Wavelet Transform을 이용한 시청각 학습시의 전두부 뇌파 활성도에 관한 연구

이준탁,정소라,백승일 동아대학교 정보기술연구소 2006 情報技術硏究所論文誌 Vol.14 No.1

Real-time estimating brain waves is useful method in studies like brain activity state. And the frontal-lobe of cerebrum is important behavior for something new which intention response and consideration activities. In this paper, analyze the frontal-lobe Waves of cerebrum using wavelet, Furier transform during 5 times repeated new visual education teaching to middle school student. Many researches be attempted to find relation in concentration and emotion with the specify brain waves. There are three waves called α,β,θ waves generated by brain and it's related memory factor and continuous concentration in reseaches. a-wave, one of the three waves generated by brain which is identified that participating in motivate brain activities like attention and memory sequences. So analyze pattern and activity of a-signal in EEG-signals which changing in study sequence of student using wavelet transform for high analysis efficiency in signal processing in this paper.

Hot Wall Epitaxy(HWE)에 의한 CdGa₂Se₄/GaAs epilayer 성장과 광전기적 특성

백승남,홍광준 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.1

The stochiometric mix of evaporating materials for the CdGa₂Se₄single crystal thin films was prepared from horizontal furnace. To obtain the single crystal thin films, CdGa₂Se₄mixed crystal was deposited on thoroughly etched semi-insulating GaAs(100) substrate by the Hot Wall Epitaxy (HWE) system. The source and substrate temperature were 630℃ and 420℃, respectively. The crystalline structure of single crystal thin films was investigated by the photoluminescence and double crystal X-ray diffraction (DCXD). The carrier density and mobility of CdGa₂Se₄single crystal thin films measured from Hall effect by van der Pauw method are 8.27×10^(17) ㎤, 345 ㎠/V ·s at 293 K, respectively. From the photocurrent spectrum by illumination of perpendicular light on the c-axis of the CuInSe₂ single crystal thin film. We have found that the values of spin orbit splitting △So and the crystal field splitting △Cr were 106.5 meV and 418.9 meV at 10 K, respectively. From the photoluminescence measurement on CdGa₂Se₄single crystal thin film, we observed free excition (Ex) existing only high quality crystal and neutral bound exicition (D^(0) ,X) having very stron peak intensity. Then, the full-width-at-half-maximum(FWHM) and binding energy of neutral donor bound excition were 8 meV and 13.7 meV, respectivity. By Haynes rule, an activation energy of impurity was 137 meV.

위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

Rat의 복강에 삽입한 Fluorouracil-Polyglycolic acid 제형의 Fluorouracil 용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitoneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adcnocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구

노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.

