Sustained-release praziquantel tablet : pharmacokinetics and the treatment of clonorchiasis in beagle dogs

Hong, Sung-Tae,Lee, Sang Hyup,Lee, Seung-Jin,Kho, Weon-Gyu,Lee, Mejeong,Li, Shunyu,Chung, Byung-Suk,Seo, Min,Choi, Min-Ho 梨花女子大學校 藥學硏究所 2003 藥學硏究論文集 Vol.- No.12

Praziquantel is rapidly absorbed and secreted; and thus fractional doses are recommended for the treatment of cestode and trematode infections. In the present study, we developed a new praziquantel tablet formula allowing sustained-release (SRP). In vitro dissolution of SRP tablets showed that praziquantel at 300 ㎎/tablet combined with hydroxypropyl methylcellulose dissolved completely at a constant rate over 10 h, whereas the conventional praziquantel tablet (PZQ) was only 40% dissolved. Pharmacokinetic studies in dogs confirmed that SRP was absorbed more slowly than PZQ. The mean value of the area under the concentration/time curve from 0 h to the final observation time, the maximum concentration in serum, and the time of maximum concentration in serum for SRP were 3.471.500 ng/min for 0.25 ㎖, 10,300 ng for 0.25 ㎖, and 192 min. while the values for PZQ were 688,600 ng/min for 0.25㎖, 2,500 ng for 0.25㎖, and 135 min. The cure rate in dogs with a heavy infection (500 metacercariae) treated with a single dose of SRP (150 ㎎/tablet) at 50 ㎎/㎏ was 80%, while in dogs treated with a single dose of SRP (300 ㎎/tablet) at 30 mg/kg it was 60%, and the cure rate with PZQ was 20%. In each case. the egg reduction rate was similar (over 90%). No abnormal liver functions or hepatic or renal pathologies were observed in dogs administered with SRP at 30 ㎎/㎏. The SRP tablet showed sustained release and slow absorption; and it had an improved anthelmintic efficacy against Clonorchis sinensis in experimental dogs. compared with conventional praziquantel.

적외선 체열촬영을 이용한 온천요법에 관한 임상적 연구

이정민 ( Jung Min Lee ),뱍인선 ( In Sun Park ),안택원 ( Taek Won Ahn ),홍서영 ( Seo Young Hong ) 한방재활의학과학회 2012 한방재활의학과학회지 Vol.22 No.1

Objectives :The purpose of this study was to investigate the influence of balneotherapy on the changes of DITI(digital infrared thermal imaging). Methods :This study was carried out on 27 patients. They went through balneotherapy with high pressure under water shower(15 min.) and whole body bathing in neutral or hot water between 32 to 40 ℃(15 min.). DITI was measured at before and after the treatment. And then the data was analyzed. Results :1. In cold hypersensitivity of hands group, temperature on PC8 rose and difference between LU4 and PC8 decreased(p<0.05)(Fig. 1, Table Ⅱ). 2. In cold hypersensitivity of feet group, temperature on LR3 rose and difference between ST32 and LR3 decreased(p<0.05)(Fig. 2, Table Ⅱ). 3. In shangrexiahanzheng(上熱下寒證) group, there were no significant changes on CV17, CV6 and difference between CV17 and CV6(Fig. 3, Table Ⅱ). Conclusions :These results demonstrated that balneotherapy has clinical effects on cold hypersensitivity of hands and feet. And further studies are required to apply the balneotherapy in order to cure various diseases in the future.

수술실 손 소독제의 종류에 따른 균주 수의 변화

홍성윤,김정민,김소영,이수정,오은실,양서인,김화실,김남초 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: The present study purposed to compare the hand washing effect of 7.5% powidone-iodine, which is used in the operation room of C university hospital in Seoul, with that of Ethyl alcohol-CHG mixture recommended by the US Association of Operating Room Nurses (2002) and to adopt a more effective hand disinfectant. Method: In a quasi-experimental design, 48 medical staff who participated in operations during the period from November 2004 to February 2005 had hand washing using the two kinds of hand disinfectants: 7.5% povidone-iodine and the ethyl alcohol-CHG mixture. Their palms were swabbed and cultured just after hand washing and again after taking dff sterile gloves after the operation. The number of colonies from the two occasions were counted and compared. Result: The number of general bacillus increased significantly in the group using 7.5% povidone-iodine compared to that in the group using the ethyl alcohol-CHG mixture. The number of general bacillus increased signficantly in doctors compared to that in nurses. The factors affecting the increase of the number of general bacillus were disinfectants and medical personnel. The number of general bacillus was expected to increase 9.41 times with 7.5% povidone-iodine than with the ethyl alcohol-CHG mixture and 14.87 times in doctors than in nurses. Conclusion: This study shows that the ethyl alcogol-CHG mixture has a stronger hand disinfection effect than 7.5% povidone iodine. Thus we need to change the hand disinfectant used in operating rooms as soon as possible in order to minimize the infection of wounds resulting from operations.

