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The rs196952262 Polymorphism of the AGPAT5 Gene is Associated with Meat Quality in Berkshire Pigs
Woo Bum Park,Sang Mi An,Go Eun Yu,Seulgi Kwon,Jung Hye Hwang,Da Hye Park,Deok Gyeong Kang,Tae Wan Kim. Hwa Chun Park1. Jeongim Ha*.,Chul Wook Kim* 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.6
High-quality meat is of great economic importance to the pig industry. The 1-acylglycerol-3- phosphate-O-acyltransferase 5 (AGPAT5) enzyme converts lysophosphatidic acid to phosphatidic acid in the mitochondrial membrane. In this study, we found that the porcine AGPAT5 gene was highly expressed in muscle tissue, influencing meat characteristics, and we also identified a non-synonymous single-nucleotide polymorphism (nsSNP) (rs196952262, c.673 A>G) in the gene, associated with a change of isoleucine 225 to valine. The presence of this nsSNP was significantly associated with meat color (lightness), lower cooking loss, and lower carcass temperatures 1, 4, and 12 h after slaughter (items T1, T4, and T12 on the recognized quality scale, respectively), and tended to increase backfat thickness and the waterholding capacity. These results suggest that nsSNP (c.673A>G) of the AGPAT5 gene is a potential genetic marker of high meat quality in pigs.
Park, Seung Ju,Lee, Seulgi,Park, Seung Eun,Kim, Seyun The Korean Society for Integrative Biology 2018 Animal cells and systems Vol.22 No.1
Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate ($5-IP_7$) are inositol metabolites with high-energy phosphoanhydride bonds. The formation of PP-IPs is catalyzed by two groups of enzymes, the IP6 kinases and the PPIP5 kinases, which both phosphorylate inositol hexakisphosphate ($IP_6$). In mammals, PP-IPs are implicated in diverse biological phenomena including cellular growth, vesicular trafficking, apoptosis, and metabolic homeostasis. Mechanistically, all the diverse actions of PP-IPs proceed in one of two ways: the PP-IPs modulate the activity of their target proteins either through allosteric binding or protein pyrophosphorylation. In this review, we highlight recent advances in our understanding of the pleiotropic functions of the mammalian PP-IPs and the metabolic enzymes that produce them. We also discuss some future challenges in the exploration of areas where PP-IPs play important but unknown roles in physiology and disease.
Inositol polyphosphate multikinase mediates extinction of fear memory
Park, Jina,Longo, Francesco,Park, Seung Ju,Lee, Seulgi,Bae, Mihyun,Tyagi, Richa,Han, Jin-Hee,Kim, Seyun,Santini, Emanuela,Klann, Eric,Snyder, Solomon H. National Academy of Sciences 2019 Proceedings of the National Academy of Sciences Vol.116 No.7
<P><B>Significance</B></P><P>Inositol polyphosphate multikinase (IPMK) is a pleiotropic enzyme for the biosynthesis of inositol polyphosphates and phosphatidylinositol 3,4,5-trisphosphate, but the neural function of IPMK has remained largely elusive. By conditionally deleting IPMK from the excitatory neurons of the postnatal forebrain in mice, we found that IPMK knockout mice exhibited normal cued fear conditioning but showed enhanced fear extinction accompanied by selective activation of p85 S6 kinase 1 in the IPMK-null amygdala following fear extinction. Electrophysiological recording analyses further uncovered facilitated hippocampal long-term potentiation from IPMK knockout mice. Thus, our data propose IPMK as a molecular player in the control of fear extinction.</P><P>Inositol polyphosphate multikinase (IPMK), the key enzyme for the biosynthesis of higher inositol polyphosphates and phosphatidylinositol 3,4,5<I>-</I>trisphosphate, also acts as a versatile signaling player in regulating tissue growth and metabolism. To elucidate neurobehavioral functions of IPMK, we generated mice in which IPMK was deleted from the excitatory neurons of the postnatal forebrain. These mice showed no deficits in either novel object recognition or spatial memory. IPMK conditional knockout mice formed cued fear memory normally but displayed enhanced fear extinction. Signaling analyses revealed dysregulated expression of neural genes accompanied by selective activation of the mechanistic target of rapamycin (mTOR) regulatory enzyme p85 S6 kinase 1 (S6K1) in the amygdala following fear extinction. The IPMK mutants also manifested facilitated hippocampal long-term potentiation. These findings establish a signaling action of IPMK that mediates fear extinction.</P>
대학생의 사회적으로 부과된 완벽주의가 학교생활적응에 미치는 영향
박슬기(Park Seulgi),신선임(Shin Sunim) 학습자중심교과교육학회 2018 학습자중심교과교육연구 Vol.18 No.16
본 연구는 대학생의 사회적으로 부과된 완벽주의와 학교적응 간의 관계에서 외로움이 매개역할을 하는지 검증하는데 그 목적이 있다. 이를 위하여 서울, 인천, 부산 지역 대학생 334명의 자료를 분석하였고 Sobel test를 통해 매개효과의 통계적 유의성을 검증하였다. 연구의 결과는 다음과 같다. 첫째, 사회부과적 완벽주의는 대학생활적응과는 유의미한 부적상관을, 외로움과는 유의미한 정적상관을 보였다. 둘째, 외로움은 사회부과적 완벽주의와 대학생활적응 간의 관계를 부분매개하는 것으로 나타났다. 이를 통해 사회부과적 완벽주의 성향이 학교적응에 직접적으로 영향을 미칠 뿐만 아니라, 외로움을 통해 학교적응에 영향을 줌을 알 수 있었다. 이러한 연구결과를 바탕으로 사회부과적 완벽주의 성향이 높은 대학생들의 학교생활적응을 돕기 위해 외로움의 정서를 공감하고 소속감을 높일 수 있는 상담 및 교육프로그램의 필요성에 대해 논의 하였다. The purpose of this study was to examine the meditating effect of loneliness on the relationship between socially prescribed perfectionism and college adjustment. The surveys were conducted on undergraduate students. 334 college students in Seoul, Incheon, and Busan were analyzed. For the statistical significance of the meditating effect, Sobel test was conducted. The results were as follows: Socially prescribed perfectionism was significantly negatively related with college adjustment and significantly positively related with loneliness. The main result was that loneliness partially mediated the relationship between socially prescribed perfectionism and college adjustment. This result means that socially prescribed perfectionism effects directly on college adjustment and socially prescribed perfectionism effects on college adjustment through loneliness. Implications and limitation of this study were discussed.
