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Shin, Ai-Hyang,Oh, Chang-Joo,Park, Jeen-Woo The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.7
Oxidative mechanisms are thought to have a major role in cataract formation and diabetic complications. Antioxidant enzymes play an essential role in the antioxidant system of the cells that work to maintain low steady-state concentrations of the reactive oxygen species. When HLE-B3 cells, a human lens cell line were exposed to 50-100 mM glucose for 3 days, decrease of viability, inactivation of antioxidant enzymes, and modulation of cellular redox status were observed. Significant increase of cellular oxidative damage reflected by lipid peroxidation and DNA damage were also found. The glycation-mediated inactivation of antioxidant enzymes may result in the perturbation of cellular antioxidant defense mechanisms and subsequently lead to a pro-oxidant condition and may contribute to various pathologies associated with the long term complications of diabetes.
자외선이 조사된 사람피부 섬유아세포에서 흰털오가피 잎추출물의 항산화작용
신애향,유수연,노빛나,김자인,김옥경,박원봉,Shin, Ai-Hyang,Lyu, Su-Yun,Noh, Bin-Na,Kim, Ja-In,Kim, Ok-Kyoung,Park, Won-Bong 대한약학회 2007 약학회지 Vol.51 No.4
We investigated antioxidative activity of the water and ethanol extracts of leaves of Acanthopanax divaricatus var. albeofructus in human dermal fibroblast (HDFs) irradiated by UVA. The irradiation of UVA did not affect the cell viability of HDFs. The antioxidative activity of the extract was investigated by xylenol orange, TBARS (thiobarbituric acid reactive substances) and antioxidant enzyme assay. Both extracts showed H202 scavenging activity and inhibited lipid peroxidation in HDF cells irradiated by UVA. The extracts also recovered enzyme activity in the same cells.
Hur, Su-Jung,Lee, Hye-Won,Shin, Ai-Hyang,Park, Sung Jean Korean Magnetic Resonance Society 2014 Journal of the Korean Magnetic Resonance Society Vol.18 No.1
Hsp90 is a good drug target molecule that is involved in regulating various signaling pathway in normal cell and the role of Hsp90 is highly emphasized especially in cancer cells. Thus, much efforts for discovery and development of Hsp90 inhibitor have been continued and a few Hsp90 inhibitors targeting the N-terminal ATP binding site are being tested in the clinical trials. There are no metabolic signature molecules that can be used to evaluate the effect of Hsp90 inhibition. We previously found a potential C-domain binder named PPC1 that is a synthetic small molecule. Here we report the metabolomics study to find signature metabolites upon treatment of PPC1 compound in lung cancer cell line, A549 and discuss the potentiality of metabolomic approach for evaluation of hit compounds.