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( Seon Young Park ),( In Hwang Kim ),( Hyun Jin Yu ),( Hyoung Rok Paik ),( Jee Soo Son ),( Ji Hyung Kim ) 한국축산학회(구 한국동물자원과학회) 2021 한국축산학회지 Vol.63 No.3
Streptococcus suis is a major pig pathogen causing severe economic losses to the swine industry. This study aimed to analyze the genome of S. suis strain INT-01 isolated from a domestic pig in Korea. We found that the genome of strain INT-01 contains 2,092,054 bp, with a guanine (G) + cytosine (C) content of 41.3%, and the capsular polysaccharide synthesis locus of this strain is almost identical to that of serotype 3 S. suis strain 4961 isolated from China, suggesting that these isolates can be classified as serotype 3. Genomic analyses revealed that strain INT-01 is an extracellular protein factor (epf)-/ muraminidase-released protein (mrp)+/ suilysin (sly)- S. suis, which is the most prevalent genotype in Korea, and several virulence-related genes associated with the pathogenicity of S. suis were also detected. The genomic information of strain INT-01 may provide important insights into the development of control strategies against S. suis infections in Korea.
Association of CCK1 Receptor Gene Polymorphisms and Irritable Bowel Syndrome in Korean
( Seon Young Park ),( Jong Sun Rew ),( Soo Mi Lee ),( Ho Seok Ki ),( Kyong Rok Lee ),( Jun Ho Cheo ),( Hyung Il Kim ),( Du Yeong Noh ),( Young Eun Joo ),( Hyun Soo Kim ),( Sung Kyu Choi ) 대한소화기기능성질환·운동학회 2010 Journal of Neurogastroenterology and Motility (JNM Vol.16 No.1
Introduction: Cholecystokinin (CCK) belongs to a group of endogenous molecules known as brain-gut neuropeptides and functions as a neuropeptide as well as a gut hormone. It remains unclear whether genetic variation of the CCK receptor plays a role in irritable bowel syndrome (IBS). The aim of this study was to determine and compare the allele and genotype frequencies of the CCK1 receptor polymorphisms between healthy controls and patients with IBS. Methods: Genotyping of 80 patients with IBS (who met the Rome III criteria) and 76 healthy controls was performed. We performed PCR amplification for the CCK1 receptor intron 1 779 T C and Exon 1 G A. We confirmed polymorphisms by direct sequencing method. Results: There was a significantly different trend for genotypic distributions of the CCK1 receptor polymorphism between patients with IBS and healthy controls (p for trend = 0.048). The CCK1 receptor intron 1 779 T C polymorphic type was more common in patients with `IBS-constipation predominant (IBS-C) and IBS-mixed (IBS-M) forms` (19/31, 61.3%) than healthy controls 32/76, 42.1% adjusted odd ratio 2.43, 95% Confidence interval 1.01-5.86). The genotypic distributions of the CCK1 receptor exon 1 polymorphism were not significantly different between the two groups (p for trend = 0.223). Conclusions: CCK1 receptor polymorphisms were associated with IBS. In particular, the CCK1 receptor intron 1 779 T C polymorphic type was associated with `IBS-C and IBS-M`. Further studies are needed in Larger number of patients with an even distribution of IBS subtypes.(J Neurogastroenterol Motil 2010;16:71-76)
( Seon Young Park ),( Jee Eun Han ),( Hyemin Kwon ),( Se Chang Park ),( Ji Hyung Kim ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.10
The emergence and spread of antimicrobial resistance in pathogenic bacteria of fish and shellfish have caused serious concerns in the aquaculture industry, owing to the potential health risks to humans and animals. Among these bacteria, Aeromonas salmonicida, which is one of the most important primary pathogens in salmonids, is responsible for significant economic losses in the global aquaculture industry, especially in salmonid farming because of its severe infectivity and acquisition of antimicrobial resistance. Therefore, interest in the use of alternative approaches to prevent and control A. salmonicida infections has increased in recent years, and several applications of bacteriophages (phages) have provided promising results. For several decades, A. salmonicida and phages infecting this fish pathogen have been thoroughly investigated in various research areas including aquaculture. The general overview of phage usage to control bacterial diseases in aquaculture, including the general advantages of this strategy, has been clearly described in previous reviews. Therefore, this review specifically focuses on providing insights into the phages infecting A. salmonicida, from basic research to biotechnological application in aquaculture, as well as recent advances in the study of A. salmonicida.
