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Sako, Keisuke,Fukuhara, Shigetomo,Minami, Takashi,Hamakubo, Takao,Song, Haihua,Kodama, Tatsuhiko,Fukamizu, Akiyoshi,Gutkind, J. Silvio,Koh, Gou Young,Mochizuki, Naoki American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.9
<P>Angiopoietin-1 (Ang1) regulates both vascular quiescence and angiogenesis through the receptor tyrosine kinase Tie2. We and another group have recently shown that Ang1 and Tie2 form distinct signaling complexes at cell-cell and cell-matrix contacts and further demonstrated that the former selectively induces expression of Krüppel-like factor 2 (KLF2), a transcription factor involved in vascular quiescence. Here, we investigated the mechanism of how Ang1/Tie2 signal induces KLF2 expression to clarify the role of KLF2 in Ang1/Tie2 signal-mediated vascular quiescence. Ang1 stimulated KLF2 promoter-driven reporter gene expression in endothelial cells, whereas it failed when a myocyte enhancer factor 2 (MEF2)-binding site of KLF2 promoter was mutated. Depletion of MEF2 by siRNAs abolished Ang1-induced KLF2 expression, indicating the requirement of MEF2 in KLF2 induction by Ang1. Constitutive active phosphoinositide 3-kinase (PI3K) and AKT increased the MEF2-dependent reporter gene expression by enhancing its transcriptional activity and stimulated the KLF2 promoter activity cooperatively with MEF2. Consistently, inhibition of either PI3K or AKT and depletion of AKT abrogated Ang1-induced KLF2 expression. In addition, we confirmed the dispensability of extracellular signal-regulated kinase 5 (ERK5) for Ang1-induced KLF2 expression. Furthermore, depletion of KLF2 resulted in the loss of the inhibitory effect of Ang1 on vascular endothelial growth factor (VEGF)-mediated expression of vascular cell adhesion molecule-1 in endothelial cells and VEGF-mediated monocyte adhesion to endothelial cells. Collectively, these findings indicate that Ang1/Tie2 signal stimulates transcriptional activity of MEF2 through a PI3K/AKT pathway to induce KLF2 expression, which may counteract VEGF-mediated inflammatory responses.</P>
Is the Iliac Wing Curved Inward in Patients with Developmental Dysplasia of the Hip?
Noriaki Sako,Nobuhiro Kaku,Hiroaki Tagomori,Hiroshi Tsumura 대한정형외과학회 2021 Clinics in Orthopedic Surgery Vol.13 No.4
Background: There is a paucity of studies on the iliac curvature in developmental dysplasia of the hip (DDH). Here, we examined the iliac curvature in DDH using three-dimensional computed tomography. Methods: We allocated cases with a center-edge angle of < 20° to the DDH group (55 cases) and cases with a center-edge angle of > 25° to the control group (57 cases) and measured the straight line (line A) between the anterior and posterior superior iliac spines. We examined which part of the iliac bone line A passes through and classified the results into 4 categories (type A, inside the iliac bone; type B, through the iliac bone; type C, outside the iliac bone; and type D, both inside and outside the iliac bone) to evaluate the iliac wing curvature. After measuring the area and internal surface of the iliac wing using line A, we examined the correlation between these values, the interspinous distance, the superior iliac angle, and the center-edge angle. Results: Distributions of the four types were compared between the two groups; there was no significant difference. The length of the portion of line A inside the ilium and the area formed by line A and the iliac wing, which shows the degree of iliac wing curvature, were not significantly different between the groups. There were no correlations between these values and the center-edge angle; however, there were weak positive correlations among the interspinous distance, the superior iliac angle, and the centeredge angle. Conclusions: The inward nature of the iliac bone in patients with DDH is mainly due to the internal rotation of the entire iliac bone and less likely due to the curvature of the iliac bone.
Noriaki Sako,Nobuhiro Kaku,Yoshiki Kitahara,Yuta Kubota,Hiroaki Tagomori,Hiroshi Tsumura 대한정형외과학회 2022 Clinics in Orthopedic Surgery Vol.14 No.2
Background: Patients with developmental dysplasia of the hip (DDH) are known to have abnormal pelvic morphologies; however, rotation of innominate bone features remains unclear. Thus, we investigated innominate bone rotation in patients with DDH by measuring the associated angles and distances using three-dimensional (3D) computed tomography. Methods: We defined four straight lines in pelvic 3D models: from the anterior superior iliac spine to the posterior superior iliac spine, from the anterior inferior iliac spine to the posterior inferior iliac spine, from the pubic tubercle to the ischial spine, and from the pubic tubercle to the ischial tuberosity. Similarly, we measured the angles formed by these lines using the vertical axis of the anterior pelvic plane on the horizontal plane and the horizontal axis on the sagittal plane. Additionally, we measured the distances between the femoral head centers and the acetabular centers in the coronal plane. Results: The difference in internal rotation angle between the superior and inferior parts of the iliac bone was significantly lower, by approximately 1.7°, in the DDH group than in the control group (p = 0.007); the difference between the inferior and superior parts of the ischiopubic bone was significantly higher, by approximately 1.5°, in the DDH group (p < 0.001). In the sagittal plane, the sum of the superior aspect of the iliac bone and the inferior aspect of the ischium was significantly lower in the DDH group (p = 0.001) than in the control group. The distances between the femoral heads and the acetabula were significantly greater in the DDH group than in the control group (p = 0.03, p < 0.01, respectively). Conclusions: Patients with DDH had a more internally rotated ilium and ischiopubic bone than normal individuals; however, it should be emphasized that internal rotation was reduced near the acetabulum, and the acetabulum was shifted laterally. Similarly, it was shown that patients with DDH had different rotations of the ilium and ischiopubic bone in the sagittal plane.
Studies of extremely dense matter in heavy-ion collisions at J-PARC
Elsevier 2019 Nuclear physics. A Vol.982 No.-
<P><B>Abstract</B></P> <P>We aim to study extremely dense matter in heavy-ion collisions at 1 −19 AGeV/c at a future project of J-PARC (J-PARC-HI). We will search for the first order phase boundary and its critical end point in the QCD phase diagram. We also aim at studying the properties of dense matter related to neutron stars and neutron star mergers, in particular the equation of state (EOS). We expect to produce the world's highest rate of 10<SUP>11</SUP>Hz of heavy-ion beams, with ion species from p to U. We design spectrometers based on a large dipole magnet to measure hadrons, dimuons, and hypernuclei. We evaluate some of key performance of the spectrometers based on detailed simulations.</P>
Partial Migratable Hierarchical File System for Satellite Image Database
Nemoto, Toshihiro,Sako, Kazuhiko,Kitsuregawa, Masaru,Takagi, Mikio 대한원격탐사학회 1995 International Symposium on Remote Sensing Vol.11 No.1
Recent attention on global environmental changes has stimulated the development of large scale global information systems. Satellite images play a very important role for understanding these global changes. We designed and implemented a partially migratable file system based on 8mm tape robotics for satellite image database. The file system migrates only the necessary portion of a file onto the disk. Two real application programs: radiometric/geometric correction and NDVI (Normalized Difference Vegetation Index) generation, were chosen and executed using our experimental file system. Large performance improvements were achieved when compared to the conventional file level migration scheme.