혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

유아에서 발생한 재발성 외음부 콘딜로마 1례의 치료

홍정희,문성택,김윤숙,전섭,최승도,선우재근,배동한 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

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재가 뇌졸중 환자의 자기효능 개념분석

정성희 남서울대학교 2008 남서울대학교 논문집 Vol.14 No.2

Purpose: This study was conducted to identify attributes of the concept of self-efficacy among stroke survivors. Method: Walker & Avant's concept analysis framework was employed to review the nursing text books and research articles which were related to stroke self-efficacy. Results: Stroke self-efficacy can be defined by the attributes as follows: 1) self-confidence, 2) change the competence of ADL(Activities of Daily Living), 3) determination of behavioral change, 4) individualization, 5) having multi aspects, 6) having free will, 7) learning by experiences. The antecedents of stroke self-efficacy are consisted of these facts: 1) experience of stroke complications, 2) restriction of ADL, 3) change in the self-care, 4) change in the role function, 5) noncompliance, 6) negative self-concept, 7) need to rehabilitation. There are consequences occurring as a result of stroke self-efficacy: 1) health promotion, 2) improvement of ADL, 3) improvement of role function, 4) increase self-respect, 5) positive self-concept. Conclusion: This concept analysis of stroke self-efficacy will be helpful to remove conceptual ambiguity and clarify the true meaning of stroke self-efficacy. Key Words : Stroke Self-Efficacy, Concept Analysis

췌십이지장절제술 후 결과에 영향을 미치는 인자

정희석,정귀애,장정환,김권천,민영돈,김성환 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

`Background : Pancreatoduodenectomy is a widely used technique in the treatment of periampullary, duodenal and cephalic pancreatic disease. Although many improvements have been made in operative technique and posmiddleerative care, pancreatoduodenectomy remains a technically difficult procedure attended by relatively high morbidity and mortality rates. Materials and methods : The hospital records of 51 patients who underwent pancreatoduodenectomy at the Chosun University Hospital between 1994 and 2001 were reviewed. Clinical data and the following morbidity and mortality were recorded The risk factors were analyzed by a Chi-square test. Results : Fifth decade was the most prevalent ages (43.1%) The mean age was 59 years (ranging from 29 to 78) and the male to female ratio was 26 to 1. The periampullary cancer was the most reason to operation (86%) and injury due to trauma, adenocarcinoma of stomach, colon cancer, chronic pancreatitis in order Posmiddleerative complications were developed in seventeen patients and anastomotic leakage was the most common complication Death within a month after operation was 3 (5.8%) and the one of the cause of death was leakage in two patients, the other cause was intraadbominal bleeding in one patients. The cardiovascular disease, pulomnary problem, diabetes, level of bilirubin were checked preoperatively and showed no statistical difference in the posmiddleerative morbidity. The other factors such as amount of bleeding, operation time were not influencing posmiddleerative complications. The occurrence of leakage in eight cases of drainage tuve inserted into the pancreaticojejunostomy site was not different from no tuve insertion statistically Conclusion: old age of the patients, diabetes mellitus and massive intraoperative hemorrhage are the risk factors influencing the results after pancreatoduodenectomy. Morbidity and mortality after pancreatoduodenctomy can be devreased if a prudent selection of paients is made and the operation is performed by accomplushed surgeon.

운동선수 및 비운동선수들의 심박수에 관한 연구

정성호,이철희,진성호 公州大學校스포츠科學硏究所 1989 스포츠科學硏究所論文集 Vol.- No.3

The purpose of this study was to investigate the effect of work on heart rate. The subjects of this study were 6 athletes whose ahtletic careers were about 5 years and 6 nonathletes. And the items which were tested were resting heart rete, maximum heart rate, and recovery heart rate in 1, 3, 5 minute. The conclusoin were as follows ; 1. The resting heart rate of athletic group was 64.16 +/-2.22 beats/min and 74.00 +/-8.48 in nonathletic group. Therefore the resting heart of athletic group was significantly lower than that of nonathletic group. (P<.05) 2. The maxium heart rates of athletic and non athletic group were 186.167 +/-3.656 beats/min and 204.000 +/-11.313 beats/min. The maximum heart rate of athletic group was significantly lower than that of nonathletic group. (P<.01) 3. The heart rates of recovery phase were shown 136.500 +/-14.152 beats/min and 159.167 +/-9.347 beats/min, 105.333 +/-8.477 beats/min and 127.000 +/-5.366 beats/min, 102.667 +/-7.1888 beats/min and 119.500 +/-7.007 beats/min in each 1, 3, 5, minute recovery phase. The heart rate of recovery phase in ahtletic group were significantly lower than of nonathletic group in each recovery phase.

