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Lee Jung-Kyu,Choi Won Seok,Song Jin Yong,Kwon Oh Seong,Lee Yeon Jin,Lee Jong Seok,Lee Sarah,Choi Se Rin,Lee Choong Hwan,Lee Ji-Yun 한국독성학회 2023 Toxicological Research Vol.39 No.1
Bisphenol A is an environmental endocrine disruptor that has similar functions to estrogen in humans. However, few studies have investigated pulmonary inflammation induced by BPA, and the effect of Athyrium yokoscense extract on this inflammatory response is unknown. In this study, we investigated this effect in A549 human alveolar epithelial cells. BPA at concentrations higher than 100 μM were cytotoxic to A549 cells at 24 and 48 h after treatment; however, AYE (100 μg/mL) had a protective effect against BPA-induced cytotoxicity. AYE also inhibited the generation of intracellular reactive oxygen species, expressions of cyclooxygenase-2 and extracellular signal-regulated kinase1/2 proteins, activities of phospholipase A2, COX- 2, nuclear factor kappa-light-chain-enhancer of activated B cells, and proinflammatory mediators including prostaglandin E2, tumor necrosis factor-α, and interleukin-6 induced by BPA in A549 cells. This study demonstrated that BPA, which induces chronic lung disease, causes oxidative stress and inflammatory response in lung epithelial cell line, and found that AYE reduces BPA-induced oxidative stress and inflammatory response by down-regulating the Erk1/2 and NF-κB pathways.
Lee, Sunmin,Lee, Sarah,Singh, Digar,Oh, Ji Young,Jeon, Eun Jung,Ryu, Hyung SeoK,Lee, Dong Wan,Kim, Beom Seok,Lee, Choong Hwan Elsevier 2017 Food chemistry Vol.221 No.-
<P><B>Abstract</B></P> <P>Two different <I>doenjang</I> manufacturing processes, the industrial process (IP) and the modified industrial process (mIP) with specific microbial assortments, were subjected to metabolite profiling using liquid chromatography-mass spectrometry (LC-MS) and gas chromatography time-of-flight mass spectrometry (GC-TOF-MS). The multivariate analyses indicated that both primary and secondary metabolites exhibited distinct patterns according to the fermentation processes (IP and mIP). Microbial community analysis for <I>doenjang</I> using denaturing gradient gel electrophoresis (DGGE), exhibited that both bacteria and fungi contributed proportionally for each step in the process viz., soybean, steaming, drying, <I>meju</I> fermentation, cooling, brining, and aging. Further, correlation analysis indicated that <I>Aspergillus</I> population was linked to sugar metabolism, <I>Bacillus</I> spp. with that of fatty acids, whereas <I>Tetragenococcus</I> and <I>Zygosaccharomyces</I> were found associated with amino acids. These results suggest that the components and quality of <I>doenjang</I> are critically influenced by the microbial assortments in each process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The mIP showed similar metabolite profiles compared to IP despite reduced time. </LI> <LI> Microbial assortments regulate differential metabolite profiles in each process. </LI> <LI> <I>Doenjang</I> quality was synchronous with microbial metabolic diversity. </LI> </UL> </P>
Public Perception of a Criminal DNA Database in Korea
Lee, Ji Hyun,Cho, Sohee,Kim, Moon Young,Lee, Seung Hwan,Lee, Hwan Young,Lee, Soong Deok,LoCascio, Sarah Prusoff,Jung, Kyu Won Center for Asian Public Opinion ResearchCollaborat 2019 Asian journal for public opinion research Vol.7 No.2
Background: Since 2010, Korea has maintained a DNA database of those convicted of or awaiting trial for certain crimes. There have been proposals to expand the list of crimes included in this database, or conversely, omit certain crimes if they are committed during protests. An understanding of the feelings of the public as we consider the ethical, legal, and social aspects of a DNA database and as revisions to laws are made is required. Methodology: Questions related to the DNA database were included in the nationally representative Korean Academic Multimode Open Survey (KAMOS) panel (June-August 2016). Results: Of 2,000 randomly selected panel members, 1,013 respondents participated in this survey, including 89.2% who supported the existence of a criminal DNA database. The current system of storing DNA profiles until a suspect's acquittal or a convict's death was supported by 79.5% of respondents. In addition, 70.8% of respondents agreed with the expansion of crime categories included in the criminal database. Many (93.4%) respondents favored genetic testing and data storage to determine the identity and cause of death for people who die of unnatural causes. Some differences in attitude related to social class were noted, with those who self-identified as members of the upper class more likely to support the database and its expansion to include additional crimes than those who self-identified as middle or lower class. Conclusion: Our findings suggest that Koreans generally support the criminal DNA database.
