입냄새 관련 인지도 조사

강은혜,강성귀,최재홍,성진효 조선대학교 구강생물학연구소 2003 Oral Biology Research (Oral Biol Res) Vol.27 No.1

The purpose of this study was to evaluate obtained information regarding a patient's halitosis and investigate about relationship between halitosis and related factors. Halitosis is general term used to describe any disagreeable odor in expired air. Also Halitosis affects a large proporation of population and may cause a significant social of psychological handicap to those suffering from it. Recently many scientist have concern about halitosis. The clinicians will be tried care to patient of halitosis more exactly, if he or she know patient's information about history, symptom, related factors of halitosis. The subjects were 77 who young peoples with 25 years old and using a questionnaire about self and other perception of halitosis, general and oral status, diet controls and cognition etc. The collected data was to analyzed and tested statistical significant. The results were as follows : 1.In presence of halitosis, the self perception was 26% and other Perception was 44%. 2.The group who was indicated malodorer by others is more sensitive in self-bad breath than other groups (p<0.05) 3.In life style, the other perception group have had more smoking than non-other perception group(p<0.05) . 4.The favorite food with strong smell have investigated kimchi , garlic, onion, coffee, spicy curry. Welsh onion and wine. 5. The kinds of food occurred to odor have investigated garlic, onion, coffee, kinds of kimchi, stew, meat and milk. 6. There was not significant correlation among other perception of halitosis and favorite food with strong smell, kinds of food occurred to odor, medical history, present health condition, food impaction to teeth, drinking habit and menstration.

카올린으로부터 합성된 고순도 알루미나의 γ→α변태에 미치는 Fe₂O₃첨가의 영향

강효경,박성수,박희찬 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

국내산 카올린으로부터 알루미늄황산염수화물을 합성하고, 이의 특성 및 열분해에 따른 알루미나의 γ→α변태에 미치는 Fe₂O₃의 첨가효과가 X-선회절분석, 시차열중량분석, 주사전자현미경, 플라즈마분광분석, BET법을 이용하여 검토하였다. 합성된 2 ㎛정도 크기의 판상입자형태로 구성된 고순도 알루미늄황산염은 Al₂(SO₄)₃·18H₂O로 동정되었으며, 이는 150℃ 부근에서의 탈수반응과 750℃부근에서의 탈황산반응을 경유하여 1000℃에서 결정성이 낮은 γ-Al₂O₃로 변화하였고, γ→α변태는 1200℃정도에서 일어났다. 0.1 wt% Fe₂O₃를 첨가한 경우의 1200℃하소물에서 생성된 FeAl₂O₄스피넬은 알루니마의 γ→α변태를 억제시켰으며, 그 이상의 양을 첨가한 경우와 1300℃로의 하소온도를 증가시킨 경우는 FeAl₂O₄의 α-Al₂O₃와 Fe₂O₃로의 분해 및 이온확산속도의 증가로 인하여 α-Al₂O₃생성이 촉진되었다. Aluminum sulfate hydrate has been prepared from the domestic kaolin, and its characteristics and the effect of Fe₂O₃addition on the γ→αtransformation of the resulting alumina have been investigated by means of the XRD, TG/DTA, SEM, plasma spectrometer, and BET methods. The aluminum sulfate having high purity and 2 ㎛-sized plate-like structure particles was identified as a crystalline Al₂(SO₄)₃·18H₂O, and decomposed to γ-Al₂O₃at 1000℃ via dehydration at ∼150℃ and desulfurization at ∼750℃. γ-Al₂O₃transformed to α-Al₂O₃at 1200℃. After calcination of the aluminum sulfate with addition of 0.1 wt% Fe₂O₃at 1200℃, the formation of FeAl₂O₄spinel prohibited the γ→αtransformation of the alumina. However, the addition of > 0.1 wt% Fe₂O₃and the increase in calcination temperature to 1300℃ accelerated the γ→αtransformation, due to the decomposition of FeAl₂O₄to α-Al₂O₃and Fe₂O₃and the velocity of ion diffusion, respectively.

흰쥐 경동맥 손상 모형에서 체외 방사선조사에 의한 신내막 과증식억제 : Intercellular Adhesion Molecule-1과 Vascular cell Adhesion Molecule-1의 역할 The Possible Role of Intercellular Adhesion Molecule-1 and Vascular Cell Adhesion Molecule-1

강동헌,승기배,장기육,임상현,정해억,임효영,김연실,채장성,김재형,홍순조,최규보 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

카올린으로부터 액상침전법에 의한 미립 알루미나 합성

박희찬,강효경,김병찬,박성수 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.56 No.-

카올린으로부터 미립 일루미나 분말을 합성하였다. 황산용액을 이용하여 액상침전법으로 알루미나를 추출하였다. 알루미나 추출에 미치는 황산농도, 반응온도 및 반응시간의 영향을 조사하였다. 이 과정에서 수화 황산알루미늄이 용출액으로부터 석출되었다. 이때 석출제로는 에탄올을 사용하였다. 이 석출물을 가영하여 미립 알루미나 분말을 얻을 수 있었다. DTA, SEM, TEM 및 XRD를 이용하여 분말의 특성을 조사하였다. Fine alumina was synthesized from kaolin. The alumina was prepared by liquid phase precipitation method using H?SO? solution. The effects of acid concentration, reaction temperature and reaction time on alumina extraction were investigated. Using an ethanol as precipitating agent, hydrated aluminum sulfate was precipitated from leach liquor. Fine alumina powder was obtained by calcining the precipitate. DTA, SEM, TEM and XRD were employed to characterize the powder.

