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광중합 시 수종의 심미적 수복재와 이장재의 사용에 따른 치수내 온도변화
장혜란,이형일,이광원,이세준 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.5
Polymerization of light-activated restorations results in temperature increase caused by both the exothermic reaction process and the energy absorbed during irradiation. Within composite resin, temperature increases up to 20℃ or more during polymerization. But, insulation of hard tissue of tooth lowers this temperature increase in pulp. However, many clinicians are concerned about intrapulpal temperature injury. The purpose of this study was to evaluate temperature changes in the pulp according to various restorative materials and bases during curing procedure. Caries and restoration-free mandibular molars extracted within three months were prepared Class I cavity of 3×6mm with high speed handpiece fissure bur. 1mm depth of dentin was evaluated with micrometer in mesial and distal pulp horns. Pulp chambers were filled with 37.0 ±0.1℃ water to CEJ. Chromium-alumina thermocouple was placed in pulp horn below restorative materials for evaluating of temperature changes. This thermocouple was connected to temperature-recording device(Multifunction analyzer MX, 6.000, JAPAN). Temperature changes was evaluated from initial 37.0℃ after temperature changes to 37.0℃. Tip of curing unit was placed in the center of prepared cavity separated 1mm from restorative materials. Curing time was 40s. The restorative materials were used with Z 100, Fuji II LC, Compoglass flow and bases were used with Vitrebond. Dycal. Resrorative materials were placed in 2mm. The depth of bases were formed in 1mm and in this upper portion, resin of 2mm depth was placed. This procedure was performed 10 times. The results were as follows : 1.All the groups showed that the temperature in pulp increased as curing time inceased 2.The temperature increase of glass ionomer was significantly higher than that of Resin and Compomer during curing procedure (P<0.05). 3.The temperature increase In glass ionomer base was significantly higher than that of Calcium hydroxide base during Resin curing procedure (P<0.05).
Ha Young‐Ran,Jeong Se‐Jin,Jang Chang‐Won,Chang Kyu‐Sik,Kim Hyun‐Woo,Cho Shin‐Hyoung,Lee Hee‐Il 한국곤충학회 2021 Entomological Research Vol.51 No.2
Mosquitoes have adapted to various environmental conditions. Symbionts with mosquitoes impact this adaptation in different environments. In the field, mosquitoes could get exposed to antibiotics during their developmental period, which could reduce or eliminate their symbiotic microbes. However, the side effects of the antibiotics on the ovary and reproductive physiology of the Asian tiger mosquito, Aedes albopictus remains unknown. In this study, we investigated the effects of tetracycline and combinations of rifampicin and tetracycline at environmentally acceptable levels on the reproductive physiology of ovaries in Ae. albopictus. Rifampicin and tetracycline in combination reduced the hatching rate and fertility of Ae. albopictus compared to the untreated control group. These antibiotics induced histopathological damage and reactive oxygen species production in the ovaries. The combination of antibiotics decreased the expression of surface protein of Wolbachia (WSP) in Ae. albopictus. Additionally, the expression of Toll like receptor 2 (TLR2) and Myd88 were triggered by the combinations. The findings demonstrate the detrimental effects of antibiotics, particularly combinations of rifampicin and tetracycline, on the reproductive capacity of Ae. albopictus females.
류재하,장세란 숙명여자대학교 약학연구소 1998 약학논문집-숙명여자대학교 Vol.15 No.-
C-17 polyacetylene compound was isolated from the roots of Panax ginseng. Its structure was determined by 'H-NMR, ^(13)C-NMR and 'H-'H COSY spectra as PQ-6 (C_(19)H_(26)O_(4); 8- acetoxy-9,10-epoxy-heptadeca-l-ene-4, 6-diyne-3-ol). This compound was previously reported from Panax quinquefolium, but purified from Panax ginseng firstly at this time. PQ-6 from ginseng showed the strong inhibitory activity of nitric oxide synthesis in LPS-activated macrophages. The IC_(50) value of this activity was 1.5㎛.
