Incidence and Mortality of Testicular Cancer and Relationships with Development in Asia

Sadeghi, Mostafa,Ghoncheh, Mahshid,Mohammadian-Hafshejani, Abdollah,Gandomani, Hamidreza Sadeghi,Rafiemanesh, Hosein,Salehiniya, Hamid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.9

Background: Testicular cancer is one of the most common cancers among young men between ages 20-34 in countries with high or very high levels of the Human Development Index (HDI). This study investigated the incidence and mortality of prostate cancer and the relationship with the HDI and its dimensions in Asia in 2012. Materials and Methods: The study was conducted based on data from the world data of cancer and the World Bank (including the HDI and its components). Standardized incidence and mortality rates of testicular cancer were calculated for Asian countries. Correlations between incidence and/ormortality rates, and the HDI and its components were assessed with the use of the correlation test, using SPSS software. Results: There was a total of 14902 incidences and 5832 death were recorded in Asian countries in 2012. Among the Asian countries, the five countries with the highest standardized incidence rates of testicular cancer were Israel, Georgia, Turkey, Lebanon and Kazakhstan and the five countries with the highest standardized mortality rates were Turkey, Georgia, Jordan, Cambodia and the Syrian Arab Republic. A positive correlation of 0.382 was observed between the standardized incidence rates of testicular cancer and the HDI (p=0.009). Also a negative correlation of 0.298 between the standardized mortality rate of testicular cancer and the Human Development Index was noted although this relation was statistically non-significant (p=0.052). Conclusions: There is a positive correlation between HDI and the standardized incidence rate of testicular cancer and negative correlation with standardized mortality rate.

A Case Report of Prolonged Hemorrhage Following Traditional Phlebotomy (Fasd)

Sadeghi Sajjad,Sadeghi Sajjad 대한약침학회 2024 Journal of pharmacopuncture Vol.27 No.1

Phlebotomy, a therapeutic method of bloodletting typically performed using a needle, has a traditional technique known as “Fasd.” In this method, blood is extracted by creating a longitudinal incision on a vein (3-5 mm) with a surgical scalpel blade, usually blade No. 11. Due to the incision in the vessel wall, establishing hemostasis is more challenging compared to conventional methods. Hemostasis is usually achieved within minutes after Fasd. We present a case highlighting an uncommon yet significant complication of traditional phlebotomy. A 55-year-old man with no prior medical conditions underwent traditional phlebotomy at an academic traditional medicine clinic. Senior MD-PhD students in Iranian Traditional Medicine, under professor supervision, performed Fasd. A sterile scalpel blade No. 11 was used to create a longitudinal incision of approximately 4 mm on the patient’s median basilic vein in the right hand. After removing 400 cc of blood, a pressure dressing was applied to the incision site. Despite attempts such as hand elevation, ice pack application, prolonged direct pressure, and tight elastic bandaging, bleeding from the incision persisted. After an hour of supportive therapy, hemostasis was eventually achieved within a few minutes using burnt cotton dressing (a traditional method for blood hemostasis). Following intravenous hydration, the patient was discharged in stable condition and reported no issues during the one-month follow-up. The traditional phlebotomy (Fasd) carries the risk of serious complications, including uncontrolled and prolonged bleeding. Further research on the efficacy and safety of burnt cotton dressing for controlling hemostasis is recommended.

Efficacy of plasmapheresis in neutropenic patients suffering from cytokine storm because of severe COVID-19 infection

Alireza Sadeghi,Somayeh Sadeghi,Mohammad Saleh Peikar,Maryam Yazdi,Mehran Sharifi,Safie Ghafel,Farzin Khorvash,Behrooz Ataei,Mohammad Reza Safavi,Elahe Nasri 대한혈액학회 2023 Blood Research Vol.58 No.2

Background With the emergence of the coronavirus disease 2019 (COVID-19) and inability of healthcare systems to control the disease, various therapeutic theories with controversial responses have been proposed. Plasmapheresis was administered as a medication. However, the knowledge of its efficacy and indications is inadequate. This study evaluated the use of plasmapheresis in critically ill patients with cancer. Methods This randomized clinical trial was conducted on 86 patients with malignancies, including a control group (N=41) and an intervention group (N=45) with severe COVID-19 during 2020-21. Both groups were treated with routine medications for COVID-19 management according to national guidelines, and plasmapheresis was applied to the intervention group. C-reactive protein (CRP), D-dimer, ferritin, lactate dehydrogenase, hemoglobin, and white blood cell, polymorphonuclear, lymphocyte, and platelet levels were measured at admission and at the end of plasmapheresis. Other variables included neutrophil recovery, intensive care unit admission, intubation requirements, length of hospital stay, and hospitalization outcomes. Results CRP (P <0.001), D-dimer (P <0.001), ferritin (P =0.039), and hemoglobin (P =0.006) levels were significantly different between the groups after the intervention. Neutrophil recovery was remarkably higher in the case than in the control group (P <0.001). However, plasmapheresis did not affect the length of hospital stay (P=0.076), which could have significantly increased survival rates (P <0.001). Conclusion Based on the study findings, plasmapheresis led to a significant improvement in laboratory markers and survival rate in patients with severe COVID-19. These findings reinforce the value of plasmapheresis in cancer patients as a critical population suffering from neutropenia and insufficient immune responses.