Lee, Su Yun,Kim, Hyang Yeon,Lee, Sarah,Lee, Jung Min,Muthaiya, Maria John,Kim, Beom Seok,Oh, Ji Young,Song, Chi Kwang,Jeon, Eun Jung,Ryu, Hyung Seok,Lee, Choong Hwan The Korean Society for Microbiology and Biotechnol 2012 Journal of microbiology and biotechnology Vol.22 No.11
The metabolite profile of meju during fermentation was analyzed using mass spectrometry techniques, including GC-MS and LC-MS, and the bacterial diversity was characterized. The relative proportions of bacterial strains indicated that lactic acid bacteria, such as Enterococcus faecium and Leuconostoc lactis, were the dominant species. In partial least-squares discriminate analysis (PLS-DA), the componential changes, which depended on fermentation, proceeded gradually in both the GC-MS and LC-MS data sets. During fermentation, lactic acid, amino acids, monosaccharides, sugar alcohols, and isoflavonoid aglycones (daidzein and genistein) increased, whereas citric acid, glucosides, and disaccharides decreased. MS-based metabolite profiling and bacterial diversity characterization of meju demonstrated the changes in metabolites according to the fermentation period and provided a better understanding of the correlation between metabolites and bacterial diversity.
〈학술논문〉 또는 〈응용논문〉 : 나노임프린트공정을 이용한 나노스케일 복합 패턴 형성 및 태양전지 응용
이기중(Ki-Jung Lee),최대근(Dae-Geun Choi),정준호(Jun-Ho Jeong),김기돈(Ki-Don Kim),최준혁(Jun-Hyuk Choi),이지혜(Jihye Lee),이순원(Soon-Won Lee),박성제(Seong-Je Park),김사라(Sarah Kim),이응숙(Eungsug Lee) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
본 연구에서는 임프린트 공정에 의해서 제작된 몰드를 이용하여 마이크로-나노의 다양한 패턴 제작 방법과 이를 이용한 마이크로-나노 스케일 복합 패턴 제작기술에 관한 연구 결과 및 태양전지 소자 응용 결과를 소개하고자 한다. 첫 번째로, 마이크로 패턴위에 나노패턴을 제작하여 접촉각 변화를 측정하여 마이크로 구조물위 나노 패턴이 주는 기판 표면 특성변화를 관찰하였다. 두번째로, 기판위 나노 패턴의 선택적 전이를 위한 변수에 대한 분석 실험, 세번째로 패턴 전사 공정의 태양전지 및 전자소자 응용 가능성 실험을 계획 중이다. In this work, we report a fabrication method of complex pattern of micro-nano scale by using nano imprint lithography(NIL) and the solar device application. Micro-patterns were firstly fabricated and then nano patterns were formatted on the micro-patterns. The change of surface property was investigated. Secondly, the variables for selective pattern transfer were studied. Finally, solar cell and electronic device application is planning for future experiment.
Large Area Asymmetric Ferromagnetic Nanoring Arrays Fabricated by Capillary Force Lithography
Sarah Kim,Jae-Woo Jung,Tae-Soo Lee,Su Yeon Lee,양승만,정종율,Jun-Ho Jeong 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.1
In this study, we have investigated the nanofabrication of asymmetric ferromagnetic ring arrays by capillary force lithography, which incorporates the essential feature of nanoimprint lithography. The capillary lithography technique enables the fabrication of large area magnetic nanostructures and makes it possible to systematically control the shape of magnetic nanostructures. We prepared various ferromagnetic Co ring arrays with various ring widths down to 100 nm. We investigated magnetization reversal of ferromagnetic nanoring arrays using the focused magneto-optical Kerr effects (FMOKE) and micromagnetic simulation. It was found that mag-netization reversal could be controlled by varying the width and asymmetry in ferromagnetic nanoring structures.