Se-Ran Yang,Soojin Jang,Jooyeon Lee,Se Min Ryu,Hanbyeol Lee,Jeong-Ran Park,Aera Jang,Dongwook Kim,Hyejin Kim 한국예방수의학회(구 한국수의공중보건학회) 2017 예방수의학회지 Vol.42 No.2
Colorectal cancer is a major cause of morbidity and mortality that accounts for over 9% of all incidences of cancer. Additionally, colorectal cancer is widely recognized as an environmental disease related to ill-defined cultural, social and lifestyle factors including physical activity, obesity, cigarette smoking and heavy alcohol consumption. Accordingly, natural phytochemicals and extracts have attracted attention because of their beneficial biological effects. Coenzyme Q10 (CoQ10) is a common supplementary medicine applied to increase bioenergetic capacity in various diseases. Therefore, in this study, we investigated whether CoQ10 treatment has any inhibitory effects and its related cellular mechanisms in human colon cancer HCT116 cells. A MTT assay revealed that CoQ10 slightly decreased the proliferation of HCT116 cells; however, glutathione- and superoxide dismutase- activity were unchanged in response to CoQ10 treatment. A DCF-DA assay revealed that CoQ10 slightly increased ROS release of HCT116 cells. However, in a nitric oxide (NO) assay, CoQ10 significantly increased NO production in a dose-dependent manner. The results of western blot analysis revealed that the protein levels of Bax, p21 and p53 were increased, whereas the protein level of Bcl2 was decreased suggesting that the CoQ10-mediated inhibitory mechanism is associated with apoptotic signaling. Taken together, our findings indicate that CoQ10 has an inhibitory effect on the growth of colon cancer cells via NO production that is associated with regulation of factors involved in apoptotic signaling including Bax, Bcl2, p21 and p53.
산후다한과 손가락 관절통을 주소로 하는 산후풍 치험 1례
장세란 ( Se Ran Jang ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2015 大韓韓方婦人科學會誌 Vol.28 No.3
Objectives: The purpose of this study is to evaluate the effects of Gamob ojunikgi-tang and Tung``s acupuncture on a postpartum disease patient with hyperhidrosis and finger pain. Methods: We treated the patient complained of hyperhidrosis and finger pain after birth. The patient was diagnosed with postpartum thyroiditis. We aimed to treat the postpartum hyperhidrosis by herbal medicine and the postpartum fingerpain by acupucture. The climateric symptoms of the patient had been estimated with visual analogue scale (VAS). Results: After medication of Bojunikgi-tang and gyeji-tang postpartum hyperhidrosis was rather worse. But after adding aconiti radix lateralis preparata and increasing ginseng and astragalus membranaceus, symptoms were improved. And finger pain was improved after Tung``s acupuncture. Conclusions: This case study shows that herbal medicine is effective treating postpartum hyperhidrosis and Tung``s acupuncture is effective treating postpartum finger pain. And postpartum patients should be considered for whether postpartum thyroiditis.
장세란 ( Se Ran Jang ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.3
Objectives: The aim of this study is to report the effect of oriental treatments for polycystic ovarian disease patient with amenorrhoea. Methods: A 27 years old women, who diagnosed polycystic ovarian disease, was enrolled in this study. She received oriental treatment such as herbal medicine, acupuncture for 8 months. And we proceeded to checkup female hormone regularly, such as Estrogen, LH, FSH, Prolactin. We observed the menstruation period and figure out LH/FSH ratio. Results: Polycystic ovarian disease patient restart cyclic menstruation. LH/FSH ratio of polycystic ovarian disease patient was decreased to normal level. Conclusions: In polycystic ovarian disease patient with amenorrhoea in this case, oriental herbal medicine and acupuncture treatment make cyclic menstruation and restore LH/FSH ratio to normal level.