간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

한일병합 100년, 한국문학의 식민성과 탈식민성 ; 1920년대 인도 시인의 유입과 탈식민성의 모색

오문석 ( Moon Seok Oh ) 민족문학사학회·민족문학사연구소 2011 민족문학사연구 Vol.45 No.-

근대시의 발전 경로에서 인도 시인의 영향은 이중적이다. 첫째는 인도에 대한 조선의 관심이 주로 서양을 매개로 한다는 점이다. 간디, 타고르, 나이두, 네루 등은 모두 서양이 주목한 정치인(혹은 종교인), 시인이라는 공통점을 갖는다. 그들은 서양에 의해서 인정받은 동양인이다. 여기에는 서구적 근대성의 시선이 작동하고 있다. 둘째는 인도의 저명인사들이 대개 ``반근대``, ``반문명``의 태도를 취한다는 점이다. 그들은 서구적 근대성의 시선에서 자유로우며, 서구문명과 서구적 근대를 부정하는 근거로 ``동양``을 제시하고 있다. 그들은 동양인의 자존심을 회복시켜주고 있다. 하지만 ``동양 담론``은 일본의 식민지 이데올로기 중의 하나이다. 동양의 동일성은 한일병합의 근거로 작용한 바 있다. 인도에서 ``동양 담론``은 ``탈근대`` ``탈문명``을 통해서 ``탈식민화``의 가능성을 내포하지만, 조선에서 ``동양 담론``은 근대문명의 동양적 결정판인 ``일본의 식민지 이데올로기``에 깊이 감염되어 있다. 동양 담론이 (서구적) 근대화의 이데올로기와 충돌하지 않았던 것이다. 하지만 1920년대 인도 시인의 영향은 달랐다. 그들이 서구적 근대화에 대한 반성의 계기를 마련해주고 있기 때문이다. 그 흔적은 타고르의 영역판 시집을 둘러싼 번역 문제에서 찾아볼 수 있다. 타고르의 시집 번역에서 가장 큰 문제는 해당 시집의 ``종교성``을 부각시키는 문제였다. 특히 『기탄잘리』의 영역판에 등장하는 ``thou``의 번역이 문제였다. 오천석은 ``thou``를 ``님/그대``로 번역하여 종교적 성격보다 연애시의 성격을 강조하였는데, 김억은 그것을 철저하게 ``you``와 구별하면서 ``주님/하느님``으로 번역하여 종교성의 의미를 살리고자 했다. 하지만 타고르의 대표 시집 3권을 완역한 이후 김억은 ``thou``와 ``you``의 동일성을 ``동양적 특성``으로 강조하게 된다. 오천석의 번역어인 ``님/그대``에 자신의 번역어인 ``주님/하느님``의 뜻이 포함될 수 있다는 것이다. 한용운의 지적처럼 ``님``은 연인에서 국가, 부처까지 무한 확장이 가능한 개념이 된 것이다. ``님``을 매개로 해서, 문학과 종교(초월)의 통일성, 님과의 합일을 통한 주체의 소멸 등의 동양적 성격이 오히려 근대적 ``서정시``의 성격으로 자리잡게 된다. 이른바 ``전통 서정시``의 기본적인 모델이 완성된 것이다. 이것은 서구적 노블의 정착을 목적으로 하는 근대 소설의 발전 경로와 다른 점이다. 또한 조선에도 ``님의 상실-회복``의 서사가 정착하게 되고, 조선(=님)의 르네상스를 이데올로기로 정립하게 된다. 근대를 기점으로 이전과 이후가 서로 결합하는 사고가 정착된 것이다. ``근대 이전``이 ``근대 이후``의 가능성을 모색하게 하는 낡은 창고로서 주목받게 된 것이다. 30년대의 ``신라``의 재발견은 그 일부에 해당한다. Indian poets such as Gandhi, Tagore, Naidu, Nehru and more influenced in the development of modern Korean poetry in two contradictory ways. First of all, Koreans were initially interested in the above mentioned poets in that they were most admired in the West. It is obvious that Koreans were strongly conscious that these political (or religious) poets were the Orientals recognized and praised by Westerns. In a certain way, it is implied that Koreans highly regarded Western perspective and modernity. On the other hand, it is noticeable that most of the eminent figures in India were against modernization and civilization. Not only did they reject to be confined to Western modernity but also unreservedly pictured the East in opposition to Western civilization and modernization. They indeed regained self-esteem and respect as Orientals. Nonetheless, it cannot be ignored that discourse on the Orient was central to Japanese imperialism and colonial ideologies. In fact, the Japanese colonization of Korea was once justified in the name of the Oriental identity. While discourse on the Orient in India suggested the possibilities of post-colonization with post-modernization and post-civilization, the discourse in Korea was deeply imbued with Japanese colonial ideologies which were regarded as the Oriental representative of modern civilization. In other words, discourse on the Orient in Korea was not incompatible with the ideologies of Western modernization. However, under the influence of Indian poets in the 1920s, Koreans were challenged to reconsider Western modernization. A controversy over translating Tagore`s poems in English into Korean was exemplary in case. What was at issue in translating Tagore`s poetry was its religious implication. Especially, how to translate ``thou`` in the English version of 『Gitanjali』 into Korean was debated. Oh Cheonseok translated ``thou`` as ``you`` indicating a lover. In doing so, the poem was more likely to be romantic than religious. In contrast, Kim Uk distinguishably understood it as ``God/Lord/Jesus`` to underline the religious implication of the poem. However, after translating all three volumes of Tagore`s poems, Kim stressed that characteristically there was no difference between ``thou`` and ``you`` in terms of an Oriental sensibility. He thus argued that Oh`s word ``you`` was equivalent to his word ``God/Lord/Jesus`` as Han Youngun`s ``Nim(you)`` was variously conceptualized as a lover, nation, Buddha, and more. From the concept of ``Nim,`` rather, Oriental characteristics such as the unity of literature and religion and the deconstruction of poetic subject into oneness with ``Nim`` have been distinguished as those of modern poetry. This is to say that the elementary model of ``traditional`` lyric poetry came to be complete. Also, it is what differs the development of modern Korean poems from that of modern Korean novels which aimed at the settlement of Western novels` style. Moreover, the narrative on ``the loss and recovery of Nim`` took root in Korea, and the Renaissance of the nation identified with Nim was established as ideology. Since the modern era, a notion to incorporate ``before the era`` and ``after the era`` has been diffused in a great degree. ``Before the modern era`` (pre-modernity) was much studied as ``an original storage`` to appreciate the potentials of ``after the modern era``(post-modernity). In the end, it partly resulted in the rediscovery of ``Shilla`` in the 1930s.

