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( Eun Ryung Han ),( Won Ryang Wee ),( Jin Hak Lee ),( Joon Young Hyon ) 대한안과학회 2011 Korean Journal of Ophthalmology Vol.25 No.2
We report a case of a retained graphite anterior chamber foreign body that was masquerading as stromal keratitis. A 28-year-old male visited with complaints of visual disturbance and hyperemia in his right eye for four weeks. On initial examination, he presented with a stromal edema involving the inferior half of the cornea, epithelial microcysts, and moderate chamber inflammation. Suspecting herpetic stromal keratitis, he was treated with anti-viral and anti-inflammatory agents. One month after the initial visit, anterior chamber inflammation was improved and his visual acuity recovered to 20/20, but subtle corneal edema still remained. On tapering the medication, after three months, a foreign body was incidentally identified in the inferior chamber angle and was surgically removed resulting in complete resolution of corneal edema. The removed foreign body was a fragment of graphite and he subsequently disclosed a trauma with mechanical pencil 12 years earlier. This case showed that the presence of an anterior chamber foreign body should always be considered in the differential diagnosis of idiopathic localized corneal edema.
Choi, Je-Min,Yoon, Byoung-Seok,Lee, Sang-Kyou,Hwang, Jae-Kwan,Ryang, Ryung Pharmaceutical Society of Japan 2007 Biological & pharmaceutical bulletin Vol.30 No.2
<P>Neohesperidin dihydrochalcone (NHDC), a non-nutritive sweetening agent, is simply produced by hydrogenation of neohesperidin. The aim of this study is to evaluate the antioxidant and radical scavenging properties of neohesperidin dihydrochalcone and other structurally related compounds (phloridzin, neohesperidin) toward different reactive radical and oxygen species including ·ABTS<SUP>+</SUP>, ·O<SUB>2</SUB><SUP>−</SUP>, ·OH, H<SUB>2</SUB>O<SUB>2</SUB>, and HOCl <I>in vitro</I>. NHDC showed remarkable radical scavenging activity against stable radical and reactive oxygen species (ROS) in concentration dependent manner. Especially, NHDC was the most potent inhibitor of H<SUB>2</SUB>O<SUB>2</SUB> and HOCl. NHDC showed HOCl scavenging activity of 93.5% and H<SUB>2</SUB>O<SUB>2</SUB> scavenging property of 73.5% which was more than those of all the tested compounds including ascorbic acid and BHT. Moreover, NHDC could inhibit protein degradation, plasmid DNA strand cleavage and HIT-T15, HUVEC cell death from HOCl attack while mannitol, BHT, and ascorbic acid could not protect them effectively. These results suggest that NHDC is a potent antioxidant, especially it is evaluated as a novel HOCl scavenger. This study implies the possibility of therapeutic effect of NHDC on ROS-related inflammatory diseases.</P>