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Sangmi Jun,Wooseok Lee,정교철,Jae-hyeon Park,박창근,이상호,이길성 한국지질과학협의회 2010 Geosciences Journal Vol.14 No.1
The objectives of this study are to analyze the relationship between the long-term stream discharge and the change of groundwater use and to estimate the potential usable water resources due to the change of groundwater use. The watershed model SWMM−GE, which considers the aquifer-stream interaction, is used to calculate the long-term stream discharge of the Gapcheon watershed in Korea according to the increasing groundwater use. In the results, the annual runoff discharge is absolutely affected by the annual rainfall, but the annual baseflow is less affected than the annual runoff discharge. The annual baseflow is decreased by increasing the groundwater use, but the potential usable water resources are increased by increasing the groundwater use. In case groundwater use is doubled, the potential usable water resources are increased by about 44% of pumping case. Excessive groundwater use, however, could dry up some streams or make instream flow insufficient. Thus, those results should be considered to determine suitable amount of ground water use.
( Seonjoo Ahn ),( Sangmi Jun ),( Hyun-joo Ro ),( Ju Han Kim ),( Seil Kim ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.10
The type strain Bacillus subtilis subsp. subtilis KCTC 3135T was deeply sequenced and annotated, replacing a previous draft genome in this study. The tar and tag genes were involved in synthesizing wall teichoic acids (WTAs), and these genes and their products were previously regarded as the distinguishing difference between B. s. subtilis and B. s. spizizenii. However, a comparative genomic analysis of B. subtilis spp. revealed that both B. s. subtilis and B. s. spizizenii had various types of cell walls. These tar and tag operons were mutually exclusive and the tar genes from B. s. spizizenii were very similar to the genes from non-Bacillus bacteria, unlike the tag genes from B. s. subtilis. The results and previous studies suggest that the tar genes and the tag genes are not inherited after subspecies speciation. The phylogenetic tree based on whole genome sequences showed that each subspecies clearly formed a monophyletic group, while the tree based on tar genes showed that monophyletic groups were formed according to the cell wall type rather than the subspecies. These findings indicate that the tar genes and the presence of ribitol as a cell-wall constituent were not the distinguishing difference between the subspecies of B. subtilis and that the description of subspecies B. s. spizizenii should be updated.
Growth patterns and their implications for preterm infants in a culture of rapid modernization
Ahn, Youngmee,Sohn, Min,Jun, Yonghoon,Lee, Sangmi SAGE Publications 2013 Journal of child health care Vol.17 No.3
<P>This prospective longitudinal study explored the growth patterns of preterm infants and the implications of rearing them in an advancing culture. The study measured the weight, length, and head circumference of 343 Korean preterm infants over 12 months corrected age. Data were analyzed using a generalized estimation equation for growth patterns of preterm infants by the degree of prematurity (mild, moderate, or severe). Results showed that the early ‘catch-up phenomenon’, accelerated growth rate, occurred around 11 months corrected age, although the mild preterm group weighed less, was shorter, and had a smaller head circumference than the moderate and severe preterm groups. This may reflect the Asian culture’s preference for big babies and draws special attention to the influence of cultural values and childrearing practices in the growth of preterm infants. Pediatric nurses should be alert to accelerated growth in preterm infants in societies in cultural transition.</P>
Thermochromic Polydiacetylene Nanotube from Amphiphilic Macrocyclic Diacetylene in Aqueous Solution
Heo, Jung-Moo,Son, Youngji,Han, Seulki,Ro, Hyun-Joo,Jun, Sangmi,Kundapur, Umesha,Noh, Jaegeun,Kim, Jong-Man American Chemical Society 2019 Macromolecules Vol.52 No.11
