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Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome
Sak, Sibel,Uyanikoglu, Hacer,Incebiyik, Adnan,Incebiyik, Hatice,Hilali, Nese Gul,Sabuncu, Tevfik,Sak, Erdal The Korean Society for Reproductive Medicine 2018 Clinical and Experimental Reproductive Medicine Vol.45 No.3
Objective: The aim of this study was to compare serum fetuin-A levels and oxidative stress markers, as indicators of insulin resistance, in women with polycystic ovary syndrome (PCOS) and in healthy controls. Methods: This prospective case-control study included 46 patients with PCOS and 48 age- and body mass index-matched control women. Levels of serum hormones, fetuin-A, and oxidative stress markers were measured in blood samples taken during the early follicular period from each participant. Results: Follicle-stimulating hormone (FSH), luteinising hormone (LH), total testosterone levels, and the LH/FSH ratio were found to be significantly higher in women with PCOS than in controls. Serum total antioxidant status, total oxidant status, and oxidative stress index parameters all indicated significantly higher levels of oxidative stress in PCOS patients than in controls. Serum fetuin-A levels, which were analyzed as an indicator of insulin resistance, were higher in the PCOS group than in the control group ($210.26{\pm}65.06{\mu}g/mL$ and $182.68{\pm}51.20{\mu}g/mL$, respectively; p= 0.024). Conclusion: The data obtained from the present study suggest that higher levels of both serum fetuin-A and oxidative stress markers might be related with PCOS.
Multi-Target Cytotoxic Actions of Flavonoids in Blood Cancer Cells
Sak, Katrin,Everaus, Hele Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
To date, cytotoxic effects of flavonoids in various cancer cells are well accepted. However, the intracellular signaling cascades triggered by these natural compounds remain largely unknown and elusive. In this mini-review, the multiplicity of molecular targets of flavonoids in blood cancer cells is discussed by demonstrating the involvement of various signaling pathways in induction of apoptotic responses. Although these data reveal a great potential of flavonoids for the development of novel agents against different types of hematological malignancies, the pleiotropic nature of these compounds in modulation of cellular processes and their interactions certainly need unraveling and further investigation.
Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells
Sak, Katrin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19
Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeutic strategies and anticancer agents is an urgent priority. Plants have remained an important source in the search for novel cytotoxic compounds and several polyphenolic flavonoids possess antitumor properties. In this review article, data about potential anticarcinogenic activity of common natural flavonoids on various human cervical cancer cell lines are compiled and analyzed showing perspectives for the use of these secondary metabolites in the treatment of cervical carcinoma as well as in the development of novel chemotherapeutic drugs. Such anticancer effects of flavonoids seem to differentially depend on the cellular type and origin of cervical carcinoma creating possibilities for specific targeting in the future. Besides the cytotoxic activity per se, several flavonoids can also contribute to the increase in efficacy of conventional therapies rendering tumor cells more sensitive to standard chemotherapeutics and irradiation. Although the current knowledge is still rather scarce and further studies are certainly needed, it is clear that natural flavonoids may have a great potential to benefit cervical cancer patients.
이삭(Sak LEE),이동원(Dong-Won LEE),김병지(Byung-Ji KIM),권순범(Soon-Bum KWON) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
Jets issuing from a conventional nozzle and convergent nozzles of a constant expansion rates and a certain normal using an annular slit are compared to investigate the characteristics of the 3 jets. In experiments, to compare the characteristics between jets, the nozzle exit mean velocity is fixed as 90㎧. The pressures along the jet axis and radial directions is measured by scanning valve system moving with 3-axis auto-traverse unit, and the velocity distribution can be obtained by calculation from the measured static and total pressures. To obtain the highly stable and convergency jets, a nozzle has to be designed with an annular slit connected to an conical cylinder, furthermore, the flow through aconstant expansion rate nozzle using annular slit is the most probable. And the pressure drop along the nozzle for the constant expansion rate nozzle is small.
Lee, Sak,Chang, Byung-Chul,Youn, Young-Nam,Kwak, Young-Lan,Yoo, Kyung-Jong Japanese Circulation Society. 2007 CIRCULATION JOURNAL Vol.71 No.10
<P><B>Background</B> An association of mitral regurgitation (MR) with ischemic cardiomyopathy (I-CMP) increases the risk of heart failure and its surgical management remains controversial. <B>Methods and Results</B> Between July 2001 and June 2006, a total of 49 patients with I-CMP underwent surgical ventricular restoration (SVR) and coronary revascularization with or without concomitant mitral annuloplasty (MAP). The mean age was 59.8 years, and all patients had New York Heart Association (NYHA) class III or IV heart failure (mean left ventricular ejection fraction (LVEF) = 24.8%). Nineteen patients had MR >grade 3 (MR group). SVR and coronary artery bypass grafting were performed in all patients, and concomitant MAP was performed in the MR group. Echocardiography was performed preoperatively, postoperatively, and at mean of 19 months after operation. Preoperative left ventricular (LV) end-diastolic and end-systolic dimensions, left atrial volume index, and MR grade were statistically significantly increased in the MR group. On the early postoperative echocardiogram, mean LVEF was significantly improved, with reduction of LV dimensions, in both groups; however, at follow up, these parameters were more significantly improved in the MR group, but unchanged in non-MR group, reaching almost the same levels as the non-MR group. <B>Conclusion</B> In patients with I-CMP, MR increases early and late mortality; however, after SVR and concomitant MAP, LV function seems to continuously improve with more significant reduction in the LV dimensions than in the non-MR group. (<I>Circ J</I> 2007; <B>71:</B> 1516 - 1520)</P>