Prostacyclin synthase 유전자의 C1117A 다형성과 이형협심증과의 관련성

성인환,임대승,김정희,이재환,최시완,정진옥 대한내과학회 2004 대한내과학회지 Vol.66 No.4

목적 : Thromboxan A2의 혀관수축반응을 저해하는 prostacylin synthase exon 8 C117A의 변이가 관동맥 연축과 관련성이 있는지를 알아보고자 하였다. 방법 : 1998년 1월 1일부터 2000년 12월 31일까지 충남대학교병원 순환기내과에서 관동맥조형술과정맥내 에르고노빈 유발검사를 시행하여 관동맥 연축이 확진된 이형협심증 환자군(45예)과 정상 대조군(59예)을 대상으로 중합효소 연쇄반응법 및 restriction fragment length polymorphism을 이용하여 분석하였다. 결과 : Prostacyclin synthase exon 8 C117A 유전자형의 빈도는 대조군에서 A/A : A/C : C/C =3.4% : 30.5% : 66.1%, 이형협심증 환자군에서 A/A : A/C : C/C = 8.9% : 42.4% : 48.9%로 두 군간에 유의한 차이가 없었다. 대조군에 비해 변이형 협심증 환자군에서 남자의 비율과 흡연률이 높았지만, prostacyclin synthase exon 8 C117A 유전자형에 따른 군에서 당뇨병, 고혈압, 흡연, 고지혈증, 비만 등의 유의한 차이는 없었다. 결론 : 한국인에서 prostacyclin synthase exon 8 C117A 유전자 다형성과 관동맥 연축이 있는 이형협심증과의 유의한 연관성은 발견할 수 없었다. Backround : Coronary artery spasm plays an important role in the pathogenesis of variant angina(VA). Prostacyclin is one of the endothelium derived relaxing factors. The association between the novel single nucleotide polymorphism in the prostacyclin synthase gene and VA is not known. Therefore, we investigated the association between VA and the polymorphysm in the prostacyclin synthase gene. Methods : We compared 45 variant angina patients who had positive intravenous ergonovine test by coronary angiography with 59 control subjects who had negative intravenouis ergonovine test and normal coronary angiogram. Using the polymerase chain reaction-single-strand conformation polymorphism analysis, we identified a single nucleotide polymorphism, C117A, in exon 8. This nucleotide change did not cause an amino acid change in codon 373. Results : There was no significant difference in characteristics between the control group and the VA group, and there was no significant difference in the genotype distributions between the control group and the VA group. Conclusion : The C117A polymorphism in exon 8 of the prostacyclin synthase gene is not associated with variant angina.

강원지역 신석기시대 움집터에 대한 고찰

정성희 동의대학교 인문사회연구소 2010 인간과 문화 연구 Vol.17 No.-

Due to the recent developments in rural areas in Korea, Gangwon province has exposed to numerous excavation opportunities that brought new research materials, ideas as well as discussions for the development and characteristics of Neolithic dwelling sites. It appears that the recent discoveries of the dwelling sites are historically significant evidences for over viewing the life and culture of the residents during the period apart from previous methods of object oriented interpretation. Geographically, Gangwon province is divided into eastern (Youngseo) and western (Youngdong) areas by a mountain range called Taebaeksanmaek. From the different living styles and culture developed as a consequence of distinctive geographical and natural environments of the western and eastern areas, it is assumed that during the Neolithic with low mobility, the differences were even more diverse. The most distinctive characteristics are found in the shape and structure of dwelling sites. Therefore the discovery plays central role in the further study and extensive research on the dwelling sites, cultural and historical connections, exchanges and interchanges of the Neolithic period in the area of Gangwon. 최근 대규모 공사에 따른 발굴조사가 활발해지면서 강원지역에서의 신석기시대 움집터 자료의 증가에 따라 강원지역 신석기시대 움집터에 대한 특징 및 변화양상 등의 연구와 논의가 증가하고 있다. 이에 최근 강원지역에서 활발하게 조사된 신석기시대 움집터의 특징과 변화양상에 대한 연구는 기존 토기나 석기 등 유물 중심의 연구에서 벗어나 강원지역 신석기시대 생활과 문화를 종합적으로 복원해볼 수 있는 학술 자료적 가치가 높을 것으로 생각된다. 강원지역은 지형적으로 태백산맥을 중심으로 영동지역과 영서지역으로 나눌 수 있다. 두 지역은 서로 다른 지형과 자연환경의 영향으로 생활권과 문화적 요소가 각각 다른 특징을 보이는데, 교통이 발달하지 못한 신석기시대에는 생활이나 문화적 요소가 더욱 달랐을 것으로 짐작된다. 그 가운데 당시 사람들의 생활 근거지였던 움집터도 그 분포양상이나 구조 등이 서로 다르게 나타나고 있다. 따라서 두 지역 간의 신석기시대 움집터에 대한 구조와 변화양상에 대한 검토를 통하여 강원지역 신석기시대 움집터에 대한 특징과 상호교류 관계, 생활상 등을 살펴볼 수 있는 연구 자료를 제공할 것으로 생각된다.