甘草의 有效性分 含量에 關한 硏究

韓宗鉉,白承和,康成溶,宋昊埈 한국전통의학연구소 1997 한국전통의학지 Vol.7 No.2

시중에 유통되고 있는 4종류의 감초(특감초,원감초,일호감초,이호감초)에 대하여 유효약리성분 glycyrrhizin, 18α-glycyrrhetinic acid 및 glycyrrhizic ammonium salt의 함량을 대한약전의 규격기준에 준하여 검토한 결과는 다음과 같았다. 1. 감초의 수분함량은 7.00-10.16%범위 였다. 2. 감초의 회분 및 산불용성 회분 함량은 3.03-4.09%, 0.02-0.11 % 범위 였다. 3. 감초 품질의 지표성분인 glycyrrhizin,18α-glycyrrhetinic acid 및 glycyrrhizic ammonium sait 을 TLC로 각각 Rt값 0.399,0.932,0.394 위치에서 암자색의 반점을 확인할 수 있었는데 특 감초,원 감초,1호 감초,2호 감초 모두 같은 위치에서 뚜렷한 암자색 반점을 확인할 수 있었고,확인되지 않은 3종 화합 물의 Rt 값은 0.28,0.66,0.78 였다. 4. 감초품질의 지표성분인 glycyrrhizin,18 α-glycyrrhetinic acid 및 glycyrrhizic ammonium salt을 HPLC로 정량한 결과 glycyrrhizin은 4종류 감초에서 분석되어 2.93-4.48g% 범위였고, 18 α-glycyrrhetinic acid는 특감초 및 일호감초에서만 13.64,3.52 g% 함유되었다. 그러나 glycyrrhizic ammonium salt 분석되지 않았다. 5. 문헌상에 기록된 감초의 종류는 16종이었고 이들에서 분리된 화학물질은 약 170여 가지였다. This study was carried out to investigate the content of glycyrrhizin, 18 α-glycyrrhetinic acid, glycyrrhizic ammonium salt, moisture, ash, residue ash in four kinds(teuk-gamcho, won-gamcho, IIho-gamcho, Eho-gamcho) in Glycyrrhizae Radix(Glycyrrhiza sp.) used in Korea. The result were as follows ; The moisture content in four kinds of gamcho was ranged from 7.00-10.16%. The ash and ash of acid residue in all gamcho types ranged from 3.03-4.09% and from 0.02-0.11 %, respectivly. The glycyrrhizin, 18 α-glycyrrhetinic acid, glycyrrhizic ammonium salt in Teuk-gamcho, Won-gamcho, IIhogamcho, Eho-gamcho verified from line of dark purplue color by TLC and Rf value of glycyrrhizin, 18 α-glycyrrhetinic acid, glycyrrhizic ammonium salt were 0.399, 0.932, O. 394, respectivly, and the Rf value unknown compoud were 0.28, 0.66, 0.78. The glycyrrhizin, 18 α-glycyrrhetinic acid, glycyrrhizic ammonium salt content of all gamcho by HPLC were ranged from 2.93-4.48g%, 3.52-13.64g%, and trace, respectively. The 16 kinds of Glycyrrhiza (Licorice) were dassified, and that the identification about 170 chemicals were phamacology action substrate by reported references.

수술-교정 치료 환자의 통제 소재

이신재,안석준,백승학,김태우,장영일,양원식,서정훈,남동석 대한치과교정학회 2002 대한치과교정학회지 Vol.32 No.4

교정치료와 악교정 수술을 필요로 하는 환자가 점증하는 현 시점에 비추어, 이에 대한 기술적인 측면의 발전과는 달리 수술-교정 치료 환자에 대한 정신사회학적 혹은 정신심리적 양상에 대한 객관적인 정보는 그리 많은 주목을 받는 편이 아니었다. 수술-교정치료는 과학적인 치료과정이긴 하지만, 어느 정도 심미적 혹은 예술적인 측면을 지니는 선택 치료의 면모를 지닌다. 그러므로 치료에 대한 환자의 주관적인 느낌은 치료 기술이나 치료의 의학적 성공 여부보다 더 큰 영향을 미칠 수 있다. 그러므로, 수술-교정 (혹은 교정) 치료에 대한 환자의 반응을 예측하기 위한 정신심리적인 정보는 치료에 유용한 지표가 될 수 있다고 가정할 수 있다. 통제 소재에 대한 연구는 인간의 다양한 행동을 예측하기 위한 유용한 지표로 알려져 왔는데, 본 연구에서는 42명의 수술-교정치료 환자와 성별/연령별로 표본 추출된 42명의 통상적 교정치료 환자를 대상으로 삼아 정신=심리적 비교 및 분석의 방법으로 두 가지 종류의 내외 통제 소재(internal/external locus of control) 검사를 시행하였다. 그 결과 수술-교정치료군에서만 남자가 여자에 비하여 낮은 외적 통제(높은 내적 통제)의 경향을 보였다. 결론적으로 수술-교정치료 환자의 정신심리적 기반은 성형 수술 환자와는 달리 교정치료 환자와 유사한 경향을 지닌 것으로 생각되었다. Surgical-orthodontic treatment is an increasingly more common dental procedure whose unique psycho-social or psychological feature has not been fairly quantified objectively. Since the treatment of a surgical-orthodontic (or orthodontic) patient is part science and part art, a subjective recognition of a patient about his or her own treatment may be more important than technical success during and after treatment. Therefore, the knowledge of the patient''s underlying psychological status could be useful in the prediction of patient's response to surgical-orthodontic (or orthodontic) treatment. The purpose of this study was to investigate and evaluate the psychological difference between conventional orthodontic patient and surgical-orthodontic patient by using locus of control (LOC) examination. Locus of control scale has been proven to be extremely useful in the prediction of a variety of human behaviors. Two types of locus of control data (I-score, Internal locus of control score ; E-score, External locus of control score) were obtained for 42 surgical-orthodontic patients and randomly selected 42 conventional orthodontic patients (as a control group) matched for age and gender. No statistically significant difference was observed in the scale of internal and external locus of control between the groups of surgical-orthodontic patients, males showed lower E-score (external locus of control score, higher internal locus of control tendency) than females. The results of this study suggested that the psychological background of surgical-orthodontic patients, in contrast with that of cosmetic surgery patients, has a similar disposition with that of orthodontic patients.

