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- 저자 : Sahar Mohamed Mahmoud (검색결과 2 건)
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Fatma Abdelghaffar,Manal G. Mahmoud,Mohsen S. Asker,Sahar S. Mohamed 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.99 No.-
Linen fabrics, one of the oldest natural cellulose fabrics, lack the functional properties for the medicalgarments that can be acquired using the green synthesis of silver nanoparticles. Therefore, the currentstudy presents a statistical design for one-pot green synthesis of silver nanoparticles (AgNPs) under UVlight using the natural polysaccharide (BSEPS) produced by Bacillus subtilis sp. suppress. The Taguchimethod was used to evaluate the optimal green synthesis of AgNPs, and obtain smaller nanoparticlessizes, by three effective factors, AgNO3 concentration, BSEPS concentration, and pH. In addition, thedeposition of AgNPs capped with BSEPS was investigated onto linen to promote antibacterial activity,functional surface properties, and dyeability. FTIR, XRD, TEM, SEM, and EDX have confirmed thefabrication and deposition of AgNPs on linen fabrics. BSEPS/AgNPs fabricating shows positive results forantibacterial activities against E. coli and S. aureus for linen fabrics, both undyed and dyed. The resultsrevealed that BSEPS/AgNPs played a dual role in reducing bacterial activity and increasing dyeability.
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Rehab Essam El-Din El-Hennamy,Sahar Mohamed Mahmoud,Nabil Ahmed El-Yamany,Hanaa Hassan Hassanein,Mohamed Elsayed Amer,Aly Fahmy Mohamed 대한백신학회 2023 Clinical and Experimental Vaccine Research Vol.12 No.1
Purpose: The present study aimed to compare the immune-enhancing potential of gold nanoparticles (AuNPs) to Alum against rabies vaccine and the related immunological, physiological, and histopathological effects. Materials and Methods: Alum and AuNPs sole and in combination with rabies vaccine were used at 0.35 mg/mL and 40 nM/mL, respectively. Rats used were categorized into six groups (20/each): control rats, rabies vaccine, aluminum phosphate gel, rabies vaccine adsorbed to Alum, AuNPs, and rabies vaccine adjuvant AuNPs. Results: Liver and kidney functions were in the normal range after AuNPs and Alum adjuvanted vaccine compared to control. Interleukin-6 and interferon-γ levels were significantly increased in groups immunized with Alum and AuNPs adjuvanted vaccine, the peak level was in the case of AuNP adjuvanted vaccine on the 14th day. Ninety days post-vaccination, total immunoglobulin G (IgG) against adjuvanted rabies vaccine showed a significantly elevated anti-rabies IgG with AuNPs and Alum adsorbed vaccine compared with unadjuvanted one. The total antioxidant capacity, malondialdehyde (MDA) levels, superoxide dismutase, and glutathione peroxidase activities were significantly increased post-adjuvanted AuNPs adjuvanted vaccine vaccination than in Alum adsorbed vaccine, while MDA was significantly decreased. The histopathological examination revealed detectable alterations post-AuNPs and Alum adjuvanted vaccine immunization compared with liver and kidney profiles post-administration of unadjuvanted and non-immunized groups, meanwhile, splenic tissue revealed hyperplasia of lymphoid follicles indicating increased immune reactivity. Conclusion: The AuNPs are promising enhancers of the immune response as Alum, and the undesirable effects of AuNPs could be managed by using suitable sizes, shapes, and concentrations.
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