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( Jin Sug Kim ),( Miji Kim ),( Kyung Hwan Jeong ),( Ju-young Moon ),( Sang Ho Lee ),( Gang Jee Ko ),( Dong-young Lee ),( So Young Lee ),( Yang Gyun Kim ),( Hyeon Seok Hwang ) 대한신장학회 2024 Kidney Research and Clinical Practice Vol.43 No.2
Background: Endostatin is released during extracellular matrix remodeling and is involved in the development of vascular pathology and cardiovascular (CV) disease. However, the role of circulating endostatin as a biomarker of vascular calcification and CV events in patients undergoing hemodialysis (HD) remains unclear. Methods: A total of 372 patients undergoing HD were prospectively recruited. Plasma endostatin levels were measured at baseline, and their associations with circulating mineral bone disease (MBD) biomarkers and abdominal aortic vascular calcification scores were analyzed. The primary endpoint was defined as a composite of CV and cardiac events. Results: Plasma levels of patients in endostatin tertile 3 were significantly associated with low-density lipoprotein cholesterol levels and predialysis systolic blood pressure in multivariate analysis. However, endostatin levels did not correlate with circulating MBD biomarkers or vascular calcification scores. Patients in endostatin tertile 3 had a significantly higher cumulative event rate for the composite of CV events (p = 0.006). Endostatin tertile 3 was also associated with an increased cumulative rate of cardiac events (p = 0.04). In multivariate Cox regression analyses, endostatin tertile 3 was associated with a 4.37-fold risk for composite CV events and a 3.88-fold risk for cardiac events after adjusting for multiple variables. Conclusion: Higher circulating endostatin levels were independently associated with atherosclerotic risk factors but did not correlate with MBD markers or vascular calcification. Higher circulating endostatin levels were associated with a greater risk of composite CV events in patients undergoing HD, and endostatin is a biomarker that helps to determine the high risk of CV events.
[P113] Clinical and histopathologic features of 4 cases of adult-onset Still`s disease
( Sang-jin Cheon ),( Sung-min Park ),( Hyun-joo Lee ),( Hyun Ju Jin ),( Hyang-suk You ),( Woo-haing Shim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ),( Gun-wook Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Adult-onset Still`s disease (AOSD) is a rare systemic inflammatory disorder characterized by classic clinical triad of persistent high spiking fever, arthralgia, and typical salmon colored maculopapular rash. Recently, comprehensive review of literature showed that cutaneous involvement occurs in about 80% of AOSD patients. However, clinical and histopathologic characteristics of skin lesion of AOSD are rarely reported in dermatologic literature. We experienced 4 cases of AOSD (M:F=1:3). The diagnosis is based upon the clinical and laboratory criteria. Among them, 2 patients clinically showed multiple persistent pruritic erythematous papules and plaque. Histopathologic examination of erythematous plaque revealed multiple dyskeratotic keratinocytes in the upper epidermis. The other 2 patients presented with disseminated pruritic urticarial rash. Histopathologic examination of urticarial lesion revealed perivascular and interstitial infiltrates with neutrophils and a few mononuclear cells in the dermis. Diagnosing of AOSD is difficult due to nonspecific symptoms and absence of characteristic laboratory test. Herein, we report rare cases of AOSD presenting with persistent pruritic papules and plaques and urticarial rash. And we considered that dyskeratotic keratinocytes in upper dermis of pruritic plaques and neutrophils infiltration in perivascular and interstitial infiltration may be clue for a suspicious of AOSD.
Effectiveness of SMEs Support by Retired Scientists and Engineers
Sang Jin Bae,Chang Ryong Ko 한국유통과학회 2017 한국유통과학회 학술대회 논문집 Vol.2017 No.-
Technology and knowledge are emerging as core elements of competitiveness for businesses. SMEs lack technology and knowledge, and are also limited in their ability to absorb external knowledge. The government is supporting SMEs’ absorption of external knowledge by utilizing retired scientists and engineers, but related research is insufficient. Thus, this study conducted an empirical analysis on the effects of support by retired scientists and engineers at SMEs. Specifically, the study confirmed the effects of company competitiveness and technology development capacities at each stage of technology commercialization. Results of the study confirmed that in an environment where technology competitiveness of SMEs are emphasized, the support of retired scientists and engineers has some effect on the competitiveness of SMEs and their technology development capacity. Therefore, this study suggests important implications for future policy development and execution of related projects.
( Sang-hyeon Won ),( Dae-lyong Ha ),( Jin-hwa Son ),( Jungsoo Lee ),( Kihyuk Shin ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Kyunghyung Seo ),( Byung-soo Kim ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Ixekizumab is a humanized IgG4 monoclonal antibody that selectively binds to the IL-17A cytokine and inhibits its interaction with the IL-17 receptor. It has emerged as an effective treatment for moderate to severe psoriasis. However, to date, there are no real-world data for the use of ixekizumab in the treatment of psoriasis in Korean patients. Objectives: To evaluate the effectiveness and safety of ixekizumab in the treatment of moderate to severe psoriasis in Korean patients. Methods: Thirty patients who were treated with ixekizumab were analyzed. All patients’ medical records, Psoriasis Area and Severity Index (PASI) score, body surface area (BSA), Physicians’ Global Assessment (PGA), and adverse events were investigated. Results: A significant reduction in mean baseline PASI score (14.1±2.6) was detected at 4 weeks of ixekizumab therapy (3.8±2.7), with a further improvement at weeks 12 and 24 (0.9±0.7 and 0.5±0.5, respectively). Our analysis showed that 100%, 87.5%, and 50% of patients achieved PASI 75, 90, and 100 responses, respectively, after 48 weeks of therapy. However, nine patients (30%) experienced a mild adverse event such as injection site reaction, urticaria, upper respiratory tract infection, and stomatitis. Conclusion: This study provides evidence for the use of ixekizumab in real-world clinical practice and confirm that it is effective and safe in treating Korean patients with moderate to severe psoriasis.
( Sang-hyeok Cho ),( Eunju Lee ),( So-ra Ko ),( Sangrak Jin ),( Yoseb Song ),( Chi-yong Ahn ),( Hee-mock Oh ),( Byung-kwan Cho ),( Suhyung Cho ) 한국미생물 · 생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.4
The symbiotic nature of the relationship between algae and marine bacteria is well-studied among the complex microbial interactions. The mutual profit between algae and bacteria occurs via nutrient and vitamin exchange. It is necessary to analyze the genome sequence of a bacterium to predict its symbiotic relationships. In this study, the genome of a marine bacterium, Pseudoruegeria sp. M32A2M, isolated from the south-eastern isles (GeoJe-Do) of South Korea, was sequenced and analyzed. A draft genome (91 scaffolds) of 5.5 Mb with a DNA G+C content of 62.4% was obtained. In total, 5,101 features were identified from gene annotation, and 4,927 genes were assigned to functional proteins. We also identified transcription core proteins, RNA polymerase subunits, and sigma factors. In addition, full flagella-related gene clusters involving the flagellar body, motor, regulator, and other accessory compartments were detected even though the genus Pseudoruegeria is known to comprise non-motile bacteria. Examination of annotated KEGG pathways revealed that Pseudoruegeria sp. M32A2M has the metabolic pathways for all seven vitamin Bs, including thiamin (vitamin B1), biotin (vitamin B7), and cobalamin (vitamin B12), which are necessary for symbiosis with vitamin B auxotroph algae. We also identified gene clusters for seven secondary metabolites including ectoine, homoserine lactone, beta-lactone, terpene, lasso peptide, bacteriocin, and nonribosomal proteins.