진화전략과 상태 관측기에 의한 영구자석 동기전동기의 센서리스 속도제어기 설계에 관한 연구

손문경,이동희,오석규 진주산업대학교 1999 산업과학기술연구소보 Vol.- No.6

Permanent magnet synchronous motor is widely applied for the industrial and home appliance because of it`s high power density and easy control. Recently sensorless speed control of PMSM is much studied because a mechanical sensor reduces reliability and increases cost. This paper investigates sensorless controller design of PMSM. Angular speed and position are estimated with observer. In order to reduce variation effect of mechanical parameters and calculation delay, reduced order state observer is designed with electrical parameters. Evolution strategy is used to optimize controller gains and observer eigenvalue. In the sensorless control of PMSM with state observer, eigenvalue affect stability and dynamic response of system,. The simulation and experimental results indicate good performances.

상태관측기를 이용한 영구자석 동기전동기의 센서리스 속도제어

손문경,이동희,오석규 진주산업대학교 1999 산업과학기술연구소보 Vol.- No.6

Sensorless PMSM is much studied for the industrial applications and home appliances because a mechanical sensor reduces reliability and increases cost. This paper investigates a field oriented control method without speed and rotor position sensor using the state observer. The observer is based on the model of the motor represented in the stationary two-axes coordinates. The control strategy is to estimate back-EMF by the state observer and to estimate the rotor speed and the rotor position angle from the estimated back-EMF. And we construct back-EMF constant compensator to compensate estimated speed error due to detuned electrical parameter. The observer is tested by simulation and experiment. The results show that the observer gives a good estimation of speed and rotor position, compensated parameter constants. The simulation and experimental results indicate good performances.

