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Fabricating Using Nano-particulates with Direct Write Technology
Sears James,Colvin Jacob,Carter Michael 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
Modern business trends call for miniaturization of electronic systems. One of the major impedances in this miniaturization is the conductive and inductive components in chips and circuit boards. Direct Write Technology can write these soft magnetic materials, thus allowing for further miniaturization of inductor devices. Another obstacle in electronics fabrication is the size limitations of thick screen-printing and the material limitations in ink jet printing. Direct Write Technologies address both of these limitations by providing feature sizes less than 20 microns with a wide range of materials possibilities. A discussion of the application of these nano-particulate materials by Direct Write Technologies will be presented.
Hard, Wear Resistant Metal Surfaces for Industrial Applications through Laser Powder Deposition
Sears James,Costello Aaron 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
Laser Powder Deposition (LPD) is a technology capable of modifying a metallic structure by adding the appropriate material to perform a desired function. LPD offers a unique fabrication technique that allows the use of soft (tough) materials as base structures. Through LPD a hard material can be applied to the base material with little thermal input (minimal dilution and heat-affected-zone {HAZ}), thus providing the function of a heat treatment or other surface modifications. These surface modifications have been evaluated through standard wear testing (ASTM G-65), surface hardness (Rc), micro-hardness (vickers), and optical microscopy.
Sergio Davinelli,Graziamaria Corbi,Stefano Righetti,Barry Sears,Hector Hugo Olarte,Davide Grassi,Giovanni Scapagnini 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.10
Cardiovascular disease (CVD) remains the leading cause of death today. Many of the biochemical alterations associated with the pathophysiology of CVD can be modified by adequate intakes of bioactive nutrients through a correct diet or supplementation. Recently, there has been growing public and clinical interest in cocoa polyphenols (CPs) and omega-3 (ω-3) fatty acids. A plethora of nutritional intervention trials and experimental studies demonstrates that consumption of these bioactive food compounds is beneficial to promote cardiovascular health. The purpose of this review is to summarize the major cardioprotective effects of CPs and ω-3 fatty acids, providing a scientific rationale for incorporating the combination of these molecules as a nutritional intervention in the prevention of CVD. Although several studies have shown the individual cardioprotective nature of these compounds, a combination treatment with CPs and ω-3 fatty acids may be a promising approach to enhance the preventive value of these molecules and reduce cardiovascular risk factors associated with aging. Therefore, this article also reviews some of the key studies on the interaction between CPs and the metabolism of ω-3 fatty acids.
Genome editing in the treatment of ocular diseases
Choi Elliot H.,Suh Susie,Sears Avery E.,Hołubowicz Rafał,Kedhar Sanjay R.,Browne Andrew W.,Palczewski Krzysztof 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Genome-editing technologies have ushered in a new era in gene therapy, providing novel therapeutic strategies for a wide range of diseases, including both genetic and nongenetic ocular diseases. These technologies offer new hope for patients suffering from previously untreatable conditions. The unique anatomical and physiological features of the eye, including its immune-privileged status, size, and compartmentalized structure, provide an optimal environment for the application of these cutting-edge technologies. Moreover, the development of various delivery methods has facilitated the efficient and targeted administration of genome engineering tools designed to correct specific ocular tissues. Additionally, advancements in noninvasive ocular imaging techniques and electroretinography have enabled real-time monitoring of therapeutic efficacy and safety. Herein, we discuss the discovery and development of genome-editing technologies, their application to ocular diseases from the anterior segment to the posterior segment, current limitations encountered in translating these technologies into clinical practice, and ongoing research endeavors aimed at overcoming these challenges.
