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Association of GnRH1 Polymorphisms with Rheumatoid Arthritis in a Korean Female
Yu Mi Kim(김유미),Kye Young Han(한계영),Eun Bi Kwak(곽은비),Wanjoo Chun(전완주),Sung Soo Kim(김성수),Hee Jae Lee(이희제) 대한정형외과학회 2010 대한정형외과학회지 Vol.45 No.5
목적: 류마티스 관절염(RA)의 병태생리에 대해 아직 명확하게 밝혀져 있지 않으나 일부의 경우 유전적 요인이 류마티스 관절염의 발생에 영향을 주는 것으로 알려져 있다. 역학조시 결과 여성이 남성보다 류마티스성 관절염의 유병률이 3배 정도 높다. Gonadal 호르몬들은 면역체계나 자가면역질환에서 성에 따른 이형을 나타내는데 영향을 주는 것으로 알려져 있다. 이 가운데 gonadotrophin-releasing hormone (GnRH)는 면역 시스템을 조절하는 데도 중요한 역할을 한다. 따라서,GnRH가 류마티스 관절염에서 성적 차이를 나타내는데 중요한 역할을 할 수 있으며 이를 증명하기 위해 GnRH1 유전자를 후보 유전자로 선택하고 이들 유전자 내의 단일염기다형성(SNP)을 분석함으로써,RA와 GnRHl 유전자 다형성과의 연관성에 대해 연구하고자 하였다. 대상 및 방법: 153명의 RA 여성 환자와 96명의 정상 대조군을 대상으로, GnHR1 유전자 내의 5개의 SNP, rs2659590, rs2321248, rs6186, rs6185, rs2321049의 유전자형과 대립유전자형의 빈도를 비교 분석하였다. 또한 RA 환자들을 erythrocyte sedimentation rate (ESR)과 골 미란 유무에 따라 나누고 GnRH1 SNP과의 연관성을 확인하였다. 결과: 한국인 여성 RA 환자들과 정상군들 사이에서 GnRH1 SNP들의 유전자형과 대립유전자들의 빈도는 유의한 차이가 없었다. 하지만, rs2659590, rs6185, rs2321248에서 ESR이 30 이상인 환자와 30 미만 환자 사이에 로지스퇴 회귀 분석 결과 유의한 상관관계가 나타났다. 하지만, 골 미란 유무는 연관성이 없었다. 결론: 본 연구에서 RA와 GnRH1 유전자 다형성 사이의 연관성은 보여주지 못하였지만, ESR의 수치와 GnRH1 유전자 다형성 간에 연관성을 보였다. 비록 그 수가 적어 제한적인 의미를 가질 수 있으나 처음으로 GnRH1 유전자의 다형성과 RA환자의 ESR 간의 연관 가능성을 시사하는데 의의가 있다. Purpose: Rheumatoid arthritis (RA) is a common, chronic inflammatory arthritis that develops most often in women. Gonadal hormones may account for the sexual dimorphism in the immune response and for the greater incidence of autoimmune disease in females. Gonadotrophin- releasing hormone (GnRH), one of the gonadal hormones, plays an important role in immune system modulation. This study examined the effects of single nucleotide polymorphisms (SNP) in GnRH on gender differences in the pathophysiology of RA. Materials and Methods: The presence of SNPs rs2659590, rs2321248, rs6186, rs6185, and rs2321 049 in the human GnRH1 gene was confirmed in Korean RA patients by Taqman" SNP genotyping assays A total of 153 unrelated female, Korean RA patients and 96 female Korean controls participated. Results: There were no significant associations between GnRH1 polymorph isms and RA. However, we found that the rs2659590, rs6185 and rs2321248 polymorphism might be associated with a susceptibility to aberrantly high erythrocyte sedimentation rates in female RA patients. Conclusion: Additional studies, with a larger number of patients and in different populations will be required to assess whether GnRH1 polymorph isms and these haplotypes could be used as susceptibility or resistance markers in RA. To our knowledge, this study is the first to analyze associations between SNPs of GnRH1 and RA.
Antitumor Activity of Protein-Plysacharides Produced form Vibrio anguillarum
Yu, Byeong-Ho,Chi, Boung-Ho,Kim, Dong-Suck,Jang, Mi-Kyung,Kim, Hae-Sung,Chung, Soo-Ja The Korean Society of Food Hygiene and Safety 1988 한국식품위생안전성학회지 Vol.3 No.3
해수로부터 분리 확인한 비브리오균에서 생산하는 단백 다당체의 항종양 활성에 대하여 조사하였다. 비브리오균을 0.5%-peptone와 0.5% yeast extract가 함유된 해수를 기질로 배양하여 단백 다당체를 얻었다. 단백다당체의 단당류의 함량은 xylose, mannose, galactose, glucose 및 fructose의 순서이고, 주요 아미노산 glutamic acid, serine 및 aspartic acid였다. 단백 다당체의 항종양 활성을 Sarcoma-180에 대하여 0.5mg/kg/day 및 5mg/kg/day을 쥐에 주사했던 바 20.9% 및 43.9%의 억제 효과가 있었다. The antitumor activity of protein-polysaccharide produced by a strain, Vibrio anguilfarum, No. 17 isolated from sea water was investigated. The extracellular protein,polysaccharide used in this experiment was obtained through the cultivation of Vibrio anguillarum No. 17 at $25^{\circ}C$ for 5-7 days in the sea water medium containing 0.5% peptone and 0.1% yeast extract. The compositional monosaccharides of protein-polysaccharide were xylose, mannose, galactose, glucose and fructose in order and its major amino acids were glutamic acid, serine and aspartic acid. The antitumor activity of the protein-polysaccharide at a dose of 0.5mg/kg/day or 5mg/kg/day against Sarcoma-180 in mice were 20.9% and 43.9%, respectively.
