정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

마케팅 커뮤니케이션 도구로서의 스포츠 스폰서십에 관한 연구

노영태,이영덕,이상봉,박병주,전동호 釜山大學校 附設 體育科學硏究所 1998 體育科學硏究所 論文集 Vol.14 No.-

The objective of this paper is to build sports sponsorship strategic through studying the state of sports sponsorship and the case study in foreign country. I propose the sports sponsorship strategic in new approach to build the structure of more positive sports sponsorship and the understanding of sports player management in korea that greets 2002 World Cup. For that, To build newly sports sponsorship strategic must have the following requires; 1. The transition of think ; from cost concept to investment concept It is necessary the transition of think from cost concept which is a short startegic to investment concept. That is, it hope to the possibility of player lastingly than to immediately short effect which is used by activating player popular in advertisements. 2. More intensive services for customs It is necessary to show the goal accomplished possible for sports fans, ad maintain sponsorship in long run. In same time, we must aware the publics to be understood of a better cooperate image. 3. To secure a specialty It is necessary to bring up the linkage industry and the manpower of specialist for activating sports as a business dimension, not as a hobby and a nation representative. It must expand specialist to the scout management, the advertisement and the event opening.

초등학생 입학 후 발생한 두통의 유병률과 임상적 특성

노영일,김은영,양은석,문경래,박상기,박영봉 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Purpose : The purpose of the study was to determine prevalence and clinical features of the occurrence of childhood headache after the start of elementary school. Method : The survey was performed by a special questionnaire on 552 children in grade 1 (195 children) and grade 6 (357 children) at the three elementary schools from 1 to 31 August, 2002 in Gwangju city. We have analyzed the prevalence and the clinical features of headache of them. Result: The prevalence of headache in grade 6(49.0%) was statistically higher than grade 1(22.6%). The onset time of headache within 6 months in grade 1 (88.2%) was significantly higher than grade 6 (64.1 %). The frequency of headache is more often in grade 6. As for the timing of occurrence of headache, grade 1 student suffered from it after school (36.4%), grade 6 student suffered from it at school (30.9%). Children who suffered from severe headache can't live in the routine life were grade 1 20.5 % and grade 6 21.1 %, respectively. According to the duration of headache, there were within 1 hour grade 1 90.9%, grade 6 81.8%, respectively. Risk factors of headache were, in grade 1, fatigue (34.0%), stress (25.0%), weather change (18.2%), anxiety (11.4%), and others (11.4%). In grade 6, there were fatigue(44.3%), stress (34.0%), weather change(10.9%), others (5.7%) and anxiety (5.1%). Conclusion : Starting school represents a remarkable life event for children. Starting school results in significantly increasing prevalence of overall headache. 목적 : 입학 전에 비해 입학 후 두통의 증가률을 알아보고, 1학년의 두통의 임상적 특징을 알아보고자 하였다. 방법 : 2002년 8월 1일부터 31일까지 광주시내 3개 초등학교 1학년과 6학년 학생 612명에게 설문지 (두통 에 대한 주요 설문지 내용 :부록)를 배부하여 그 중 작성이 불량한 60명을 제외한 552명 (1학년 195명, 6학년 357명)을 대상으로 두통의 유병률을 알아보았으며, 임상적 특징은 두통이 있는 학생 219명 (1학년 44명, 6학년 175명)을 대상으로 분석하였다. 결과 : 두통의 빈도는 1학년 44명 (22.6%), 6학년 175명 (49.0%)로 6학년에서 의의 있게 높았다(0.001). 두통의 초발 시기가 6개월 이상인 경우 1학년 11.8%, 6학년 35.9%이였으며, 6개월 미만인 경우는 1학년 88.2%, 6학년 64.1%로 입학 전보다 입학 후에 더 높았으며 6개월 미만의 초발 두통이 1학년에서 의의 있게 높았다(p=o. 03). 두통의 발생빈도는 6학년에서 통계학적으로 의의 있게 높았다(P=0. 03). 두통이 가장 자주 발생하는 시기는 1학년에서 학교 수업 후 (36.4%)이었고, 6학년에서는 학교 수업 중(30.9%)이었다. 학교나 일상 생활을 하기 힘들 정도의 두통은 각각 1학년에서 20.5%, 6학년에서 21.1%이었다. 두통의 지속시간은 1시간 이내인 경우가 각각 1학년 90.9%,6학년 81.8%이었다. 두통의 유별인자는 1학년에서 피로, 수면 부족이 34.0%로 가장 많았으며, 스트레스, 기후 변화, 불안, 기타 순이었고, 6학년은 피로 수면 부족 44.3%로 가장 많았으며, 스트레스 34.0%, 기후 변화, 기타, 불안 순이었다.

제주해협의 해류와 월별 유량변화

노홍길,방익찬,김상현,현경훈,김준택,양영진,홍창수 제주대학교 해양연구소 1997 해양자원연구소연구보고 Vol.21 No.-

Currents are measured in the Straits of Cheju by detecting surface buoy tracks and mooring current meters in 1996-1997. As a result, north-eastward currents are decteted in the Straits of Cheju all the year round, which is weak in spring and strong in summer and fall. Average speeds of 20 cm/s to the east. 7 cm/s to the north and 22 cm/s to the north-east appeared in the surface. Currents are fast in the middle of the strait and slow near Cheju Island. East-west components of the currents are about 3 times faster than the north-south ones. Also. it is shown that surface buoys released within the distance of 6 miles away from Cheju do not drift out of the Straits of Cheju because of tongue-like warm waters appeared in the eastern entrance of the strait. Volume transports calculated by geostrophic calculation are shown to be 0.05-0.2 Sv in winter and 0.4-0.5 Sv in summer.

