Selenium 공급방법이 수경재배 토마토의 생장과 Se 흡수에 미치는 영향

이철규(Cheol-Kyu Lee),조경철(Kyung-Cheol Cho),이정현(Jeong-Hyun Lee),조자용(Ja-Yong Cho),서범석(Beom-Seok Seo),양원모(Won-Mo Yang) (사)한국생물환경조절학회 2005 생물환경조절학회지 Vol.14 No.4

토마토 ‘모모타로’를 공시하여 셀레늄 10㎎ㆍL?¹의 관주 및 엽면시비 등의 단용 및 혼용처리가 수경재배 토마토의 생육 및 과실 내 셀레늄 축적 함량에 미치는 영향을 구명하였다. 토마토 종자를 50공 트레이에 파종하여 70일 동안 육묘한 후 유묘를 코코피트 슬라이브를 이용한 수경재배 시스템에 정식하였다. 양액은 일본원예시험장 배양액 표준처방으로 조성하였으며, pH 5.8~6.2와 EC 2.3 ㎎ㆍL?¹ 등으로 조절하여 공급하였다. 셀레늄은 무기태 SeO₂와 sugar fatty acid ester에 킬레이트화 한 유기태 셀레늄을 10 ㎎ㆍL?¹으로 조성하여 관주, 엽면시비, 관주와 엽면시비를 병행하여 처리하였다. 초장, 엽수, 엽면적 및 엽록소 등의 토마토 생장반응은 셀레늄의 엽면시비, 그리고 엽면시비와 관주를 병행한 처리구에서 현저히 증가하였다. 과실 내 셀레늄 축적 함량은 킬레이트화 한 유기태 셀레늄을 엽면시비와 관주를 병행하여 처리한 경우에 0.302 ㎎ㆍL?¹으로 가장 높았다. 무기태와 유기태 셀레늄의 엽면시비와 관주 등의 단용 처리 보다는 혼용 처리가 전반적인 과실 생장과 체내 셀레늄 축적에 효과적이었다. 무기태 설레늄(SeO₂) 보다는 sugar fatty acid ester에 킬레이트화한 유기태 셀레늄 처리가 셀레늄을 함유한 기능성 토마토의 수경재배에 더 효과적이었다. This study was conducted to clarify the effects of supplying methods of selenium on the growth and Se uptake of hydroponically grown tomato plants. Tomato seeds (Lycopersicum esculentum Mill. cv. Momotaro T-93, Daki Seed Co.) were sown in plug tray with fifty holes, and raised for sixty days. Tomato seedlings transplanted to coco fiber slabs were supplied with the nutrient solutions adjusted to EC 2.3 dSㆍm?¹ and pH 5.8~6.2 recommended by the Japanese Horticultural Experiment Station. Selenium forms used were inorganic SeO₂ (here in after referred to Se) and organic selenium chelated with sugar fatty acid ester (here in after referred to chelated-Se). 10 ppm selenium solutions were treated to tomato plants with foliar applications, drenching, and foliar application plus drenching. Growth characteristics in terms of plant height, number of leaves, leaf area and chlorophyll content were significantly increased in the plot of foliar application of Se, and in the plot of foliar application plus drenching of chelated-Se than other plots, respectively. Transported contents of selenium into the tomato fruits were highest as 0.302 ppm in the plot of foliar application plus drenching of chelated-Se. Also, it had tended to be higher in the plot of foliar application plus drenching than in the plots of foliar application or drenching in both of Se and chelated-Se. Foliar application and drenching of organic chelated-Se were effective to produce the functional tomato fruits.