설계강우의 시간적 분포모형 적용성 연구

서진호,이상배,조흥제,민병형 東亞大學校 海洋資源硏究所 1995 硏究論文集 Vol.8 No.1

위천대표유역의 11녀간의 단독강우사상 3,550개를 선별하여 Yen-Chow의 삼각형 및 사다리꼴, Huff, Pilgrim-Cordery 및 Mononobe의 방법에 의한 지속시간별 설계강우의 시간적분포 특성치를 제시하였다. Yen-Chow 방법의 삼각형분포의 특성치 a 값은 0.44에서 0.50까지 분포하였고, 사다리꼴은 지속시간이 길어질수록 무차원 특성변수 h 의 값이 점차 커지는 경향을 나타내었다. Huff 4분기법에 의한 분석결과는 2구간 강우가 지배적이고 3구간 강우가 낮은 분포를 나타내었다. 또한 Pilgrim-Cordery 방법에서는 6시간까지는 점방위 강우형이고, 6시간이상은 점차 후방위로 변화하였다. Mononobe 방법은 시간별 강우량을 중앙집중형으로 나타내었다. 본 방법들의 적용성을 검토하기 위해 위천유역의 32개 관측 강우-유출자료를 이용하였고, 분석결과 Yen-Chow 방법의 삼각형분포가 비교적 재현성이 높게 나타났다. 이들 설계강우의 시간적분포모형들은 미계측유역의 유출해석에 중요한 수단을 제공할 것으로 판단된다. The historical data from 3,550 event storms during 11 years in Wi-stream basin have been used to investigate the statistical parameter of the time distribution for design storms by the method of Yen-Chow, Huff, Pilgrim-Cordery and Mononobe. The dimensionless value of triangular hyetograph, a , ranges from 0.44 to 0.50 and trapezoidal hyetograph, h , value increases as the duration time is getting longer in Yen-Chow method. In the Huff, the second-quartile storms occurred most frequently and third-quartile storms occurred most infrequently. In the Pilgrim-Cordery, the shapes for shorter than 6-hour durations are advanced tendency. However, for longer than 6-hour durations show delayed tendency. In the Mononobe, every one hour rainfall occured Centered Type. The application of these methods for each duration time was tested by using the observed rain-fall-runoff data of Wi-stream basin. As a result, the reappearance of hydrographs of triangular hyetograph by Yen-Chow method showed promising, and it was approved to be used for prediction of the ungaged basins.

Fast and Scalable Hydrodynamic Synthesis of MnO₂/Defect-Free Graphene Nanocomposites with High Rate Capability and Long Cycle Life

Hong, Seok Bok,Jeong, Jae-Min,Kang, Heon Gyu,Seo, Donghyuk,Cha, Younghyun,Jeon, Hyeonyeol,Lee, Geun Young,Irshad, Mobina,Kim, Do Hyun,Hwang, Sung Yeon,Kim, Jung Won,Choi, Bong Gill American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.41

<P>The integration of metal oxides and carbon materials provides a great potential for enhancing the high energy and power densities of supercapacitors, but the rational design and scalable fabrication of such composite materials still remain a challenge. Herein, we report a fast, scalable, and one-pot hydrodynamic synthesis for preparing ion conductive and defect-free graphene from graphite and MnO<SUB>2</SUB>/graphene nanocomposites. The use of this hydrodynamic method using Taylor-Couette flow allows us to efficiently fast shear-exfoliate graphite into large quantities of high-quality graphene sheets. Deposition of MnO<SUB>2</SUB> on graphene is subsequently performed in a fluidic reactor within 10 min. The prepared MnO<SUB>2</SUB>/graphene nanocomposite shows outstanding electrochemical performances, such as a high specific capacitance of 679 F/g at 25 mV/s, a high rate capability of 74.7% retention at an extremely high rate of 1000 mV/s, and an excellent cycling characteristic (∼94.7% retention over 20 000 cycles). An asymmetric supercapacitor device is fabricated by assembling an anode of graphene and a cathode of MnO<SUB>2</SUB>/graphene, which resulted in high energy (35.2 W h/kg) and power (7.4 kW/kg) densities (accounting for the mass of both electrodes and the electrolyte) with a high rate capability and long cycle life.</P> [FIG OMISSION]</BR>