Determining plasma boundary in Alvand-U tokamak

Sadeghi Yahya 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9

One of the major topic of tokamak research is the determination of the magnetic profile due to magnetic coil fields and plasma current by mean of data from magnetic probes. The most practical approach is to use the current filament method, which models the plasma column with multiple current carrying filaments and the total current of these filaments is equal to the plasma current. Determining the plasma boundary in Alvand-U tokamak is the main purpose of this paper. In order to determine the magnetic field profile and plasma boundary, information concerning the magnetic coils, their position, and current is required in the computing code. Then, the plasma shape is determined and finally the plasma boundary is extracted by the code. In the conducted research, we discuss how to determine the plasma boundary and the performance of the computing code for extraction of the plasma boundary. The developed algorithm shows to be effective by running it in the regular pc machine with characteristics of Intel (R) core (TM) i3-10100 CPU @3.60 GHz and 8.00 GB of RAM. Finally, we present results of a test run for computing code using a typical experimental pulse.

Production of Recombinant Human Interleukin-11 (IL-11) in Transgenic Tobacco (Nicotiana tabacum) Plants

Sadeghi, Abdorrahim,Mahdieh, Majid,Salimi, Somayeh The Korean Society of Plant Biotechnology 2016 식물생명공학회지 Vol.43 No.4

Interleukin-11 (IL-11) is a cytokine that plays a key regulatory role in the immune system. Recombinant human IL-11 (rhIL-11) exerts a preventative effect against apoptotic cell death and inhibits preadipocyte differentiation. IL-11 also is used to stimulate the bone marrow to produce platelets in order to prevent low platelets that may be caused by chemotherapy. Unfortunately, the high production cost of IL-11 associated. In this study, we investigated the feasibility of transgenic plants for the cost-effective production of rhIL-11. Production of rhIL-11 proteins in whole-plant expression system will be more economical when compared to the current E. coli based expression system. The human rhIL-11 gene was codon optimized to maximize plant host system expression. IL-11 expression vector under the control of a constitutive cauliflower mosaic virus 35S (CaMV 35S) promoter was introduced into tobacco by Agrobacterium-mediated transformation. The 5'-leader sequence (called ${\Omega}$) of tobacco mosaic virus (TMV) as a translational enhancer was added to construct. Transgenic tobacco plants expressing various levels of rhIL-11 protein were generated. Western blotting of the stably transformed lines demonstrated accumulation of the appropriately sized rhIL-11 protein in leaves. This research demonstrated the efficacy of using tobacco as an expression system for the production of rhIL-11.

A simplified algorithm for conceptual estimation of the material quantities of rubble-mound breakwaters

Sadeghi, Kabir,Nouban, Fatemeh Techno-Press 2020 Ocean systems engineering Vol.10 No.1

A simplified algorithm is proposed for fast estimation of the material quantities required for the construction of rubble-mound breakwaters. The proposed algorithm is able to employ only the data available at feasibility study phase such as the maximum draught of the design ship selected to transport the cargos to the harbor despite, because at the feasibility phase, information for the planned harbor is likely to be very limited. A linear-constant waterdepth model together with a proposed section configuration for the breakwaters, which is customary for harbors, is considered to calculate the quantity of materials. The numerical simulation of the wave characteristics has been verified using the recorded wave data collected by a buoy installed near the Neka harbor in Caspian Sea waters. A case study has been also applied to four harbors to validate the proposed algorithm. The estimated weights using the proposed linear-constant and multi-linear waterdepth models were compared using the bathymetry maps and layouts of these harbors. A computer program, written in QBasic language, has been developed to simulate the wave characteristics and to estimate the material quantities needed to construct a rubble-mound breakwater. The obtained results show that taking into account the acceptable accuracies normally applied to the feasibility study and conceptual design phases, the proposed algorithm is sufficiently accurate and highly effective for the conceptual estimation of materials' quantities of breakwaters in the feasibility study phase of harbor projects.

