주요우울증에 대한 Milnacipran의 효과 및 안정성 : Fluoxetine과의 비교

이민수,함병주,기백석,김정범,연병길,오강섭,오병훈,이철,정한용,지익성,최병무,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This 6-week, open label randomized, multicenter study was conducted to evaluate the antidepressant effect and safety of milnacipran and fluoxetine in patients with major depression. Methods : The study was done in patients with major depression diagnosed by DSM-IV who score ≥17 in 17 items Hamilton Rating Scale for Depression (17-item HAM-D) and score ≥25 in Montgomery and Asberg Depression Rating Scale (MADRS). A total of 87 patients were randomized to milnacipran group and fluoxetine group. In cases of the patients taking other antidepressants, 6 weeks of each medication was administered after 7 days of drug excretion period. The evaluation was done using 17 item HAM-D, MADRS, Clinical Global Impression Scale (CGI), and COVI scale after baseline, 1 week, 2 weeks, 4 weeks, and 6 weeks. The side effects that had occurred during the period of our study were put in records by developed/disappeared time, severities, incidences, managements and results. Results : A total of 87 patients were enrolled. 70 (mitnacipran group 39 ; fluoxetine group 31) of them were included for the 6 weeks of research and 17 of them dropped out with in the first week, not due to adverse reactions or deficiency of effects. Total 17 item HAM-D scores, total points of MADRS, and CGI showed significant decrease after 1 week in each treatment group and continued decrease after 2 weeks and 4, 6 weeks. But there was no difference between milnacipran group and fluoxetine group in the antidepressant effect. There were no significant changes in vital sign, CBC, chemistry, and EKG in each treatment group. The commonly reported side elfects of minlacipran were nausea (25.0%), headache (10.7%), vomiting (7.1%),constipation (7.1%), dizziness (7.1%) and those of fluoxetne were GI trouble (11.1%), diarrhea (11.1%), insomnia (11.1%),agitation (5.6%), and dizziness (5.6%). Conclusion : Milnacipran was effective for the improvement of depressive symptoms and was well tolerated and safe in patients with depression.

Comparison of efficacy and safety of milnacipran and fluoxetine in Korean patients with major depression

Lee, Min-Soo,Ham, Byung Joo,Kee, Baik Seok,Kim, Jung‐,Bum,Yeon, Byeong Kil,Oh, Kang‐,Seob,Oh, Byoung Hoon,Lee, Chul,Jung, Han Yong,Chee, Ik‐,Seung,Choe, Byeong Moo,Paik, In Ho Informa UK (Librapharm) 2005 Current medical research and opinion Vol.21 No.9

<P>OBJECT: To compare efficacy and safety of milnacipran and fluoxetine in a population of Korean patients with major depression. RESEARCH DESIGN AND METHODS: The design was a multi-centre, randomised, comparative clinical study. Patients with major depression (DSM-IV diagnostic criteria) scoring over 17 points on the 17-item Hamilton Depression Scale (HAM-D) and over 21 points on the Montgomery-Asberg Depression Rating Scale (MADRS) were recruited and randomised to receive milnacipran (50 mg/day increasing after 1 week to 100 mg/day) or fluoxetine (20 mg/day) for 6 weeks. All previous medication was stopped at least 7 days before entry into the study. Patients were evaluated (HAM-D, MADRS and clinical global impression scale, CGI) at baseline and after 1, 2, 4 and 6 weeks of treatment. All adverse events which developed during the study period were recorded. RESULTS: 70 patients (milnacipran 39; fluoxetine 31) were included in the study. Total score on both HAM-D, MADRS and CGI decreased significantly in both groups after 1 week and continued to decrease throughout the study. There was no significant difference between the two groups for any measurement at any time point. Both antidepressants were well tolerated. In the milnacipran group, 13 patients reported 28 adverse reactions, and in the fluoxetine group 11 patients reported 18 adverse reactions. Two patients discontinued due to adverse events in the milnacipran group and three in the fluoxetine group. There were no clinically significant modifications in vital signs, routine blood laboratory tests, biochemistry or ECG throughout the study. Nausea and headache were the most frequently reported adverse events with milnacipran while digestive disturbances, diarrhoea and insomnia were more common with fluoxetine. CONCLUSION: Milnacipran, like fluoxetine, was found to be effective and well tolerated for the treatment of major depression in this population of depressed Korean patients. Principal limitations of the study were its open design, its small sample size and its relatively short duration.</P>

Multibody dynamic analysis of a heavy load suspended by a floating crane with constraint-based wire rope

Ham, Seung-Ho,Roh, Myung-Il,Lee, Hyewon,Ha, Sol Elsevier 2015 Ocean engineering Vol.109 No.-

