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Designing Micro- and Nano-particles for Treating Rheumatoid Arthritis
Samir Mitragotri,유진욱 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.11
Rheumatoid arthritis (RA) is a chronic, destructive autoimmune disease that can cause disability and have a negative socioeconomic impact. Despite significant advances in therapeutic options, limitations on the routes of administration and the requirement for frequent and long-term dosing often lead to systemic adverse effects and patient non-compliance. Micro and nanoparticle systems that selectively deliver drugs to inflamed synovium have the potential to improve drug efficacy while leaving extrasynovial tissues unaffected. This review summarizes key design parameters of RA-targeted drug carriers and discusses design considerations for improving RA therapies.
Bio-inspired, bioengineered and biomimetic drug delivery carriers
Yoo, Jin-Wook,Irvine, Darrell J.,Discher, Dennis E.,Mitragotri, Samir Nature Publishing Group, a division of Macmillan P 2011 Nature reviews. Drug discovery Vol.10 No.7
Synthetic carriers such as polymer and lipid particles often struggle to meet clinical expectations. Natural particulates ?? that range from pathogens to mammalian cells ?? are therefore worth examining in more depth, as they are highly optimized for their specific functions in vivo and possess features that are often desired in drug delivery carriers. With a better understanding of these biological systems, in conjunction with the availability of advanced biotechnology tools that are useful for re-engineering the various natural systems, researchers have started to exploit natural particulates for multiple applications in the delivery of proteins, small interfering RNA and other therapeutic agents. Here, we review the natural drug delivery carriers that have provided the basis and inspiration for new drug delivery systems.