Lee, Sarah,Do, Seon-Gil,Kim, Sun Yeou,Kim, Jinwan,Jin, Yoojeong,Lee, Choong Hwan American Chemical Society 2012 Journal of agricultural and food chemistry Vol.60 No.45
<P>Metabolite profiling of four different-sized Aloe vera plants was performed using gas chromatography–ion trap–mass spectrometry (GC-IT-MS) and ultra performance liquid chromatography–quadrupole–time of flight–mass spectrometry (UPLC-Q-TOF-MS) with multivariate analysis. Amino acids, sugars, and organic acids related to growth and development were identified by sizes. In particular, the relative contents of glucose, fructose, alanine, valine, and aspartic acid increased gradually as the size of the aloe increased. Anthraquinone derivatives such as 7-hydroxy-8-<I>O</I>-methylaloin, 7-hydroxyaloin A, and 6′-malonylnataloins A and B increased gradually, whereas chromone derivatives decreased continuously as the size of the aloe increased. The A30 aloe (size = 20–30 cm) with relatively high contents of aloins A and B, was suggested to have antioxidant components showing the highest antioxidant activity among the four different sizes of aloe. These data suggested that MS-based metabolomic approaches can illuminate metabolite changes associated with growth and development and can explain their change of antioxidant activity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2012/jafcau.2012.60.issue-45/jf3026309/production/images/medium/jf-2012-026309_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jf3026309'>ACS Electronic Supporting Info</A></P>
Lee, Seung-Hoon,Lee, Seung Woo,Oh, Taegon,Petrosko, Sarah Hurst,Mirkin, Chad A.,Jang, Jae-Won American Chemical Society 2018 Nano letters Vol.18 No.1
<P>Plasmon-induced interfacial charge separation (PICS) is one of the key processes responsible for the improved conversion efficiencies of energy-harvesting devices that incorporate metal nanostructures. In this Letter, we reveal a mechanism of PICS by visualizing (with nanometer-scale resolution) and characterizing plasmon-exciton coupling between <I>p</I>-type poly(pyrrole) (PPy) nanowires (NWs) and Ag nanoparticles (NPs) using light-irradiated Kelvin probe force microscopy (KPFM). Under blue-light irradiation, the Ag NPs are expected to donate electrons to the PPy NWs via a hot electron injection process. However, in this Letter, we observe that under blue-light irradiation the plasmonically and excitonically excited electrons in the semiconductor back-transfer to the metal. The PICS in this system can be explained by comparing it with a similar one where Au NPs are attached to <I>n</I>-type ZnO NWs; we observed a net electron transfer from the Au NPs to the ZnO NWs (an upward band bending is formed at the interface of the two materials, presumably obstructing electron back-transfer). Indeed, energy band matching between the metal and the semiconductor components of hybrid nanostructures influences PICS pathways. These experimental findings and our proposed mechanism consistently explain the PICS occurring in the PPy NW-Ag NP system with important implications on explaining their cooperative optoelectronic activities.</P> [FIG OMISSION]</BR>
Lee, Joohee,Yoo, Yeon Hwa,Lee, Sarah,Kim, Hak Sun,Kim, Sungjun Korean Society of Magnetic Resonance in Medicine 2018 Investigative Magnetic Resonance Imaging Vol.22 No.1
Gelatinous transformation of bone marrow is characterized by hypoplasia of fat cells with focal loss of hematopoietic cells and deposition of extracellular gelatinous substances. It is known to be associated with devastating underlying diseases that starve bone marrow. Here, we present a case of a patient whose magnetic resonance (MR) imaging findings of vertebral column were interpreted as metastasis or hematologic malignancy, however, the final diagnosis revealed a gelatinous transformation of bone marrow. This is the first report of gelatinous transformation of bone marrow without evidence of underlying devastating disease.
Lee, Dong-Soo,Kim, Yeon-Sil,Jung, So-Lyoung,Lee, Kyo-Young,Kang, Jin-Hyoung,Park, Sarah,Kim, Young-Kyoon,Yoo, Ie-Ryung,Choi, Byung-Ock,Jang, Hong-Seok,Yoon, Sei-Chul Saikon Pub. Co 2012 TUMOR BIOLOGY Vol.33 No.4
<P>Although many biomarkers have emerged in non-small cell lung cancer (NSCLC), the predictive value of site-specific spread is not fully defined. We designed this study to determine if there is an association between serum biomarkers and brain metastasis in advanced NSCLC. We evaluated 227 eligible advanced NSCLC patients between May 2005 and March 2010. Patients who had been newly diagnosed with stage IV NSCLC but had not received treatment previously, and had available information on at least one of the following pretreatment serum biomarkers were enrolled: carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA 21-1), cancer antigen 125 (CA 125), cancer antigen 19-9, and squamous cancer cell antigen. Whole body imaging studies and magnetic resonance imaging of the brain were reviewed, and the total number of metastatic regions was scored. Brain metastasis was detected in 66 (29.1%) patients. Although serum CEA, CYFRA 21-1, and CA 125 levels were significantly different between low total metastatic score group (score 1-3) and high total metastatic score group (score 4-7), only CEA level was significantly different between patients with brain metastasis and those without brain metastasis (p < 0.0001). The area under the receiver operating curve of serum CEA for the prediction of brain metastasis was 0.724 (p = 0.0001). The present study demonstrated that the pretreatment serum CEA level was significantly correlated with brain metastasis in advanced NSCLC. These findings suggested the possible role of CEA in the pathogenesis of brain invasion. More vigilant surveillance would be warranted in the high-risk group of patients with high serum CEA level and multiple synchronous metastasis.</P>