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Cardiovascular Fitness and Associated Comorbidities in An Executive Health Program
Otto A Sanchez(Otto A Sanchez ),Anton S. Hesse(Anton S. Hesse ),Morgan R. Betker(Morgan R. Betker ),Christopher J. Lundstrom(Christopher J. Lundstrom ),William E. Conroy(William E. Conroy ),Zan Gao(Za 사피엔시아 2022 Exercise Medicine Vol.6 No.-
Objectives: Low cardiorespiratory fitness, defined as a VO2 max below the 25th percentile for age and sex, is associated with greater body mass index (BMI), blood pressure, and plasma cholesterol values and is an independent risk factor for cardiovascular and metabolic diseases. Given that sedentarism has substantially increased in the U.S. population in the last 20 years and that office workers have the lowest cardiorespiratory fitness of the workforce, we aimed to assess the prevalence of low cardiorespiratory fitness in an corporate wellness program and determine its relationship with associated comorbidities. Methods: For this retrospective observational analysis demographics, height, weight, blood pressure at rest, plasma glucose, lipids, comorbidities, and VO2 max data was extracted from the medical records of 199 participants attending the Executive Health Program at M Health Fairview of the University of Minnesota. Participants were predominantly white, middle-aged men with near-optimal blood pressure values. Results: Participants with low cardiorespiratory fitness had a VO2 max [mean (range) of 28 (19.4 - 36.1) mL/kg/min], and was observed in 33% of all participants. Participants with low cardiorespiratory fitness were more likely to have higher BMI, dyslipidemia and hypertension than those in the excellent to superior category of cardiorespiratory fitness, VO2 max [mean (range) 45.6 (31.8 - 61.2) mL/kg/min]. Prevalence of obesity (17%) was lower than in the general U.S. population, and those who were obese were more likely to be of low cardiorespiratory fitness. Those with low cardiorespiratory fitness had a four fold relative risk of belonging to the group at high risk of cardiovascular and metabolic diseases when compared to those with a fair to superior cardiorespiratory fitness. Conclusions: Low cardiorespiratory fitness identified in a third of all participants, is a modifiable risk factor associated with risk for cardiovascular and metabolic disease, should be evaluated in executive health programs.
Guardo, Laura Alonso,Gala, Carlos Cano,Poveda, David Sanchez,Juan, Pablo Rueda,Sanchez Montero, Francisco Jose,Garzon Sanchez, Jose Carlos,Lamas, Juan Ignacio Santos,Sanchez Hernandez, Miguel Vicente The Korean Pain Society 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode ($Interstim^{(R)}$, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal.
Sanchez-Torrijos Jorge,Queral Cesar,Paris Carlos,Rebollo Maria Jose,Sanchez-Perea Miguel,Posada Jose Maria 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.12
The classical Probabilistic Safety Analysis (PSA) does not include any time dependence explicitly. However, the success criteria (SC) could evolve during the cycle for some initiating events. In that sense, there is a type of sequence in which this time-dependency is quite important, the family of Anticipated Transient without Scram (ATWS) sequences in Pressurized Water Reactors. Therefore, a new riskinformed approach is proposed in this paper, which makes it possible to obtain the time-dependent SC evolution of the safety functions affected by the Moderator Temperature Coefficient (MTC) value. Then, the evolution of the ATWS conditional core damage probability (CCDP) could be obtained using a PSA model. To quantify the CCDP, the average values of the time-dependent failure probabilities must be computed. Finally, the comparison between the CCDP obtained through the application of the classical PSA approach and the new one makes it possible to quantify the impact of time-dependence on the SC of the headers that this new risk-informed ATWS approach can provide.
