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Stimulation of Cell Growth by Erythropoietin in RAW264.7 Cells: Association with AP-1 Activation
Seong Seu-Run,Lee Jae-Woong,Lee Yong-Kyoung,Kim Tae-Il,Son Dong-Ju,Moon Dong-Cheol,Yun Young-Won,Yoon Do-Young,Hong Jin-Tae The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.3
Erythropoietin (EPO), a hematopoietic factor, is required for normal erythrocyte developments, but it has been demonstrated to have many other functions, and its receptor is localized in other tissues. In the present study, we investigated whether EPO can promote other cell proliferation and possible molecular mechanisms. EPO restored the inhibition of the RAW264.7 and PC12 cell growth by fetal bovine serum (FBS) withdrawal in a dose dependent manner, but not that of other cell types tested. The restoring effect of EPO was completed when the RAW264.7 cells were cultured in the medium containing as low as 3% of FBS, and 10 U/mL EPO could replace FBS. The restoring effect of EPO in the RAW264.7 cells was associated with the increased of c-Fos and c-Jun expression as well as AP-1 activation. These data demonstrate that EPO can stimulate RAW264. 7 cell as well as PC12 cell growth even when the cells were cultured without FBS or in the presence of small amounts of FBS in the medium, and this stimulating effect is associated with the activation of AP-1 transcription factor.
Myeloid cell leukemia-1 promotes epithelial-mesenchymal transition of human gastric cancer cells
LEE, WAN-SIK,KIM, NURI,PARK, YOUNG-RAN,OH, HYUNG-HOON,MYUNG, EUN,KIM, SEUNG-HUN,YU, HYUNG-MIN,KIM, MI-YOUNG,OAK, CHAN-YOUNG,CHUNG, CHO-YUN,PARK, HYUNG-CHUL,MYUNG, DAE-SEONG,CHO, SUNG-BUM,JOO, YOUNG-EU Spandidos Publications 2015 ONCOLOGY REPORTS Vol.34 No.2
<P>Epithelial-mesenchymal transition (EMT) is a critical process that occurs during cancer progression, and cancer stem cells have been shown to acquire the EMT phenotype. Myeloid cell leukemia-1 (Mcl-1) has been implicated in cancer progression and is overexpressed in a variety of human cancers. However, the interaction between Mcl-1 and EMT in human gastric cancer (GC) is unclear. We investigated the impact of Mcl-1 expression levels on EMT and the underlying signaling pathways in human GC cells. We used the human GC cell lines, AGS and SNU638, and small interfering RNAs (siRNAs) to evaluate the effects of Mcl-1 knockdown on cell adhesion, migration and invasion. Expression of Mcl-1 and other target genes was determined using reverse transcription-polymerase chain reaction assays and western blotting. The results revealed that expression levels of Mcl-1 mRNA and protein in the AGS and SNU638 cells were reduced following transfection with Mcl-1 siRNAs. Knockdown of Mcl-1 led to increased cellular adhesion to fibronectin and collagen. Expression levels of vimentin, MMP-2, MMP-9 and Snail protein were decreased following knockdown of Mcl-1. However, expression of E-cadherin was increased in the AGS cells following knockdown of Mcl-1. The expression of cancer stemness markers, such as CD44 and CD133, was not altered by knockdown of Mcl-1. Knockdown of Mcl-1 suppressed tumor cell migration and invasion in both human GC cell lines. Signaling cascades, including the β-catenin, MEK1/2, ERK1/2 and p38 pathways, were significantly blocked by knockdown of Mcl-1. Our results indicate that Mcl-1 expression induces EMT via β-catenin, MEK1/2 and MAPK signaling pathways, which subsequently stimulates the invasive and migratory capacity of human GC cells.</P>
A Comprehensive In Vivo and In Vitro Assessment of the Drug Interaction Potential of Red Ginseng
Seong, Sook Jin,Kang, Woo Youl,Heo, Jae-Kyung,Jo, Jungjae,Choi, Won Gu,Liu, Kwang-Hyeon,Lee, Sangkyu,Choi, Min-Koo,Han, Yong-Hae,Lee, Hye Suk,Ohk, Boram,Lee, Hae Won,Song, Im-Sook,Yoon, Young-Ran Elsevier 2018 Clinical therapeutics Vol.40 No.8
<P><B>Abstract</B></P> <P> <B> Purpose:</B> Red ginseng is one of the world's most popular herbal medicines; it exhibits a wide range of pharmacologic activities and is often co-ingested with other herbal and conventional medicines. This open-label, randomized, 3-period study investigated the in vivo herb–drug interaction potential for red ginseng extract with cytochrome P-450 (CYP) enzymes and organic anion-transporting polypeptide (OATP) 1B1.</P> <P> <B>Methods:</B> Fifteen healthy male volunteers (22-28 years; 57.1-80.8 kg) were administered a single dose of cocktail probe substrates (caffeine 100 mg, losartan 50 mg, omeprazole 20 mg, dextromethorphan 30 mg, midazolam 2 mg, and pitavastatin 2 mg) and single or multiple doses of red ginseng extract for 15 days.</P> <P> <B>Findings:</B> The pharmacokinetic profiles of the probe substrates and metabolites after single- or multiple-dose administration of red ginseng extracts were comparable to the corresponding profiles of the control group. The geometric mean ratio of AUC<SUB>0–t</SUB> and 90% CIs for the probe substrate drugs between the control and multiple doses of red ginseng for 15 days were within 0.8 to 1.25 (CYP2C9, CYP3A4, and OATP1B1 probe substrates) or slightly higher (CYP1A2, CYP2C19, and CYP2D6 probe substrates). Additional assessments of the in vitro drug interaction potential of red ginseng extracts and the ginsenoside Rb1 on drug-metabolizing enzymes and transporters using human liver microsomes, cryopreserved human hepatocytes, and transporter-overexpressed cells were negative.</P> <P> <B>Implications:</B> Red ginseng poses minimal risks for clinically relevant CYP- or OATP-mediated drug interactions and is well tolerated. Clinical Research Information Service registry no.:</P>
Seong-Ran Lee 보안공학연구지원센터 2015 International Journal of Bio-Science and Bio-Techn Vol.7 No.6
The present study is to investigate the analysis of experiments on the information systems for the improving self-management after intracranial hemorrhage surgery. The subjects of this paper were 136 patients who had visited a general hospital located in Metropolitan area. The pairwise t-test was done to compare the before and after application effect of self-management after intracranial hemorrhage surgery. The results of this study are as follows. Firstly, in terms of respondents which have suffered from headache, subjects’ score(54.92±4.18) after application by information systems significantly decreased than subjects(73.92±3.26) before application(t=2.49, p=.000) Secondly, for self-management, the change of follow-up survey showed higher level in the experimental group than the control group, regardless of the time elapsed of 8 weeks after application by information systems as compared with previous status. Therefore, this paper showed that health improving behaviors using the information systems as measurement tools was a good way to enhance the practice rate of self-management in patients after intracranial hemorrhage surgery.
