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        Structural performance of timber frame joints - Full scale tests and numerical validation

        S.A. Aejaz,A.R. Dar,J.A. Bhat 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.74 No.4

        The force resisting ability of a connection has direct implications on the overall response of a timber framed structure to various actions, thereby governing the integrity and safety of such constructions. The behavior of timber framed structures has been studied by many researchers by testing full-scale-connections in timber frames so as to establish consistent design provisions on the same. However, much emphasis in this approach has been unidirectional, that has focused on a particular connection configuration, with no research output stressing on the refinement of the existing connection details in order to optimize their performance. In this regard, addition of adhesive to dowelled timber connections is an economically effective technique that has a potential to improve their performance. Therefore, a comparative study to evaluate the performance of various full-scale timber frame Nailed connections (Bridled Tenon, Cross Halved, Dovetail Halved and Mortise Tenon) supplemented by adhesive with respect to Nailed-Only counterparts under tensile loading has been investigated in this paper. The load-deformation values measured have been used to calculate stiffness, load capacity and ductility in both the connection forms (with and without adhesion) which in turn have been compared to other configurations along with the observed failure modes. The observed load capacity of the tested models has also been compared to the design strengths predicted by National Design Specifications (NDS-2018) for timber construction. Additionally, the experimental behavior was validated by developing non-linear finite element models in ABAQUS. All the results showed incorporation of adhesive to be an efficient and an economical technique in significantly enhancing the performance of various timber nailed connections under tensile action. Thus, this research is novel in a sense that it not only explores the tensile behavior of different nailed joint configurations common in timber construction but also stresses on improvising the same in a logical manner hence making it distinctive in its approach.

      • Association Between p16, hMLH1 and E-cadherin Promoter Hypermethylation and Intake of Local Hot Salted Tea and Sun-dried Foods in Kashmiris with Gastric Tumors

        Mir, Manzoor R.,Shabir, Nadeem,Wani, Khursheed A.,Shaffi, Sheikh,Hussain, Ishraq,Banday, Manzoor A.,Chikan, Naveed A.,Bilal, S.,Aejaz, Sheikh Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

        The aim of this study was to evaluate the methylation status of three important cancer related genes viz. p16, E-cadherin and hMLH1 promoters and to associate the findings with specific dietary habits in Kashmiris, a culturally distinct population in India, with gastric cancer. The study subjects were divided into three age groups viz. 0-30yrs ($1^{st}$), 31-60yrs ($2^{nd}$) and 61-90yrs ($3^{rd}$). A highly significant association between the intake of local hot salted tea in $2^{nd}$ (p=0.001) and $3^{rd}$ (p=0.009) age groups was observed with the promoter hypermethylation of E cadherin. Again a highly significant association between the aberrant methylation of hMLH1 (p=0.000) and p16 (p=0.000) promoters and the intake of local hot salted tea was observed in the $2^{nd}$ age group of gastric cancer patients. The intake of sun-dried food was also significantly associated with the promoter hypermethylation of E cadherin (p=0.003) and p16 (p=0.015) genes in $3^{rd}$ age group. The results of the present study suggest a close association between the aberrant methylation of p16, E-cadherin and hMLH1 promoters and the intake of local hot salted tea and sun-dried foods in Kashmiri population.

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