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Saeed, Sheikh Arshad,Ahmed, Sagheer The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.11
The objective was to devise an animal model of myocardial infarction (MI) against which cardioprotective drugs might be tested. We describe the effects of nimesulide, a COX experience with development and validation of such a model. The rabbit was chosen in preference to rodents because its heart and cardiac circulation more closely resemble those of human. Thus, the cardiovascular system of anaesthetized male rabbits, 1 to 1.5 kg (n=11), was stressed by a single bolus intravenous injection of isoprenaline (ISP), 65 mg/kg. The effects of the injection were followed for sixteen days and were evaluated in four ways: 1) measurements of creatinine kinase isozyme and troponin-I (TPI) in serum 2) Electrocardiographic (ECG) changes (ST elevation and Q wave development) 3) Cardiac histopathology observed in tissue sections of the isolated of the heart. The histopathological analysis showed that rabbit heart on 2nd day after ISP injection showed changes of coagulation necrosis. Day 4 total coagulation with the loss of nuclear and striation associated with heavy interstitial infiltrate of neutrophils was found. Day 8 after infarction showed collagen deposition with capillary channels in between the remaining islands of myocytes in the infarcted area. On the 16th day scarring was complete. Coronary perfusion rates (CPR) and heart rate (HR) of the infarcted and nimesulide (a COX-2 inhibitor) treated rabbits displayed significant improvement (n=11) on each corresponding day after infarction as compared to the infarcted and saline treated rabbits (P<0.05). All four indices revealed similarities with effects commonly associated with MI in humans.
Augmenting yogurt quality attributes through hydrocolloidal gums
Rafiq, Lubna,Zahoor, Tahir,Sagheer, Ambreen,Khalid, Nazia,Rahman, Ubaid ur,Liaqat, Atif Asian Australasian Association of Animal Productio 2020 Animal Bioscience Vol.33 No.2
Objective: The present work was undertaken to determine the possibility of using xanthan and guar gums as stabilizers to enhance the yogurt quality. Methods: Yogurt was manufactured from standardized milk (3.5% fat, 8.5% solid-not-fat contents) with the addition of 2% to 3% starter culture. Enzyme-hydrolyzed xanthan gum (0.1%, 0.5%, 1.0%) and guar gum (0.1%, 0.5%, 1.0%) were added to the yogurt as stabilizers. Prepared yogurt samples were kept at refrigeration temperature (4℃±2℃) for 21 days and various quality and sensory parameters were studied at regular intervals (7 days). Results: Results showed that yogurt with 0.5% xanthan gum (T5) was best in terms of preventing syneresis and improving the viscosity, water holding capacity and texture of the product. Additionally, adding gums did not adversely affect the sensorial attributes of the product. Conclusion: Modified gums were found useful in augmenting yogurt quality and therefore addition of gums is highly recommended for manufacturing yogurt.
Sheikh Arshad Saeed,Sagheer Ahmed 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.11
The objective was to devise an animal model of myocardial infarction (MI) against which cardioprotective drugs might be tested. We describe the effects of nimesulide, a COX experience with development and validation of such a model. The rabbit was chosen in preference to rodents because its heart and cardiac circulation more closely resemble those of human. Thus, the cardiovascular system of anaesthetized male rabbits, 1 to 1.5 kg (n=11), was stressed by a single bolus intravenous injection of isoprenaline (ISP), 65 mg/kg. The effects of the injection were followed for sixteen days and were evaluated in four ways: 1) measurements of creatinine kinase isozyme and troponin-I (TPI) in serum 2) Electrocardiographic (ECG) changes (ST elevation and Q wave development) 3) Cardiac histopathology observed in tissue sections of the isolated of the heart. The histopathological analysis showed that rabbit heart on 2nd day after ISP injection showed changes of coagulation necrosis. Day 4 total coagulation with the loss of nuclear and striation associated with heavy interstitial infiltrate of neutrophils was found. Day 8 after infarction showed collagen deposition with capillary channels in between the remaining islands of myocytes in the infarcted area. On the 16th day scarring was complete. Coronary perfusion rates (CPR) and heart rate (HR) of the infarcted and nimesulide (a COX-2 inhibitor) treated rabbits displayed significant improvement (n=11) on each corresponding day after infarction as compared to the infarcted and saline treated rabbits (P<0.05). All four indices revealed similarities with effects commonly associated with MI in humans.
Flocculation and viscoelastic behavior of industrial papermaking suspensions
Mustafa S. Nasser,Mohammed J. Al-Marri,Abdelbaki Benamor,Sagheer A. Onaizi,Majeda Khraisheh,Mohammed A. Saad 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.2
The effects of the surface charge type and density C496, C492 and A130LMW polyacrylamides (PAMs) on the rheological behavior of real industrial papermaking suspensions were quantitatively related to the degree of flocculation for the same industrial papermaking suspensions. The floc sizes were larger but less dense when anionic PAM was used, and this due to the repulsive forces between the anionic PAM and colloidal particles, leading to the development of open structure flocs of less density. On the other hand, rheological measurements showed that the papermaking suspension is thixotropic with a measurable yield stress. The results showed that the magnitude of the critical stress, τc, complex viscosity, η *, elastic modulus, G', and viscous modulus, G'', depend on the number of interactions between the PAM chains and particle surface and the strength of those interactions. Cationic PAM showed higher values of η *, G', G'' and τc compared to anionic PAM. This behavior is in good agreement with Bingham yield stress, τB, adsorption and effective floc density results. Similar to oscillatory measurements, creep measurements also showed that the deformation was much lower for the cationic PAM based suspensions than for the anionic PAM based suspensions. Furthermore, the results revealed that increasing the cationic PAM surface charge decreases the floc size but increases the adsorption rate, elasticity and effective floc density proposing differences in the floc structures, which are not revealed clearly in the Bingham yield stress measurements.
Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue
Bood, Mattias,Fü,chtbauer, Anders F.,Wranne, Moa S.,Ro, Jong Jin,Sarangamath, Sangamesh,El-Sagheer, Afaf H.,Rupert, Dé,borah L. M.,Fisher, Rachel S.,Magennis, Steven W.,Jones, Anita C.,H&oum Royal Society of Chemistry 2018 Chemical Science Vol.9 No.14
<▼1><P>A highly fluorescent, non-perturbing, pentacyclic adenine analog was designed, synthesized, incorporated into DNA and photophysical evaluated.</P></▼1><▼2><P>Emissive base analogs are powerful tools for probing nucleic acids at the molecular level. Herein we describe the development and thorough characterization of pentacyclic adenine (pA), a versatile base analog with exceptional fluorescence properties. When incorporated into DNA, pA pairs selectively with thymine without perturbing the B-form structure and is among the brightest nucleobase analogs reported so far. Together with the recently established base analog acceptor qA<SUB>nitro</SUB>, pA allows accurate distance and orientation determination <I>via</I> Förster resonance energy transfer (FRET) measurements. The high brightness at emission wavelengths above 400 nm also makes it suitable for fluorescence microscopy, as demonstrated by imaging of single liposomal constructs coated with cholesterol-anchored pA–dsDNA, using total internal reflection fluorescence microscopy. Finally, pA is also highly promising for two-photon excitation at 780 nm, with a brightness (5.3 GM) that is unprecedented for a base analog.</P></▼2>