<P>Creation of tubular structures through the self-assembly of macrocyclic molecules has gained great attention in the chemical, biochemical, and material sciences. Through a designed introduction of two octaethylene oxide and two diacetylene moieties, we prepared a macrocycle <B>MCDA-BisOEG</B>, which is water-soluble and photopolymerizable and displays a lower critical solution temperature (LCST) behavior. The hydrodynamic diameter of <B>MCDA-BisOEG</B>, measured by dynamic light scattering method, was ca. 6.5 nm at 25 °C and increased sharply to ca. 2 μm at temperatures above 34 °C (LCST). Below the LCST, the macrocycle in aqueous solution formed tubular structures, which upon UV irradiation generated blue conjugated polydiacetylene (PDA) nanotubes. The PDA nanotubes undergo a blue-to-red color change when heated above the LCST. No polymerization occurs above the LCST owing to the disordered aggregation of the diacetylene monomer. This is the first example of the preparation of a macrocycle-based, thermoresponsive, conjugated polymer nanotube in aqueous solution.</P> [FIG OMISSION]</BR>
Ultrastructural Abnormalities in APP/PSEN1 Transgenic Mouse Brain as the Alzheimer's Disease Model
Kim, Mi Jeong,Huh, Yang Hoon,Choi, Ki Ju,Jun, Sangmi,Je, A Reum,Chae, Heesu,Lee, Chulhyun,Kweon, Hee-Seok Korean Society of Microscopy 2012 Applied microscopy Vol.42 No.4
Alzheimer's disease (AD) is a progressive neurodegenerative disorder. Neuropathological hallmarks of AD are amyloid plaques, dystrophic neurite, and alteration of subcellular organelles. However, the morpho-functional study of this degenerative process and ultimate neuronal death remains poorly elucidated. In this study, immunohistochemical and ultrastructural analyses were performed to clarify the abnormal morphological alterations caused by the progression of AD in APP/PSEN1 transgenic mice, express human amyloid precursor protein, as a model for AD. In transgenic AD mice brain, the accumulation of Amyloid ${\beta}$ plaques and well-developed dystrophic neurites containing anti-LC3 antibody-positive autophagosomes were detected in the hippocampus and cortex regions. We also found severe disruption of mitochondrial cristae using high-voltage electron microscopy and three-dimensional electron tomography (3D tomography). These results provide morpho-functional evidence on the alteration of subcellular organelles in AD and may help in the investigation of the pathogenesis of AD.
Choi Won Joon,Kim Gi-Ae,Park Jaewon,Jang Sangmi,Jung Woo Jin,Shim Jae-Jun,Park Yewan,Choi Gwang Hyeon,Kim Jin-Wook,Jeong Sook-Hyang,Jang Eun Sun 대한의학회 2022 Journal of Korean medical science Vol.37 No.33
Background: Angiotensin type II receptor blockers (ARBs) are the most widely used antihypertensive drugs. This study aimed to elucidate the likelihood and pattern of ARB-induced liver injury in a hospital-based cohort. Methods: Data of patients receiving fimasartan (n = 5,543), candesartan (n = 6,406), valsartan (n = 6,040), and losartan (n = 9,126) were retrieved from the clinical data warehouse of two tertiary hospitals. Patients with alanine aminotransferase (ALT) levels > 5 times the upper normal limit were assessed according to the Roussel Uclaf Causality Assessment Method (RUCAM). Results: A total of 27,115 patients were enrolled, including 14,630 (54.0%) men, with a mean age of 64.6 years (standard deviation, 13.6). During 31,717 person-years of ARB therapy, serum ALT levels > 120 IU/L were found in 558 (2.1%) person-years, and levels > 200 IU/L were found in 155 (0.6%) person-years. The incidence of ALT elevation > 120 IU/L per 106 cumulative defined daily doses was 6.6, 3.6, 3.9, and 4.0 in the fimasartan, candesartan, valsartan, and losartan groups, respectively (P = 0.002). An ALT level > 200 IU/L with RUCAM score ≥ 6 was found in 20 patients, suggesting probable drug-induced liver injury for 11 (0.2%) patients receiving fimasartan, five (0.1%) receiving candesartan, four (0.1%) receiving valsartan, and none receiving losartan (P < 0.001). Conclusion: Approximately 2% of patients receiving ARB therapy had significant ALT elevation (4.24/106 cumulative defined daily doses [cDDDs]), which was associated with probable ARB-related liver injury in 0.07% of patients (0.15/106 cDDDs). Elevation of ALT was more commonly associated with fimasartan than the other ARBs. Clinicians should be aware of the possibility of ARB-related ALT elevation in patients with unexplained chronic abnormal ALT.
