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The Role of Corticosteroids in Stress-Induced Gastric Ulceration in Rats
Sang Kuk Byun,Yea Eun Lee,Sunhee Shin,Ja Young Jang,Byong-il Choi,Dongsun Park,Jeong Hee Jeon,Sang-Seop Nahm,Seock-Yeon Hwang,Yun-Bae Kim 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.2
Although the mechanism of stress-induced gastric ulcer has not been defined yet, it is clear that gastric ulcer is occurred by stress. Moreover, the gastric ulcerogenic action of corticosteroids that increase in blood during stress is controversial. To elucidate the involvement of corticosteroids in stress-induced gastric ulceration, we used adrenalectomized or macrophage-depleted animals. Rats were bilaterally-adrenalectomized and were given saline solution as a drinking water for 6 days. Separately, the animals for macrophage depletion were intraperitoneally administered with silica (SiO₂, 500 ㎎/㎏) for 6 days prior to challenge with water-immersion restraint stress (WIRS) for 4 hr. Adrenalectomy greatly reduced blood cortisol concentrations. Also, silica treatment lowered the number of macrophages to 48% of control and the differential count from 7.34% in normal animals to 2.48%, leading to a marked decrease in blood cortisol and corticosterone levels. WIRS significantly enhanced corticosteroid levels in normal and sham operated rats, and induced severe gastric ulcers. In contrast, adrenalectomy and silica treatment remarkably attenuated the stress-induced gastric ulceration, reducing the ulcer index to 30% and 10% of control level, respectively. Taken together, it is suggested that compensatory secretion of corticosteroids following macrophage activation may playa role in stress-induced gastric ulceration.
SP 시험법을 사용한 고압 수소가스 하에서 배관용 강의 수소취화거동 연구
신형섭(Hyung-Seop Shin),김기현(Ki-Hyun Kim),박성수(Sung-Su Park),이윤희(Yoon-Hee Lee),백운봉(Un-Bong Baek),남승훈(Seung-Hun Nahm) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
최근, 화석연료의 고갈과 환경오염의 문제로 인해 차세대 신재생 에너지에 대한 관심이 증대되고 있다. 그 중 수소연료는 친환경, 저장의 용이, 손쉬운 제조 등과 같은 장점에 반해 가연범위가 넓고, 폭발의 위험성이 단점으로 대두되고 있다. 한편, 수소 에너지를 저장하기 위해서는 천연가스 배관을 이용하여 저장하게 되는데, 재료내부의 수소의 침투로 인하여 수소취화가 발생하게 된다. 본 연구에서는 SP 시험법을 이용하여 고압분위기 하에서 수소취화거동을 평가하였다. 시험에 사용된 시험편은 10×10×t0.5 ㎜ 의 API X65 강을 사용하였고, 실험 조건은 20 ㎫ 범위에서 수소, 질소, 헬륨가스를 사용하여 실험을 수행하였다. 또, 수소장입시간에 따른 영향을 평가하기 위하여 수소장입시간을 달리하여 실험을 수행하였다. 실험 후 주사전자 현미경을 이용하여 파면을 관찰 하였다. 실험 결과, 대기압, 저압 수소 분위기에 비해 고압 수소 분위기 하에서 수소침투로 급격한 강도저하를 관찰할 수 있었으며, 파면에서 취성파면인 벽개 파면도 관찰할 수 있었다. Recently, development of alternative and novel energy resources for future energy had increased interest due to environmental problems and fossil energy exhaustion. Hydrogen energy have many merits such as eco-friendly, easy storage and easy manufacturing but it has also demerit such as highly combustible and explosive. On the other hand, natural gas pipe used to store hydrogen, but hydrogen embrittlement occurred in the materials. In this study, hydrogen embrittlement was investigated using SP test under high pressurized conditions. The specimen used were API X65, with the dimensions of 10×10×0.5 ㎜. Tests were carried out at different pressurized hydrogen, nitrogen, and helium condition. Furthermore, effect of charge time was investigated. Fracture surface was observed using SEM. The results revealed that high pressurized condition had lower strength than lower pressurized condition. And also cleavage surface was observed in the fracture surface.