Gene Expression of CYP1A1 and its Possible Clinical Application in Thyroid Cancer Cases
Gallegos-Vargas, JA,Sanchez-Roldan, J,Ronquillo-Sanchez, MD,Carmona-Aparicio, L,Floriano-Sanchez, E,Cardenas-Rodriguez, N Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
Background: Thyroid cancer is the most common endocrine malignancy, and exact causes remain unknown. The role of CYP450 1A1 (CYP1A1) in cancer initiation and progression has been investigated. The aim of this work was to analyze, for the first time, CYP1A1 gene expression and its relationship with several clinicopathological factors in Mexican patients diagnosed with thyroid cancer. Materials and Methods: Real-time PCR analysis was conducted on 32 sets of thyroid tumors and benign pathologies. Expression levels were tested for correlations with clinical and pathological data. All statistical analysis were performed using GraphPad Prism version 3.0 software. Results: We found that female gender was associated with thyroid cancer risk (P<0.05). A positive relationship was identified between CYP1A1 mRNA levels and the presence of chronic disease, alcohol use, tumor size, metastasis and an advanced clinical stage (P<0.05). Conclusions: The results suggest that CYP1A1 gene expression could be used as a marker for thyroid cancer.
Rey David Vargas-Sanchez,Felix Joel Ibarra-Arias,Brisa del Mar Torres-Martinez,Armida Sanchez-Escalante,Gaston Ramon Torrescano-Urrutia 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.11
The present paper reviews the findings of different research studies on the effect of natural ingredients in the Japanese quail (Coturnix coturnix japonica) diet on carcass characteristics and meat quality. The results show a relationship between the type and concentration of ingredients used in diets and carcass characteristics and meat quality. The inclusion of medicinal herbs (thyme, black seed, and mint), plants (canola), seeds (chickpea), spices (cinnamon and coriander), worms (earthworms), bee products (propolis), phytochemicals (lycopene), and edible fungi (common mushrooms) in the diet improved carcass quality characteristics compared to the control diets (basal diets). The inclusion of medicinal herbs (spearmint and green tea), spices (cinnamon), vegetables (tomato), plants (verbena and canola), seeds (marijuana), and edible fungi (oyster mushrooms) improved meat quality. In conclusion, the use of ingredients of natural origin in the diet of Japanese quail improves carcass quality characteristics and meat quality.
( Laura Alonso Guardo ),( Carlos Cano Gala ),( David Sanchez Poveda ),( Pablo Rueda Juan ),( Francisco Jose Sanchez Montero ),( Jose Carlos Garzon Sanchez ),( Juan Ignacio Santos Lamas ),( Miguel Vice 대한통증학회 2016 The Korean Journal of Pain Vol.29 No.1
Background: Sacral nerve stimulation is a therapeutic option with demonstrated efficacy for conditions presenting with perineal pain caused by different etiologies. We aimed to assess whether a sacral electrode (InterStimⓡ, Medtronic, Minneapolis, MN, USA) inserted through the caudal pathway is able to offer an acceptable level of sacral stimulation and rate of catheter migration. Methods: We present 12 patients with pelvic pain who received sacral neuromodulation via the sacral hiatus with the InterStim electrode. We evaluated patient satisfaction as well as migration and removal of the electrode, if necessary. Results: Our experience included 12 patients, 10 women and two men, with a mean age of 60 years. In eight of the 12 patients, the initial therapy was effective, and the final system implantation was performed. During subsequent follow-up, patient satisfaction was good. To date, there have been no cases of electrode displacement or migration. Conclusions: The caudal insertion of the InterStim electrode, with its own fixation system, and initially designed for transsacral insertion, appears in our experience to be a satisfactory option which can minimize electrode displacements, achieving similar results in therapeutic efficacy and causing no difficulties in removal. (Korean J Pain 2016; 29: 23-28)
