tooth movement is a result of mutual physiologic responses between the periodontal ligament and alveolar bone stimulated by mechanical strain. The PDL cell and osteoblast are known to have an influence on bone formation by controlling collagen synthesis and alkaline phosphatase activation. Moreover, recent studies have shown that the PDL cell and osteoblast release osteoprotegerin(OPG) and the receptor activator of nuclear factor κB ligand (RANKL) to control the level of osteoclast differentiation and activation which in turn influences bone resorption. In this study, progressively increased, continuous tenslonal force was applied to PDL cells. The objective was to progressively increased. continuous tensional force was applied to PDL cells. The objective was to find out which kind of biochemical reactions occur after tensional force application and to illuminate the alveolar bone resorption and apposition mechanism. Continuous and progressively increased tensile force was applied to PDL cells cultured on a petriperm dish wlth a flexible membrane. The amount of PGE_(2) and ALP synthesis were measured after 1, 3, 6 and 12 hours of force application. Secondly, RT-PCR analysis was carried out for OPG and RANKL whlch control osteoclast differentiation and MMP-1, -8, -9, -13 and TIMP-1 which regulate the resolution of collagen and resorption of the osteoid layer. According to the results, we concluded that progressively increased, continuous force application to human PDL cells reduces PGE_(2) synthesls, and increases OPG mRNA expression.
Seung-Ho Ohk,Hyunjoo Jeong,Jong-Pil Kim,Yun-Jung Yoo,Jeong-Taeg Seo,Dong-Min Shin,Syng-Ill Lee The Korean Academy of Oral Biology 2013 International Journal of Oral Biology Vol.38 No.3
Xylitol is a sugar alcohol with a variety of functions including bactericidal and anticariogenic effects. However, the cellular mechanisms underlying the role of xylitol in bone metabolism are not yet clarified. In our present study, we exploited the physiological role of xylitol on osteoclast differentiation in a co-culture system of osteoblastic and RAW 264.7 cells. Xylitol treatment of these co-cultures reduced the number of tartrate-resistant acid phosphatase (TRAP)- positive multinucleated cells induced by 10 nM 1α,25(OH)2 D3 in a dose‐dependent manner. A cell viability test revealed no marked cellular damage by up to 100 mM of xylitol. Exposure of osteoblastic cells to xylitol decreased RANKL, but not OPG, mRNA expression in the presence of 10 -8 M 1α,25(OH)2D3 in a dose‐dependent manner. Furthermore, bone resorption activity, assessed on bone slices in the coculture system, was found to be dramatically decreased with increasing xylitol concentrations. RANKL and OPG proteins were assayed by ELISA and the soluble RANKL (sRANKL) concentration was decreased with an increased xylitol concentration. In contrast, OPG was unaltered by any xylitol concentration in this assay. These results indicate that xylitol inhibits 1α,25(OH)2D3-induced osteoclastogenesis by reducing the sRANKL/OPG expression ratio in osteoblastic cells.
송진옥(Jin-Ohk Song),조근호(Keun-Ho Joe),원승희(Seung-Hee Won),서정석(Jeong-Seok Seo),문석우(Seok-Woo Moon),김소연(So-Youn Kim) 대한생물치료정신의학회 2006 생물치료정신의학 Vol.12 No.1
저자들은 본 연구를 통해 비정신과 의사들에서 벤조디아제핀의 처방 경향과 벤조디아제핀이라는 약물에 대한 인식 정도를 파악하고자 하였다. 이에 대구, 서울, 충주 소재 3개 대학병원에 근무하는 74명의 비정신과의사를 대상으로 설문조사를 시행하였고, 성별, 연령 혹은 계열(내과계, 외과계 및 기타 계열)에 따른 처방 현황 및 인식 정도를 비교 분석하였다. 연구 결과 비정신과의사들에게 벤조디아제핀이 광범위하게 처방되고 있으며, 각 과별로 다양한 질환에서 환자의 증상에 따라 정신과 약물이라는 특별한 장벽 없이 사용하고 있음을 확인하였다. 또한 현실적인 처방에 있어서는 적정 용량 이내에서 가능한 한 단기간 사용하고자 노력하고 있음도 확인하였다. 벤조디아제핀 장기 처방 영역에 있어서, 계열 별로 어느 정도 차이를 보이는데, 벤조디아제핀의 감량이나 중단을 위한 의사의 시도에 저항하는 환자의 비율에 대한 질문에 있어 내과계 의사는 환자의 36.6%에서, 외과계 의사는 환자의 40.3%에서 그러한 경향이 있다고 응답한 반면, 기타 과목 의사는 12.1%의 환자에서만 그러한 경향이 있다고 응답하였다(χ²=9.79, p=0.007). 또한, 외래 진료 중 벤조디아제핀을 장기 처방 받고 있는 환자를 우연히 발견하는 비율은, 내과계 의사는 진료 중 “벤조디아제핀 장기 복용 중인 사실을 알게 되는 환자의 비율이 내원 환자의 10% 이상에 달한다.”