우황청심원의 고문헌기록 및 실험적 연구결과 분석을 통한 임상응용 확대의 필요성 고찰

오영택,오현묵,김서우,김원용,손창규,조정효,Oh, Young-Taeck,Oh, Hyeon-Muk,Kim, Seo-Woo,Kim, Won-Yong,Son, Chang-Gue,Cho, Jung-Hyo 대전대학교 한의학연구소 2017 혜화의학회지 Vol.26 No.1

Objectives: The aim of this study is (1) to investigate the historic changes and pharmacological efficacies of Woohwangchungsim-won and (2) to discuss the necessities for Woohwangchungsim-won's clinical applications. Methods: This study was performed through (1) investigating the ancient literature records related with Woohwangchungsim-won and analyzing Woohwangchungsim-won's composition, dosage and indications, (2) searching articles about Woohwangchungsim-won on 10 major Korean web and 3 major foreign web article search engines and analyzing Woohwangchungsim-won's pharmacological efficacies and indications. Results: Woohwangchungsim-wom has been used for cerebrovascular diseases such as stroke and palpitation. Also, there are some ancient literature records of Woohwangchungsim-won's clinical applications in neuropsychiatric disorders such as depression and bipolar disorder. In addition, there have been a number of experimental studies which demonstrate Woohwangchungsim-won's neuroprotective effect on cerebral cortex and hippocampus injury. So, it is possible to infer that Woohwangchungsim-won can be used for the treatments of neuropsychiatric disorders associated with neuronal cell death in cerebral cortex and hippocampus. But there have been no or less experimental studies which demonstrate the pharmacological efficacy of Woohwangchungsim-won on such disease. Conclusion: It is necessary that further experimental studies which demonstrate Woohwangchungsim-won's pharmacological efficacy on neuropsychiatric disorders should be done and Woohwangchungsim-won's clinical applications should be expanded on the basis of those related experimental results.

A hot-water extract of <i>Sanguisorba officinalis</i> ameliorates endotoxin-induced septic shock by inhibiting inflammasome activation : HSO attenuates inflammasome activation

Seo, Dong-Won,Cho, Yong-Il,Gu, Suna,Kim, Da-Hee,Yi, Young-Joo,Lee, Sang-Myeong Center for Academic Publications Japan 2018 Microbiology and immunology Vol.62 No.1

<P>The inflammasome is a multiprotein signaling complex that mediates inflammatory innate immune responses through caspase 1 activation and subsequent IL-1 secretion. However, because its aberrant activation often leads to inflammatory diseases, targeting the inflammasome holds promise for the treatment of inflammation-related diseases. In this study, it was found that a hot-water extract of Sanguisorba officinalis (HSO) suppresses inflammasome activation triggered by adenosine 5-triphosphate, nigericin, microbial pathogens, and double stranded DNA in bone marrow-derived macrophages. HSO was found to significantly suppress IL-1 production in a dose-dependent manner; this effect correlated well with small amounts of caspase 1 and little ASC pyroptosome formation in HSO-treated cells. The anti-inflammatory activity of HSO was further confirmed in a mouse model of endotoxin-induced septic shock. Oral administration of HSO reduced IL-1 titers in the serum and peritoneal cavity, increasing the survival rate. Taken together, our results suggest that HSO is an inhibits inflammasome activation through nucleotide-binding domain and leucine-rich repeat pyrin domain 3, nucleotide-binding domain and leucine-rich repeat caspase recruitment domain 4 and absent in melanoma 2 pathways, and may be useful for treatment of inflammasome-mediated diseases.</P>

윤상인두근 기능 이상에 의한 중증 연하장애 환자에서 풍선확장치료 및 보툴리눔독소 주사치료의 효과: 증례 보고

Won Kyung Lee,Han Gil Seo,Min Yong Seong,Jiwoon Yeom,Woo Hyung Lee,Tai Ryoon Han,오병모 대한연하장애학회 2017 대한연하장애학회지 Vol.7 No.2

Objective: To investigate changes of swallowing function after ballooning dilatation (BD) and the Botox injection (BI) into the cricopharyngeus muscle in patients with severe dysphagia. Method: Nine severe dysphagic patients with cricopharyngeal dysfunction (CPD) who underwent BD and/or BI into the cricopharyngeal muscle were retrospectively reviewd. Patients who had severe dysphagia (Functional Oral Intake Scale (FOIS)≤2) after at least 3 months of the conventional swallowing therapy were included by a thorough review of medical records with videofluoroscopic swallowing study (VFSS). Before and after several interventions (BD and/or BI), swallowing function was evaluated using VFSS. Result: Among 9 patients, 5 underwent both BD and BI, and the other 4 patients underwent only BD. Four among 9 cases showed that interventions were effective. Of the 5 cases with both BD and BI, 2 cases were effective for treatment of CPD. In all the effective 4 cases, pyriform sinus residue seemed to be related with FOIS. Of those cases, one case had long-term effect (more than 4 months) and the other 3 case had short term effect (less than 4 months). Conclusion: Interventions were effective in 4 among 9 cases with severe CPD and the therapeutic effect was sustained for more than 4 months. The results suggest that in CPD patients, the BD or BI into UES could be considered in selected patients.