Sanchez, Cesar,Camus, Mauricio,Medina, Lidia,Oddo, David,Artigas, Rocio,Sepulveda, Alejandra Perez,Domainguez, Francisco,Razmilic, Dravna,Navarro, Maria Elena,Galindo, Hector,Acevedo, Francisco Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Background: Pathological factors, based mainly on immunohistochemistry (IHC) and histological differentiation, are mostly used to differentiate breast cancer (BC) subtypes. Our present aim was to describe the characteristics and survival of a relapsing BC patient cohort based on clinico-pathologic subtypes determined for the primary tumors. Methods: We used a clinico- pathological definition of BC subtypes based on histological grade (HG), estrogen receptor (ER), progesterone receptor (PgR),and epidermal growth factor receptor type 2 (HER2) expression assessed by IHC. We determined variables associated with loco-regional recurrence (LRR), second primaries (SP), systemic recurrence (SR) and post-recurrence survival (PRS). Results: Out of 1,702 patients, 240 (14%) had an event defined as recurrence. Those with recurrent disease were significantly younger than those without,and were initially diagnosed at more advanced stages, with larger tumors, greater lymph nodal involvement and higher HG. With a median follow up of 61 months (1-250), 4.6% of patients without recurrence and 56.6% of patients with an event defined as recurrence had died. The median PRS for the LRR group was 77 months; 75 months for those who developed a SP and 22 months for patients with an SR (p <0.0001). In SR cases, the median PRS was shorter for ER- tumors than for ER+ tumors (15 vs. 26 months, respectively; p = 0.0019, HR 0.44; CI: 0.25-0.44). Conclusions: Subtype, defined through classic histopathologic parameters determined for primary tumors, was found to eb related to type of recurrence and also to prognosis after relapse.
Sanchez-Majado S.,Torralba J. M.,Jimenez-Morales A. 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The corrosion performance of a powder metallurgical aluminum alloy in aeronautical environments was studied for both as sintered and heat treated states. Sintered samples were obtained by uniaxial pressing of an Al-Cu-Mg prealloyed powder followed by liquid phase sintering. The heat treatments applied were T4 and T6. Corrosion behaviour was assessed by means of potentiodynamic polarization. Results for the equivalent commercial wrought counterpart, AA2024-T3, are also presented for comparison. Similar corrosion performance was observed for both as sintered and AA2024-T3 samples, while corrosion resistance of the PM materials was improved by the heat treatment, especially in the T4 state.
Sanchez-Aguilera, Abel,Lee, Yun-Jung,Lo Celso, Cristina,Ferraro, Francesca,Brumme, Kristina,Mondal, Subhanjan,Kim, Chaekyun,Dorrance, Adrienne,Luo, Hongbo R,Scadden, David T,Williams, David A National Academy of Sciences 2011 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.108 No.23
<P>Engraftment and maintenance of hematopoietic stem and progenitor cells (HSPC) depend on their ability to respond to extracellular signals from the bone marrow microenvironment, but the critical intracellular pathways integrating these signals remain poorly understood. Furthermore, recent studies provide contradictory evidence of the roles of vascular versus osteoblastic niche components in HSPC function. To address these questions and to dissect the complex upstream regulation of Rac GTPase activity in HSPC, we investigated the role of the hematopoietic-specific guanine nucleotide exchange factor Vav1 in HSPC localization and engraftment. Using intravital microscopy assays, we demonstrated that transplanted Vav1(-/-) HSPC showed impaired early localization near nestin(+) perivascular mesenchymal stem cells; only 6.25% of Vav1(-/-) HSPC versus 45.8% of wild-type HSPC were located less than 30 μm from a nestin(+) cell. Abnormal perivascular localization correlated with decreased retention of Vav1(-/-) HSPC in the bone marrow (44-60% reduction at 48 h posttransplant, compared with wild-type) and a very significant defect in short- and long-term engraftment in competitive and noncompetitive repopulation assays (<1.5% chimerism of Vav1(-/-) cells vs. 53-63% for wild-type cells). The engraftment defect of Vav1(-/-) HSPC was not related to alterations in proliferation, survival, or integrin-mediated adhesion. However, Vav1(-/-) HSPC showed impaired responses to SDF1α, including reduced in vitro migration in time-lapse microscopy assays, decreased circadian and pharmacologically induced mobilization in vivo, and dysregulated Rac/Cdc42 activation. These data suggest that Vav1 activity is required specifically for SDF1α-dependent perivascular homing of HSPC and suggest a critical role for this localization in retention and subsequent engraftment.</P>