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Seo, Hee-Jeong,Ham, Hyang-Do,Jin, Hyung-Yong,Lee, Woo-Hyung,Hwang, Hyun-Sub,Park, Soon-Ah,Kim, Yong-Sung,Choi, Suck-Chei,Lee, Seoul,Oh, Kyung-Jae,Kim, Byung-Sook,Park, Byung-Rim,Lee, Moon-Young The Korean Society of Pharmacology 2010 The Korean Journal of Physiology & Pharmacology Vol.14 No.4
The hypothalamic-pituitary-adrenal (HPA) axis is the primary endocrine system to respond to stress. The HPA axis may be affected by increased level of corticotrophin-releasing factors under chronic stress and by chronic administration of monosodium glutamate (MSG). The purpose of this study was to investigate whether chronic MSG administration aggravates chronic variable stress (CVS)-induced behavioral and hormonal changes. Twenty-four adult male Sprague-Dawley rats, weighing 200~220 g, were divided into 4 groups as follows: water administration (CON), MSG (3 g/kg) administration (MSG), CVS, and CVS with MSG (3 g/kg) administration (CVS+MSG). In addition, for the purpose of comparing the effect on plasma corticosterone levels between chronic stress and daily care or acute stress, 2 groups were added at the end of the experiment; the 2 new groups were as follows: naive mice (n=7) and mice exposed to restraint stress for 2 h just before decapitation (A-Str, n=7). In an open field test performed after the experiment, the CVS+MSG group significant decrease in activity. The increase in relative adrenal weights in the CVS and CVS+MSG group was significantly greater than those in the CON and/or MSG groups. In spite of the increase in the relative adrenal weight, there was a significant decrease in the plasma corticosterone levels in the CVS+MSG group as compared to all other groups, except the naive group. These results suggest that impaired HPA axis function as well as the decrease in the behavioral activity in adult rats can be induced by chronic MSG administration under CVS rather than CVS alone.
Seo, Mi Kyoung,Kim, Young Hoon,McIntyre, Roger S.,Mansur, Rodrigo B.,Lee, Yena,Carmona, Nicole E.,Choi, Ah Jeong,Kim, Gyung-Mee,Lee, Jung Goo,Park, Sung Woo Hindawi 2018 Neural plasticity Vol.2018 No.-
<P>Recent studies have shown that antipsychotic drugs have epigenetic effects. However, the effects of antipsychotic drugs on histone modification remain unclear. Therefore, we investigated the effects of antipsychotic drugs on the epigenetic modification of the BDNF gene in the rat hippocampus. Rats were subjected to chronic restraint stress (6 h/d for 21 d) and then were administered with either olanzapine (2 mg/kg) or haloperidol (1 mg/kg). The levels of histone H3 acetylation and MeCP2 binding at BDNF promoter IV were assessed with chromatin immunoprecipitation assays. The mRNA levels of total BDNF with exon IV, HDAC5, DNMT1, and DNMT3a were assessed with a quantitative RT-PCR procedure. Chronic restraint stress resulted in the downregulation of total and exon IV BDNF mRNA levels and a decrease in histone H3 acetylation and an increase in MeCP2 binding at BDNF promoter IV. Furthermore, there were robust increases in the expression of HDAC5 and DNMTs. Olanzapine administration largely prevented these changes. The administration of haloperidol had no effect. These findings suggest that the antipsychotic drug olanzapine induced histone modification of BDNF gene expression in the hippocampus and that these epigenetic alterations may represent one of the mechanisms underlying the actions of antipsychotic drugs.</P>
Comparison of serological tests for bovine brucellosis in South Korea
Ah-Ryeong Joe, Jin Ju Lee, Eun Ji Yum, Yoon-Jeong Seo, So-Ra Sung, Jeong-Soo Choi, Soon-Seek Yoon 한국예방수의학회 2023 예방수의학회지 Vol.47 No.3
Regarding to diagnosis for bovine brucellosis, more than one serological test should be conducted to confirm the infection by Brucella with a reliable result due to various factors including false positive serological reactions. In this study, we compared confirmatory serological tests to determine the appropriate way to detect and confirm the Brucella infection in South Korea. Several serological tests, including serum agglutination test (SAT), indirect (I)- and competitive (C)-ELISA, and fluorescence polarization assay (FPA), for detection of bovine brucellosis were performed with sera from 537 cattle. In addition, comparison of diagnostic efficacy was performed with bacterial isolation represented true positive. Of 537 serum samples, 426 (79.3% of prevalence), 433 (80.6%), 414 (77.1%), and 409 (76.2%) sera were positive for SAT, C-ELISA, I-ELISA, and FPA respectively. Based on the results of serology, the correlation among the serological tests revealed observed agreements of more than 92% with kappa (k) value of more than 0.77. The correlation between serological tests with bacterial isolation appeared observed agreements of between 79.9% and 84.7% with k value of between 0.42 and 0.59. Particularly, FPA recorded almost perfect agreements with C-ELISA and I-ELISA as well as the highest correlation with bacterial isolation. Accordingly, this investigation presented the comparison of correlation and diagnostic efficacy of serological tests for bovine brucellosis in South Korea. We suggest this finding will be a useful data to re-establish the potential serological diagnostic methods that can apply to maintain the low prevalence.