( Sang Ho Park ),( Bom Yee Jung ),( Soo Young Lee ),( Dong Soo Yu ),( So-youn Woo ),( Seong-taek Yun ),( Jong Tae Lee ),( Jin-wou Kim ),( Young Bok Lee ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.5
Background: Hot springs have been traditionally used as an alternative treatment for a wide range of diseases, including rheumatoid arthritis, bronchial asthma, diabetes, hypertension, psoriasis and atopic dermatitis. However, the clinical effects and therapeutic mechanisms associated with hot springs remain poorly defined. Objective: The purpose of this study was to demonstrate the different effects of hot springs on cellular viability and secretion of inflammatory cytokines on keratinocyte in two geographically representative types of hot springs: NaHCO<sub>3</sub>-type and NaCl-type, which are the most common types in South Korea. Methods: We performed WST-1, BrdU measurements, human inflammatory cytokine arrays and enzyme-linked immunosorbent assay in HaCaT cells stimulated with toll-like receptor 3 by polyinosinic-polycytidylic acid. Results: The interaction effects of cell viability and cell proliferation were not significantly different regardless of polyinosinic-polycytidylic acid stimulation and cultured hot springs type. Cytokine array and enzyme-linked immunosorbent assay analysis showed increased expression of inflammatory cytokines such as interleukin-6 and granulocyte-macrophage colony-stimulating factor by polyinosinic-polycytidylic acid stimulation, with expression levels differing according to hot springs hydrochemical composition. Cytokine reduction was not significant. Conclusion: The effects and mechanisms of hot springs treatment in keratinocytes were partially elucidated. (Ann Dermatol 33(5) 440∼447, 2021)
Optimal Stem Cell Transporting Conditions to Maintain Cell Viability and Characteristics
Yu, Na-Hee,Chun, So Young,Ha, Yun-Sok,Kim, Hyun Tae,Kim, Dae Hwan,Kim, Jeongshik,Chung, Jae-Wook,Lee, Jun Nyung,Song, Phil Hyun,Yoo, Eun Sang,Kim, Bum Soo,Kwon, Tae Gyun 한국조직공학과 재생의학회 2018 조직공학과 재생의학 Vol.15 No.5
Yu Ri Seo,Jong Sung Kim,Sung Soo Kim,Jin Gyu Jung,Seok-Jun Yoon 대한가정의학회 2021 Korean Journal of Family Medicine Vol.42 No.1
Background: This study aimed to examine the relationship between alcohol consumption and metabolic syndrome in Korean women as determined by facial flushing. Methods: Of the female patients aged <65 years who visited the health promotion center at Chungnam National University Hospital from January 2016 to March 2017, 1,344 women were included. After adjusting for confounding factors such as age, body mass index, smoking, exercise, and menopausal status, multiple logistic regression analysis was performed to assess the association between alcohol consumption and the risk of metabolic syndrome in the facial flushing and non-facial flushing groups compared with the non-drinkers. Results: Even after adjusting for confounding factors, the risk of metabolic syndrome was significantly high in all drinking subgroups (≤2 standard drinks: odds ratio [OR], 1.68; 95% confidence interval [CI], 1.10–2.68; 2<, ≤4 standard drinks: OR, 2.48; 95% CI, 1.29–4.74; and >4 standard drinks: OR, 4.16; 95% CI, 2.03–8.30) of the facial flushing group. The risk of metabolic syndrome was significantly high only in the subgroup of weekly alcohol consumption >4 standard drinks (OR, 2.20; 95% CI, 1.07–4.52) in the non-facial flushing group. Conclusion: This study suggests that Korean women experiencing facial flushing when drinking have a higher risk of developing metabolic syndrome even with a low weekly drinking amount than those who do not experience face flushing.
Polarization-selective vortex-core switching by tailored orthogonal Gaussian-pulse currents
Yu, Young-Sang,Lee, Ki-Suk,Jung, Hyunsung,Choi, Youn-Seok,Yoo, Myoung-Woo,Han, Dong-Soo,Im, Mi-Young,Fischer, Peter,Kim, Sang-Koog American Physical Society 2011 Physical review. B, Condensed matter and materials Vol.83 No.17