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Sasaki, Satoshi,Tsuji, Tomiko The Korean Society of Community Nutrition 2003 Journal of community nutrition Vol.5 No.2
Although a generation-related difference in nutrient and food-group intake has been broadly recognized in the Japanese population, few studies have examined the difference and correlation of intakes with consideration of a family line and co-habitation status. We conducted a dietary survey using female college students in dietetic course in Aichi, Japan, and their mothers and grandmothers. A validated self-administered diet history questionnaire was used for assessment of intakes. Data from 110 families were included in the analysis. The means of 13 nutrients and 10 food groups (of the 15 and 14, respectively) showed significant differences among the three generations. A significant difference was observed in the carbohydrate, protein, saturated fatty acid, cholesterol, and fish intakes between the students living with their mothers and those apart. In the correlation analyses between generations, moderate correlation was observed for most nutrients and food groups between the students and their mothers living together (correlation range = 0.30-0.61 for nutrients, and = 0.21 -0.56 for food groups). A wide variation with no consistency was observed for the correlation between the students and their grandmothers (-0.18 -0.59 and -0.33 -0.65, respectively), No meaningful correlation was observed between any two generations living apart. Among the food groups examined, pulses, fish, and vegetables showed relatively large differences for the correlation between two groups with different living conditions. When living together, the correlation coefficients for nutrients and food groups between the students and their mothers decreased according to the increase in frequency of eating out by the students. These results suggest that living together and eating together were an important factor for the resemblance in dietary habits between generations in the population with a marked generation-related difference in intakes. (J Community Nutrition 5(2) : 93-104, 2003)
Sasaki, Satoshi,Shimoda, Taeko,Katagiri, Akane,Tsuji, Tomiko,Amano, Keiko The Korean Society of Community Nutrition 2002 Journal of community nutrition Vol.4 No.2
We examined the association between eating frequency of rice vs. bread at breakfast and nutrient and food-group intake among 1771 female college students aged 18-20 years. The frequency of main staples at breakfast and the nutrient and food group intake for the previous month were assessed with a validated self-administered diet history questionnaire. We divided main staples into rice, bread, and noodles. As the eating frequency for noodles was almost negligible, we computed the difference of eating frequency of rice minus that of bread(mean = 0.7 times/week). Among 16 nutrients examined, the difference of eating frequency correlated significantly and negatively only with fat intake, especially saturated fatty acid (SFA) (r=-0.31, p<0.001), and significantly and positively with the intake of n-3 poly-unsaturated fatty acid, iron, sodium, protein, carotene, potassium, dietary fiber, and vitamin C (r=0.08-0.15, p<0.001) after adjusting for the energy intake, the residential area, the population size, and the living status with their families. In conclusion, the more frequent intake of rice compared to bread at breakfast correlated with the higher intake of the several vitamins and minerals, and the lower intake of fat, especially SFA. The only unfavorable aspect of the rice group was the higher sodium intake.
Satoshi Yamamura,Masaki Ikarashi,Masami Sasaki 한국응용곤충학회 2008 Journal of Asia-Pacific Entomology Vol.11 No.3
Information on the biology of the alpine moth, Syngrapha ottolenguii, is very limited. On the main island of Japan, Honshu, we determined a natural host plant of S. ottolenguii to be Empetrum nigrum in alpine fields; the larvae showed a characteristic nocturnal feeding behavior on this plant. During daytime, the moths hid in the lower layer of the dense E. nigrum shrub. S. ottolenguii exhibited a univoltine life cycle with hibernation at the second or third instar larval stage under deep snow, where the temperature stayed stable at 0 °C for about 6 months. They could be reared with a generation time of about 60 days on an artificial diet under 16L– 8D at 20 °C. The larva was classified as a monosetose with subventral (SV) setae on the second and third thoracic segments. Information on the biology of the alpine moth, Syngrapha ottolenguii, is very limited. On the main island of Japan, Honshu, we determined a natural host plant of S. ottolenguii to be Empetrum nigrum in alpine fields; the larvae showed a characteristic nocturnal feeding behavior on this plant. During daytime, the moths hid in the lower layer of the dense E. nigrum shrub. S. ottolenguii exhibited a univoltine life cycle with hibernation at the second or third instar larval stage under deep snow, where the temperature stayed stable at 0 °C for about 6 months. They could be reared with a generation time of about 60 days on an artificial diet under 16L– 8D at 20 °C. The larva was classified as a monosetose with subventral (SV) setae on the second and third thoracic segments.