<P><B>Abstract</B></P> <P>In this study, we derived a Discrete Euler–Lagrange (DEL) equation to represent the motion of a multibody system, in which many bodies are connected physically by joints or wire ropes. By discretizing and re-formulating the traditional Euler–Lagrange equation, we obtained a discrete time integrator, called the Stömer–Verlet method. Similarly, we discretized the equations of constraints of joints and wire ropes by the midpoint rule. Then, we adapted regularization and stabilization methods, to overcome numerical instability and the stiffness problem.</P> <P>The DEL equation can be formulated automatically, by defining the equations of joint constraints and their derivatives. In addition, the stretching of the wire rope is mathematically modeled as constraints for stability. To apply the DEL equation to a floating vessel, hydrostatic and hydrodynamic forces are considered as external forces.</P> <P>We applied the DEL equation to a mass–spring system with the large spring coefficient. And we tested a spring pendulum modeled by a constraint-based wire rope. Despite the large spring coefficient, the DEL equation with the constraint-based wire rope shows relatively stable motion. We tested the automatic formulation by three-dimensional multiple pendulums. Finally, we simulated a floating crane and a heavy load connected by constraint-based wire rope, based on set of regular waves with different wave heights, directions and periods.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The regularized Discrete Euler-Lagrange (DEL) equation with constraints is derived. </LI> <LI> The stretching of a wire rope is mathematically modeled as constraints. </LI> <LI> We apply the DEL equation to several test cases to compare the stability and performance. </LI> <LI> We simulate a floating crane operating a heavy load connected by a constraint-based wire rope based on set of regular waves. </LI> </UL> </P>

Numerical analysis of wreck removal based on multibody system dynamics

Ham, Seung-Ho,Roh, Myung-Il,Kim, Ju-Sung Springer-Verlag 2018 Journal of marine science and technology Vol.23 No.3

Dynamic Effect of a Flexible Riser in a Fully Connected Semisubmersible Drilling Rig Using the Absolute Nodal Coordinate Formulation

Ham, Seung-Ho,Roh, Myung-Il,Hong, Jeong-Woo ASME International 2017 Journal of offshore mechanics and Arctic engineeri Vol.139 No.5

Integrated method of analysis, visualization, and hardware for ship motion simulation

Ham, Seung-Ho,Roh, Myung-Il,Zhao, Luman Society for Computational Design and Engineering 2018 Journal of computational design and engineering Vol.5 No.3

Traditionally, graphs were the only way to show the results of ship motion analyses. They did not usually impose any feeling about how fast the ship could move or how large the positions of the ship changed. Currently, integrated simulations combining physics-based analyses with IT technologies, such as virtual reality (VR), motion platforms, or other hardware, can offer a potential solution. In ship motion analyses, the dynamic ship response can be obtained by considering the environmental loads, such as ocean waves, and VR technology can be used to visualize the analysis results in the virtual world. We can see the ship motion relative to textures of real objects, including the water and sky, as if in the real world. The results calculated from the ship motion analysis can also be transferred to the motion platform to generate realistic movements. However, it is not easy to integrate three different technologies in one system because they have different purposes and have been developed individually. To solve this problem, an integrated simulation framework based on three different technologies is proposed. The proposed framework can be used to synchronize the simulation time and exchange the data through the middleware using a standardized data structure. Furthermore, we can easily add new components or remove the existing components in the simulation. To verify the efficiency and applicability of the proposed framework, the motion simulation of a drillship is applied.

Integrated method of analysis, visualization, and hardware for ship motion simulation

Seung-Ho Ham,Myung-Il Roh,Luman Zhao 한국CDE학회 2018 Journal of computational design and engineering Vol.5 No.3

Traditionally, graphs were the only way to show the results of ship motion analyses. They did not usually impose any feeling about how fast the ship could move or how large the positions of the ship changed. Currently, integrated simulations combining physics-based analyses with IT technologies, such as virtual reality (VR), motion platforms, or other hardware, can offer a potential solution. In ship motion analyses, the dynamic ship response can be obtained by considering the environmental loads, such as ocean waves, and VR technology can be used to visualize the analysis results in the virtual world. We can see the ship motion relative to textures of real objects, including the water and sky, as if in the real world. The results calculated from the ship motion analysis can also be transferred to the motion platform to generate real-istic movements. However, it is not easy to integrate three different technologies in one system because they have different purposes and have been developed individually. To solve this problem, an integrated simulation framework based on three different technologies is proposed. The proposed framework can be used to synchronize the simulation time and exchange the data through the middleware using a stan-dardized data structure. Furthermore, we can easily add new components or remove the existing compo-nents in the simulation. To verify the efficiency and applicability of the proposed framework, the motion simulation of a drillship is applied.