Pentadecafluorroctyl Polyacrylate에 依한 Nylon 6 纖維의 撥水加工에 關한 硏究

李廷玟,任洪彬,劉承坤,裵基瑞 충남대학교 공업교육연구소 1978 論文集 Vol.1 No.2

This study has been investigated on the effects of fluorochemical repellent agent on the water repellent finishes of nylon 6 fibre with pentadecafluorooctyl polyacrylate. Contact angles of various liquids on the fluorochemical treated nylon 6 surface are measured. The critical surface tension of about 46 dynes per cm on the nylon 6 surface is resulted. The effect of fluorochemical repellent was most favourable at 1% concentration repellent agent and the critical surface tension is resulted the value of about 10.5 dynes per cm. The use of antistatic agent in the fluorochemical repellent was most favourable below 0.5% concentration. It was found that the repellent effects were improved by repeated treatments with the solution of lower concentration of repellent.

Benzo(a) pyrene에 의해 유도된 간장해에 미치는 황련 수침액의 영향

윤수홍,하헌,서민지 한국환경독성학회 1993 환경독성보건학회지 Vol.8 No.1

The present study was undertaken to find a protective effect of Coptis Rhizoma Extract on liver injury induced by benzo (a)pyrene in rats. This crude drug significantly suppressed the increase of several biochemical parameters such as transaminase, lactate dehydrogenase and alkaline phosphatase in serum and liver and total cholesterol. But there were little changes in elevated serum phospholipid level. The results suggested that Coptis Rhizoma prevent bezo (a)pyrene-induced hepatic injury.

택사추출액이 benzo(a)pyrene에 의해 유도된 간장해에 미치는 영향

尹水弘,徐旼志,河勳 대구효성가톨릭대학교 1996 연구논문집 Vol.52 No.2

The protective and therapeutic effects of Alismae Rhizome extracts depending on solvent polarity on rat liver injury induced by benzo(a)pyrene were investigated. As parameters in serum and liver, alkaline phosphatase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase activities were observed. The results were as follows: B(a)P intoxication significantly increased alkaline phosphatase, transaminase activities of serum and liver compared with normal group. Especially CHCI₃fraction revealed the most powerful liver protective and/or therapeutic effect of 4 extracts in serum transaminase activities and in hepatic alkaline phosphatase and glutamate oxaloacetate transaminase, maybe due to presence of alkaloid, triterpenoid and flavonoid in this fraction. Above-mentioned results strongly suggested that Alismae Rhizoma be a promising liver-protective drug. So more study will be needed to find principle hepatotropic Alismatis Rhizoma.

비틀림 負荷를 받는 中實 中共軸의 應力擴大係數의 解析

李洪西,河榮旻 충주대 산업과학기술연구소 1998 産業科學論文集 Vol.6 No.-

Generally, for the fracture problem in an actual construction, three-dimensional cracks exist in most cases, and in crack propagation, the stress intensity factors KI, KII and KIII usually act in single or mixed modes. Stress intensity factors are important parameters affecting stress-strain behavior in the vicinity of a crack tip. They are used for the strength evaluation of machines, structures, and various machine elements. In fracture problems, stress intensity factors obtained theoretically and experimentally have been effectively utilized in the analytical evaluation of the effect of cracks. In the paper, the mixed mode stress intensity factors KI, KII and KIII are determined experimentally by combining the caustic method and photoelastic stress freezing method.

ROM과 7-Segment LED를 이용한 온도 디스플레이

김태홍,박민서 동양대학교 1999 동양대학교 논문집 Vol.5 No.1

Analog-digital (A-D) converters are used to convert analog signal such as voltage, temperature and pressure to digital. But the outputs of A-D converters are usually in hexadecimal form which is difficult to supply to next stage with different input form. To interface between different requirements, we need second converter. In this paper, the second conversion was showed for the temperature measured in analog form and converted into digital and to change into BCD (binary coded decimal) using ROM. The signal was finally supplied to 7-segment LEDs to display the temperature.