생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

한국인 알코올 의존 환자에서 알코올 대사 효소 유전자형 빈도의 남녀 차이

김성곤,김철민,이덕기,황인복,이현숙,김성연,전은숙,송영상,박제민,최병무,김명정 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : There are a number of preceding epidemiological studies reporting gender differences in the genetic etiology of alcohol dependence. The author investigated gender difference in the frequencies of ADH2 and ALDH2 genoypes between the patients with alcohol dependence and normal control. Methods : The subjects were 141 alcohol dependent patients (104 males, 37 females) and 138 normal control (79 males, 59 females). The frequencies of 1/1 and 1/2+2/2 (2+ afterward) genotypes for ADH2 and ALDH2 were investigated in male and female between alcohol dependence and normal control group. DNA was extracted from WBC in peripheral venous blood and PCR-RFLP method was used out for genotyping. Results : First, the frequency of ADH2 1/1 genotype was significantly higher in alcohol dependent patients than normal control in both genders. Second, while there was no gender difference in the frequency of ADH2 1/1 genotype in normal controls, in the patient group however, the frequency was significantly higher in females than males. Third, in male subjects with alcohol dependence, the frequency of ALDH2 1/1 genotype was significantly higher than in male normal control subjects. On the other hand, in female subjects with alcohol dependence, the frequency of ALDH2 2+ genotype was significantly higher than in female normal control subjects. Conclusion : These results suggest that while the risk of alcohol dependence is predominantly affected by ALDH2 1/1 geno-type in male, the female ADH2 1/1 genotype is mainly associated with the risk of alcohol dependence. This means that there are gender differences in the genetic etiology of alcohol dependence.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

The Preparation of Fluorine-Containing Soil Release Polymer and Its Application in Fabric Treatment Agents

김재원,하종욱,박인준,이수복,오성근 한국공업화학회 2005 응용화학 Vol.9 No.1

The fluorine-containing soil-release polymer was prepared by radical polymerization. This was used as the fabric treatment agents to improve water/oil repellency and soil release property because soil release polymer is oleophobic in air/water and hydrophilic in water. The dual function is based on interface rearrangement of the oleophobic and hydrophilic segments in air and water. The micro-phase separation by environmental response was investigated by transmission electron microscopy(TEM) and atomic force microscopy(AFM). For the evaluation of the water/oil repellency and soil release property, we used the AATCC test method.

변형된 EM 알고리즘을 이용한 GMM 기반 문맥독립 화자식별 시스템의 성능향상

김성종,안종복,정익주 강원대학교 정보통신연구소 2005 정보통신논문지 Vol.9 No.-

In speaker identification systems, it was proved in previous other experimental theses that the performance of GMM is better than that of any other speaker modeling techniques. The EM algorithm is used to build a GMM-based speaker identification system. This paper introduces the modified EM algorithm to enhance the identification rate. The experiments examine algorithmic issues (initialization, variance limiting and model order selection). As a result of the experiments, the modified EM algorithm achieves 95.044% identification accuracy comparing with basic EM algorithm (94.605% identification accuracy) and is shown to outperform the basic EM algorithm.

애국가의 첫 학습시기 및 부르는 형태에 대한 연구 : -진주시 국민학교 3학년 대상- -Centering on the 3rd Students in the Elementary Schools in Jinju City