( Sang Jun Suh ),( Hyung Joon Yim ),( Ji Hye Seo ),( Han Ah Lee ),( Tae Hyung Kim ),( Young Sun Lee ),( Jong Jin Hyun ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Jong Eun Yeon ),( Kwan So 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). However, the influence of sorafenib on the replication of HBV remains unknown. Herein, we evaluated the rate of HBV reactivation during sorafenib therapy in chronic hepatitis B (CHB) patients with advanced HCC. Methods: Four hundreds thirty five advanced HCC patients who visited three hospitals affiliated with Korea University from January 2004 to December 2012 were retrospectively reviewed. Among them, 327 patients were HBsAg positive. Two hundred sixty four received antiviral therapy before initiation of sorafenib therapy, and 64 patients were treatment naive with regard to anti-HBV therapy. Patients who received sorafenib less than 4 weeks, those who had not follow-up HBV DNA value, and patients who received other treatment than sorafenib were excluded. Finally, 133 and 28 patients were analyzed, respectively in each group. HBV reactivation were defined as increase of HBV DNA >10 times of baselines or ≥ 2000 IU/mL in patients with baselines HBV DNA < 2000 IU/mL. We further investigated reactivation rates in propensity score matched liver cirrhosis patients without HCC. Results: Mean age was 54.87±9.34 and 83.2% were male. All patients were Barcelona Clinic of Liver Cancer Stage C and the sum of tumor diameter was 10.42±5.78 cm. Mean baseline HBV DNA level was 2.84±1.60 log IU/mL. Median survival was 5.97 months. At 12, 24, and 48 weeks of the sorafenib therapy, HBV reactivation occurred in 5.26%, 12.0%, 14.3% of antiviral therapy group while it developed in 28.6%, 39.3%, and 42.9% of HBV therapy naïve group, respectively. The reactivation rates was significantly higher in patient who didn’t received antiviral therapy (p = 0.001). The antiviral therapy (HR 0.250, C.I. 0.104-0.604, p = 0.002) was independent factor related to HBV reactivation by logistic regression analysis. When the 28 HBV therapy naive HCC patients who received sorafenib were compared with propensity score matched 84 HBV therapy naïve liver cirrhosis patients without HCC, the cumulative reactivation rates were also significantly higher in the former group by log-rank test (p <0.001). Conclusions: The risk of HBV reactivation is high in CHB patients receiving sorafenib due to advanced HCC. It would be necessary to administer pre-emptive antiviral therapy before sorafenib initiation.