Lee, Hae Won,Lim, Mi-sun,Seong, Sook Jin,Lee, Joomi,Park, Jeonghyeon,Seo, Jeong Ju,Yun, Hwi-yeol,Baek, In-hwan,Kwon, Kwang-il,Yoon, Young-Ran Informa UK, Ltd. 2011 Expert opinion on drug metabolism & toxicology Vol.7 No.12
<P><B><I>Objectives:</I></B> An enteric-coated formulation of triflusal (triflusal EC), an antiplatelet agent, was developed to reduce the high incidence of gastrointestinal adverse events (AEs). The aim of this study is to compare the pharmacokinetics, pharmacodynamics and safety of triflusal EC with triflusal in healthy Korean male subjects to determine bioequivalence and non-inferiority for the purposes of marketing approval.</P><P><B><I>Methods:</I></B> A randomized, open-label, two-period, crossover study was conducted in 38 subjects. Either triflusal EC or triflusal was administered orally as a single 900 mg loading dose (day 1) followed by eight 600 mg/day maintenance doses on days 2 - 9, with a 13-day washout period. The plasma concentrations of 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), the predominant active metabolite of triflusal, were assessed after administration of the loading dose, using HPLC/MS/MS. The platelet aggregation response to arachidonic acid was determined using turbidimetric aggregometry. </P><P><B><I>Results:</I></B> The 90% CIs, for the geometric mean ratios of the log-transformed AUC<SUB>τ</SUB> and C<SUB>max</SUB> of HTB were seen to be within the predetermined range of 0.8 - 1.25. Triflusal EC was also shown to be non-inferior in its anti-aggregatory effect. No serious AEs were reported during this study.</P><P><B><I>Conclusions:</I></B> The pharmacokinetic and pharmacodynamic profiles of the two triflusal formulations met the requirements for bioequivalence and non-inferiority, respectively. Both formulations were well tolerated.</P>
High Brightness, Large Scale GaN Based Light-Emitting Diode Grown on 8-Inch Si Substrate
Lee, Seung-Jae,Song, Jae-Chul,Park, Hyung-Jo,Park, Jun-Beom,Jeon, Seong-Ran,Lee, Cheul-Ro,Jeon, Dae-Woo,Baek, Jong Hyeob The Electrochemical Society 2015 ECS journal of solid state science and technology Vol.4 No.8
<P>A crack-free, uniform InGaN/GaN light-emitting diode (LED) structure with strain-engineered buffer layer was grown on an 8-inch diameter Si(111) substrate. The full width at half maximum (FWHM) of (002) and (102) ω-scan is 280 and 420 arcsec, respectively. For LED on 8-inch Si, multiple quantum well (MQW) photoluminescence (PL) wavelength uniformity of 0.55% (2.4 nm) has been achieved by using proper curvature engineered wafer carrier. We demonstrated high brightness 1×1 mm<SUP>2</SUP> LED devices utilizing vertical chip process then evaluated their device properties. The electro-optical characteristics of the fabricated vertical LED (VLED) shows around 1 W light output power at 1 A injection current with operating voltage of 4.0 V.</P>
Lee, Ran,Ahn, Hye-Ran,Shin, Min-Ho,Kim, Hee-Nam,Lee, Young-Hoon,Choi, Seong-Woo,Kweon, Sun-Seog The Korean Academy of Medical Sciences 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.23
<P><B>Background</B></P><P>We investigated the association between pentraxin 3 (PTX3), a novel inflammatory marker, and bone mineral density (BMD) in the general Korean population.</P><P><B>Methods</B></P><P>We selected a sub-cohort of 1,440 subjects (757 men and 683 women) from participants in the community-based Dong-gu Study. The mean age was 66.0 ± 8.1 years for men and 63.7 ± 7.9 years for women. The plasma PTX3 levels were measured using an enzyme-linked immunosorbent assay, and BMD was measured in the femoral neck and lumbar spine using dual-energy X-ray absorptiometry. Linear regression analyses were used to evaluate the association between the plasma PTX3 levels and BMD.</P><P><B>Results</B></P><P>PTX3 was inversely associated with the BMD of the lumbar spine (<I>P</I> = 0.010) and femoral neck (<I>P</I> < 0.001) in men but not in women. For men, the association with the BMD of the femoral neck remained after adjustment for multiple comparison (<I>P</I> = 0.020).</P><P><B>Conclusion</B></P><P>This study suggests that PTX3 levels might be inversely associated with BMD in elderly men.</P>