Dynamic analysis of block offloading using self-propelled modular transporters

Ham, Seung-Ho,Roh, Myung-Il Elsevier 2018 AUTOMATION IN CONSTRUCTION - Vol.96 No.-

<P><B>Abstract</B></P> <P>A self-propelled modular transporter (SPMT) is a platform vehicle with a large array of wheels that is used for transporting outsized objects. In a shipyard, a number of connected SPMTs are used to move outsized blocks transported from abroad to the floating dock to increase the productivity and reduce the operation time. This operation is called offloading. This study proposes a method of analyzing the offloading operation dynamically. To develop this method, multibody dynamics was used to analyze the motion of the transportation barge, and a floating dock connected by hinge joints was adopted. The modeling of the mechanical parts of the SPMT was also proposed, taking into consideration the axle compensation mechanism to maintain the level of the platform when the SPMT drives over an uneven roadway by lifting up the wheel. Furthermore, a non-interpenetration constraint method between a plane and the cylinder was derived for the collision between the wheels of the SPMT and the decks of the transportation barge and floating dock. The non-interpenetration constraint method was successfully applied to the dynamic analysis of block offloading using SPMTs. From the dynamic analysis, the safety criteria according to the given wave conditions were evaluated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This study presents the method for analyzing dynamically offloading operation using SPMTs. </LI> <LI> The method includes the multibody formulation and axle compensation mechanism for the SPMT. </LI> <LI> Safety criteria are evaluated to check the feasibility of the operation under the given environmental conditions. </LI> <LI> This study could find safe environmental conditions for offloading operation using SPMTs. </LI> </UL> </P>

Development and validation of a simulation-based safety evaluation program for a mega floating crane

Ham, Seung-Ho,Roh, Myung-Il,Lee, Hyewon,Hong, Jin-Wuk,Lee, Hong-Rae Elsevier 2017 Advances in engineering software Vol.112 No.-

<P><B>Abstract</B></P> <P>The motions of the mega floating crane and the lifted module must be evaluated in advance, to determine whether they satisfy the safety criteria or not. Due to the limitations of the existing dynamic analysis programs, we develop a differentiated program that is dedicated to the mega floating crane. This program is focused on reducing modeling time, while increasing modeling accuracy. Furthermore, it can model the block loader that distributes the tension in wire ropes between the lifted module and the block loader equally, and link beams that are used to connect hooks by hinge joints. The equations of motion based on multibody system dynamics are derived. Wave, wind, and current are included as external environmental loads. A direct volume calculation method below the water plane is adopted to find the buoyant force and center of buoyancy. External loads are verified by commercial program. Finally, the simulation results of the module erection are validated by comparison with the measurement of real operation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We develop a differentiated program that is dedicated to a mega floating crane. </LI> <LI> The program executes dynamic analysis him- or herself. </LI> <LI> The program reduces modeling time and effort. </LI> <LI> The program supports mechanical equipment for more accuracy. </LI> <LI> Simulation results are validated by comparison with the measurement of real operation. </LI> </UL> </P>

가속열화시험 데이터를 활용한 엘리베이터 와이어로프 수명 예측

김승호(Seung Ho Kim),김상부(Sang Boo Kim),김성호(Sung Ho Kim),함승훈(Sung Hoon Ham) 대한기계학회 2017 大韓機械學會論文集A Vol.41 No.10

엘리베이터 와이어로프의 수명은 제품의 매우 중요한 특성 가운데 하나로서 사용자의 안전 및 장비의 정비 정책과 밀접한 관계가 있다. 엘리베이터 와이어로프의 수명을 사용조건에서 측정하는 것은 매우 비경제적이다. 이 연구에서는 엘리베이터 와이어로프 (8x19W-IWRC)의 가속열화시험 데이터를 활용하여 와이어로프의 수명을 추정하는 방법을 다루었다. 굽힘피로시험기를 이용하여 가속열화시험을 진행하였으며 가속변수로는 인장하중을 사용하였다. 와이어로프의 수명은 대수정규분포를 가정하였고, 선형회귀모형을 이용하여 가수명을 구한 후 가속수명모형을 이용하여 와이어로프의 수명을 추정하는 방법과 고장 확률에 대한 로지스틱 회귀모형을 이용하여 추정하는 방법을 제시하고 두 모형의 수명 추정결과를 비교하였다. The life of elevator wire ropes is one of the most important characteristics of an elevator, which is closely related to the safety of users and its maintenance policy. It is not cost effective to measure the lifetime of elevator wire ropes during their use. In this study, the life estimation of elevator wire ropes (8x19W-IWRC) is considered using accelerated degradation test data. A bending fatigue tester is used to perform the accelerated degradation tests, incorporating the acceleration factor of tensile force. Assuming that the life of wire ropes is log-normally distributed, two life estimation methods are suggested and their results are compared. The first method estimates the life of wire ropes utilizing the accelerated life model with pseudo lives obtained from a linear regression model. The second method estimates the life using a logistic model based on failure probability.