전격성 경과를 취한 만성 호산구성 폐렴 환자 1예

윤호상,진춘조,유광하,이상엽,이수인,정상만,김선두,이순제,이길도,전혜정 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Chronic eosinophilic pneumonia(CEP) is a rare disease of unknown etiology characterized by chronic infiltration of the lung with eosinophils. It presents with profound systemic symptoms comprising fever, night sweats, weight loss, dyspnea and blood eosinophilia with nonsegmental air-space consolidation confined to the outer third of the lung, the "photographic negative of pulmonary edema". Histopathologic features of chronic eosinophilic pneumonia are intraalveolar and interstitial infiltrations with eosinophils, histiocytes, giant cells, scattered lymphocytes and plasma cells. Glucocorticoid therapy cause prompt resolution of symptoms as well as disappearans of blood eosinophils, elevated serum Ig E levels and the roentgenographic lesions. Infrequent radiographic findings include nodular infiltrates, consolidations, cavitations, atelectasis and pleural effusions. Deaths from CEP although rare, have been reported, but the majorities of CEP have benign courses and do not need a therapy with ventilator. We report a case of chronic eosinophilic pneumonia, which had a sudden course associated with diffuse pneumonic consolidations on the both lung and bilateral pleural effusion.

Bloodstream Infections and Clinical Significance of Healthcare-associated Bacteremia: A Multicenter Surveillance Study in Korean Hospitals

Son, Jun Seong,Song, Jae-Hoon,Ko, Kwan Soo,Yeom, Joon Sup,Ki, Hyun Kyun,Kim, Shin-Woo,Chang, Hyun-Ha,Ryu, Seong Yeol,Kim, Yeon-Sook,Jung, Sook-In,Shin, Sang Yop,Oh, Hee Bok,Lee, Yeong Seon,Chung, Doo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.7

<P>Recent changes in healthcare systems have changed the epidemiologic paradigms in many infectious fields including bloodstream infection (BSI). We compared clinical characteristics of community-acquired (CA), hospital-acquired (HA), and healthcare-associated (HCA) BSI. We performed a prospective nationwide multicenter surveillance study from 9 university hospitals in Korea. Total 1,605 blood isolates were collected from 2006 to 2007, and 1,144 isolates were considered true pathogens. HA-BSI accounted for 48.8%, CA-BSI for 33.2%, and HCA-BSI for 18.0%. HA-BSI and HCA-BSI were more likely to have severe comorbidities. <I>Escherichia coli</I> was the most common isolate in CA-BSI (47.1%) and HCA-BSI (27.2%). In contrast, <I>Staphylococcus aureus</I> (15.2%), coagulase-negative <I>Staphylococcus</I> (15.1%) were the common isolates in HA-BSI. The rate of appropriate empiric antimicrobial therapy was the highest in CA-BSI (89.0%) followed by HCA-BSI (76.4%), and HA-BSI (75.0%). The 30-day mortality rate was the highest in HA-BSI (23.0%) followed by HCA-BSI (18.4%), and CA-BSI (10.2%). High Pitt score and inappropriate empirical antibiotic therapy were the independent risk factors for mortality by multivariate analysis. In conclusion, the present data suggest that clinical features, outcome, and microbiologic features of causative pathogens vary by origin of BSI. Especially, HCA-BSI shows unique clinical characteristics, which should be considered a distinct category for more appropriate antibiotic treatment.</P>

Tetraethylene glycol 과 Thioglycolic acid가 包含된 킬레이트 樹脂의 合成과 金屬이온의 分離

李宣夏 건국대학교 1986 論文集 Vol.23 No.1

The synthesis, characterization, and separation of a new chelating resin are described. The new chelating resin is synthesized from a highly cross-linked macroporous resin (Amberlite XAD-4). Tetraethylene glycol and thioglycolic acid are attached to the resin. It is highly selective for Barium(II), Bismuth(III), Zirconium(IV) and Mercury(II) in acidic- aqueous soltion. The metal ions are sequentially separated with 0.1 to 2. OM hydrochloric acrid.

이온교환 크로마토그래피에서 이온첨가법에 의한 전이금속이온의 분리

이선하 경운대학교 산업기술연구소 2002 産業技術硏究論文誌 Vol.5 No.1(B)

Distribution coeffisients of various transition elements with the strong acidic cation-exchanger(Amberlite IR-120, 100-200 mesh)were measured at various concentration of hydrochloric acid, hydrobromic acid and perchloric acid. For the separations of Cr(Ⅲ)-Mn(Ⅱ), Mn(Ⅱ)-Fe(Ⅲ) and Fe(Ⅲ)-Co(Ⅱ) by elution through the resin column, when Ba(Ⅱ) were added to the mixed solution of Cr(Ⅲ)-Mn(Ⅱ), Mn(Ⅱ)-Fe(Ⅲ) and Fe(Ⅲ)-Co(Ⅱ). They were separated respectively into each ion by using the eluent of hydrochloric acid through cation exchange resin column.