( Seon Young Park ),( Sung Bum Cho ),( Chang Hwan Park ),( Jae Kyun Joo ),( Young Eun Joo ),( Hyun Soo Kim ),( Sung Kyu Choi ),( Jong Sun Rew ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2013 Journal of Neurogastroenterology and Motility (JNM Vol.19 No.1
Background/Aims The patients with rectal prolapse suffer from not only a prolapse rectum but also associated dysfunction. However, most surgical techniques are successful regarding the prolapse, but either do not solve or even worsen defecation dysfunction. The purpose of this study was to investigate the functional and physiological results after surgical correction in patients with rectal prolapse. Methods This study is a retrospective review of a single-institution experience. Patients with rectal prolapse who underwent anorectal manometry before and after Delorme`s procedure were included. The primary outcomes measured were improvement of clinical symptoms and physiologic study. Results Consecutive 19 patients with rectal prolapse (17 females, mean age of 68.1 ± 10.8 years) underwent anorectal manometry before and after Delorme`s procedure. The two most prevalent symptoms before operation were rectal tenesmus (15/19, 78.9%) and excessive straining (13/19, 68.4%). The two most prevalent symptoms after operation were rectal tenesmus (14/19, 73.6%) and excessive straining (13/19, 68.4%). No significant differences in resting anal pressure, squeezing anal pressure, defecation index, and rectal sense were found postoperatively. However, vector asymmetry index before surgery was higher than that after surgery (35.0 vs. 32.0, P = 0.018). Ten patients (52.5%) had type I dyssynergic defecation before surgery. No improvement of dyssynergic pattern occurred after surgery. Conclusions In conclusion, dyssynergic defecation was not improved after reduction of rectal prolapse in patients with rectal prolapse. Further study about combination treatment with biofeedback therapy in these subgroups may be necessary. (J Neurogastroenterol Motil 2013; 19:85-89).
( Seon Young Park ),( Kyoung Won Yoon ),( Chang Hwan Park ),( Tae Jin Seo ),( Hae Kyung Chung ),( Ho Sung Rew ),( Sung Beom Cho ),( Wan Sik Lee ),( Hyeun Soo Kim ),( Sung Kyu Choi ),( Jong Sun Rew ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2011 Gut and Liver Vol.5 No.3
Although arteriovenous malformations (AVM) occur frequently in digestive organs, pancreatic AVM is rare. The clinical symptoms of pancreatic AVM are variable and include gastrointestinal bleeding, abdominal pain, jaundice, portal hypertension, pancreatitis, and duodenal ulcer. However, choledochoduodenal or pancreaticoduodenal fistulas complicated with ascending infection and pancreatitis is extremely rare. Herein, we report a case of pancreaticoduodenal fistula associated with a pancreatic AVM that induced recurrent anemia and ascending infection. (Gut Liver 2011;5:391-394)
Seon-Young Park,이준규,Jung-Wook Kim,Tae Hee Lee,Chang-Hwan Park,Jae-Yong Jang,Byung-Wook Kim,Byung Ik Jang,Quality management and Endoscopic sedation committee of Korean Society of Gastrointestinal Endo 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6
Background/Aims: This study aimed to determine the current status of facilities, equipment, and personnel for endoscopic sedationfrom endoscopy units of representative hospitals in South Korea. Methods: A questionnaire survey was conducted on 50 qualified endoscopy units accredited by the Korean Society of GastrointestinalEndoscopy. Results: All included endoscopy units had regulations and educational programs regarding sedation training for endoscopists andnursing personnel. There present one assisting nurse during endoscopy in 35 units (70%) and at least two nurses in 12 units (24.0%). All endoscopy units had examination rooms equipped with oxygen supply and suction systems. Endoscopist-directed sedationwas performed in 48 units (96.0%). Propofol-based sedation was the most used sedation method. All units had a separate recoverybay. The daily number of patients per bed was greater than 10 in 17 units (34.0%). In 26 (52.0%) units, a single nurse cared for ≥10patients per day. All the units fulfilled the discharge criteria. Conclusions: This study presents data regarding endoscopic sedation clinical practice in 50 endoscopy units in South Korea. Thisstudy presents the current status of endoscopic sedation clinical practice in 50 qualified endoscopy units accredited by the KSGE,which provide excellent quality management.