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Electrical Switching Phenomena in V_2O_5 - TeO_2 Glass Semiconductors
RHEE, Chunghi,YOON, Se Won 慶熙大學校 1974 論文集 Vol.8 No.-
10∼70 mole%를 포함한 몇개의 V_2O_5-TeO_2유리의 電流-電壓 特性이 유리의 組成 成分과 電極사이 간격에 따라서 조사되었다. 유리표면에서 非可逆的인 스윗칭이 한번 일어난 後에는 電壓을 每번 올렸다 내림에 따라 S型. 負性微分抵抗 特性이 再現됨을 發見하였다. 첫번째 스윗칭이 생긴후 形成된 필라멘트가 結晶化 하는 것으로 보아 스윗칭 현상은 不規則的인 유리質 狀態로부터 規則的인 結晶質 狀態로의 相變化와 관계됨을 알수있다. 結晶化된 狀態는 構造가 安定하여 S型 特性을 再現시키며 이 現象은 電子的 過程보다는 熱 果에 현저히 基因하고 있다. Current-voltage characteristic of se-veral V_2O_2-TeO_2 glasses containing 10-70 molar percent V_2O_2 was investigated as a function of composition and electrode separation. It has been found that the irreversible switching phenomenon occurs once on a virgin surface of the glasses and s-type negative differential resis-tance is reproduced in each voltage recycling. Evidence of devitrification of the filament formed after the first switching reveals that the switching action is associated with a phase transi-tion from a disordered glassy-state to an ordered devitrified-state due to self-heating effects. The devitrified state is structure stable and yields a reproducible s-type characueristic, which is attributed predominantly to thermal effects rather than to electronic processes.
Yoon, Se-Hee,Cho, Jang-Hee,Kwon, Owen,Choi, Ji-Young,Park, Sun-Hee,Kim, Yong-Lim,Yoon, Young-Ran,Won, Dong-Il,Kim, Chan-Duck Lippincott Williams Wilkins, Inc. 2013 Transplantation Vol.95 No.6
BACKGROUND: We prospectively studied renal transplant recipients receiving tacrolimus to determine the relationship between the CYP3A4, CYP3A5, and ABCB1 genetic polymorphisms and the pharmacokinetics (PK) and pharmacodynamics (PD) of tacrolimus and its metabolites. METHODS: Renal transplant recipients receiving tacrolimus were genotyped for CYP3A4*4, CYP3A4*5, CYP3A4*18, CYP3A5*3, ABCB1 c.1236C→T, ABCB1 c.2677G→A/T, and ABCB1 c.3435C→T. Dose-adjusted trough concentration (C0) of tacrolimus and its metabolites (M-I and M-III) and PK and PD (T-cell and monocyte subsets) were determined on transplantation days –2, 5, 30, and 90 and correlated with the corresponding genotypes. RESULTS: The dose-adjusted C0 of tacrolimus and its metabolites and AUC0–12 were significantly higher and the mean fluorescence intensity (MFI) of HLA/DR in monocytes was significantly lower in patients with CYP3A5*3/*3 than in patients with CYP3A5*1/*1 or CYP3A5*1/*3. However, there was no significant difference in the dose-adjusted C0 of tacrolimus and its metabolites, PK and PD among the ABCB1 genotypes. The MFI of HLA/DR in monocytes showed a significant negative correlation with dose-adjusted C0 of tacrolimus and its metabolites and AUC0–12. In a multiple regression analysis, the presence of the CYP3A5*3/*3 genotype was a significant independent variable determining the dose-adjusted C0 of tacrolimus and its metabolites, AUC0–12, and the MFI of HLA/DR in monocytes. CONCLUSIONS: This study demonstrates that the CYP3A5 genetic polymorphisms are associated with the individual differences in PK and PD as well as in C0 of tacrolimus and its metabolites. The MFI of HLA/DR in monocytes might be considered to be a significant tool for monitoring tacrolimus efficacy.
Effects of partially earth-anchored cable system on dynamic wind response of cable-stayed bridges
Won, Jeong-Hun,Yoon, Ji-Hyun,Park, Se-Jun,Kim, Sang-Hyo Techno-Press 2008 Wind and Structures, An International Journal (WAS Vol.11 No.6
In this study, a partially earth-anchored cable system is studied in order to reduce the dynamic wind response of cable-stayed bridges. The employment of earth-anchored cables changes the dynamic characteristics of cable-stayed bridges under wind loads. In order to estimate the changes in the member forces, the spectral analysis for wind buffeting loads are performed and the peak responses are evaluated using 3-D finite element models of the three-span cable-stayed bridges with the partially earth-anchored cable system and with the self-anchored cable system, respectively. Comparing the results for the two different models, it is found that the earth-anchored cables affect longitudinal and vertical modes of the bridge. The changes of the natural frequencies for the longitudinal modes remarkably decrease the peak bending moment in the pylon and the movements at the expansion joints. The small changes of the natural frequencies for the vertical modes slightly increase bending moments and deflections in the girder. The original effects of the partially earth-anchored cable system are also shown under wind loads; the decrement of girder axial forces and bearing uplifting forces, and the increment of cable forces in the earth-anchored cables.
Yoon, Seong-Hoe,Nam, Woong,Park, Won-Se,Kim, Hyung-Jun The Korean Association of Oral and Maxillofacial S 2007 대한구강악안면외과학회지 Vol.33 No.1
The fibromatoses are a broad group of fibrous proliferations. They have a biologic behavior and histopathologic pattern that is intermediate between those of benign fibrous lesions and fibrosarcoma. Because they are not common diseases, it is important to differentiate the fibromatoses from other similar diseases. In this report, we present a case of fibromatosis, and possible other diseases to be differentiated, with a review of literatures.