Random mesh-like Ag networks prepared via self-assembled Ag nanoparticles for ITO-free flexible organic solar cells

Seo, Ki-Won,Noh, Yong-Jin,Na, Seok-In,Kim, Han-Ki Elsevier 2016 Solar energy materials and solar cells Vol.155 No.-

<P><B>Abstract</B></P> <P>Highly-transparent and flexible random mesh-like Ag networks formed by self-assembled Ag nanoparticles for use in transparent and flexible electrodes for ITO-free flexible organic solar cells (FOSCs) was demonstrated. By transferring a self-assembled Ag nanoparticle network onto a PET substrate, embossed and intaglio-type mesh-like Ag network electrodes were fabricated. Electrical, optical, morphological, and mechanical properties of the embossed and intaglio-type mesh-like Ag network electrodes were compared in detail. Although both mesh-like Ag networks exhibited similar sheet resistance, optical transmittance, and flexibility, the intaglio-type Ag networks were advantageous to use as transparent electrodes for FOSCs due to the high aspect ratio of emboss-type Ag networks. Regardless of organic active materials, FOSCs with intaglio-type Ag networks exhibited better performance than FOSCs with emboss-type Ag networks due to ease in forming uniform organic layer coatings on the intaglio-type Ag networks embedded in the substrate. This indicated that intaglio-type mesh-like Ag network electrodes are a promising flexible and transparent anode for printable ITO-free FOSCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Characteristics of mesh-like Ag network electrodes were investigated for ITO-free FOSCs. </LI> <LI> By embedding an Ag network into a PET substrate, an intaglio-type Ag network electrode was achieved. </LI> <LI> Intaglio-type Ag network is a promising printable transparent electrode to replace high-cost ITO electrodes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Development of PRIDE UNDA for safeguards application

Seo, Hee,Lee, Chaehun,Lee, Seung Kyu,Won, Byung-Hee,Ahn, Seong-Kyu,Shin, Hee-Sung,Na, Sang-Ho,Song, Dae-Yong,Kim, Ho-Dong,Park, Geun-Il,Park, Se-Hwan Atomic Energy Society of Japan 2016 Journal of nuclear science and technology Vol.53 No.6

Clinical relevance of necrotizing change in patients with community‐acquired pneumonia

Seo, Hyewon,Cha, Seung‐,Ick,Shin, Kyung‐,Min,Lim, Jae‐,Kwang,Yoo, Seung‐,Soo,Lee, Jaehee,Lee, Shin‐,Yup,Kim, Chang‐,Ho,Park, Jae‐,Yong,Lee, Won‐,Kee BLACKWELL SCIENCE 2017 RESPIROLOGY Vol.22 No.3

<P><B>ABSTRACT</B></P><P><B>Background and objective</B></P><P>Few studies have analysed a large number of patients with necrotizing pneumonia (NP) diagnosed based on computed tomography (CT) scans. The aim of the present study was to document the incidence and clinical features of NP in patients with community‐acquired pneumonia (CAP).</P><P><B>Methods</B></P><P>This retrospective study was conducted on CAP patients who had been admitted to a tertiary referral centre and who had available enhanced CT scan images. Patients were allocated into NP and non‐NP groups, and they were compared with respect to various clinical variables.</P><P><B>Results</B></P><P>Of the 830 patients included in the present study, necrotizing change was observed in 103 patients (12%). Patients with NP experienced more symptoms of pneumonia, had higher blood levels of inflammatory markers and more often required pleural drainage compared to patients with non‐NP. Although the use of mechanical ventilation, vasopressor infusion, 30‐day mortality, in‐hospital mortality and clinical deterioration did not differ between the NP and non‐NP groups, the median length of hospital stay (LOS) was significantly longer in the NP group. Multivariate analysis using Cox proportional hazards model showed that necrotizing change independently predicted LOS in patients with CAP.</P><P><B>Conclusion</B></P><P>NP affects approximately one‐tenth of hospitalized CAP patients. It may be associated with more severe clinical manifestations and may increase the need for pleural drainage. NP was found to be an independent predictor of LOS, but not of mortality in CAP patients.</P>

