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Rai, Santosh Kumar,Kumar, Pardeep,Panwar, Vinay Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.11
The present paper studies the thermal-hydraulic behaviour of the rectangular supercritical natural circulation loop (SCNCL) using numerical model of one dimensional. Then the results of this model is confirmed with experimental and benchmark results. Variations with several geometric parameters like loop diameter, riser length, and heater length and operating conditions like heater inlet enthalpy, pressure, friction factor, and inlet and exit loss coefficient on steady-state performance are investigated for various orientations like HHHC, HHVC, VHVC and VHHC of the heater and cooler. The chances of existing static instability (Ledinegg excursion) has been investigated, which reveals that it can arise only in a low inlet enthalpy condition, far from the suggested various orientations of heater and cooler.
Raghvendra Upadhyay,Santosh Kumar Rai,Goutam Dutta 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.3
The present study numerically investigates Density wave oscillations (DWOs), a dynamic instability and captures Heat transfer deterioration (HTD) phenomenon for a Supercritical water reactor (SCWR) of the U. S. reference design. A Thermal-hydraulic (TH) model is employed to solve the nonlinearly coupled mass, axial momentum and energy conservation equations in a time domain using characteristics based implicit finite difference scheme accounting for the compressible flow dynamics of supercritical water. The analysis of DWOs is carried out to obtain the marginal stability thresholds. Next, the steady as well as transient safety analyses are carried out to determine the occurrence of HTD, access its severity and identify the safe operating conditions. Finally, the common operating conditions are predicted where the U. S. SCWR will be stable as well as safe.
Manisha Khatri,Manisha Tiwari,Santosh K Rai,Ranjit Ranbhor,Krishna Kishore 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7
On the basis of our earlier studies, a series of N-{4-[4-(aryl) piperazin-1-yl]-phenyl}-amine derivatives containing terminal carbamoyl fragment with alkyl spacer of different lengths (15-20) were synthesized as ligands, for 5-hydroxytryptamine-1A (5-HT1A) receptor. Molecular modeling studies were undertaken to explain the influence of spacer length on ligands affinity towards 5-HT1A receptor. Compound 19 showed all the specific interactions responsible for recognition. The protonated amine of the ligand forms an ionic hydrogen bond with the negatively charged Asp116 of transmembrane3 helix (TM3), while the carbamoyl moiety interacts with Asn386 and Tyr390 of TM7. The aryl group is involved in forming a CH-π interaction with Phe362. The strong interaction of compound 19 with 5-HT1A receptor in docking studies was confirmed by radio ligand binding studies. Compound 19 showed high affinity for the receptor (Ki = 0.018 nM). In vivo pharmacological testing of compound 19 (3 mg/kg body weight) showed increased open arm entries, as well as time spent in Elevated plus Maze test. Toxicological analysis also revealed no significant biochemical or morphological alterations in the vital organs of experimental animals. Furthermore our results suggest that these compounds share some pharmacological effects with established anxiolytics and might prove to be effective compounds for the treatment of anxiety.
Piyush Aggarwal,Anupriya Anwariya,Anwin Joseph Kavanal,Ashwani Sood,Santosh Ranjan Jena,Bhagwant Rai Mittal 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.3
Peptide receptor radionuclide therapy (PRRT) has become an established treatment for patients with inoperable and/ormetastatic, well-differentiated neuroendocrine tumors with overexpression of somatostatin receptor type 2 (SSTR-2). Thepost-therapy 177Lu-DOTATATE whole-body scan not only assesses the biodistribution of the lesions seen on pre-therapy68 Ga-SSTR PET/CT scan but also provides a quick assessment of disease status and dosimetry during treatment. Like anyother radionuclide scan, the whole-body 177Lu-DOTATATE scan may also show abnormal radiotracer uptake, which mayrequire further imaging to establish its exact etiology. Though radiotracer emboli mimicking focal pulmonary lesions havebeen described with 18F-FDG and 68 Ga-DOTANOC PET/CT scans, similar artifacts with post-therapy 177Lu-DOTATATEscans have not been described. Herein, we report two cases of hot emboli in the post-therapy 177Lu-DOTATATE scans.