모세관 전기영동법을 이용한 1,2,4-트리메틸벤젠 대사체의 분석

강종성,홍정희,임정미,이용문,장재연 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

방향족 탄화수소인 tnmethylbenzene (TMB)은 그 사용량이 늘어갈 뿐 아니라 직업적으로 폭로되는 양도 증가하고 있으므로 생물학적 모니터링 및 흡수, 대사, 배설에 관한 연구가 중요시되고 있다. 일반적으로 TMB는 간의 산화효소에 의해 하나의 메틸기가 산화되고 이것은 glycine과 포합되어 배설되는 것으로알려져 있다. 본 연구에서는 1,2,4-TMB의 대사체를 합성하고, 모세관의 전기영동법으로 분석할 수 있는 방법을 개발하였다. 모세관 전기영동법으로 흰쥐의 뇨 중에서 1,2,4-TMB의 대사체인 3,4, 2,4, 2,5-dimethylbenzoic acid 및 3,4 2,4 2,5-dimethylhippuric acid를 분석하기 위하여 내경 75㎛, 총길이 35cm (검출기까지 29cm)인 용융실리카 모세관을 15℃로 유지하면서 양단에 10kV의 전압을 걸어주고, 전해질로는 15mM β-CD, 3% 2-프로판올을 포함하는 01m 인산완충액 (pH 7)을 사용하였으며, 검출신호는 UV 210nm와 254nm에서 동시에 모니터링하였다. 뇨 시료의 분석 결과 배설된 1,2,4-TMB의 대사체의 상대량은 3,4-이성질체가 56.&%, 2,4-이성질체가 30.5%, 2,5-이성질체가 12.8%였다. 이 방법은 노동자의 뇨 분석에도 적용될 수 있을 것으로 생각된다. The metabolites of 1,2,4-trimethylbenzene (TMB) were synthesized and determined by capillary electrophoresis (CE). The optimum conditions of CE for the separation and determination of 3,4-, 2,4-, 2,5-dimethylbenzoic acid and 3,4-, 2,4-, 2,5-dimethylhippuric acid from the rat wine were as following: the fused silica capillary(75μm i.d. X 36 cm length, 29 cm to detector) was used and kept at 15℃ The applied voltage was 10kV and compounds were detected at UV 210 nm and 254 nm. The running electrolyte was 0.1 M phosphate buffer (pH 7) contalI1ing 15 mM of β -CD and 3% of 2-propanol. The relative amount of the metabolite of 1,2.4-TMB in the rat urine was 56.7% of 3,4-isomer, 30.5% of 2,4-lsomer and 12.8% of 2,5-isomer. This method can be applied to the analysis of TMB-metabolites in human wine.

개에서 발생한 슬개골 탈구 1례

이병희,정성목,조종기,신상태 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

A five year old female Yorkshire terrier dog with a history of hindlimb lameness was referred to the Veterinary Teaching Hospital of Chungnam National University. The patient had been treated surgically two times for patellar luxation in other animal hospital. On physical examination, hindlimb lameness, pain on left hindlimb and Lt/Rt medial patellar luxation (Grade Ⅲ) were observed. On the results of hindlimb radiographs, bilaterally medially luxated patella and degenerative joint disease (DJD) sign at both stifle joints were observed. According to physical examination and radiographs, it was diagnosed as bilateral medial patellar luxation (Grade Ⅲ). The left hindlimb of patient was surgically treated with trochlear wedge resection (TWR), tibial tuberosity transposition (TTT), patellar and tibial antirotational suture and lateral retinacular overlap. After the surgical treatment, the patient was slowly recovered.

개에서 각막궤영에 대한 치료 1례

박희서,정성목,박창식,김명철 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10

A five years old female Shih-tzu was presented to the Veterinary Mediccal Teaching Hospital of Chungnam National University. The dog had been treated corneal damage on left eye in the local animal hospital for 2 months caused by trauma. Conjunctival congestion. corneal edema. blepharospasm, photophobia, epiphora. purullent discharge were observed. In Schirmer tear test. the result was within normal range, in slit lamp examination there was no indication of any abnormality except the corneal region. Corneal epithelium was stained by fluorescein dye and antibiotic susceptibility test was performed. For treatment, antibiotics and mucolytic agent, NSAIDs and atropine were topically administered for two weeks. As a result, non-healing corneal ulceration had finally disappeared when rechecked after only topical treatment.