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Seoyoung Jang,Jungmin Woo 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.3
Long-acting injectable (LAI) antipsychotics are useful in the treatments for schizophrenic patients with poor adherence due to their maintaining feature of therapeutic plasma level without daily administrations. However, their long-lasting property can cause complicated problems such as a long-lasting side effect. We report a patient who experienced LAI-induced extrapyramidal symptoms (EPSs) for 5 months after a single injection. During that period, every trial to ameliorate this condition turned out to be a failure. The 3-month formulation of paliperidone palmitate is now close at hand. We have to be aware of possible long-lasting adverse events and confirm the tolerability to LAI before use.
장서영(Seoyoung Jang),임효덕(Hyo-Deog Rim),김경민(Kyungmin Kim),김병수(Byung-Soo Kim),우정민(Jungmin Woo) 대한생물치료정신의학회 2020 생물치료정신의학 Vol.26 No.3
Following the development of human immunodeficiency virus (HIV) treatments, the mean lifespan of patients with an HIV infection has increased to a level comparable to the general population. Patients receiving HIV treatment can achieve viral suppression and perform routine activities without the risk of infection transmission. Recently, the quality of life (QoL) and mental health of patients are becoming the primary outcomes in HIV treatment. The objective of this review was to investigate psychiatric disorders in patients with an HIV infection and available treatment programs. A search for clinical studies and scientific publications was performed. Patients with an HIV infection had a higher prevalence of psychiatric disorders than the general population. The psychopathological factors in HIV infection included neurobiological changes of infection, side-effects of medications, negative social perception, and unresolved intrapsychic conflicts. Severe and unmanaged psychiatric disorders with HIV infection negatively impacted HIV infection transmission and treatment adherence. However, psychiatric treatment programs and referrals to a psychiatric professional were found to be insufficient in most countries. This review revealed a need for psychiatric interventions in clinical practice to improve patients’ mental health and HIV treatment adherence. Psychiatric interventions integrated with conventional HIV treatment can be efficacious to achieve this goal. In addition, clinicians need to investigate and recognize HIV-related stigma as the relationship between patients and clinicians has a significant role in the patient’s treatment adherence.
코티졸, Dehydroepiandrosterone Sulphate와 우울증상 심각도와의 상관성
장서영(Seoyoung Jang),서민수(Min-Soo Seo),우정민(Jungmin Woo) 대한생물치료정신의학회 2016 생물치료정신의학 Vol.22 No.2
Objectives:Cortisol and dehydroepiandrosterone sulfate(DHEAS) are neuroactive steroids related mood disorder as well as stress response. The purposes of this study are to examine the correlations between cortisol, DHEAS and severity of depressive symptoms and to evaluate the possibility of cortisol and DHEAS as biomarkers for depression. Methods:A total of 60 participants who had no history of psychiatric disease were recruited. We assessed the severity of depressive symptoms using the Beck Depression Inventory(BDI) and the Hamilton Depression Rating Scale(HAMD). The blood samples were collected between 12 PM to 14 PM. We applied an ELISA to measure the level of cortisol and DHEAS. Results:The depressive group showed higher cortisol level(Base on BDI : 13.64±7.91 ug/dL, p<0.001 ; Base on HAMD: 14.14±8.34 ug/dL, p<0.001). Cortisol level showed positive correlation with the severity of depressive symptoms based on BDI (r=0.572 ; p<0.01) and HAMD(r=0.638 ; p<0.01). DHEAS level significantly correlated with BDI score (r=0.398 ; p<0.01) but not with HAMD score. Conclusion:These findings suggest that cortisol and DHEAS may have a role as biomarkers for evaluating depression. DHEAS was associated with only one side of two scales. This may suggest the level of steroid hormone is different depending on specific depressive symptoms.
Poultry Industry Trends and Consumer Analysis in Korea: Native Korean Chicken and Processed Chicken
Seoyoung Park,Nayeong Kim,Yunjeong Jang,Dongmin Lee,Junghoon Moon 한국농식품정보과학회 2019 Agribusiness and Information Management Vol.11 No.2
Poultry is one of the three major meats in Korea and is a representative source of protein. The annual per capita consumption of chicken has been showing steady growth trends, with an increase of approximately 89% in 2018 compared to that of 2005. In this study, we investigated the domestic chicken production and consumption, and conducted an overall study on the domestic chicken industry. By using consumer panel data, we analyzed the characteristics of consumers buying chicken. Specifically, poultry was categorized into two types: traditional raw chicken and processed chicken, which emphasizes convenience. The purchase of raw chickens has generally been on the decline. From these, however, the proportion of native Korean chicken and chicken cuts is on the rise. Processed chicken, on the other hand, continues to grow, especially online. After examining the consumption characteristics of consumers who buy chicken, it was found that the purchase share increased with increasing age of native Korean chickens, whereas the purchase share increased with decreasing age of processed chicken. Based on these results, we confirmed that it is necessary to establish differentiated marketing and promotion strategies for each consumer target for the growth of chicken market.
Jang, Hyowon,Lee, Chang Yeol,Lee, Seoyoung,Park, Ki Soo,Park, Hyun Gyu The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.8
<P>A new isothermal nucleic acid amplification method termed FERA (Flap endonuclease-initiated Enzymatic Repairing Amplification) is developed for the ultrasensitive detection of target nucleic acids. In the FERA method, flap endonuclease (FEN) catalyzes the hydrolytic cleavage at the junction of single- and double-stranded DNAs which is formed only in the presence of target nucleic acids, and releases short oligonucleotides to promote the cyclic enzymatic repairing amplification (ERA) combined with FEN-based amplification. As a result, a large amount of single- and double-stranded DNAs are generated under the isothermal conditions, leading to the high fluorescence intensity from the SYBR I green dye. Relying on the powerful amplification method, we successfully determined the target nucleic acids with a limit of detection as low as 15.16 aM, which corresponds to approximately 180 molecules in 20 μL reaction volume, and verified the practical applicability by detecting long target nucleic acids derived from <I>Chlamydia trachomatis</I>.</P>