Clinical proteomic analysis of scrub typhus infection
Park, Edmond Changkyun,Lee, Sang-Yeop,Yun, Sung Ho,Choi, Chi-Won,Lee, Hayoung,Song, Hyun Seok,Jun, Sangmi,Kim, Gun-Hwa,Lee, Chang-Seop,Kim, Seung Il BioMed Central 2018 Clinical proteomics Vol.15 No.1
<P><B>Background</B></P><P> Scrub typhus is an acute and febrile infectious disease caused by the Gram-negative α-proteobacterium <I>Orientia tsutsugamushi</I> from the family Rickettsiaceae that is widely distributed in Northern, Southern and Eastern Asia. In the present study, we analysed the serum proteome of scrub typhus patients to investigate specific clinical protein patterns in an attempt to explain pathophysiology and discover potential biomarkers of infection.</P><P><B>Methods</B></P><P>Serum samples were collected from three patients (before and after treatment with antibiotics) and three healthy subjects. One-dimensional sodium dodecyl sulphate–polyacrylamide gel electrophoresis followed by liquid chromatography-tandem mass spectrometry was performed to identify differentially abundant proteins using quantitative proteomic approaches. Bioinformatic analysis was then performed using Ingenuity Pathway Analysis.</P><P><B>Results</B></P><P>Proteomic analysis identified 236 serum proteins, of which 32 were differentially expressed in normal subjects, naive scrub typhus patients and patients treated with antibiotics. Comparative bioinformatic analysis of the identified proteins revealed up-regulation of proteins involved in immune responses, especially complement system, following infection with <I>O. tsutsugamushi</I>, and normal expression was largely rescued by antibiotic treatment.</P><P><B>Conclusions</B></P><P>This is the first proteomic study of clinical serum samples from scrub typhus patients. Proteomic analysis identified changes in protein expression upon infection with <I>O. tsutsugamushi</I> and following antibiotic treatment. Our results provide valuable information for further investigation of scrub typhus therapy and diagnosis.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s12014-018-9181-5) contains supplementary material, which is available to authorized users.</P>
Mitoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure
Hong Hyun Jung,Joung Kyong Hye,Kim Yong Kyung,Choi Min Jeong,Kang Seul Gi,Kim Jung Tae,Kang Yea Eun,Chang Joon Young,Moon Joon Ho,Jun Sangmi,Ro Hyun-Joo,Lee Yujeong,Kim Hyeongseok,Park Jae-Hyung,Kang 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Genetic variations in mitoribosomal subunits and mitochondrial transcription factors are related to type 2 diabetes. However, the role of islet mitoribosomes in the development of type 2 diabetes has not been determined. We investigated the effects of the mitoribosomal gene on β-cell function and glucose homeostasis. Mitoribosomal gene expression was analyzed in datasets from the NCBI GEO website (GSE25724, GSE76894, and GSE76895) and the European Nucleotide Archive (ERP017126), which contain the transcriptomes of type 2 diabetic and nondiabetic organ donors. We found deregulation of most mitoribosomal genes in islets from individuals with type 2 diabetes, including partial downregulation of CRIF1. The phenotypes of haploinsufficiency in a single mitoribosomal gene were examined using β-cell-specific Crif1 (Mrpl59) heterozygous-deficient mice. Crif1beta+/− mice had normal glucose tolerance, but their islets showed a loss of first-phase glucose-stimulated insulin secretion. They also showed increased β-cell mass associated with higher expression of Reg family genes. However, Crif1beta+/− mice showed earlier islet failure in response to high-fat feeding, which was exacerbated by aging. Haploinsufficiency of a single mitoribosomal gene predisposes rodents to glucose intolerance, which resembles the early stages of type 2 diabetes in humans.