Jung Mi Han,Jae Hyung Park,Sung Min Nam,Da Eun Lee,Sung Chuel Ahn,Jin Seok Seo,Jong Hwan Lee,Sang Seop Nahm,Nong Hoon Choe,Byung Joon Chang 한국예방수의학회 2018 예방수의학회지 Vol.42 No.1
To elucidate the effect of cellular phone electromagnetic wave (EMW) exposure on the developing cerebellar cortex of neonatal Sprague-Dawley rats, animals were exposed to cellular phone electromagnetic waves for 1 hr per day for 3 weeks. At the end of the experimental period, animals were sacrificed by cardiac perfusion, after which histological samples were prepared and observed microscopically. In the EMW exposure group, external granule cells were remained partially in the external granular layer without migrating into the internal granular layer. In addition, dark stained shrunken Purkinje cells with pyknotic nuclei increased and the outline of cells became irregular and showed degenerative signs, such as mitochondrial swelling and disrupted cristae. Moreover, the cisternae of rough endoplasmic reticula and Golgi complex were severely swollen. Bergmann glial cells adjacent to the dark stained Purkinje cells were swollen and cytoplasmic organelles were scant. Dark stained shrunken granule cells were also observed and the outline of cells was irregular. The results of the present study suggest that cellular phone EMW exposure to neonatal Sprague-Dawley rats leads to a partial delay of early migration of cerebellar cortical cells and degenerative changes in Purkinje cells, Bergmann glial cells and granule cells.
Effect of Adrenalectomy on in Utero-Exposure Teratogenicity of Dioxin
Ja Young Jang,Sunhee Shin,Byong-il Choi,Dongsun Park,Jeong Hee Jeon,Sang-Seop Nahm,Seok-Yeon Hwang,Yun-Bae Kim 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.3
The present study was conducted to elucidate the role of glucocorticoids in 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD)-induced teratogenesis, since TCDD exposure increased glucocorticoids release and exhibited synergistic teratogenicity with glucocorticoids. Pregnant C57BLl6J mice were bilaterally adrenalectomized on gestational day (GD) 7, and orally challenged with TCDD (14 ㎍/㎏) on GD12. Cesarian section was performed on GD18 for the evaluation of maternal and fetal toxicities. The body weights of dams underwent adrenalectomy decreased transiently, showing gradual recovery in 4-5 days. Although TCDD did not affect the resorption and death rates as well as body weights of fetuses, but caused severe fetal malformations; 45.2% for cleft palate and 100% for hydronephrosis. Unexpectedly, TCDD-induced cleft palate was further enhanced to 65.5% by adrenalectomy. In contrast, the degrees of renal pelvic (mean score 3.073) and ureteral (mean score 3.243) dilatations induced by TCDD were markedly attenuated to scores of 2.547 and 2.801, respectively, following adrenalectomy. Therefore, it is proposed that TCDD might induce fetal anomalies via binding to aryl hydrocarbon receptors independent of glucocorticoid receptors activation, in spite of previous suggestions of glucocorticoid-mediated cleft palate.
Yun, Tae Sik,Lin, Chunmei,Yon, Jung-Min,Park, Seul Gi,Gwon, Lee Wha,Lee, Jong-Geol,Baek, In-Jeoung,Nahm, Sang-Seop,Lee, Beom Jun,Yun, Young Won,Nam, Sang-Yoon The Korean Society of Veterinary Science 2018 大韓獸醫學會誌 Vol.58 No.4
Although hyaluronic acid (HA) has been developed as a nanoparticle (NP; 320-400 nm) for a drug delivery system, the tissue targeting efficacy and the pharmacokinetics of HA-NPs are not yet fully understood. After a dose of 5 mg/kg of cyanine 5.5-labeled HA-NPs or HA-polymers was intravenously administrated into mice, the fluorescence was measured from 0.5 h to 28 days. The HA-NPs fluorescence was generally stronger than that of HA-polymers, which was maintained at a high level over 7 days in vivo, after which it gradually decreased. Upon ex vivo imaging, liver, spleen, kidney, lung, testis and sublingual gland fluorescences were much higher than that of other organs. The fluorescence of HA-NPs in the liver, spleen and kidney was highest at 30 min, where it was generally maintained until 4 h, while it drastically decreased at 1 day. However, the fluorescence in the liver and spleen increased sharply at 7 days relative to 3 days, then decreased drastically at 14 days. Conversely, the fluorescence of HA-polymers in the lymph node was higher than that of HA-NPs. The results presented herein may have important clinical implications regarding the safety of as self-assembled HA-NPs, which can be widely used in biomedical applications.