異功散이 마우스 黑色腫의 肺轉移 抑制에 미치는 抗癌 및 免疫作用에 關한 硏究

李膳求,河智容 대한동의병리학회 1997 동의생리병리학회지 Vol.11 No.1

종양은 그 발생원인과 성장기전이 자세히 밝혀져 있지 않는 질병으로 최근 성인사망의 제 1원인으로 급격히 발생빈도가 증가하고 있다. 종양환자의 수는 점점 증가하는 추세이며, 그에 따른 사망자의 수도 늘고 있다. 종양을 치료하는 방법으로 수술요법·방사선요법·화학약물요법·골수이식·면역요법·호르몬요법 등이 사용되어 왔으나 최근에 천연물 특히 전통적인 한약재를 이용한 종양파괴 및 종양에 있어 성장을 억제하는 약재의 연구가 시도되어 왔다. 한의학의 특정 약재 및 처방의 항암효과가 경험적으로 알려져 왔으며, 과학적이고 객관적인 병태를 통하여 이러한 약재의 효능을 검증하려는 실험이 최근에 시도되고 있다. 이에 본 연구는 補眞氣虛弱 및 治 久嗽不己 脾胃虛弱 등의 효능이 있는 異功散을 이용하여 B16세포의 전이억제능, 흑색종의 증식억제 및 면역능에 대하여 연구하고자 하였다. 본 연구에서는 시험관내 세포독성능을 알아보기 위하여 MTT법으로 각 농도별로 처리된 이공산을 B16세포에 적정농도로 처리하여 생존율 및 IC50을 측정하였다. 또한 생쥐를 이용한 동물실험으로써 흑색종을 폐에 전이시켜 이공산 투여후 흑색종의 집략수를 측정하였다. 동시에 항암효과와 면역능과의 관련성을 알아보기 위하여, Interleukin-2생산능과 NK-Activity를 측정하였다. 이공산의 생쥐에 대한 폐전이 흑색종의 억제효능과 면역반응에 미치는 영향을 알아보기 위한 실험에서 시험관내 세포독성 측정에서는 2㎍/well의 농도로부터 2배 희석시켜 MTT법으로 측정한 결과 유의성있는 억제를 보였으며 2,2124㎍/well의 IC50을 얻었다. 흑색종의 억제능을 측정한 결과 7일과 14일째에 유의성있는 억제를 보였고, 21일째는 흑색종이 폐의 전면에 분포되어 측정되지 않았다. 이 공산 투여후 생쥐의 IL-2의 생산능을 측정한 결과 이공산 투여군에 있어 투여 7일, 14일, 21일째에 모두 유의성있는 증가를 보였다. 그리고 NK-Activity를 측정한 결과 이공산 투여군이 대조군과 비교하여 유의한 차이는 보이지 못하였다. 이상의 결과를 종합하여 볼 때 이공산이 B16세포에 대하여 직접 세포독성능을 나타내며 보조 T 세포를 자극하여 IL-2의 생산능을 증가시켜 흑색종의 전이 및 증식을 억제하는 것으로 추정된다. 따라서 전이억제의 기전과 면역반응에 관련된 연구가 더욱 진행되어야 할것으로 사료된다. Herbal medicine as a candidate for effective cancer treatment recently gain positive concerns in field of therapeutic oncology. that is why some oriental medicine has been empirically safer in toxicity than anticancer drugs used in western medicine, and to show excellent therapeutic efficacy in human trial. Thus, these effects by clinically applied-herbs have not yet fully demonstrated in experimental tumor model. This study was initiated to evaluate antitumor effect of Ikongsan as candidate of antitumor-hebal agent against B16 melanoma metastasized into murine lung, and to examine association between immune parameter an anti-metastasis effect by Ikongsan. In experiment to test whether Ikongsan can directly kill cancer cells in vitro or not, Ikongsan showed direct killng action in concentration or higher against B16 melanoma cells using MTT assay. And also, in another experiment to know whether Ikongsan can inhibit growth and metastasis of cancer cell or not, Ikongsan significantly inhibited lung metastasis induced by intravenous injected-melanoma in inbred C57BL/6 mouse. When we quatiated interleukin-2 production, we could obtain results that in Ikongsan-treated group(7th, 14th, 21th), IL-2 production was significantly increased, But, NK activity in Ikongsan-treated group was not in significantly difference as compared to that of Ikongsan-nontreated group. These results show that Ikongsan can inhibit growth of B16 melanoma cells through biological mechanisms.

