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Mei, J.,Dong, P.,Kalnaus, S.,Jiang, Y.,Wei, Z. Pergamon Press 2017 Engineering fracture mechanics Vol.182 No.-
<P><B>Abstract</B></P> <P>It has been well established that fatigue damage process is load-path dependent under non-proportional multi-axial loading conditions. Most of studies to date have been focusing on interpretation of S-N based test data by constructing a path-dependent fatigue damage model. This paper presents a two-parameter mixed-mode fatigue crack growth model which takes into account of crack growth dependency on both load path traversed and a maximum effective stress intensity attained in a stress intensity factor plane ( e . g . , <SUB> K I </SUB> - <SUB> K III </SUB> plane). By taking advantage of a path-dependent maximum range (PDMR) cycle definition (Dong et al., 2010; Wei and Dong, 2010), the two parameters are formulated by introducing a moment of load path (MLP) based equivalent stress intensity factor range ( Δ <SUB> K NP </SUB> ) and a maximum effective stress intensity parameter <SUB> K Max </SUB> incorporating an interaction term <SUB> K I </SUB> · <SUB> K III </SUB> . To examine the effectiveness of the proposed model, two sets of crack growth rate test data are considered. The first set is obtained as a part of this study using 304 stainless steel disk specimens subjected to three combined non-proportional modes I and III loading conditions (i.e., with a phase angle of 0°, 90°, and 180°). The second set was obtained by Feng et al. (2007) using 1070 steel disk specimens subjected to similar types of non-proportional mixed-mode conditions. Once the proposed two-parameter non-proportional mixed-mode crack growth model is used, it is shown that a good correlation can be achieved for both sets of the crack growth rate test data.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Presented a two-parameter mixed-mode fatigue crack growth model. </LI> <LI> Both load path dependency and mean stress effect are considered. </LI> <LI> Validated by non-proportional mixed mode I and III crack growth tests on 304 steel. </LI> <LI> Good correlations are achieved both for test data obtained in this study and from others. </LI> </UL> </P>
Response of plasma rotation to resonant magnetic perturbations in J-TEXT tokamak
Yan, W,Chen, Z Y,Huang, D W,Hu, Q M,Shi, Y J,Ding, Y H,Cheng, Z F,Yang, Z J,Pan, X M,Lee, S G,Tong, R H,Wei, Y N,Dong, Y B IOP 2018 Plasma physics and controlled fusion Vol.60 No.3
<P>The response of plasma toroidal rotation to the external resonant magnetic perturbations (RMP) has been investigated in Joint Texas Experimental Tokamak (J-TEXT) ohmic heating plasmas. For the J-TEXT’s plasmas without the application of RMP, the core toroidal rotation is in the counter-current direction while the edge rotation is near zero or slightly in the co-current direction. Both static RMP experiments and rotating RMP experiments have been applied to investigate the plasma toroidal rotation. The core toroidal rotation decreases to lower level with static RMP. At the same time, the edge rotation can spin to more than 20 km s<SUP>−1</SUP> in co-current direction. On the other hand, the core plasma rotation can be slowed down or be accelerated with the rotating RMP. When the rotating RMP frequency is higher than mode frequency, the plasma rotation can be accelerated to the rotating RMP frequency. The plasma confinement is improved with high frequency rotating RMP. The plasma rotation is decelerated to the rotating RMP frequency when the rotating RMP frequency is lower than the mode frequency. The plasma confinement also degrades with low frequency rotating RMP.</P>
Lee, N. Y.,Choi, H.-K.,Shim, J.-H.,Kang, K.-W.,Dong, Z.,Choi, H. S. Oxford University Press 2009 Carcinogenesis Vol.30 No.4
<P>Phosphorylation of proteins on serine or threonine residues that immediately precede proline (pSer/Thr-Pro) is specifically catalyzed by the peptidyl-prolyl cis-trans isomerase Pin1 and is a central signaling mechanism in cell proliferation and transformation. Although Pin1 is frequently overexpressed in hepatocellular carcinoma (HCC), the molecular mechanism of Pin1 in HCC has not been completely elucidated. Here, we show that Pin1 interacts with p70S6K in vitro and ex vivo. Overexpression of Pin1 resulted in enhanced p70S6K phosphorylation induced by insulin in SK-HEP-1 cells. In contrast, Pin1(-/-) mouse embryonic fibroblasts (MEFs) exhibited significantly decreased insulin-induced p70S6K phosphorylation compared with Pin1(+/+) MEFs. Furthermore, Pin1 enhanced the insulin-induced extracellular signal-regulated protein kinase (ERK)1/2 phosphorylation through its interaction with p70S6K, whereas the inhibition of p70S6K activity by rapamycin suppressed insulin-induced ERK1/2 phosphorylation in SK-HEP-1 cells. Hence, Pin1 affected activator protein-1 activity through p70S6K-ERK1/2 signaling in SK-HEP-1 cells. Most importantly, Pin1-overexpressing JB6 Cl41 cells enhanced neoplastic cell transformation promoted by insulin much more than green fluorescent protein-overexpressing JB6 Cl41 control cells. These results imply that Pin1 amplifies insulin signaling in hepatocarcinoma cells through its interaction with p70S6K, suggesting that Pin1 plays an important role in insulin-induced tumorigenesis and is a potential therapeutic target in hepatocarcinoma.</P>