Screening and characterization of alleviating effect for premenstrual syndrome from natural plants
Yoon Seo Lee,Yeong-Geun Lee,Hye Won Ryu,Taehyun Kim,Hee Ju Lee,Sang Hyeon Yu,Dae Won Park,Juha Park,Se Chan Kang 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Premenstrual syndrome(PMS) occurs during the luteal phase of the menstrual cycle, which promoting PMS symptoms including physical, mental, and behavioral changes. The exact cause of PMS is unknown but is believed to be related to increasing prolactin secretion leads to an imbalance of estrogen and progesterone ratio. Estrogen decreases the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) and increases prolactin (PRL). LH and FSH, released from the anterior pituitary, then enter into a complex feedback loop with progesterone and estrogen. The menstrual cycle is caused by the complex interaction of these hormones. To identify herbs with prolactin secretion inhibitory activity, 61 kinds of herbal extracts were used for experiments, and Hordeum vulgare extract (HVE), Chrysanthemum zawadskii extract (CZE), and Inula helenium extract (IHE) were selected that could alleviate PMS symptoms. We confirmed that HVE, CZE, and IHE inhibited prolactin secretion and restored imbalance sex hormones(estrogen, FSH, LH, progesterone) in hyperprolactinemic mice and rat models. And extracts significantly suppressed the expression of inflammatory markers in uterine tissue. In addition, prolactin level suppression and anti-inflammatory effects by HVE, CZE, and IHE were tested in vitro. HVE, CZE, and IHE were separated through activity-guided fractionation to find active compounds alleviating PMS. As a result, each active compound structures were determined using NMR. These compounds significantly inhibited prolactin secretion in the pituitary cell. These results suggest that HVE, CZE, and IHE have potential therapeutic agents for PMS.
Se hee PARK,Hi jo SHIN,Sang woon KIM,Taek changae LEE,Hae jin LEE,Ki hoan NAM,Won kee YOON,Hyoung chin KIM,Hyo jung KWON,Young Suk WON 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Corynebacterium was gram positive diphtheroid rods shape bacteria. This bacterium was induce sever disease in immunodeficiency mice such as of Corynebacterium-assoicated hyperkeratosis and pseudotuberculosis. In Korea, we isolated 110 strains of Corynebacterium species from experimental mice and identification with several method. When identified based on 16s rRNA sequence analysis, major isolated Corynebacterium species in Korea were C. mastitidis(46.4%, n=51), C. bovis(23.7%, n=26), C. amycolatum(13.7%, n=15), and C. lowii(15.5%, n=17). When comparing the identified result based on the 16S rRNA sequence with the rpoB gene sequence, biochemical test, and MALDI TOF, rpoB gene method was most similar with 16s rRNA sequence (96.4%), and next MALDI-TOF method(73.1%), biochemical method(15.3%). The low accuracy of MALDI TOF is because C. lowii is not included in the data base. Excluding the results of C. lowii, the accuracy is quite high at 97.4%. C. amycolatum and C. bovis was sometimes isolated from immune deficient nude mice with skin disease. Histopathologically, mild to severe hyperkeratosis with infiltration of lymphocytes plasma and neutrophils and gram positive short rod bacteria found in hyperkeratic area. And we cannot found any disease from C. mastitidis and C. lowii contaminated animals. In conclusion, we isolated 110 strains of Corynebacterium from Korea experimental mice. Different type of identification method showed different diagnostic result. Especially biochemical test has low correlated with 16s rRNA sequence, rpoB gene sequence and MALDI-TOF result. So, it will be important to choose an appropriate identification method for accurate diagnosis of Corynebacterium from mice,
Yoon, Hye-Jin,Mikami, Bunzo,Park, Hyun-Ju,Yoo, Ja-Kyung,Suh, Se-Won Korean Crystallographic Association 2007 韓國結晶學會誌 Vol.18 No.1
UDP-N-acetylglucosamine enolpyruvyl transferase (MurA; EC 2.5.1.7) catalyzes the first committed step of peptidoglycan biosynthesis in bacteria, i.e., transfer of enolpyruvate from phosphoenolpyruvate to UDP-N-acetyl-glucosamine. Because the crystallization condition contained a high concentration of ammonium sulfate, our inhibitor binding studies were not successful. Therefore, we employed a docking approach to investigate the inhibitor binding. Our results will be useful in structure-based design of specific inhibitors of MurA for antibacterial discovery.
Yoon, Se Young,Hong, Min Eui,Chang, Won Seok,Sim, Sang Jun Springer-Verlag 2015 BIOPROCESS AND BIOSYSTEMS ENGINEERING Vol.38 No.7
<P>Under autotrophic conditions, highly productive biodiesel production was achieved using a semi-continuous culture system in Neochloris oleoabundans. In particular, the flue gas generated by combustion of liquefied natural gas and natural solar radiation were used for cost-effective microalgal culture system. In semi-continuous culture, the greater part (similar to 80 %) of the culture volume containing vegetative cells grown under nitrogen-replete conditions in a first photobioreactor (PBR) was directly transferred to a second PBR and cultured sequentially under nitrogen-deplete conditions for accelerating oil accumulation. As a result, in semi-continuous culture, the productivities of biomass and biodiesel in the cells were increased by 58 % (growth phase) and 51 % (induction phase) compared to the cells in batch culture, respectively. The semi-continuous culture system using two stage photobioreactors is a very efficient strategy to further improve biodiesel production from microalgae under photoautotrophic conditions.</P>