http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Salma Omar (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
Multimodal Treatment of Sarcomas Linked to BCOR-CCNB3 Fusion in Pediatrics: A 3-Patient Case Series
Salma Omar,Karen Albritton,Kenneth Heym,Jason Wang,Anish Ray 대한소아혈액종양학회 2022 Clinical Pediatric Hematology-Oncology Vol.29 No.2
In 2012, a new neoplasm was classified according to fusion of the B-cell lymphoma (BCL-6) corepressor (BCOR) gene and the testis-specific cyclin B3 (CCNB3) gene on the X-chromosome, known as a BCOR-CCNB3 fusion positive sarcoma. Traditionally, BCOR sarcomas have been classified as ‘Ewing-like’ due to similarities in morphology. However, BCOR-CCNB3 fusion positive sarcomas are molecularly and genetically distinct. Previous studies have focused on clinical and pathologic characterization of this specific malignancy, but standard treatment modalities are not well documented. We present three pediatric patients diagnosed with BCOR-CCNB3 sarcomas. A two- year-old girl and a 16-year-old boy were treated using a five-drug therapy consisting of vincristine, doxorubicin, etoposide, ifosfamide, and cyclophosphamide. A 12-year- old girl received a two-drug therapy using a combination of ifosfamide and doxo-rubicin. All three patients are in remission following chemotherapy and surgery, con-firming the effectiveness and safety of the outlined regimens. There is a lack of con-sensus regarding an appropriate therapy algorithm for Ewing sarcoma patients with BCOR. The present study adds to the extant literature by detailing effective, yet vary-ing treatment modalities.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