생체분해성 안과제형의 안구내흡수정도와 안독성

민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.

Ⅲ급 부정교합의 수술-교정 치료시 상악 소구치 발치가 치열궁 폭경 변화에 미치는 영향

이신재,홍성준,김영호,백승학,서정훈 대한치과교정학회 2005 대한치과교정학회지 Vol.35 No.1

본 연구에서는 Ⅲ급 수술-교정 치료 방법에 영향을 미치는 치열 상의 요소를 파악함으로써 술전 교정시 상악 소구치 발치와 비치의 판단에 필요한 임상적 정보를 얻고자 골격성 Ⅲ급 부정교합 환자의 수술-교정 치료시 흔히 선택되는 상악 제1소구치 발치로 치료된 군과 비발치로 치료된 군 간의 치료전/후 상/하악 개별 치아 이동 양상과 치열궁 폭경의 변화 양상을 비교 분석하였다. 이를 위하여 비발치로 Ⅲ급 수술-교정 치료를 마친 환자 (24명) 와 술전교정 치료시 상악 제1소구치가 발치된 환자 (31명) 의 치료 전/후 모형 상에서 개개 치아의 근원심/협설측 각도변화와 상/하 치열궁 폭경의 변화를 측정한 후, 두 군 사이의 교정적 치아 이동 양상을 비교 분석한 후 상/하 치열궁의 조화를 이루는데 필요한 치열궁 폭경의 변화와 이에 기여하는 치아 변위와의 관계를 분석하기 위하여 상관 분석과 회귀 분석을 시행한 결과 발치 군은 비발치 군에 비하여 상악 치열궁 폭경의 감소가 컸으며, 이는 상악 구치의 inclination 감소에 크게 영향 받은 것으로 관찰되었다. 하악 치열에서는 inclination의 증가와 폭경의 증가가 있었으나, 비발치/발치군간의 차이는 유의하지 않았다. 본 연구의 결과 결론적으로 Ⅲ급 수술-교정 치료시 술전 상악소구치 발치는 상악 구치부 치열궁 폭경의 감소에 크게 영향을 미치므로, 상악 소구치 발치에 대한 판단은 상/하악 치열궁의 폭경 및 구치부 경사도 문제와 연계하여 고려해야 할 사항으로 생각되었다. Collective changes caused by orthodontic tooth movement evaluated in a specific treatment modality could give suggestive information on the specific treatment strategy. The aim of this study was to investigate retrospectively the characteristics of the orthodontic tooth movement during surgical-orthodontic treatment in order to provide an effective presurgical orthodontic treatment planning for the maxillary premolar extraction modality in the skeletal Class Ⅲ malocclusion patient. Pre- and post-treatment dental casts of skeletal Class Ⅲ malocclusion patients with nonextraction (N=24) and the maxillary premolar extraction (N=31) were collected. The angulation and inclination measuring gauge (Invisitech Co. Seoul, Korea) was used to evaluate the orthodontic tooth movement. The changes in the maxillary and mandibular dental arch widths were also measured from the canines to the second molars. As a result, more palatal Inclination change in the maxillary dentition was found with the premolar extraction modality than with the nonextraction modality. Linear regression analysis showed that the inter-arch width coordination was mainly due to the inclination changes of maxillary posterior teeth. We conclude that the indications and proper treatment planning for surgical-orthodontic treatment in skeletal Class Ⅲ malocclusion with maxillary premolar extraction could depend partly on the magnitude of the transverse inter-arch coordination especially in the maxillary dentition.

