시선제어 시스템에서의 비선형 토크보상 적용

盧澈均,尹錫榮,金廣泰 慶一大學校 1997 論文集 Vol.14 No.2

Line of sight(LOS) control systems are precision electro-optical-mechanical gimbal assemblies designed to control the angular position of the LOS of a sensor precisely, therefore they are isolated from the base vehicle dynamics and LOS is pointed toward the target in a desired direction. Nonlinear torque disturbances in their systems cause LOS jitter which limit system performance. Major sources of nonlinear disturbance are friction torque by rotation and gimbal imbalance torque by nonlinear environment. This paper describes the compensation technique for reducing LOS jitter due to nonlinear friction coupling of the host vibration. Proposed compensator controls the feedforward torque command of plant adaptively to converge the error between reference model without friction and plant output to zero. Simulation results show that proposed compensator is effective in cancelling the nonlinear torque and improving the stabilization performance.

토끼에서 Etofenprox와 Spinosad 합제의 국소자극성 시험

황윤환,김명석,송인배,박병권,양승호,임용현,송치용,안성한,남현수,임정교,정상일,명노일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

This study was performed to evaluation the skin and eye irritation of etofenprox 8% and spinosad 4% combination in male New Zealand White rabbits. In skin irritation test, the combination of etofenprox and spinosad did not showed any change of body weight but caused slight skin irritation with the P.I.I. (primary irritation index) value 0.25. The etofenprox and spinosad combination showed severe eye irritation 1 h, 24 h, 48 h, and 72 h after ocular treatment, having the A.O.I. (acute ocular irritation) value of 37.3. Therefore, these result indicated that the combination of etofenprox and spinosad might be irritant formulation on eye and skin.

空氣流動中의 噴射가스 燃料의 擴散에 關한 實驗的 硏究 (Ⅰ)

朴涇錫,金錫魯 慶熙大學校 1989 論文集 Vol.18 No.-

The mixture formation process has a great, influence on the performance and exhaust gas characteristics in the direct injection engines, such as Hydrogen engines and Diesel engines. This paper presents a fundamental study on the mixing process of compound jets. In this experimental study, the tracers used are CO_2, H_2 and He. The average-velocity of the air injected is 3m/sec, 5m/sec, 8m/sec, and 10m/sec. To observe spreading behavior of gas fuel, the Schlieren apparatus was used to take a picture of the fluid density. Then the values of the potential core length(Z_P), the potential core length and the transient length (Z_t), and the visual extension angle (φ) were obtained by visualized photo-analysed. The visual extension angle is decreased irrelatively for variety of injected gas, and is increased with constant grade in the area transient jet is occured. Experimental parameters are the average injection velocity of the tracer and the average injection velocity of the air.

한국산 마의 영양성분 분석

조영숙,박석규,박정로,김종홍,이종일,문주석 순천대학교 기초과학연구소 1993 基礎科學硏究誌 Vol.4 No.-

Tubers of Korean yams were analyzed in proximate, amino acid and fatty acid compositions. The yams were composed of moisture (70.6-86.1%), protein (5.8-9.2%), crude fat (0.2-0.9%) and reducing sugar (0.7-2.9%). The pH and titratable acidity of yam juice were 6.0-6.3 and 0.9-1.1 ㎎%, respectively. Total amino acid contents of the yams were 21.2-26.9% comprising essential amino acids of 49.2-57.3%, and the major amino acids were glutamic acid (2.9-4.3%), arginine (3.0-4.2%) and aspartic acid (2.2-2.8%). Thirteen fatty acids were detected, and the major fatty acids were linoleic (42.2-49.4%), palmitic (25.5-27.8%) and oleic acid (4.7-13.7%).

항결핵 6개월 단기요법의 성과 고찰

서지원,정연채,김남재,홍석철,김주옥,김선영,노흥규 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

To evaluate the effect of 6-month short term antituberculosis chemotherapy with INH, Rifampin, Ethambutol, and Pyrazinamide(2HREZ/4HRE) in the patients with pulmonary and/or extrapulmonary tuberculosis, the authors prescribed 2HREZ/4HRE regimen in 79 tuberculosis patients for 6 months with measuring the sputum staining for AFB, chest X-ray findings, recurrence rates and possible side reactions of the treatment. The result were as follow; 1. Pulmonary Tuberculosis 1) Among the 56 pulmonary tuberculosis patients who had taken 2HREZ/4HRE regimen. 32 patients showed initial positivity in sputum AFB smear stain(57.2%). Negative conversion occurred usually within 2 months after initiation of chemotherapy and the mean period of negative conversion was 1.4 months. 2) Among the 56 pulmonary tuberculosis patients, chest X-ray finding changed in 41 patients (37.21%). From these 41 patients 39 patients showed continuous improvements in chest X-ray finding, though 3 patients showed initial aggravation in spite of continuous medication. The remainder 2 cases aggravated due to the failure of treatment. 3) Treatment failure occurred in 2 patients (3.57%) during the chemotherapy among 56 patients of pulmonary tuberculosis and they were infected with secondary drug-resistant strains of M. tuberculosis. 2. Extrapulmonary tuberculosis. Among 8 patients with tuberculous pleurisy and 15 patients with superficial tuberculous lymphadenitis, there were no evidence of treatment failure after completion of antituberculosis chemotherapy for 6 months with 2HREZ/4HRE regimen. 3. Follow-up study was performed from 6 months to 50 months after completion of antituberculosis chemotherapy and the relapse was not noted in both pulmonary and extrapulmonary tuberculosis patients group during this period. 4. Serum AST/ALT elevated in 9 patients(11.4%) during the treatment and this occurred usually within 3 months after the initiation of antituberculosis chemotherapy. However treatment interruption occurred in 2 patients (2.5%) due to the development of hepatitisone due to drug-induced hapatitis and the other due to type B viral hepatitis. In conclusion, we could find this 2HREZ/4HRE 6-months short-term antituberculosis regimen is effective and could be recommanded as a promising regimen for the treatment of tuberculosis.

