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      저자 : Sakarkar, D.M. (검색결과 2 건)
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        Pharmacological effects of extract of $Carthamus$ $tinctorius$ on volume and acidity of stimulated gastric secretion

        Mandade, Rajesh,Sreenivas, S.A.,Sakarkar, D.M.,Wanare, Ravi 경희한의학연구센터 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4

        Over production of gastric acid in response to various stimuli is responsible for peptic ulceration in majority of patients. Calcium plays an important role in the release of various stimulant mediators. The aerial part of $Carthamus$ $tinctorius$ L. are reported to have calcium channel blocking activity. This study was designed to find out the effects of extract on the volume and acidity, free and total, of $Carbachol$ induced gastric secretion and to compare the results with that of $Cimetidine$ $and$ $Verapamil$ on the same parameters. The animals were kept on fasting for 48 h after which the pylorus of each animal was ligated. The extract was administered 200 and 400 mg/kg of body weight, $Cimetidine$ 2.5 mg/kg and $Carbachol$ 600 ${\mu}g$/kg and $Verapamil$ 10 mg/kg body weight, intraperitoneally, in pylorus ligated rats. It was found that the extract reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with $Carbachol$ ($P$ <0.001). $Cimetidine$ also had the same effects. When the difference of mean values, brought about by extract, was compared with those of $Cimetidine$, it was found that these differences in the volume and free acidity were significant indicating that $Cimetidine$ is more effective than the extract. The extract can, however, be used effectively in the treatment of peptic ulcer. Although, the extract reduced gastric acidity significantly, but is less effective than $Cimetidine$.

      • KCI등재

        Pharmacological effects of extract of Carthamus tinctorius on volume and acidity of stimulated gastric secretion

        Rajesh Mandade,S. A. Sreenivas,D. M. Sakarkar,Ravi Wanare 경희대학교 융합한의과학연구소 2011 Oriental Pharmacy and Experimental Medicine Vol.11 No.4

        Over production of gastric acid in response to various stimuli is responsible for peptic ulceration in majority of patients. Calcium plays an important role in the release of various stimulant mediators. The aerial part of Carthamus tinctorius L. are reported to have calcium channel blocking activity. This study was designed to find out the effects of extract on the volume and acidity, free and total, of Carbachol induced gastric secretion and to compare the results with that of Cimetidine and Verapamil on the same parameters. The animals were kept on fasting for 48 h after which the pylorus of each animal was ligated. The extract was administered 200 and 400 mg/kg of body weight, Cimetidine 2.5 mg/kg and Carbachol 600 μg/kg and Verapamil 10 mg/kg body weight, intraperitoneally,in pylorus ligated rats. It was found that the extract reduced the volume, free and total acidity of gastric secretion, which were statistically highly significant when compared with Carbachol (P<0.001). Cimetidine also had the same effects. When the difference of mean values,brought about by extract, was compared with those of Cimetidine, it was found that these differences in the volume and free acidity were significant indicating that Cimetidine is more effective than the extract. The extract can, however, be used effectively in the treatment of peptic ulcer. Although, the extract reduced gastric acidity significantly, but is less effective than Cimetidine

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