Heo, Youn-Jung,Kim, Jueng-Eun,Weerasinghe, Hasitha,Angmo, Dechan,Qin, Tianshi,Sears, Kallista,Hwang, Kyeongil,Jung, Yen-Sook,Subbiah, Jegadesan,Jones, David J.,Gao, Mei,Kim, Dong-Yu,Vak, Doojin Elsevier 2017 Nano energy Vol.41 No.-
<P><B>Abstract</B></P> <P>We report organic cation additives in lead iodide solutions as a practical approach for roll-to-roll production of perovskite solar cells. Sequential deposition, which is known to be more reliable than 1 step process, is modified to be even more reliable and suitable in roll-to-roll process. Addition of less than stoichiometric amount of organic cations in PbI<SUB>2</SUB> solution effectively improves processability by working as crystallization retardant and make dried PbI<SUB>2</SUB> film more reactive for faster conversion to perovskite. The printing-friendly sequential deposition is used in air with slot die coating, an industrial up-scaling technique, to produce a perovskite solar cell on glass with a 14.4% power conversion efficiency (PCE). The process is then used in actual roll-to-roll machine in air to produce flexible perovskite solar cells with up to 11.0% PCE.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Conventional sequential deposition is modified to be more suitable for roll-to-roll process. </LI> <LI> Reactive intermediate shows more rapid conversion to perovskite than conventional PbI<SUB>2</SUB> intermediate. </LI> <LI> Fully slot die coated perovskite solar cells under ambient condition shows a power conversion efficiency of 14.4%. </LI> <LI> Roll-to-roll processed flexible perovskite solar cells show power conversion efficiency of 11%. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Riyaz Ul Hassan Syed ),( Gary Strobe ),( Brad Geary ),( Joe Sears ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.1
A Nodulisporium sp. (Hypoxylon sp.) has been isolated as an endophyte of Thelypteris angustifolia (Broadleaf Leaf Maiden Fern) in a rainforest region of Central America. It has been identified both on the basis of its morphological characteristics and by scanning electron microscopy as well as ITS sequence analysis. The endophyte produces volatile organic compounds (VOCs) that have both fuel (mycodiesel) and use for biological control of plant disease. When grown on potato dextrose agar, the organism uniquely produces a series of ketones, including acetone; 2-pentanone; 3-hexanone, 4-methyl; 3-hexanone, 2,4- dimethyl; 2-hexanone, 4-methyl, and 5-hepten, 2-one and these account for about 25% of the total VOCs. The most abundant identified VOC was 1,8 cineole, which is commonly detected in this group of organisms. Other prominent VOCs produced by this endophyte include 1-butanol, 2- methyl, and phenylethanol alcohol. Moreover, of interest was the presence of cyclohexane, propyl, which is a common ingredient of diesel fuel. Furthermore, the VOCs of this isolate of Nodulisporium sp. were selectively active against a number of plant pathogens, and upon a 24 h exposure caused death to Phytophthora palmivora, Rhizoctonia solani, and Sclerotinia sclerotiorum and 100% inhibition to Phytophthora cinnamomi with only slight to no inhibition of the other pathogens that were tested. From this work, it is becoming increasingly apparent that each isolate of this endophytic Nodulisporium spp., including the Daldina sp. and Hypoxylon spp. teleomorphs, seems to produce its own unique set of VOCs.
Optical probe of Heisenberg-Kitaev magnetism inα−RuCl3
Sandilands, Luke J.,Sohn, C. H.,Park, H. J.,Kim, So Yeun,Kim, K. W.,Sears, Jennifer A.,Kim, Young-June,Noh, Tae Won American Physical Society 2016 Physical review. B Vol.94 No.19
<P>We report a temperature-dependent optical spectroscopic study of the Heisenberg-Kitaev magnet alpha-RuCl3. Our measurements reveal anomalies in the optical response near the magnetic ordering temperature. At higher temperatures, we observe a redistribution of spectral weight over a broad energy range that is associated with nearest-neighbor spin-spin correlations. This finding is consistent with highly frustrated magnetic interactions and in agreement with theoretical expectations for this class of material. The optical data also reveal significant electron-hole interaction effects, including a bound excitonic state. These results demonstrate a clear coupling between charge and spin degrees of freedom and provide insight into the properties of thermally disordered Heisenberg-Kitaev magnets.</P>
Ham, Mira,Lee, Joo-Won,Choi, A Hyun,Jang, Hagoon,Choi, Goun,Park, Jiyoung,Kozuka, Chisayo,Sears, Dorothy D.,Masuzaki, Hiroaki,Kim, Jae Bum American Society for Microbiology 2013 Molecular and cellular biology Vol.33 No.12
<P>Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme that regulates cellular redox potential. In this study, we demonstrate that macrophage G6PD plays an important role in the modulation of proinflammatory responses and oxidative stress. The G6PD levels in macrophages in the adipose tissue of obese animals were elevated, and G6PD mRNA levels positively correlated with those of proinflammatory genes. Lipopolysaccharide (LPS) and free fatty acids, which initiate proinflammatory signals, stimulated macrophage G6PD. Overexpression of macrophage G6PD potentiated the expression of proinflammatory and pro-oxidative genes responsible for the aggravation of insulin sensitivity in adipocytes. In contrast, when macrophage G6PD was inhibited or suppressed via chemical inhibitors or small interfering RNA (siRNA), respectively, basal and LPS-induced proinflammatory gene expression was attenuated. Furthermore, macrophage G6PD increased activation of the p38 mitogen-activated protein kinase (MAPK) and NF-κB pathways, which may lead to a vicious cycle of oxidative stress and proinflammatory cascade. Together, these data suggest that an abnormal increase of G6PD in macrophages promotes oxidative stress and inflammatory responses in the adipose tissue of obese animals.</P>
Stat3 Activation in Murine Colitis Induced by Enterotoxigenic Bacteroides fragilis :
Wick, Elizabeth C.,Rabizadeh, Shervin,Albesiano, Emilia,Wu, XinQun,Wu, Shaoguang,Chan, June,Rhee, Ki-Jong,Ortega, Guillermo,Huso, David L.,Pardoll, Drew,Housseau, Franck,Sears, Cynthia L. Oxford University Press 2014 Inflammatory bowel diseases Vol.20 No.5
<P>Enterotoxigenic Bacteroides fragilis (ETBF), a molecular subclass of the common human commensal, B. fragilis, has been associated with inflammatory bowel disease. ETBF colitis is characterized by the activation of Stat3 and a Th17 immune response in the colonic mucosa. This study was designed to investigate the time course and cellular distribution of Stat3 activation in ETBF-colonized mice.</P>