라고 응답한 의사가 8명에나 이른 반면, 외과계 의사나 기타 과목 의사는 각각 1명씩 밖에 없었다. 또한 기타 과목 의사는 “벤조디아제핀 장기 복용 중인 사실을 알게 되는 환자의 비율이 내원 환자의 0.1% 미만이다.” 혹은 “그런 환자가 전혀 없다”라고 응답한 사람이 전체의 63.6%인 7명에 해당하여 약 22%가 그렇게 대답한 내과 의사와는 의미 있는 차이를 보였다. 본 연구 결과, 벤조디아제핀의 처방 및 인식에 있어 연령 혹은 성별에 따른 차이는 없었으나, 약물 선호 경향 및 장기 처방에 관한 인식에 있어 계열 별로 몇몇 문항에서 차이를 보였다. 이는 벤조디아제핀을 장기간 처방함에 있어 의사의 인식 혹은 진료 중 벤조디아제핀의 복용력에 대한 의사의 보다 높은 수준의 주의가 필요하다는 의미일 수 있겠다. Objectives : Nowadays benzodiazepines were expended their usages into diverse area not only by the psychiatrists but also the non-psychiatric doctors. This study was performed to investigate the non-psychiatric doctors' attitude toward benzodiazepines when they prescribe. Methods : 74 doctors with various medical specialties except psychiatry working at one of the following general hospitals were recruited, Daegu catholic university medical center, Kunkuk university Cheung-ju hospital, and Chung-Ang university medical center. 11-item questionnaires were distributed and requested to fill-up, which were about benzodiazepine prescription. The answers were interpreted with χ² analysis. Results : Benzodiazepines were prescribed to manage diverse diseases by non-psychiatric doctors. Alprazolam is the most popular to physician, but diazepam to other doctors including surgeons and others. Symptoms for which benzodiazepines were prescribed showed no differences depending on their specialties. Most of the doctors intended to avoid the administration of benzodiazepine with higher dosages. 36.5% of non-psychiatrists maintained benzodiazepines until the symptoms disappear without considerations about the total administered durations of benzodiazepine. 17.6% of non-psychiatrists discontinue benzodiazepine within 3 months and only 13.5% of them discontinue benzodiazepine with 1 month. Non-psychiatrists reported approximately 33.4% of patients resisted when doctors intend to decrease the benzodiazepine dosage but 62.2% of doctors reported less than 10% of all patients demanded re-escalation of benzodiazepine dosage. Conclusion : Depending on the specialties, the detection rates of benzodiazepine long-term users are varied. It means more surveillance needed to prevent long-term benzodiazepine use.
Nucleotide Sequence of a Bacteriolytic Enzyme Gene from Alkalophilic Bacillus sp.
JUNG, MYEONG HO,OHK, SEUNG, HO,YUM, DO YOUNG,KONG, IN SOO,BAI, DONG HOON,YU, JU HYUN 한국미생물 · 생명공학회 1993 Journal of microbiology and biotechnology Vol.3 No.2
The nucleotide sequence of Bacillus sp. bacteriolytic enzyme gene, lytP and its flanking regions were determined. A unique open reading frame for a protein of Mw. 27,000, and a putative terminator sequence, were found behind a concensus ribosome binding site located 8 nt upstream from ATG start codon. The primary amino acid sequence deduced from nucleotide sequence revealed a putative protein of 255 amino acid residues with an Mw. of 27,420. No significant homology could be found between the amino acid sequence of Bacillus sp. bacteriolytic enzyme and that of other cell wall hydrolases.
The principles of artificial intelligence and its applications in dentistry
Yoohyun Lee,Seung-Ho Ohk 대한구강생물학회 2023 International Journal of Oral Biology Vol.48 No.4
Digital dentistry has witnessed significant advancements in recent years, driven by extensive research following the introduction of cutting-edge technologies such as CAD/CAM and 3D oral scanners. Until now, 2D images obtained via x-ray or CT scans were critical to detect anomalies and for decision-making. This review describes the main principles and applications of supervised, unsupervised, and reinforcement learning in medical applications. In this context, we present a diverse range of artificial intelligence networks with potential applications in dentistry, accompanied by existing results in the field.