김성복 진주교육대학교 1983 論文集 Vol.27 No.1

The Korean National Anthem, along with the national flag of Korea (the Taegeuk flag),'is regarded very significant for us, because it is ar anthenl which syfnboliges our country in· e31e internafioeal society and it is recogniged as fur rational symbol or emblem. As the Korean National Anthem is an anthem to be sung by all our'BeoBle in the atatf of the nUnd of haying affections for our cou?try and in the posture of giving allegiance and loyalty to our fatherland, it is very imrortant to give .:orrect educations on the Anthem to the children or stlidents fesfeciallf in the lewer grades of primary school. ) who learn'the Anthem for the first time This atudf .has mafe a solver of the 3earnieg of the Anthem on three thousaBld stu-dents in the third rear grade o.』 the frinlarr achoots· in fiHju City by siring question-aires concerning the problems. The following items ·af the questionaires are anrwered and the results are investigfted analytically : 1. The tiue of the first Beaming 2. The media of the first learning 3. The ability If singing before entering school 4. teaming in the school 5. Teaching in the school 6. The time and flare sung rnosf frequently 7. Present ability to sing 8. Which stanga do you waat to sing 9. The ohject relnecered while singing 10. 7hf attitude of rlind while singing 11. Conception and intention 12. The inclination of recosnition To put together the results of this study : 1. It is thought to be ncessary to have correct education on the Anthem in the frinarr school curriculum. 2. It is to he But an emphasis on the necessity of effectiye teaching of the true meaning of the Anthem, the attitude of mind whild singing, courtesr and historical tackgrounds by ufing nudie-visual aids. 3. It is thought'to be necesfarr for the teachers to egert themselves to teach the Anthfm well, by reflecting on the adurating on the Anthem whi,ch is considered to have some inaefficiency hitherto. and by having lesronsibllities to teach the children to grow to be rartriotic persons by sincer and correct education.

글룩의 오페라 개혁 이전의 프랑스, 독일, 영국 오페라의 사적고찰(17∼18세기)

김성복 진주교육대학교 1980 論文集 Vol.21 No.-

Opera which wart generated at Firenze, Italy, at the clone of 16c was spread across the whole of Europe in all directions, and it went on extending throngh France, Germany, and England. By the way, among these three countries that imported Italian opera, the most aucesaful country was France. France which imported opera at the middle of 17c made good use of their Ballot, so they bad come to make Italian opera that is the national opera. This opera has the originality and individuality at the beginning of 18c in accordance with a sort of French temper. R. Cambert, J. B. Lully. A. Campra. J. P. Rameau and etc can be said to be the representative composers of French opera of 17∼18c. R. Cambert was the founder of French opera, and he had been holding the right to a monopoly of French opera performances until J.B, Lnlly's appearance. J. B. Lully con be considered as the man who made opera take ell a French style. He came from Firenze, Italy, and was naturalized in France. He left many works and achievements under Louis's XIV love and care cooperating with the literary man Molie´re and the poet P. Quinault. A. Campra was famous as an early opera composer of France after J. B Lully, and an another conspicuous man was J. P. Rameau. He was the composer who succeeded French opera after J. B Lully rind left the largest achievements as a composer. He left immortal traces as opera composer and musical theorist, also. At the time of Bouffon's Quarrel, he was the man who continued to support the value of French music and opera by safeguarding French opera and was one of the moat famous compasers at the time of the late Baroque music. On the one hand, there was Singspiel which had been called a musical in Germany, but it could not be regarded as an opera. Though Germany imported opera earlier from Italy than France and England, because they didn't use the opera style originally, the development. of German opera had fellen behind. Italian opera had been extended across the whole of Germany from about 1618, Germany played a role as a branch office of Italian opera, so German opera composers could'nt succeed in life unless they composed opera to Italian styles. But, only the Diatrict of Hamburg had gotten out of the influences of Italian opera, and the national music sect of Germany was generated under free sovereign power of that district from 1678, so we came to call this the Hamburg music sect. But about 60 years later even Hamburg was with drawn because of the power of Itaiian opera from about 1738, so German opera had. gradually disappeared. After that, they had to wait far Mozart's appearance in order to get their own real German opera. H. Schiitz who is known ns the founder of German opera can be regarded as the representative opera composer of Germany and we can suppose that R. Keiser, J. Matteson and etc fire the representatives of Hamburg music sect. At the clave of loc in English opera, though there was a light musical combined with dance and play, because this had use to be performed at oxy the Royal-Court by a part of the aristocracy, it was not thought of opera. At the beginning of 17c this Came to appeal on open stage from about 1635, and had been called "Masque". A myth or an allegorical character was its contents. Because opera was developed γacidly In 1655 after the restoration of Imperial regime of Charles II, opera had been imported from France. It can be said that the representative composers of English opera are P. Humphrey, M. Lock. J. Blow, and H. Purcell. Among them, H. Purcell was the cost conspicuous composer who left immense achievements on English music and the history of opera. There is "Dido and Apneas" as his masterpiece that is opera on a small scale style. This skillfully expressed. a transparent color sense of rich Ballet music and dramatic power of expression. He is the first and last man who was thought to composer of a full-length English opera, at came time in spite of his short life of 36 years, he left many achievements in musical history.

