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Seo Sowon,Yeom Seok Ran,Park Sung-Wook,Wang Il Jae,Cho Suck Ju,Yang Wook Tae,Cho Youngmo 대한외상학회 2023 大韓外傷學會誌 Vol.36 No.2
Purpose: The purpose of this study was to investigate (1) the association among helmet wearing, incidence rate of traumatic brain injury (TBI), and in-hospital mortality; TBI was diagnosed when the head Abbreviated Injury Scale (AIS) was ≥1, and as severe TBI when head AIS was ≥3; and (2) the association between helmet type and incidence rate of TBI, severe TBI, and in-hospital mortality of motorcycle accidents based on the newly revised Emergency Department-based Injury In-depth Surveillance (EDIIS) data. Methods: Data collected from EDIIS between January 1, 2020 and December 31, 2020 were analyzed. The final study population comprised 1,910 patients, who were divided into two groups: helmet wearing group and unhelmeted group. In addition, the correlation between helmet type and motorcycle accident was determined in 596 patients who knew the exact type of helmet they wore. A total of 710 patients who wore helmet but did not know the type were excluded from this analysis. Multivariate logistic regression was performed in both the groups to investigate the factors affecting the primary (occurrence of TBIs) and secondary outcomes (severe TBI and in-hospital mortality). Results: The prevalence of Injury Severity Scores, TBIs, and severe TBIs as well as in-hospitalmortality were the highest in the unhelmeted group. Additionally, the results from the group that wore and knew the type of helmet worn indicated that wearing a full-face helmet decreased the incidence of TBIs in comparison to a half-face helmet. Conclusions: The wearing of a helmet in motorcycle accidents is very important as it plays a role in reducing the occurrence of TBIs and severe TBIs and in-hospital mortality. The use of a full-face helmet lowered the incidence of TBIs.
서채현,강소원,최성숙,Chae Hyeon Seo,Kang SoWon,Sungsook Choi 한국식품위생안전성학회 2023 한국식품위생안전성학회지 Vol.38 No.6
To develop a functional probiotic that inhibits gingipain, a major virulence factor of Porphyromonas gingivlais (P. gingivalis), we screened over 30 probiotic strains for their ability to inhibit gingipian activity. We investigated the inhibition of expression of gingipain genes kgp, rgpA, and rgpB as well as gingipain activity, using freeze dried cell-free supernatants of Weisiella cibaria SPM402 (WC402) and Lactobacillus paracasei SMP412 (LP412), both of which demonstrated antibacterial activity against P. gingivalis. Thus, it was verified that kgp expression was reduced by approximately 0.71±0.02 folds and rgpB expression was reduced by approximately 0.71±0.14 folds at a concentration of WC402 10 mg/mL. Meanwhile, at the same concentration of 10 mg/mL of LP412, kgp expression was reduced by approximately 0.19±0.08 folds, rgpA expression was reduced by approximately 0.09±0.02 folds, and rgpB expression was reduced by approximately 0.24±0.03 folds. At a concentration of 10 mg/mL, Kgp activity was inhibited by approximately 78.65±3.58% (cell associated gingipain, CAG), 82.45±1.22% (cell-free gingipain, CFG) by WC402 and 80.71±2.11% (CAG), and 85.81±0.05% (CFG) by LP412 respectively. Rgp activity was also effectively inhibited by approximately 78.6±1.01% (CAG), 86.78±0.47% (CFG) and 82.93±1.26% (CAG), 88.81±0.36% (CFG) by WC402 and LP412 respectively. Based on these results, W. cibaria SPM402 and L. paracasei SPM412 can be regarded as functional probiotics with the ability to inhibit gingipain activity and exhibit antibacterial effects against P. gingivalis. 치주질환의 원인균인 Porphyromonas gingivlais (P. gingivalis)의 병인인자중 하나인 gingipain 효소에 대한 억제활성을 갖는 유산균을 개발하고자 본 연구실에 보관중인 30여종의 유산균 배양상등액의 활성을 검색하였다. 그 결과 발효식품에서 분리, 동정한 Weisiella cibaria SPM402와 Lactobacillus paracasei SMP412가 P. gingivalis에 대한 항균효과, gingipain 유전자 발현억제 및 gingipain 효소활성 억제능이 확인되었다. W. cibaria SPM402 의 배양 상등액 WC402는 10 mg/mL에서 kgp 유전자는 0.71±0.02배 발현되었고, rgpB 유전자는 0.71±0.14배 발현되 약간의 발현억제 효과가 확인되었다. 반면 L. paracasei SMP412의 배양상등액 LP412는 10 mg/mL 농도에서 kgp 유전자는 0.19±0.08배, rgpA 유전자는 0.09±0.02배, rgpB 유전자는 0.24±0.03배 발현되어 LP412의 뛰어난 gingipain 유전자 발현억제 효과를 확인하였다. 10 mg/mL농도에서, Kgp 효소 활성은 WC 402에 의해 78.65±3.58% (CAG), 82.45±1.22% (CFG), LP412에 의해 80.71±2.11% (CAG), 85.81±0.05% (CFG) 억제되었다. 동일한 농도에서 Rgp 활성은 WC402에 의해 78.6±1.01% (CAG), 86.78±0.47% (CFG), LP412에 의해 82.93 ±1.26% (CAG), 88.81±0.36% (CFG) 억제되었다. 이상의 결과들을 통해 WC402와 LP412는 P. gingivalis에 대한 항균효과 뿐 아니라 병인인자 gingipain을 효과적으로 억제하는 기능성 유산균임을 확인하였다.