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Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1
Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.
Yoon, Byoung-Ha,Kim, Mirang,Kim, Min-Hyeok,Kim, Hee-Jin,Kim, Jeong-Hwan,Kim, Jong Hwan,Kim, Jina,Kim, Yong Sung,Lee, Daeyoup,Kang, Suk-Jo,Kim, Seon-Young Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.11
The stepwise development of T cells from a multipotent precursor is guided by diverse mechanisms, including interactions among lineage-specific transcription factors (TFs) and epigenetic changes, such as DNA methylation and hydroxymethylation, which play crucial roles in mammalian development and lineage commitment. To elucidate the transcriptional networks and epigenetic mechanisms underlying T-cell lineage commitment, we investigated genome-wide changes in gene expression, DNA methylation and hydroxymethylation among populations representing five successive stages of T-cell development (DN3, DN4, DP, $CD4^+$, and $CD8^+$) by performing RNA-seq, MBD-seq and hMeDIP-seq, respectively. The most significant changes in the transcriptomes and epigenomes occurred during the DN4 to DP transition. During the DP stage, many genes involved in chromatin modification were up-regulated and exhibited dramatic changes in DNA hydroxymethylation. We also observed 436 alternative splicing events, and approximately 57% (252) of these events occurred during the DP stage. Many stage-specific, differentially methylated regions were observed near the stage-specific, differentially expressed genes. The dynamic changes in DNA methylation and hydroxymethylation were associated with the recruitment of stage-specific TFs. We elucidated interactive networks comprising TFs, chromatin modifiers, and DNA methylation and hope that this study provides a framework for the understanding of the molecular networks underlying T-cell lineage commitment.
Optical Characteristics of Double Layered Plasmonic Structure Using Nanopatterning Process
Kim, Doo Gun,Kim, Seon Hoon,Ki, Hyun Chul,Kim, Tae Un,Kim, Hong-Seung,Choi, Young Wan,Jo, Min Hyeok,Shin, Jae Cheol American Scientific Publishers 2018 Journal of Nanoscience and Nanotechnology Vol.18 No.3
<P>A double layered plasmonic device based on transferring technique with polystyrene nano-beads is analyzed and demonstrated to increase the sensing characteristics of plasmonic sensor system. The double layered plasmonic devices are calculated using the three-dimensional finite-difference time-domain method for the width and thickness of the nano-hole structures. The double layered plasmonic devices with different diameters of the Au nano-hole are fabricated by transferringmethod with commercially available chloromethyl latex with a diameter of 0.42 mu m. The optimum sensing characteristic of the proposed plasmonic device is obtained with the film and the hole thickness of 15 and 15 nm in the 246 nm wide nano-hole size. The best sensitivity of the proposed plasmonic sensor is 67.7 degree/RIU when the sensitivity of the conventional plasmonic sensor is 42.2 degree/RIU.</P>
Measurement of Therapeutic Proton Beam Using a Fiber-Optic Cerenkov Radiation Sensor
Kim, Seon Guen,Jang, Kyoung Won,Shin, Sang Hun,Hong, Seung Han,Sim, Hyeok In,Jeon, Hye Su,Jang, Jae Seok,Kim, Jae Seok,Kwon, Gu Won,Yoo, Wook Jae,Kim, Me Young,Shin, Dong Ho,Cho, Seung Hyun,Lee, Bong Trans Tech Publications, Ltd. 2014 Advanced materials research Vol.1033 No.-
<P>Tumor therapy using the high-energy radiation has evolved over the decades as typical non-invasive treatment method due to its advantage compared with surgery. But, the radiotherapy can damage or destroy normal cells as well as destroying tumor cells and cause side effects of treatment. Even though most side effects are temporary, these effects can be extremely fatal for patient. Therefore, the exact measurement of the exposure dose of patient during radiation therapy is very important for patient safety. In the case of the conventional fiber-optic radiation sensor that consists of a scintillator for high-energy radiation dosimetry, additional correction is necessary due to the quenching effects of the scintillator. In this study, we measured the exposure dose of the high-energy proton beam without the scintillator by using the Cerenkov radiation that generated inside the plastic optical fiber. As a result of this study, we confirmed a Bragg peak of the proton beam without a scintillator. Also it was in good agreement with the result of the ionization chamber.</P>
Kim, Min-Hyeok,Jang, Ji-Soo,Koo, Won-Tae,Choi, Seon-Jin,Kim, Sang-Joon,Kim, Dong-Ha,Kim, Il-Doo American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.24
<P>Bimodally meso- (2-50 nm) and macroporous (>50 nm) WO<SUB>3</SUB> microbelts (MBs) functionalized with sub-3 nm Pt catalysts were fabricated via the electrospinning technique followed by subsequent calcination. Importantly, apoferritin (Apo), tea saponin and polystyrene colloid spheres (750 nm) dispersed in an electrospinning solution acted as forming agents for producing meso- and macropores on WO<SUB>3</SUB> MBs during calcination. Particularly, mesopores provide not only numerous reaction sites for effective chemical reactions, but also facilitate gas diffusion into the interior of the WO<SUB>3</SUB> MBs, dominated by Knudsen diffusion. The macropores further accelerate gas permeability in the interior and on the exterior of the WO<SUB>3</SUB> MBs. In addition, Pt nanoparticles with mean diameters of 2.27 nm were synthesized by using biological protein cages, such as Apo, to further enhance the gas sensing performance. Bimodally porous WO<SUB>3</SUB> MBs functionalized by Pt catalysts showed remarkably high hydrogen sulfide (H<SUB>2</SUB>S) response (<I>R</I><SUB>air</SUB>/<I>R</I><SUB>gas</SUB> = 61 @ 1 ppm) and superior selectivity to H<SUB>2</SUB>S against other interfering gases, such as acetone (CH<SUB>3</SUB>COCH<SUB>3</SUB>), ethanol (C<SUB>2</SUB>H<SUB>5</SUB>OH), ammonia (NH<SUB>3</SUB>), and carbon monoxide (CO). These results demonstrate a high potential for the feasibility of catalyst-loaded meso- and macroporous WO<SUB>3</SUB> MBs as new sensing platforms for the possibility of real-time diagnosis of halitosis.</P> [FIG OMISSION]</BR>