이태리 오페라의 사적 고찰 : 17~18C 17~18세기

김성복 진주교육대학교 1979 論文集 Vol.19 No.1

Generally, Opera was generated as a residual product of Renaissance. Of course, before then there was such a mystery drama, a miracle play, passion in a church, but it was only a religious drama rather than opera. It was not expression of emotion which can express the human relation. At any rate, because Christ was the focus of a religious drama, it can't be regarded as the beginning of opera. We have to think that opera must have a form of Renaissance at all events. Musical activity stressed on Camerata was spreader gradually at Firenze, Italy. And it was extended to Venezia, Napoli, Roma, and was developed with its every local Characteristics. After Monteverdi, development of Orchestra and dramatic effect was developed greatly. At all extents, Italian opera of 17-l8c had primary importance of the element of Vocal music, and a little dramatic effect. But it brought about development Bel-Canto which is the moat brilliant in the art of Vocal music. As a historical view, the opera conglomerated with music and drama had the support of the general public at this period, and 17-l8c was the moat splendid period of opera. We can understand that 17-l8c was the most improtant period of the history of opera through many works, and this period decided the direction of opera of next generation.

광고방송(라디오, 텔레비젼)에 의한 상품선전노래가 국민학교 학생에게 미치는 영향 : 진주시를 중심으로 mainly about Jinju city

김성복 진주교육대학교 1978 論文集 Vol.16 No.1

The aim of this research is to determine the influence of radio and T.V. Commercial Jingles on primary school students. It is based on a questionaire composed of 19 items divided into 5 categories: "Media" "Singing style" "Concern" "Relevance" to Daily Life" and "Comparison with "School music" With the cooperation of the Gyon-nam Educational Committee, the questionaire was filled out by 3141 6th grade primary school students in Jinju on Dec, 10th 1977. The results of this Survey are presented in this paper along with an analysis of social and educational effects of commercial jingles.

방사선 촬영실내 세균 오염도에 관한 연구

김영은,이성길,김창복 광주보건대학 2004 論文集 Vol.29 No.-

As a result of measuring the bacterial contamination level of radiographic room, It was examined 27 of Gram (+) cocci, 1 of Gram (-) Bacillus was found in the air of a cubic meter (㎥) radiographic room. As a result of measuring the radiographic table, a large number of Gram (+) cocci was detected in the B, F and Gram (+) Bacillus was detected in the F, G hospital. as a result of measuring the radiographic cassette, a large number of Gram (+) cocci was detected in the B, G hospital and Gram (+) Bacillus was detected in the B, G and D, E hospital. After independent culturing and monitoring, it was clear up the D, E, F, G hospital Gram (+) cocci was the simple Gram (+) Bacillus. On the contrary, the D, G hospital appeared saprophytic Staphylococcus epidermis. This study verifies that a number of saprophytic bacteria can survive in the air of the radliographic room, radiogrphic table and radiograhic cassette. There was the hospital which is uncountable, and was very detected. These results notified all visiting person and patients could be infected from the baterial contamination in radiographic room. Also, it means that all visitors could be changed baterial transmitter. It is provides comfortable environment and better medical service to the disinfection that minor filming is indoor and personal hygiene in order to prevent this bacillary infection and must listen to the safe department of radiology on bacillary infection in ten thousand. This study verifies that common potentially pathogenic bacteria can survive in radiographic processing room. Therefore, effective cleaning regimens are of fundamental importance in controlling and preventing potential nosocomial transmission in the diagnostic imaging department