( Sang Jun Suh ),( Hyung Joon Yim ),( Young-sun Lee ),( Han Ah Lee ),( Tae Hyung Kim ),( Sun Young Yim ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Jong Eun Yeon ),( Kwan Soo Byun ),( Soon 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Various models for the prediction of hepatocellular carcinoma (HCC) in the patients with chronic hepatitis B (CHB) were suggested. The aim of study is to identify if the HCC risk scores are improved as antiviral therapy is prolonged in the patients with CHB-related liver cirrhosis. Methods: The patients with CHB who received entecavir (ETV) or tenofovir (TDF) were investigated retrospectively. Patients with liver cirrhosis patients diagnosed by sonography, CT or biopsy were enrolled. We calculated the HCC risk scores at pre-antiviral therapy, and each year from year 1 to 5 of post-antiviral therapy. The models were GAG-HCC, CU-HCC, REACH-B, modified REACH-B (mREACH-B), LSM-HCC, and PAGE-B. The primary endpoint was decrease of the risk scores after antiviral therapy. The secondary endpoint was finding the best model by AUROC after antiviral therapy. Results: A total of 362 patients were enrolled, and 198 and 164 patients were treated by ETV and TDF respectively. Child- Pugh scores were 5.7±1.3 and MELD were 9.9±3.8. Fifty six patient (15.5 %) occurred HCC at median 1.6 years (0.1-9.7 years). Most HCC scores (GAG, CU-HCC, REACH-B) decreased at year 1 and plateaued from year 1 to 5. mREACH-B and LSM-HCC scores decreased until year 2 and plateaued after year 2. PAGE-B showed no decrease from pre to post-antiviral therapy. The AUROC of PAGE-B was largest at baseline (GAG-HCC 0.472, CU-HCC 0.753, REACH-B 0.633, mREACH-B 0.688, LSM-HCC 0.649, and PAGE-B 0.760). After antiviral therapy, the AUROC changed. AUROCs of models employing HBV DNA levels increased (GAG-HCC, REACH-B, and LSM-HCC), that of liver stiffness based models (mREACH-B and PAGE-B) were persistent, and that of models employing hepatic function (CU-HCC) decreased (GAG-HCC 0.582, CU-HCC 0.686, REACH-B 0.689, mREACH-B 0.689, LSM-HCC 0.716, and PAGE-B 0.755 at 1year). The decrease of scores from baseline to each years were not different between ETV and TDF (all P>0.05). AUROC were largest in PAGE-B, however the scores were not changed after antiviral therapy. Second largest AUROC is that of LSM-HCC at year 1 and its AUROC became larger after antiviral therapy Conclusions: In conclusion, HCC prediction models such as PAGE-B and LSM-based models worked well in patients with HBV-related cirrhosis and decrease of the scores was associated with effects of the antiviral therapy.
Ah Reum Lee,Yu Ock Shin,Joo Young Lee,Min Yeong Kim,Sung Ho Shin,Bu-Il Seo,Young-Bae Seo,Man Hee Rhee,TakakoYokozawa,Chan Hum Park,Seong-SooRoh 한국약용작물학회 2015 한국약용작물학술대회 발표집 Vol.2015 No.05
Purpose Rhei Rhizoma (RR) is one of the herbal medicines traditionally used to treat diverse inflammatory diseases. The present study was undertaken to elucidate the antioxidant and anti-inflammatory activities of Rhei Rhizoma on experimental reflux esophagitis (RE) in rats. Methods The antioxidant activity of RR in vitro was measured in terms of radical scavenging capacity such as DPPH and ABTS. RE was produced by ligating both the pylorus and the transitional junction between the forestomach and the corpus. Rhei Rhizoma (125 and 250 mg/kg) were administered every day for 7 days, and its effect was estimated on comparison with RE control and normal rats. Results RR scavenged DPPH and ABTS effectively and IC50ofDPPH and ABTS radical scavenging activity of RR were 4.8 μg/ml and 15.75 μg/ml. The administration of RR decreased the elevated serum ROS in RE control rats. The RE control rats exhibited the down-regulation of antioxidant-related proteins such as Nrf2 and HO-1expression levels in the esophagitis; however, the level in the RR-treated RE rats was significantly higher than that in the RE control rats. Moreover, RE control rats exhibited the up-regulation of the protein expression related to oxidative stress at the esophagitis, but RR administration significantly reduced the expression of inflammatory proteins through the MAPK-independent signaling pathways. The expression of inflammatory mediators and cytokines by NF-κB activation was modulated through blocking the degradation of IκBα. In addition, the oral administration of RR regulated the gastric mucosal damage in RE rats. Conclusion The administration of Rhei Rhizoma effectively ameliorates the inflammatory damage of esophageal mucosa through radical scavenging activity and the activation of the Nrf2/HO-1 pathway.