마취흰쥐에서 天麻鉤藤飮의 心血管作用에 對한 硏究

배남규,문석재,임동윤,권오성 대한본초학회 1997 大韓本草學會誌 Vol.12 No.2

The present study was attempted to investigate the cardiovascular effects of Cheonmagudeumg-Eum (CMGDE), which is known to be one of chinese medical prescriptions used in treatment of hypertension, in the anesthetized rats and to clarify the mechanism of its pharmacological action, making use of its water extract. 1. CMGDE (5-45 ㎎/㎏), given into a femoral vein of the rat, produced a dose-dependent hypotensive and bradycardic responses while even much larger doses of it (10-90 ㎎/㎏), given into the rectum, did induced negligible hypotensive responses. 2. CMGDE-induced depressor responses were inhibited greatly by pretreatment with phentolamine (an adrenergic α-receptor antagonist), but not by pretreatment with atropine (an antimuscarinic agent) and chlorisondamine (an autonomic ganglionic blocker). 3. Pressor responses evoked by intravenous norepinephrine were attenuated significantly by pretreatment of CMGDE-infusion with a rate of 45㎎/㎏/20min. 4. In the rat aortic strips, phenylephrine (an adrenergic α1-receptor agonist) and high potassium (a membrane depolarizing agent) caused potent contractile responses, respectively. However, in the presence of CMGDE (2㎎/㎖), the contractile responses of phenylephrine (10-5M) and high potassium (5.6×10 exp (-2)M) were markedly inhibited. Taken together, these experimental results suggest strongly that Cheonmagudeung-Eum may cause the hypotensive responses in the anesthetized normotensive rat, indicating that this cardiovascular effects of CMGDE is likely due to the blockade of adrenergic α-receptors without cholinergic effects.

리마틸 정(부시라민 100㎎)에 대한 부시린 정의 생물학적 동등성

조혜영,이문석,오인준,김동현,문재동,이용복 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.2

Bucillamine is a novel cysteine derivative with two free intramolecular sulfhydryl groups, and has a preventive and therapeutic effect on adjuvant arthritis, suggesting its antirheumatic action. With respect to the effect on the immune system, bucillamine-exerted such immunoregulating actions are to nomalize an excessive reduction or acceleration in immune reaction. It is useful not only in patients with early stage of rheumatoid arthritis (RA) but also in those with active RA retained for more than 10 years. The purpose of the present study was to evaluate the bioequivalence of two bucillamine tablets, Rimatil^TM (Chong Kun Dang Pharmaceutical Co., Ltd.) and Bucilin^TM (Kuhn Il Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 23.67±2.09 years in age and 65.03±6.73 kg in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After three tablets containing 100 mg of bucillamine per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of bucillamine in serum were determined using GC/MS with mass selective detector. Pharmacokinetic parameters such as AUC_t, C_max, and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were -0.29%, -3.20% and 8.22%, respectively, when calculated against the Rimatil^TM tablet. The powers (1-β) for AUC_t and C_max were 84.31 % and 91.16%, respectively. Minimum detectable differences (Δ) at α=0.10 and 1-β=0.8 were less than 20% (e.g., 18.58% and 16.51% for AUC_t and C_max respectively). The 90% confidence intervals were within ±20% (e.g., -12.77∼12.20 for AUC_t and -14.30∼7.90 for C_max). Two parameters met the criteria of KFDA for bioequivalence, indicating that Bucilin^TM tablet is bioequivalent to Rimatil^TM tablet.