신경인성방광에서 요역동학적 고찰

노준,전상준,정치영,이기봉,이길용,소영석,김철성,장대수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and objectives : A disparity between clinical and urodynamic findings is commonly found and its application to the clinical management of neurogenic bladder is pratically as well embrassing as it reading. We investigated urodynamic study for the diagnosis and management of neurogenic bladder. Materials and methods : From July 1997 to June 2001, total of 83 patients of neurogenic bladder were evaluated by urodynamic study. Results : urodynamically, there were 20 cases(24%) showing detrusor hyperreflexia with detrusor external sphincter dyssynergia(DESD), 12 cases(15%) detrusor areflexia with low compliance. A disparity between the clinical and urodynamic assessment was noted in 26 cases(31%), clinically severe symptom with complication was particularily common in detrusor hyperreflexia with DESD, detrusor areflexia with low compliance and catheter indwelling patients. Conclusion : In neurogenic bladder, clinically symptom with complication was particularly common in detrusor hyperreflexia with DESD, detrusor areflexia with low compliance and catheter indwelling patients.

스포츠와 정치에 관한 이론적 고찰

성영호,이석영,노덕선,권지윤 龍仁大學校 體育科學硏究所 1997 體育科學硏究論叢 Vol.7 No.1

An attempt of indicating al perspective for the systematic arrangement of studies on sports and politics was made examining the contents and method of preceding studies conies concerned. Main results are as follow; 1. The concrete domains of the study on sports and politics are classified into such five categories as sports policy sports and political ideology, political functions of sports, sports and social regime, and sports international relations. After indicating the problems to be solved in terms of the systematic arrangement of the studies in each category, they are mutually related and a guideline for the systematization of studies on sports and politics is presented. 2. Politics can basically be understood as policy which has a certain logical relation with public interests and power, for the analysis of mutual relation between sports and politics standing on the basic of policy it is inevitable to clarify the meaning of in fluence relation and function Especially logical improvement of the method of functional analysis is indispensable.

대학입학선발지표와 학업성취도의 연관성분석 : 중앙대학교 사례

노영기,박상규 중앙대학교 통계연구소 1998 統計論文集 Vol.- No.5

대학의 학업성취도를 나타내는 평점평균은 많은 요인의 영향을 받는 것으로 알려져 있다. 현실적으로 획득 가능한 이러한 요인을 찾아 평점평균과의 관련성을 통계적으로 분석·평가하고자 한다. 여기서 얻어진 결과는 요즈음 활발히 논의되고 있는 대학 교육제도나 입시제도의 개혁에 적으나마 도움이 되는 기초자료를 제공할 수 있으리라 믿어진다. 분석대상은 1996학년도 중앙대학교에 입학한 학생들의 입학성적과 96년도의 평점평균자료를 대상으로 삼았다.

Diesel 機關에 있어서 熱發生率을 利用한 最適 噴射時期 및 壓力에 關한 實驗的 硏究

盧相舜,吳永澤,許柄武 全北大學校 1987 論文集 Vol.29 No.-

The purpose of this study is to examine the effects of many factors by means of rate of heat release calculation in Diesel Engine. In this study, first, rate of heat release was calculated with computer process, next, the effects of those factors to rate of heat release were examined, and then, the effects of injection pressure and injection time to rate of heat release were analyzed. The concluding remarks are as the followings. 1. To calculate the precise rate of heat rlease, compensation of air column vibration and the method of least square were used. 2. On calculating the rate of beat release, specific heat is variable with function of temperature. 3. Controlling of engine performance and smoke was shown to a fixed quantity by means of analyzing indicator diagram. 4. BTDC 9˚CA and 12.7 MPa are most suitable injection time and injection pressure to get a max. engine performance. 5. When the injection time is earlier than that time, knocking was occured, because of high combustion max.-pressure and high rate of pressure rise. When the injetion time is later than TDC, the engine performance due to decreasing the degree of constant volume is decreased. 6. In case too low injection pressure, engine performance is decreased, and the injection pressure is too high engine performance is also decreased.

구멍炭화덕 溫突暖房 標準型 開發에 關한 硏究

盧相舜,金鍾一,吳永澤 全北大學校 1980 論文集 Vol.22 No.-

By establishing a cultivated Ondol(B) with insulated multicolumn type that channel whose thermal efficieney is excellent according to the references and the standard briquette used Ondol(A) with preheated chamber and secondary air pipe, this experiment was made; and the following is the result. 1. When the air pipe was opened fully the period till changing briquettes at B was 8 hours, while it was 7 hours at A. But by controlling the air through the secondary air pipe, the period was able to be extended to 15 hours. 2. The mean temperature of the floor and the room at A was high than at B by 2.97℃ and 2.22℃ each. 3. The distribution of the isothermal lines were thicker at A than at B and the highly heated area was distributed widely and the warm air reached even to the corner of the Ondol. 4. When briquettes were changed the ignition was done more easily at A and the fire was hardly extinguished.

Al₂O₃-에폭시 복합재료의 크랙성장에 의한 파괴

노영창,김상욱,박철수 서울市立大學校 1987 論文集 Vol.21 No.2

Al₂O₃-filled epoxy resin composites system was studied with the linear elastic fracture mechanics and its mechanical properties. The effect of the Al₂O₃partical volume fraction(Vp)were also studied. The Young's modulus increased significantly with Vp, it shows empirical equation, Ec=Em(1-Vp_-2 56. The yield stress also increased with Vp, however, plastic flow appeared before fracture for low value of Vp and un-filled epoxy resin matrix. Between crack velocity of 10-5 and 10-1m/sec, the crack propagation occured in continuous and stable manner, so the stress intensity factor and crack opening displacement reached maximum values for Vp of 0.14/0.21.