최소차 하천의 임계면적에 따른 유역 지형매개변수의 변화특성

안승섭,박노삼,김종호,임기석,송시훈 한국환경과학회 2005 한국환경과학회지 Vol.14 No.1

The size of minimum order stream has a very sensitive effect on runoff analysis model using the divergence characteristic of stream. Therefore, in this study, the threshold area of minimum order stream has been examined the change characteristic of topographical parameters. The subject basin of the research was the upper basin of the Kumho water gage station which is located in the middle of the Kumho river. The 1:25,000 numerical geography which was constructed 10×lOm mesh was used. The range of investigation of topographical parameters are number of stream order, length, area, slope, basin relief, sinuosity ratio, drainage density and total stream length etc. It was found from the result of analysis that the threshold value of minimum order stream has a very big effect on topographical parameters of basin. It was found that the threshold area of minimum ord er stream revealed under 0.10km². Furthermore, the parameters showed a serious change except for over 0.10km².

ICR계 마우스에서 홍화씨 에탄올 추출물의 급성독성시험

황윤환,박병권,임종환,김명석,송인배,명노일,정상일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1

The present study was carried out to investigate the potential acute toxicity of safflower seed by a single oral dose in ICR mice. Twenty animals of each sex were randomly assigned to four groups of 5 rats each and were administered singly by gavage at dose levels of 0, and 2,500 mg/kg bodyweight. Mortalities, clinical findings, and body weight changes were found and complete gross postmortem examinations were performed. Throughout the study period, no treatment-related deaths were observed. There were no adverse effects in clinical signs, body weight, and gross findings at any dose tested. The results showed that the single oral administration of safflower seed did not cause any toxic effect at the dose levels of 2,500 mg/kg in rats and the minimal lethal dose was considered to be over 2,500 mg/kg body weight for both sexes.

한국의 발톱진균증 환자의 삶의 질에 관한 연구

조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]

Revisiting the thickness reduction approach for near-foldable capacitive touch sensors based on a single layer of Ag nanowire-polymer composite structure

Kim, Kwang-Seok,Kim, Sun Ok,Han, Chul Jong,Kim, Dae Up,Kim, Jin Soo,Yu, Yeon-Tae,Lee, Cheul-Ro,Kim, Jong-Woong Elsevier 2018 Composites science and technology Vol.165 No.-

<P><B>Abstract</B></P> <P>Although a percolated network of silver nanowires (AgNWs) is considered the most promising flexible transparent electrode because of its high conductivity, high transmittance, excellent flexibility, and facile patternability, it has encountered a serious delay in its application to most optoelectronic devices. Here, we analyzed the reasons and tried to resolve the current issues to achieve near-foldable transparent touch sensors by employing an inverted layer processing method. A hydroxylated polydimethylsiloxane (PDMS) was used as a preliminary substrate for deposition and patterning of AgNWs, and then the nanowires were completely transferred to the newest version of colorless polyimide (cPI) by hydrophobic recovery of the PDMS surface. For the first time, we designed an automatic apparatus for testing the foldability of the fabricated composite film by a spacer inserting method. The testing of various AgNWs/cPI films with this method revealed that the thickness reduction approach could be an efficient and powerful tool to attain near-foldable electrodes if the AgNWs are solidly adhered to the substrate. Based on these findings, we could successfully demonstrate a near-foldable touch sensor, which is capable of sensing human touches even in the folded state.</P>

Biphasic Regulation of Mitogen-Activated Protein Kinase Phosphatase 3 in Hypoxic Colon Cancer Cells

Kim, Hong Seok,Kang, Yun Hee,Lee, Jisu,Han, Seung Ro,Kim, Da Bin,Ko, Haeun,Park, Seyoun,Lee, Myung-Shin Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.10

Hypoxia, or low oxygen tension, is a hallmark of the tumor microenvironment. The hypoxia-inducible factor-1α (HIF-1α) subunit plays a critical role in the adaptive cellular response of hypoxic tumor cells to low oxygen tension by activating gene-expression programs that control cancer cell metabolism, angiogenesis, and therapy resistance. Phosphorylation is involved in the stabilization and regulation of HIF-1α transcriptional activity. HIF-1α is activated by several factors, including the mitogen-activated protein kinase (MAPK) superfamily. MAPK phosphatase 3 (MKP-3) is a cytoplasmic dual-specificity phosphatase specific for extracellular signal-regulated kinase 1/2 (Erk1/2). Recent evidence indicates that hypoxia increases the endogenous levels of both MKP-3 mRNA and protein. However, its role in the response of cells to hypoxia is poorly understood. Herein, we demonstrated that small-interfering RNA (siRNA)-mediated knockdown of MKP-3 enhanced HIF-1α (not HIF-2α) levels. Conversely, MKP-3 overexpression suppressed HIF-1α (not HIF-2α) levels, as well as the expression levels of hypoxia-responsive genes (LDHA, CA9, GLUT-1, and VEGF), in hypoxic colon cancer cells. These findings indicated that MKP-3, induced by HIF-1α in hypoxia, negatively regulates HIF-1α protein levels and hypoxia-responsive genes. However, we also found that long-term hypoxia (>12 h) induced proteasomal degradation of MKP-3 in a lactic acid-dependent manner. Taken together, MKP-3 expression is modulated by the hypoxic conditions prevailing in colon cancer, and plays a role in cellular adaptation to tumor hypoxia and tumor progression. Thus, MKP-3 may serve as a potential therapeutic target for colon cancer treatment.