자일리톨과 불화나트륨을 함유한 저작성 정제가 교정환자의 구강위생에 미치는 영향에 관한 임상시험

유상훈,안석준,이신재,백승학,김태우,장영일,남동석 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.2

본 연구는 불화나트륨과 자일리톨 성분으로 구성된 구강 청정용 저작성 정제(덴포정, 하미즐, 부천, 경기)가 교정치료 중인 환자의 구강위생 상태에 미치는 영향을 알아보기 위해 시행되었다. 교정치료 중인 18세 이상의 성인 환자 30명을 대상으로 약제 상요 전, 2주 후, 4주 후에 피험자의 상악과 하악 전치 부위 및 구치 부위에서 각각 치은 지수, 치은 출혈 지수, 치태 지수를 측정하여 다음과 같은 결과를 얻었다. 1. 상하악 전치부와 구치부 모두에서 치태 지수가 약제 사용 전에 비해 사용 2주 후와 4주 후 유의성 있게 감소하였다(p<0.05). 또한, 적용 2주 후와 4주 후의 지수를 비교하였을 때 4주 후에 좀 더 개선된 경향을 보였으나, 통계적 유의성은 나타나지 않았다(p<0.05). 2. 치은 지수, 치은 출혈 지수도 상하악 전치부와 구치부 모두에서 적용 전에 비하여 2주 후와 4주 후 유의성 있게 감소하였다(p<0.05). 적용 2주 후와 4주 후의 지수의 비교 검증에서 통계학적으로 유의할 만한 차이가 보이지 않아 구강위생 상태의 개선이 계속 유지됨을 보였다. 본 연구의 결과는 치태 지수, 치은 지수, 치은 출혈 지수가 실험 정제 적용 후에 감소하여 구강위생 상태가 개선되었음을 보였다. 이러한 결과를 통해 덴포정을 교정치료 중인 환자에서 부가적으로 사용하였을 경우 치주조직의 건강을 증진시키는데 도움을 줄 수 있으리라고 생각된다. The aim of this study was to evaluate the effect a chewable tablet containing sodium fluoride and xylitol (DenPo, Hamizzle, Bucheon, Kyungki) on the oral hygiene state in the orthodontic patients. The subjects consisted of 30 adult orthodontic patients, who have worn the fixed orthodontic appliance at least 6 months. They were instructed to use the tablet forth a day. Gingival index (GI), plaque index (PI), and sulcus bleeding index (SBI) of upper and lower anterior and posterior regions were measured before using the tablet (TO), 2 weeks after using the tablet (T1), and 4 weeks after using the tablet (T2). The data were analyzed with Wilcoxon signed ranks tests. The results were as follows ; 1. PI was decreased significantly in the T1 and T2 stage compared with TO stage in the both anterior and posterior regions (p<0.05). Although PI was decreased in the T2 stage compared with T1, there was not statistical significance(p>0.05). 2. GI and SBI showed similar results compared with PL. In the T1 and T2 stage, there was statistically significant decrease in the GI and SBI (p<0.05). This study showed that the DenPo tablet could be used as an adjunct to improve oral hygiene in the orthodontic patients. The decrease of the indices may suggest that DenPo tablet could be effective in the plaque removal and prevention of gingival inflammation in the orthodontic patients.