수부의 외상성 중수지 관절 탈구의 치료

이승구,송석환,이주엽,문창윤,오재찬 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목적 : 수부의 중수지 관절 탈구의 관혈적 정복이 필요했던 예에서는 정복을 방해하는 구조물에 대해 분석하고 도수 정복이 가능했던 예에서는 성별 및 탈구 형태에 따른 특성에 대해 알아보고자 하였다. 대상 및 방법 : 총 27예의 수부 중수지 관절 탁구 환자 (무지 11예, 이지 14예, 소지 2예)를 대상으로 연구하였다. 탈구된 중수지 관절의 정복을 방해하는 해부학적 구조는 수술시에 확인을 하였으며, 도수 정복이 가능하였던 예들에서도 연령과 손상된 구조물, 그리고 최종적인 임상 결과를 평균 7개월간 추시 관찰하였다. 결과 : 무지 중수지 관절의 탈구 11예 중 파열된 전방 관절낭, 수장판과 단무지 굴건의 파열을 동반한 복합 탈구가 8예 있어 관혈 정복을 시행하였으며, 2예에서만 도수 정복이 가능하였다. 관절염이 있던 1예는 관절 유합술을 시행하였다. 다른 수지의 중수지 관절의 탈구는 Kaplan의 개념에 따라 탈구를 수술 정복하였고 파열된 수장판을 복원하였으며, 1예에서 수술시 표재 중수 횡인대만의 절개와 이완으로 정복할 수 있었다. 소지 중수지 관절 탈구의 2예에서 파열된 요측 측부인대가 수술시 관찰되었고 이를 복원하여 수지의 불안정성을 예방하였다. 이들의 최종 결과는 특별한 운동 제한이나 불안정성 없이 좋은 결과를 보였다. 결론 : 적절한 국소 마취하에 도수 정복을 1~2회 시행할 수 있지만 단순 정복이 가능한 탈구가 부적절한 견인으로 정복이 불가능한 복합 탈구로 진행할 수 있다. 그리고 복합 탈구는 대부분 관혈적 정복이 필요하기 때문에, 정복 방해 구조물에 대한 충분한 이해와 적절한 조치가 필요하다. Purpose : To analyse the obstacles to prevent the reduction for dislocation of the metacarpophalangeal (MP) joints of the hand and evaluate the relationship between the sex and dislocation type in closed reduction case. Materials and Methods : Total 27 cases of MP joint dislocation of the hand (11 cases of thumb, and 14 index and 2 little finger) were reviewed retrospectively. The anatomical structures to prevent the reduction were confirmed at operation and the cases which were reduced immediately were also analysed for their ages and differences of damaged structures, and finally their complications or outcome were reviewed for average 7 months after reduction. Results : In 11 cases of thumb MP joint dislocations, the complex dorsal dislocations in which the protruded metacarpal neck was caught by buttonhole of torn anterior joint capsule, volar plate and FPB were reduced by open method in 8 cases, and closed reduction was done in 2 cases but one old case required arthrodesis. In other finger MP joint dislocations, the Kaplan's concept to prevent the reduction was confirmed. But reduction of torn volar plate and incision of transverse metacarpal ligament were sufficient to reduce the dislocation with gentle longitudinal traction during the operation. In two cases of little finger MP joint dislocation, the ruptured radial collateral ligaments were noted after open reduction and it must the repaired to prevent the finger instability later. Their overall end results were good without any significant restriction of MP joints motions and finger instabilities. Conclusion : One or two times of closed reduction with proper local anesthesia could be tried, but simple reducible dislocation can be converted to complex irreducible ones by the inappropriate traction method, and so proper reduction technique by closed or even in open way is important with the knowledge of anatomical obstacles to prevent the reduction of the metacarpophalangeal joints.

돌극형 동기발전기의 온도분포해석에 관한 연구

안영주,황영문,오석규 釜山大學校生産技術硏究所 1995 生産技術硏究所論文集 Vol.49 No.-

회전기기의 설계에 있어서 전기자에서 온도 상승의 계산은 가장 중요한 문제의 하나로 인식되어 왔다. 제시된 많은 온도상승 계산방법에도 불구하고 실제 설계에 사용되는 예는 드물다. 대부분의 경우 이들 방법은 기기의 복잡한 내부 구조 때문에 넓은 범위의 온도 분포를 측정하기에 부적절하다. 본 논문에서, 전기자를 7부분으로 나누어 열 등가회로를 구성하여 시뮬레이션 하였다. 실험은 열전대를 설치한 돌극형 동기발전기로 행하였다. 시뮬레이션 결과 실제 측정한 온도분포와 잘 부합됨을 알 수 있었다. The calculations of the temperature rise in the armature have long been considered among some of the most important problems in the design of the rotating machine. Despite the many methods of calculation of temperature rise proposed, very few have been used in the actual design. In most cases, these methods are inadequate for measuring a wide range of temperature distribution because of the complicated structure of the machine. In this paper, the armature is divided into seven portions, and the thermal equivalent circuit is introduced as a simulation of the armature. The experiment is performed on the salient-pole type synchronous generator with he armature in which the thermocouples were installed. The simulation results are verified by estimated temperature distribution.