대뇌 피질 신경 세포 일차 배양에서 6-hydroxydopamine에 의한 신경세포사멸의 특성

정재훈,강효정,손성향,정영기,곽병주,노재성 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 본 연구는 생쥐 태자 대뇌 피질 세포 일차 배양에서 파킨슨씨병의 동물 모델을 만드는데 사용되는 신경독성 물질인 6-hydroxydopamine(6-OHDA)에 의한 신경세포 사멸의 특성을 관찰한 것이다. 방 법 : 생쥐태자의 신경세포를 배양하여 6-OHDA를 처리하고 이와 더불어 여러가지 신경세포 사멸에 영향을 주는 물질을 투여하여 신경세포의 사멸을 정량적으로 분석하고 형태학적 분석을 전자현미경을 통하여 관찰하였다. 결 과 : 배양한 신경세포에 6-OHDA를 처리하면 투여 양에 비례하여 신경세포의 사멸이 증가하여 50μM 66-OHDA를 24시간 투여하여 일으킨 신경세포 사멸의 형태학적 특징은 세포질의 수축 및 염색질의 응축(nuclear chromatin condensation) 및 핵질의 fragmentation을 동반하는 고사(apoptosis) 형태이다. 이 때의 신경세포의 사멸은 항고사 물질인, 1㎍/ml cycloheximide와 caspase 억제제인 10μMzVAD-fmk에 의해 약화되었으나 글루타메이트 길항제(10μM MK-801 혹은 50μM CNQX)나 항산화제 (100μM trolox 혹은 100μM N-acetyl-cysteine)는 6-OHDA에 의한 신경세포의 사멸을 막지 못했다. 결 론 : 이상의 형태학적 및 약물학적 특징은 6-OHDA가 고사성 신경세포 사멸을 유도한다는 것을 의미하고, 항산화제들이 효과가 없다는 것과 caspase 억제제가 보호효과가 있다는 것은 6-OHDA에 의한 고사성 신경세포 사멸에는 산화적 스트레스보다는 caspase cascade와 관여된 기전이 기여한다는 것을 시사한다. 또한 6-OHDA에 의한 신경세포의 사며른 도파민성 신경세포에 선택적이지 않으며, 일차 대뇌피질 신경세포 배양 시스템이 6-OHDA에 의한 신경세포사멸인구에 사용될 수 있음을 보여준다 Objectives : We examined the patterns of cell death induced by the 6-hydroxydopamine, a selective dopaminergic toxin that used to produce Parkinson's disease model. Method : Neocortices from 14 - or 15-day-old fetal mice for neuron-glia co-cultures were used for this experiments. Results : Cortical cell cultures exposed to 10-100μM 6-hydroxydopamine for 24 hr underwent neuronal death without injuring glia. The degenerating neurons showed hallmark of apoptosis featuring cell body shrinkage, nuclear chromatin condensation and aggregation, nuclear membrane disintegration with intact plasma membrane, and prominent internucle- osomal DNA fragmentation. Neither the glutamate antagonists (10μM MK-801 and 50μM CNQX) nor antioxidants(trolox, 100μM, N-acetyl-cysteine, 100μM prevented the 6-OHDA induced neuronal injury. The death was attenuated by addition of two different anti-apoptotic agents, 1㎍/ml cycloheximide and caspase inhibitor(100μM zVAD-fmk). Conclusion : These features suggest that 6-OHDA induced apoptotic type of neuronal death in cortical neuronal culture. Considering the protective effect of caspase inhibitors, a mechanism involing caspase cascade rather than oxidative stress is responsible for the 6-OHDA-induced neuronal apoptosis. In addition, our results showed that 6-OHDA-induced apoptosis is not confined to dopaminergic neurons and the primary cortical culture system so this system is suitable for the study of 6-OHDA-induced neuronal apoptosis.

방사선조사와 Paclitaxel의 병합요법에 의한 신내막 과증식억제

장기육,승기배,강동헌,임상현,정해억,임효영,김태균,김연실,채장성,김재형,홍순조,윤세철,최규보 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.6

고등학교 지구과학 실험·실습 요목 비교 분석

정원우,이윤종,기우항,김영호,양승영,강용희,안병호,임성규,윤일희,김중욱,윤성효,강동진 경북대학교 과학교육연구소 1997 科學敎育硏究誌 Vol.21 No.-

The purpose of this study is to investigate the status of the experimental and practical education in high school earth. The present status and reasonable management of the experimental and practical education in high school earth science have been grasped from the questionaires. To do this, eighty eight earth science teachers in Korea are administered questionaires. The frequency of the experimental and practical items in the seven kind of earth science text books were investigated. The problems and the reasonable management for experimental and practical education were proposed in this paper.