Vibration Control of a Micro-Actuator for the Hard Disk Drive using Self-Sensing Actuation
Minoru Sasaki,Satoshi Ito 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
In this paper, self-sensing control of a micro-actuator for the hard disk drive is presented. The micro-actuator is a suspension driving type. The micro-actuator uses a PZT actuator pair, installed on the assembly of the suspension. The self-sensing micro actuator can be used to form a combined actuation and sensing mechanism. Direct velocity feedback control and positive position feedback control of a self-sensing micro-actuator for an HDD is presented. The experimental results show that the direct velocity feedback controller and the positive position feedback controller are effective in suppressing the vibration modes. Experiments successfully demonstrate that the self-sensing actuator can be used for active feedback control of the HDD suspension assembly vibration.
Two-Degree-of-Freedom Control of a Stacker Crane
Minoru Sasaki,Toshimi Shimizu,Kengo Suzuki,Shingo Naito,Satoshi Ito 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper presents a motion control of a stacker crane applying a two-degree-of-freedom control. The two-degree-of-freedom control system consists of a feed forward controller based on an inverse system and a feed backcontroller with suppressing the vibration effectively and stabilizing. Feedback control of the motion of the stacker crane is derived by considering the time rate of change of the total energy of the system. This approach has the advantage overthe conventional methods in the respect that it allows one to deal directly with the system’s partial differential equations without resorting to approximations. The paper concludes by presenting some numerical results and experimental results for a special case using a proposed control system. These results show that the two-degree-of-freedom control system can realize faster and precise tracking control of the flexible stacker crane system.
Self-Tuning Control of a Two-Link Flexible Manipulator using Neural Networks
Minoru Sasaki,Akihiro Asai,Toshimi Shimizu,Satoshi Ito(편집자) 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
In this paper, a self-tuning control of a two-link flexible manipulator using neural networks is presented. The neural networks learn the gains of PI controllers for the flexible manipulator. Numerical results show that this presented neural network control system can suppress the vibration of the flexible manipulator and track the desired joint angles.Simulation results show that the self-tuning control system using neural network can be used effectively for the position control of the two-link flexible manipulator.
Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase ‘Synoviolin’
Yamasaki, Satoshi,Yagishita, Naoko,Sasaki, Takeshi,Nakazawa, Minako,Kato, Yukihiro,Yamadera, Tadayuki,Bae, Eunkyung,Toriyama, Sayumi,Ikeda, Rie,Zhang, Lei,Fujitani, Kazuko,Yoo, Eunkyung,Tsuchimochi, K Wiley (John WileySons) 2007 The EMBO journal Vol.26 No.1
<P>Synoviolin, also called HRD1, is an E3 ubiquitin ligase and is implicated in endoplasmic reticulum -associated degradation. In mammals, Synoviolin plays crucial roles in various physiological and pathological processes, including embryogenesis and the pathogenesis of arthropathy. However, little is known about the molecular mechanisms of Synoviolin in these actions. To clarify these issues, we analyzed the profile of protein expression in synoviolin-null cells. Here, we report that Synoviolin targets tumor suppressor gene p53 for ubiquitination. Synoviolin sequestrated and metabolized p53 in the cytoplasm and negatively regulated its cellular level and biological functions, including transcription, cell cycle regulation and apoptosis. Furthermore, these p53 regulatory functions of Synoviolin were irrelevant to other E3 ubiquitin ligases for p53, such as MDM2, Pirh2 and Cop1, which form autoregulatory feedback loops. Our results provide novel insights into p53 signaling mediated by Synoviolin.</P>
Igawa, Satoshi,Sato, Yuichi,Ishihara, Mikiko,Kasajima, Masashi,Kusuhara, Seiichiro,Nakahara, Yoshiro,Otani, Sakiko,Fukui, Tomoya,Katagiri, Masato,Sasaki, Jiichiro,Masuda, Noriyuki Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Background: Pemetrexed monotherapy has come to be recognized as one of the standard second-line therapies for advanced non-squamous non-small cell lung cancer (NSCLC). However, there have been no reports of studies that have evaluated the efficacy of pemetrexed according to type of active EGFR mutation, i.e., an exon 19 deletion or an L858R point mutation. Materials and Methods: The records of non-squamous NSCLC patients harboring an EGFR mutation who received pemetrexed monotherapy as a second or later line of chemotherapy at Kitasato University Hospital between March 2010 and October 2015 were retrospectively reviewed, and the treatment outcomes were evaluated. Results: The overall response rate and progression-free survival time (PFS) of the 53 patients with non-squamous NSCLC were 15.1% and 2.3 months, respectively. There were significant differences between the disease control rate (37.5% vs. 76.2%) and PFS time (1.8 months vs. 3.3 months) of the exon 19 deletion group and the L858R point mutation group, and a multivariate analysis identified type of EGFR mutation as well as performance status (PS) as independent predictors of PFS. Conclusions: The clinical data obtained in this study provided a valuable rationale for considering type of EGFR mutation as well as non-squamous histology as predictors of the efficacy of pemetrexed monotherapy.