Shin, Sun-Hee,Jeon, Jeong-Hee,Park, Dong-Sun,Jang, Min-Jung,Choi, Jae-Hong,Choi, Bong-Ho,Joo, Seong-Soo,Nahm, Sang-Seop,Kim, Jong-Choon,Kim, Yun-Bae 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
We examined the effects of trans-resveratrol on male reproductive functions; ex-vivo penile erection and in-vivo sperm counts and quality. For the ex-vivo study, the relaxation effects of resveratrol on isolated New Zealand white rabbit corpus cavernosum, precontracted by phenylephrine ($5{\times}10^{-5}\;M$) were measured. The in-vivo study measured reproductive organ weights, blood testosterone levels, testicular histopathology, sperm counts, as well as the epididymal sperm motility and deformity of male ICR mice given an oral dose of resveratrol (50 mg/kg) for 28 days. Resveratrol elicited a concentration-dependent relaxing effect on corpus cavernosum, leading to a median effective concentration ($EC_{50}$) of 0.29 mg/mL. Repeated treatment with resveratrol (50 mg/kg) did not cause an increase in body weight, reproductive organ weight or testicular microscopic findings; however, resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.
C57BL/6 마우스에서 기능성 샴푸 Bonogen의 양모 촉진 효과
홍진태(Jin-Tae Hong),이세라(Se-Ra Lee),김환희(Hwan Hee Kim),조영광(Young-Kwang Jo),백인정(In-Jeoung Baek),연정민(Jung-Min Yon),남상섭(Sang-Seop Nahm),곽동훈(Dong Hoon Kwack),이정은(Jung Eun Lee),이범준(Beom-Jun Lee),윤영원(Young-Won 한국독성학회 2006 Toxicological Research Vol.22 No.3
Bonogen shampoo is composed of several plant extracts which are known to be used in oriental medicine. This study was carried out to investigate the effects of Bonogen shampoo on hair growth in an alopecia model of C57BL/6 mice. There were eight male and female experimental groups including distilled water (DW; negative control), a commercial shampoo [M], 3% minoxidil (MXD) and Bonogen shampoo (BNG). Dorsal skin hair of six-week-old mice was trimmed with an electric clipper carefully not to damage the skin. The next day, mice without skin scratch were selected, randomized and separated in 10 mice per group. The test compounds were topically treated with 0.15 ml per mouse on dorsal skin for 21 days daily and then washed thoroughly with DW. The hair regrowth was determined photographically at 0, 4, 7, 10, 15, 18, and 21 days and histologically at day 21. No clinical signs were observed in all mice. Although body weight was slightly increased in 3% MXD group than other groups, it was not significant. Hair regrowth began to be promoted after 14 days and appeared a distinct regrowth pattern in all animals by topical treatment of test compounds at 18 days. In particular, the topical treatment of bonogen shampoo or 3% MXD for 21 days to dorsal skin accelerated hair regrowth faster than DW or M shampoo. At 21 days, the hair regrowth promotion speed was in order of 3% MXD > BNG > M > DW. The bonogen shampoo or 3% MXD also promoted hair follicle elongation compared to the negative control. These results suggest that bonogen shampoo has hair growth promoting activities and may be useful for treatment of bald or alopecia.
Yon, Jung-Min,Kim, Jae Seung,Lin, Chunmei,Park, Seul Gi,Gwon, Lee Wha,Lee, Jong-Geol,Baek, In-Jeoung,Nahm, Sang-Seop,Nam, Sang-Yoon The Korean Society of Veterinary Science 2019 大韓獸醫學會誌 Vol.59 No.2
We investigated whether ${\beta}$-carotene (${\beta}-CA$) or ellagic acid (EA), originating from various fruits and vegetables, has a preventive effect against male infertility induced by exogenous scrotal hyperthermia. ICR adult mice were intraperitoneally treated with 10 mg/kg of ${\beta}-CA$ or EA daily for 13 days consecutively. During this time, mice were subjected to transient scrotal heat stress in a water bath at $43^{\circ}C$ for 20 min on day 7, and their testes and blood were obtained on day 14 for histopathologic and biochemical analyses. Heat stress induced significant testicular weight reduction, germ cell loss and degeneration, as well as abnormal localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) and manganese superoxide dismutase (MnSOD) in spermatogenic and Leydig cells. Heat stress also altered the levels of oxidative stress (lipid peroxidation, SOD activity, and PHGPx, MnSOD, and $HIF-1{\alpha}$ mRNAs), apoptosis (Bax, Bcl-xL, caspase 3, $NF-{\kappa}B$, and $TGF-{\beta}1$ mRNAs), and androgen biosynthesis (serological testosterone concentration and $3{\beta}$-hydroxysteroid dehydrogenase mRNA) in testes. These changes were all improved significantly by ${\beta}-CA$ treatment, but only slightly improved by EA treatment. These findings indicate that ${\beta}-CA$, through modulations of oxidative stress, apoptosis, and androgen biosynthesis, is a potent preventive agent against testicular injuries induced by scrotal hyperthermia.