Immature <i>Citrus sunki</i> Peel Extract Exhibits Antiobesity Effects by β-Oxidation and Lipolysis in High-Fat Diet-Induced Obese Mice

Kang, Seong-Il,Shin, Hye-Sun,Kim, Hyo-Min,Hong, Youn-Suk,Yoon, Seon-A,Kang, Seung-Woo,Kim, Jeong-Hwan,Kim, Moo-Han,Ko, Hee-Chul,Kim, Se-Jae Pharmaceutical Society of Japan 2012 Biological & pharmaceutical bulletin Vol.35 No.2

<P>The peel of <I>Citrus sunki</I> H<SMALL>ORT</SMALL>. <I>ex</I> T<SMALL>ANAKA</SMALL> has been widely used in traditional Asian medicine for the treatment of many diseases, including indigestion and bronchial asthma. In this study, we investigated the antiobesity activity of immature <I>C. sunki</I> peel extract (designated CSE) using high-fat diet (HFD)-induced obese C57BL/6 mice and mature 3T3-L1 adipocytes. In the animal study, body weight gain, adipose tissue weight, serum total cholesterol, and triglyceride in the CSE-administered group decreased significantly compared to the HFD group. Also, CSE supplementation reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase. Moreover, it significantly decreased the accumulation of fatty droplets in liver tissue, suggesting a protective effect against HFD-induced hepatic steatosis. Dietary supplementation with CSE reversed the HFD-induced decrease in the phosphorylation levels of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), which are related to fatty acid β-oxidation, in the epididymal adipose tissue. Also, CSE increased AMPK and ACC phosphorylation in mature 3T3-L1 adipocytes. CSE also enhanced lipolysis by phosphorylation of cAMP-dependent protein kinase (PKA) and hormone-sensitive lipase (HSL) in mature 3T3-L1 adipocytes. These results suggest that CSE had an antiobesity effect <I>via</I> elevated β-oxidation and lipolysis in adipose tissue.</P>

Anti-Obesity Properties of a <i>Sasa quelpaertensis</i> Extract in High-Fat Diet-Induced Obese Mice

KANG, Seong-Il,SHIN, Hye-Sun,KIM, Hyo-Min,HONG, Youn-Suk,YOON, Seon-A,KANG, Seung-Woo,KIM, Jeong-Hwan,KO, Hee-Chul,KIM, Se-Jae Japan Society for Bioscience, Biotechnology, and A 2012 Bioscience, biotechnology, and biochemistry Vol.76 No.4

<P>This study explores the anti-obesity properties of a <I>Sasa quelpaertensis</I> leaf extract (SQE) in high-fat diet (HFD)-induced obese C57BL/6 mice and mature 3T3-L1 adipocytes. SQE administration with HFD for 70 d significantly decreased the body weight gain, adipose tissue weight, and serum total cholesterol and triglyceride levels in comparison with the HFD group. SQE administration also reduced the serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactate dehydrogenase, and the accumulation of lipid droplets in the liver, suggesting a protective effect against HFD-induced hepatic steatosis. SQE administration restored the HFD-induced decreases with phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in epididymal adipose tissue. SQE also induced AMPK phosphorylation in mature 3T3-L1 adipocytes. These results suggest that SQE exerted an anti-obesity effect on HFD-induced obese mice by activating AMPK in adipose tissue and reducing lipid droplet accumulation in the liver.</P>

Callophyllis japonica extract improves high-fat diet-induced obesity and inhibits adipogenesis in 3T3-L1 cells

Kang, Seong-Il,Shin, Hye-Sun,Kim, Hyo-Min,Yoon, Seon-A,Kang, Seung-Woo,Ko, Hee-Chul,Kim, Se-Jae The Korean Society for Integrative Biology 2012 Animal cells and systems Vol.16 No.6

The anti-obesity potential of an ethanolic extract of the edible red alga Callophyllis japonica extract (CJE) was investigated in mice fed a high-fat diet (HFD). CJE administration into HFD mice revealed suppression of body weight, adipose tissue weight, serum total cholesterol, triglyceride, and glucose levels in a dose-dependent manner. Also, it reduced serum levels of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase, and lactate dehydrogenase, as well as the accumulation of fatty droplets in liver tissue. CJE and its ethyl acetate fraction inhibited adipogenesis in 3T3-L1 adipocytes by down-regulating the adipocyte-specific transcriptional regulators. Taken together, these results suggest that CJE reduces obesity in mice fed an HFD by inhibiting lipid accumulation and adipogenesis in the adipose tissues.