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RISS 인기검색어
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- 저자 : S.P. Subbiah, (검색결과 4 건)
- 무료
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Approximating bone ECM: Crosslinking directs individual and coupled osteoblast/osteoclast behavior
Hwang, M.P.,Subbiah, R.,Kim, I.G.,Lee, K.E.,Park, J.,Kim, S.H.,Park, K. IPC Science and Technology Press 2016 Biomaterials Vol.103 No.-
<P>Osteoblast and osteoclast communication (i.e. osteocoupling) is an intricate process, in which the biophysical profile of bone ECM is an aggregate product of their activities. While the effect of microenvironmental cues on osteoblast and osteoclast maturation has been resolved into individual variables (e.g. stiffness or topography), a single cue can be limited with regards to reflecting the full biophysical scope of natural bone ECM. Additionally, the natural modulation of bone ECM, which involves collagenous fibril and elastin crosslinking via lysyl oxidase, has yet to be reflected in current synthetic platforms. Here, we move beyond traditional substrates and use cell-derived ECM to examine individual and coupled osteoblast and osteoclast behavior on a physiological platform. Specifically, preosteoblast-derived ECM is crosslinked with genipin, a biocompatible crosslinker, to emulate physiological lysyl oxidase-mediated ECM crosslinking. We demonstrate that different concentrations of genipin yield changes to ECM density, stiffness, and roughness while retaining biocompatibility. By approximating various bone ECM profiles, we examine how individual and coupled osteoblast and osteoclast behavior are affected. Ultimately, we demonstrate an increase in osteoblast and osteoclast differentiation on compact and loose ECM, respectively, and identify ECM crosslinking density as an underlying force in osteocoupling behavior. (C) 2016 Elsevier Ltd. All rights reserved.</P>
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Fibroblast-derived matrix (FDM) as a novel vascular endothelial growth factor delivery platform
Du, P.,Hwang, M.P.,Noh, Y.K.,Subbiah, R.,Kim, I.G.,Bae, S.E.,Park, K. Elsevier Science Publishers 2014 Journal of controlled release Vol.194 No.-
Vascular endothelial growth factor (VEGF) is one of the most important signaling cues during angiogenesis. Since many delivery systems of VEGF have been reported, the presentation of VEGF using a more physiologically relevant extracellular matrix (ECM), however, has yet to be thoroughly examined. In this study, we propose that fibroblast-derived extracellular matrix (FDM) is a novel platform for angiogenic growth factor delivery and that FDM-mediated VEGF delivery can result in an advanced angiogenic response. The FDMs, activated by EDC/NHS chemistry, were loaded with varying amounts of heparin. Different doses of VEGF were subsequently immobilized onto the heparin-grafted FDM (hep-FDM); 19.6+/-0.6, 39.2+/-3.2, and 54.8+/-8.9ng of VEGF were tethered using 100, 300, and 500ng of initial VEGF, respectively. VEGF-tethered FDM was found chemoattractive and VEGF dose-dependent in triggering human umbilical vein endothelial cells (ECs) migration in vitro. When hep-FDM-bound VEGF (H-F/V) was encapsulated into alginate capsules (A/H-F/V) and subjected to release test for 28days, it exhibited a significantly reduced burst release at early time point compared to that of A/V. The cell proliferation results indicated a substantially extended temporal effect of A/H-F/V on EC proliferation compared to those treated with soluble VEGF. For a further study, A/H-F/V was transplanted subcutaneously into ICR mice for up to 4weeks to assess its in vivo effect on angiogenesis; VEGF delivered by hep-FDM was more competitive in promoting blood vessel ingrowth and maturation compared to other groups. Taken together, this study successfully engineered an FDM-mediated VEGF delivery system, documented its capacity to convey VEGF in a sustained manner, and demonstrated the positive effects of angiogenic activity in vivo as well as in vitro.
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Vertex Antimagic Total Labeling of Digraphs
PANDIMADEVI, J.,SUBBIAH, S.P. Department of Mathematics 2015 Kyungpook mathematical journal Vol.55 No.2
In this paper we investigate the properties of (a, d)-vertex antimagic total labeling of a digraph D = (V, A). In this labeling, we assign to the vertices and arcs the consecutive integers from 1 to |V|+|A| and calculate the sum of labels at each vertex, i.e., the vertex label added to the labels on its out arcs. These sums form an arithmetical progression with initial term a and common difference d. We show the existence and non-existence of (a, d)-vertex antimagic total labeling for several class of digraphs, and show how to construct labelings for generalized de Bruijn digraphs. We conclude this paper with an open problem suitable for further research.
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Topologies associated with Disemigraphs
C.V.R. Harinarayanan,S.P. Subbiah,,C.Y. Ponnappan,R. Sundareswaran,V. Swaminathan 장전수학회 2011 Proceedings of the Jangjeon mathematical society Vol.14 No.1
In this paper, an attempt is made to associate a topology on the vertex set of a directed semigraph (disemigraph) in such a way that there exists a one to one correspondence between the set of all topologies on a set V having the property of completely additive closure and the set of all equivalence classes of directed semigraphs de¯ned on V .
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