식도 중복 낭종으로 오인된 식도 평활근종 1예

Won Yong Seo,김광하,이호석 대한상부위장관ㆍ헬리코박터학회 2021 Korean Journal of Helicobacter Upper Gastrointesti Vol.21 No.2

Esophageal leiomyoma is a benign tumor that accounts for two-thirds of esophageal benign tumors. In general, patients with esophageal leiomyoma are asymptomatic; however, as the tumor grows in size, symptoms such as dysphagia, chest discomfort, obstruction, or bleeding can appear. A 65-year-old man visited our clinic to receive treatment for a subepithelial tumor in the lower esophagus, which was incidentally found during endoscopy for work-up of chest discomfort and indigestion. On endoscopic ultrasonography (EUS), the tumor was 2.6×1.9 cm in size, with a cystic lesion located in the submucosal and proper muscle layers and thick cystic wall. Therefore, it was highly likely to be a duplication cyst. As the patient had symptoms such as chest discomfort, surgical resection was performed. The tumor was finally diagnosed as a leiomyoma with cystic degeneration. Leiomyoma with cystic change that has similar EUS features to duplication cyst is rare. Thus, we report the case with a literature review.

Normal Postoperative Computed Tomography Findings after a Variety of Pancreatic Surgeries

Seo, Ji Won,Hwang, Ho Kyoung,Lee, Minwook,Kim, Ki Whang,Kang, Chang Moo,Kim, Myeong-Jin,Chung, Yong Eun unknown 2017 KOREAN JOURNAL OF RADIOLOGY Vol.18 No.2

<P>Pancreatic surgery remains the only curative treatment for pancreatic neoplasms, and plays an important role in the management of medically intractable diseases. Since the original Whipple operation in the 20th century, surgical techniques have advanced, resulting in decreased postoperative complications and better clinical outcomes. Normal postoperative imaging findings vary greatly depending on the surgical technique used. Radiologists are required to be familiar with the normal postoperative imaging findings, in order to distinguish from postoperative complications or tumor recurrence. In this study, we briefly review a variety of surgical techniques for the pancreas, and present the normal postoperative computed tomography findings.</P>

Pilot-scale investigation of sludge reduction in aerobic digestion system with endospore-forming bacteria

Seo, Kyu Won,Choi, Yong-Su,Gu, Man Bock,Kwon, Eilhann E.,Tsang, Yiu Fai,Rinklebe, Jö,rg,Park, Chanhyuk Elsevier 2017 CHEMOSPHERE - Vol.186 No.-

<P><B>Abstract</B></P> <P>A pilot-scale investigation of membrane-based aerobic digestion system dominated by endospore-forming bacteria was evaluated as one of the potential sludge treatment processes (STP). Most of the organic matter in the sludge was removed (90.1%) by the particular bacteria in the STP, which consisted of mixed liquor suspended solid (MLSS) contact reactor (MCR), MLSS oxidation reactor (MOR), and membrane bioreactor (MBR). The sludge was accumulated in the MBR without wasting, and then the effluent in STP was fed into the first step in water resource recovery facility (WRRF). According to the analysis of microbial communities in all reactors, various <I>Bacillus</I> species were present in the STP, mainly due to their intrinsic resistance to the extreme conditions. As the surviving <I>Bacillus</I> species might consume degraded microorganisms for their growth, these endospore-forming bacteria-based STP could be suitable for the sludge reduction when they operated for a long time.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A pilot-scale sludge treatment process was developed and investigated. </LI> <LI> Membrane-based aerobic digestion system could accumulate the sludge. </LI> <LI> 90% of sludge reduction was achieved in sludge treatment process. </LI> <LI> <I>Bacillus</I> species was dominant and influenced on the sludge reduction. </LI> <LI> Endospore-forming bacteria-based process could be suitable for sludge reduction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>