柴胡桂枝湯이 CCl₄로 誘發된 白鼠의 肝損傷에 미치는 影響

河智容,朴慶寔,李善熙 대한동의병리학회 1996 동의생리병리학회지 Vol.10 No.2

肝은 人體內의 血量을 調節하고 각종 大事, 分泌, 合成에 관여하는 중요한 기관이며, 病理的으로는 대사물질에 의한 중독에 민감하게 반응하여 간세포의 변성, 괴사, 지방축적, 간효소의 누출 등을 일으킨다. 간에 손상을 줄 수 잇는 요인 은 많으며, 최근에는 중독에 의한 손상이 증가하고 있다. 시호계지탕은 상한론에 ‘傷寒六七日 發熱徵惡寒 肢節煩疼 徵嘔 心下支結 外證未去者 柴胡桂枝湯主之에 사용된 처방으로 임상적으로 간손상에 사용되었으나, 실험적 연구는 실시되지 않앗다. 따라서 본 연구에서는 Sprague-Dawely 흰쥐에 사염화탄소로 중독성 간손상을 일으킨 후 시호계지탕을 투여하여 간손상에 미치는 영향을 알아보았다. Sprague-Dawely 흰쥐에 CCI₄와 Olive oil을 1:4로 혼합하여 4주간 격일로 경구투여하여 간손상을 유발하였다. 그 후 시호계지탕을 10㎎/㎏(B.W)로 하여 매일 경구투여 하였다. 실험 첫주부터 매주 각 군의 평균몸무게와 평균 사료섭취량을 측정하였고, 실험 마지막날 채혈한 뒤 순수혈청에서 AST, ALT, TP, Albumin, Gloulin, ALP, LDP를 검사 하였다. AST는 CCI₄處理群에 비하여 CCI₄處理後柴胡桂枝湯投與群 A와 CCI₄處理後柴胡桂枝湯投與群 B 모두 減少하였으며, CCI₄處理後柴胡桂枝湯投與群 B의 境遇는 有意性이 認定되었다. (P〈0.05). ALT는 CCI₄處理群에 비하여 CCI₄處理後柴胡桂枝湯投與群 A와 CCI₄處理後柴胡桂枝湯投與群 B 모두 유의성있는 감소를 보였다. (P〈0.05). CCI₄處理群과 比較하여 CCI₄處理後柴胡桂枝湯投與群 A와 CCI₄處理後柴胡桂枝湯投與群 B는 Tota protein의 경우 큰 차이가 없었으며, Albumin은 감소하였고, Globulin은 增加하였으나 有意性은 없었다. Albumin과 Globulin의 比率은 減少하였으나, 有意性은 없었다. ALP는 CCI₄處理群에 比하여 CCI₄處理後柴胡桂枝湯投與群 A와 CCI₄處理後柴胡桂枝湯投與群 B 모두 有意性있는 減少를 보였다.(P〈0.05). LDH는 특별한 傾向을 찾을 수 없었다. 肝의 重量을 測定한 結果 CCI₄處理後群에 比하여 CCI₄處理後柴胡桂枝湯投與群 A와 CCI₄處理後柴胡桂枝湯投與群 B 모두 有意性 있는 減少를 보였다. (P〈0,05). 體重과 飼科 攝取量의 變化는 CCI₄處理群에 比하여 CCI₄處理後柴胡桂枝湯投與群 A와 CCI₄處理後柴胡桂枝湯投與群 B이 增加하였으나 유의성은 없었다. 以上으로 보아 柴胡桂枝湯이 CCI₄로 誘發된 肝損傷의 境遇에 AST, ALT, ALP, 肝의 重量變化에서 有意性있는 減少(P〈0.05)를 보였으며, 體重과 飼科 攝取量의 增加로 보아 肝損傷 回復에 대한 治療效果가 있을 것으로 思料된다. This study was carried out to investigate the effects of Sihogyejitang extract on the recovery of liver in CCI₄-intoxicated rats. In this study, SD-Rats were divided into 4 experimental groups; Control(Placebo, 0.85% NaCl), Experi-mental (CCI₄-intoxicated+Placebo, 0.85% NaCl), Siho A(Treated with Sihogyejitang extract (10㎎/㎏) after CCI₄intoxication), Siho B(Treated with Sihogyejitang extract (50㎎/㎏) after CCI₄-intoxication), Biochemical assays for serum enzyme activities such as AST, ALT, TOtal protein, Albumin, Globulin, ALP, LDH, and Biological assay for Liver weight, Body weight, Food, intake were performed. The results obtained were summarized as follows: 1. Siho A group showed lower serum AST activity than CCI₄-intoxicated group significantly, and Siho B group showed lower than Control group(P〈0.05). 2. Both siho A group and siho B group showed lower serum ALT activity than CCI₄-intoxicated group significantly. 3. As to Total protein, Siho A group and Siho B group were classed with CCI₄-intoxicated group. As to Albumin, Siho A group and siho B group were decreased than CCI₄-intoxicated gruop, but not significant. As to Globulin, siho A group and B group were increased than CCI₄-intoxicated group, but not significant. As to Globulin, ratio siho A group and Siho B group were decreased than CCI₄-intoxicated group, but not significant. 4. As to ALP, Siho A group and Siho B group were decreased than CCI₄-intoxicated group significantly(P〈0,05). 5. As to serum LDH, There were no trend in all groups. 6. As to liver weight, Siho A group and Siho B group were decreased than CCI₄-intoxicated group significantly. 7. As to Body weight and Food intake, Siho A group and Siho B group were increased than CCI₄-intoxicated group, buy not significantly.