Dong, G.Z.,Lee, J.H.,Ki, S.H.,Yang, J.H.,Cho, I.J.,Kang, S.H.,Zhao, R.J.,Kim, S.C.,Kim, Y.W. North-Holland ; Elsevier Science Ltd 2014 european journal of pharmacology Vol.740 No.-
Arachidonic acid (AA) is a ω-6 polyunsaturated fatty acid that is found in the phospholipids of membranes and released from the cellular membrane lipid bilayer by phospholipase A2. During this process, AA could produce excess reactive oxygen species and induce apoptosis and mitochondrial dysfunction by selectively inhibiting complexes I and III. Isorhamnetin, an O-methylated flavonol aglycone, has been shown to have cardio-protective, anti-adipogenic, anti-tumor, and anti-inflammatory effects. In the present study, we investigated the effects of isorhamnetin on hepatotoxicity and the underlying mechanisms involved. Our in vitro experiments showed that isorhamnetin dose-dependently blocked the hepatotoxicity induced by treatment with AA plus iron in HepG2 cells. Furthermore, isorhamnetin inhibited the AA+iron induced generation of reactive oxygen species and reduction of glutathione, and subsequently maintained mitochondria membrane potential in AA+iron treated HepG2 cells. In addition, isorhamnetin activated AMP-activated protein kinase (AMPK) by Thr-172 phosphorylation of AMPKα, and this was mediated with Ca(2+)/calmodulin-dependent protein kinase kinase-2 (CaMKK2), but not liver kinase B1. Experiments using CaMKK2 siRNA or its selective inhibitor, STO-609, revealed the role of CaMKK2 in the isorhamnetin-induced activation of AMPK in HepG2 cells. These results indicate isorhamnetin protects against the hepatotoxic effect of AA plus iron, and suggest that the AMPK pathway is involved in the mechanism underlying the beneficial effect of isorhamnetin in the liver.
Radiative decay of theψ(2S)into two pseudoscalar mesons
Bai, J. Z.,Ban, Y.,Bian, J. G.,Blum, I.,Chen, A. D.,Chen, G. P.,Chen, H. F.,Chen, H. S.,Chen, J.,Chen, J. C.,Chen, X. D.,Chen, Y.,Chen, Y. B.,Cheng, B. S.,Choi, J. B.,Cui, X. Z.,Ding, H. L.,Dong, L. Y American Physical Society 2003 Physical review. D, Particles and fields Vol.67 No.3
First Resolution of Microlensed Images
Dong, Subo,Mé,rand, A.,Delplancke-Strö,bele, F.,Gould, Andrew,Chen, Ping,Post, R.,Kochanek, C. S.,Stanek, K. Z.,Christie, G. W.,Mutel, Robert,Natusch, T.,Holoien, T. W.-S.,Prieto, J. L.,Shap American Astronomical Society 2019 The Astrophysical journal Vol.871 No.1
Aerodynamic stability of stay cables incorporated with lamps: a case study
S.Y. Li,Z.Q. Chen,G.C. Dong,J.H. Luo 한국풍공학회 2014 한국풍공학회지 Vol.18 No.1
Lamps installed on stay cables of cable-stayed bridges may alter the configuration of circular cross section of the cables and therefore result in aerodynamically unstable cable vibrations. The background of this study is a preliminary design of lamp installation on the cable-stayed He-dong Bridge in Guangzhou, China. Force measurements and dynamic response measurements wind tunnel tests were carried out tovalidate the possibility of cable galloping vibrations. It is observed that galloping will occur and the critical wind velocity is far less than the design wind velocity at Guangzhou City stipulated in Chinese Code. Numerical simulations utilizing software ANSYS CFX were subsequently performed and almost the same results as the wind tunnel tests were obtained. Moreover, the pressure and velocity contours aroundcable-lamp model obtained from numerical simulations indicated that the upstream steel wire in the preliminary design is the key factor for the onset of the galloping vibrations. A modification for thepreliminary design of lamp installation, which suggests to remove the two parallel steel wires, is proposed,and it effectiveness is validated in further wind tunnel tests.
Dong, Ren G.,Sinsel, Erik W.,Welcome, Daniel E.,Warren, Christopher,Xu, Xueyan S.,McDowell, Thomas W.,Wu, John Z. Occupational Safety and Health Research Institute 2015 Safety and health at work Vol.6 No.3
The hand coordinate systems for measuring vibration exposures and biodynamic responses have been standardized, but they are not actually used in many studies. This contradicts the purpose of the standardization. The objectives of this study were to identify the major sources of this problem, and to help define or identify better coordinate systems for the standardization. This study systematically reviewed the principles and definition methods, and evaluated typical hand coordinate systems. This study confirms that, as accelerometers remain the major technology for vibration measurement, it is reasonable to standardize two types of coordinate systems: a tool-based basicentric (BC) system and an anatomically based biodynamic (BD) system. However, these coordinate systems are not well defined in the current standard. Definition of the standard BC system is confusing, and it can be interpreted differently; as a result, it has been inconsistently applied in various standards and studies. The standard hand BD system is defined using the orientation of the third metacarpal bone. It is neither convenient nor defined based on important biological or biodynamic features. This explains why it is rarely used in practice. To resolve these inconsistencies and deficiencies, we proposed a revised method for defining the realistic handle BC system and an alternative method for defining the hand BD system. A fingertip-based BD system for measuring the principal grip force is also proposed based on an important feature of the grip force confirmed in this study.