괭생이모자반 추출물의 기능성 원료 표준화를 위한 Fucose 분석법 개발 및 검증
박슬기(Seulgi Park),양형기(Hyungki Yang),김영경(Young Kyoung Kim),장내인(Nae In Chang),엄애선(Ae-Son Om) 한국식품영양과학회 2023 한국식품영양과학회지 Vol.52 No.12
This study developed and validated a high-performance liquid chromatography (HPLC) analysis method for the quantification of fucose in Sargassum horneri extracts. HPLC was performed using a YMC-Pack ODS-AQ column (250 ㎜×4.6 ㎜, 5 ㎛) with a flow rate of 1.0 mL/min at 40℃, and detection was conducted at a wavelength of 250 ㎚. The validation of the method was assessed by evaluating specificity, accuracy, precision, limit of detection, limit of quantitation, and linearity. With respect to specificity, the retention time of the fucose standard solution matched that of the fucose in the Sargassum horneri extract. The linearity exhibited a correlation coefficient (R²) above 0.998. The accuracy assessment revealed a recovery rate ranging from 94.0±2.5% to 95.6±0.4% for different concentrations. The overall relative standard deviation (%RSD) for precision was 0.94%, indicating good repeatability, and the mean value over three days of analysis was 9.69±0.05 ㎎/g with a %RSD of 0.47%, demonstrating reproducibility. The limits of detection and quantitation were determined as 2.04 ㎍/mL and 6.19 ㎍/mL, respectively. Based on these results, the developed HPLC analysis method for fucose in Sargassum horneri extract could be considered reliable and reproducible.
Okmin Park,Seulgi Han,Sanghyun Park,Jamil Ur Rahman,Sang-il Kim,Sungmo Choi 대한금속·재료학회 2024 대한금속·재료학회지 Vol.62 No.1
Carbon fiber reinforced polymer (CFRP) has been extensively used in civil engineering forapplications such as reinforcing and retrofitting various architectural materials. Therefore, understanding thedegradation of CFRP under high temperatures is important. This study aims to investigate the thermomechanicaland microstructural properties of CFRP plates at elevated temperatures up to 350 oC. The platetypeCFRP composites were subjected to temperatures of 50, 100, 150, 200, 250, 300, and 350 oC, and thencompared with pristine CFRP samples. X-ray diffraction analysis was conducted to examine the crystalstructures of the carbon fibers and epoxy resin matrices in the CFRP. At temperatures higher than 150 oC,the FWHM increased due to the degradation and softening of the resin matrix. Delamination and debondingbetween the matrix and fibers were observed in samples exposed to temperatures above 200 oC. The maximumtensile strength of the CFRP plates exposed at 350 oC significantly decreased to 0.605 GPa, a reduction ofapproximately 40% compared to the pristine sample. On the other hand, Young's modulus remained relativelyunchanged across the different temperatures. This suggests that the polymer matrix degradation plays acrucial role in the mechanical properties of CFRP, as the matrix layers contribute significantly to thedistribution of forces.
Kwon, Seulgi,An, Sang Mi,Yu, Go Eun,Hwang, Jung Hye,Park, Da Hye,Kang, Deok Gyeong,Kim, Tae Wan,Park, Hwa Chun,Ha, Jeongim,Kim, Chul Wook,Plaizier, J. Canadian Science Publishing 2018 Canadian journal of animal science Vol.98 No.4
<P> Litter size is an important trait in the pig industry. Therefore, a lot of effort has been put into improving this trait. DNA methylation is an essential epigenetic modification present in unique DNA sequences. Alterations in methylation can affect transcription and phenotypic variation. The purpose of this study was to investigate the effect of DNA methylation on litter size. Methylation-specific restriction enzymes are simple and useful tools for detecting DNA methylation status. We used a pair of methylation-sensitive isoschizomers, which have the same recognition site, HpaII and MspI. Insulin-like growth factor binding protein 4 (IGFBP4) is a key regulator of ovarian follicular development and fetal growth in eutherian mammals. In this study, we discovered that IGFBP4 was hyper-methylated in the uterus tissue of a larger litter size group using bisulfite sequencing, and validated the positive relationship between the methylation status of IGFBP4 and the total number born of pigs using the porcine methylation-specific restriction enzyme polymerase chain reaction (PMP) assay. We suggest that the IGFPB4 gene can be used as a prognostic biomarker for hyperprolific sows and that the PMP assay is a useful tool for methylation status screening. </P>