법랑모세포 분화와 법랑질 형성과정에서 OD314, Apin protein의 발현 및 기능

박종태,최용석,김흥중,정문진,오현주,신인철,박주철,손호현 대한치과보존학회 2006 Restorative Dentistry & Endodontics Vol.31 No.6

본 연구에서는 법랑모세포 분화와 법랑질 형성에 연관이 있는 OD314 일명 Apin protein의 기능을 밝힐 목적으로, in-situ hybridization에 의한 OD314 mRNA 발현과 법랑모세포 세포주에서 OD314 enamel matrix protein의 발현, 그리고 OD314 유전자를 과발현/억제시킬 수 있는 construct를 제작한 후 법랑질 형성 중에 OD314의 기능을 알아보고자 RT-PCR를 시행하여 다음과 같은 결과를 얻었다. 1. OD314 mRNA는 발생중인 상아모세포보다 법랑모세포에서 강하게 발현되었다. 2. Tuftelin은 석회화 결정이 형성되는 14일까지 발현이 지속되고, 그 이후부터 점차 감소하였다. Amelogenin과enamelin은 7일부터 그 발현이 점점 감소하였다. 3. U6-OD314 siRNA construct를 이용하여 transfection한 법랑모세포 세포주는 OD314와 tuftelin,MMP2 mRNA 발현이 감소하였으며, CM-OD314를 transfection하여 OD314의 과발현을 유도한 경우에는 OD314와 MMP20 mRNA의 발현이 뚜렷이 증대되었다. 이 결과는 OD314가 법랑모세포의 분화와 법랑질의 형성 그리고 석회화 과정에 중요한 역할을 하는 새로운 인자임을 시사한다. This study was aimed to elucidate the biological function of OD314 (Apin protein), which is related to ameloblast differentiation and amelogenesis. Apin protein, calcifying epithelial odontogenic (pindborg) tumors (CEOTs)-associated amyloid, were isolated from CEOTs, and has similar nucleotide sequences to OD314. We examined expression of the OD314 mRNA using in-situ hybridization during tooth development in mice. Expression of OD314 and several enamel matrix proteins were examined in the cultured ameloblast cell line up to 28 days by reverse transcription-polymerase chain reaction (RT-PCR) amplification. After inactivation and over-expression of the OD314 gene in ameloblast cell lines using U6 vector-driven RNA interference and CMV-OD314 construct, RT-PCR were performed to evaluate the effect of the OD314 during amelogenesis. The results were as follows: 1. In in-situ hybridization, OD314 mRNAs were more strongly expressed in ameloblast than odontoblast. 2. When ameloblast cells were cultured in the differentiation and mineralization medium for 28 days, the tuftelin mRNA expression was maintained from the beginning to day 14, and then gradually decreased to day 28. The expressions of amelogenin and enamelin were gradually decreased according to the ameloblast differentiation. 3. Inactivation of OD314 by U6-OD314 siRNA construct down-regulated the expression of OD314, MMP-20, and tuftelin, whereas over-expression of OD314 by CMV-OD314 construct up-regulated the expression of OD314 and MMP-20 without change in tuftelin. These results suggest that OD314 is considered as an ameloblast-enriched gene and may play the important roles in ameloblast differentiation and mineralization.

리마틸 정(부시라민 100 mg)에 대한 부시린 정의 생물학적 동등성

조혜영,이문석,오인준,김동현,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Bucillamine is a novel cysteine derivative with two free intramolecular sulfhydryl groups, and has a preventive and therapeutic effect on adjuvant arthritis, suggesting its antirheumatic action. With respect to the effect on the immune system, bucillamine-exerted such immunoregulating actions are to nomalize an excessive reduction or acceleration in immune reaction. It is useful not only in patients with early stage of rheumatoid arthritis (RA) but also in those with active RA retained for more than 10 years. The purpose of the present study was to evaluate the bioequivalence of two bucillamine tablets, Rimatil^TM (Chong Kun Dang Pharmaceutical Co., Ltd.) and Bucilin^TM (Kuhn Il Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers. 23.67±2.09 years in age and 65.03±6.73㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After three tablets containing 100㎎ of bucillamine per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of bucillamine in serum were determined using GC/MS with mass selective detector. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_mex and T_max between two tablets were -0.29%, -3.20% and 8.22%, respectively, when calculated against the Rimatil^TM tablet. The powers (1-β) for AUC_t and C_max were 84.31% and 91.16%, respectively. Minimum detectable differences (Δ) at α=0.10 and 1-β=0.8 were less than 20% (e.g., 18.58% and 16.51% for AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -12.77∼12.20 for AUC_t and -14.30∼7.90 for C_max). Two parameters met the criteria of KFDA for bioequivalence, indicating that Bucilin^TM tablet is bioequivalent to Rimatil^TM tablet.