Enhanced Natural Gas Sweetening with Ultralow H2S Concentration via Polycarbonate-Silica Mixed Matrix Membranes

Sadeghi Rahman,Hassanajili Shadi 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.4

Mixed matrix membranes (MMMs) are brought up as prospecting media to sweeten natural gas in recent decades. But the majority of experiments have conducted on CO 2 /CH 4 gas pair separation, and H 2 S removal from CH 4 through MMMs has been paid less consideration. Thereupon, polycarbonate (PC) permeability and permselectivity as a polymer with inherent gas transport properties and two PC-based MMMs containing octylsilane (OS) and polydimethylsiloxane (PDMS)-modifi ed nanosilica were investigated under various operational conditions for this gas couple. The infl uence of operational parameters including transmembrane pressure, feed temperature, H 2 S inlet concentration and physical aging on the permeability of mixed gas and selectivity of the H 2 S/CH 4 pair was assessed. It was observed that addition of silica nanoparticles causes more H 2 S permeability and selectivity. As a result, it can be used for methane upgradation. Membranes fabricated with PDMS-modifi ed nanosilica showed the highest permeability of H 2 S and also the superior selectivity of H 2 S/CH 4 . Therefore, it could be possibly applied to mitigation of H 2 S concentration in the outlet gas stream.

Design and simulation of a blanket module with high efficiency cooling system of tokamak focused on DEMO reactor

Sadeghi, H.,Amrollahi, R.,Zare, M.,Fazelpour, S. Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.2

In this study, the neutronic calculation to obtain tritium breeding ratio (TBR) in a deuterium-tritium (D-T) fusion power reactor using Monte Carlo MCNPX is done. In addition, by using COMSOL software, an efficient cooling system is designed. In the proposed design, it is adequate to enrich up to 40% ⁶Li. Total tritium breeding ratio of 1.12 is achieved. The temperature of helium as coolant gas never exceed 687℃. As regards the tolerable temperature of beryllium (650℃), the design of blanket module is done in the way that beryllium temperature never exceed 600℃. The main feature of this design indicates the temperature of helium coolant is higher than other proposed models for blanket module, therefore power of electricity generation will increase.

Nurse Attitude-Related Barriers to Effective Control of Cancer Pain among Iranian Nurses

Sadeghy, Adel,Mohamadian, Robab,Rahmani, Azad,Fizollah-zadeh, Hussein,Jabarzadeh, Franak,Azadi, Arman,Rostami, Hussein Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4

Background: Many cancer patients still experience pain worldwide. There are many barriers for effective control of cancer pain and many of these are related to health care providers. There is a need for further investigation of these barriers. The aim of this study was to investigate nurse-related barriers to control of cancer pain among Iranian nurses. Materials and Methods: In this descriptive study 49 nurses from two hospitals affiliated to Tabriz and Ardebil Universities of Medical Sciences participated using a census sampling method. A demographic and profession related checklist and Barriers Questionnaire II (BQ-II) were used for data collection. Results: The results showed negative attitudes of participants regarding control of cancer pain. Participants believed that cancer pain medications do not manage cancer pain at acceptable levels; patients may become addicted by using these drugs; cancer pain medications have many uncontrollable effects; and controlling cancer pain may distract the physicians from treating disease. Conclusions: Iranian nurses have negative attitudes toward pain control in cancer patients especially about effectiveness of pain medication and their side effects. Educational intervention to reduce these misconceptions is needed.

Real-Time Implementation of Brain Emotional Learning Developed for Digital Signal Processor-Based Interior Permanent Magnet Synchronous Motor Drive Systems

Sadeghi, Mohamad-Ali,Daryabeigi, Ehsan The Korean Institute of Power Electronics 2014 JOURNAL OF POWER ELECTRONICS Vol.14 No.1

In this study, a brain emotional learning-based intelligent controller (BELBIC) is developed for the speed control of an interior permanent magnet synchronous motor (IPMSM). A novel and simple model of the IPMSM drive structure is established with the intelligent control system, which controls motor speed accurately without the use of any conventional PI controllers and is independent of motor parameters. This study is conducted in both real time and simulation with a new control plant for a laboratory 3 ph, 3.8 Nm IPMSM digital signal processor (DSP)-based drive system. This DSP-based drive system is then compared with conventional BELBIC and an optimized conventional PI controller. Results show that the proposed method performs better than the other controllers and exhibits excellent control characteristics, such as fast response, simple implementation, and robustness with respect to disturbances and manufacturing imperfections.