자화-생물처리에 의한 염색폐수의 처리

이선하,차승훈,김재현 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(A)

The purpose of this study is to investigate treatment efficiency in dyeing wastewater treatment by the high rate aeration system(HRA) and a combination of the HRA with manetized wastewater treatment system(MWS). At the hydraulic retention time of 16hr, 24hr, 30hr, BOD removal efficiencies of HRA system were 93%, 96% and 98%, combination of the HRA with MWS system were 94%, 96.8% and 98.2%, resoectively. In case of COD, at the hydraulic retention time of 16hr, 24hr, 30hr, COD removal efficiencies of HRA system were 66%, 77.1% and 83.1%, combination of the HRA with MWS system were 70.2%, 80.1% and 86.6%, resoectively. The comparison of the HRA and combination of the HRA with MWS, effluent BOD of the former was 22.7㎎/ℓ and the latter was 19.4㎎/ℓ, therefore biological treatment efficiency identified to increase by the MWS

다중모델기법을 이용한 비선형시스템의 퍼지모델링

이철희,하영기,서선학 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

In this paper, a new approach to modeling of nonlinear systems using fuzzy theory is presented. To express the various and complex behavior of nonlinear system, we combine multiple model method with hierachical prioritized structure, and the mountain clustering technique is used in partitioning of system. TSK rule structure is adopted to form the fuzzy rules, and Back propagation algorithm is used for learning parameters in consequent parts of the rules. Also we soften the paradigm of Mamdani's inference mechanism by using Yager's S-OWA operators. Computer simulations are performed to verify the effectiveness of the proposed method.

탄화규소 세라믹 필터를 이용한 여과기술에 관한 연구

이선하,이동섭 경운대학교 산업기술연구소 2000 産業技術硏究論文誌 Vol.3 No.1(B)

Candle type SiC filters applicable to hot gas filtration of IGCC and PFBC were manufactured and tested using two different dusts collected from cokes and water glass manufacturing processes. Particle sizes, porosities, and mean pore sizes of manufactured SiC filters range 150∼300㎛, ∼40%, and 43∼83㎛, respectively. Collection efficiencies of two different types of dusts rage 99.09∼99.95% at 600℃ and latm test condition. At the same condition, Darcy's resistance coefficients rage 1.149×10^10∼3.514×10^11m^-2 and differential pressures range 187∼391㎜H₂O. Also it was found that the smaller the mean pore size, the higher the differential pressure at the same operating conditions. SiC filters have high potential as a fine dust removal medium from HTHP processes like PFBC and IGCC. Furthermore, long-term performance tests of the filters are necessary for the commercialization of SiC filters.

집중강우에 대한 고탁도 응집불량 원수의 처리

이동주,채선하 대한상하수도학회 2003 상하수도학회지 Vol.17 No.1

The purpose of this study were to investigate the characteristics of lake water quality in the rains and to suggest optimal operating conditions of coagulation with jar-test. The raw water with high turbidity during the rainy season had law pH and ionic concentration and much of quarts, kaolinite. As a results, it is difficult to remove turbidity by coagulation. In conclusion, for the raw water during the rainy season, Increasing of pH and addition of lime was effective for removal of turbidity. The addition of bentonite prevents from charge reverse and greatly enhances the removal of turbidity.