Treatment of Keratocystic Odontogenic Tumors in Nevoid Basal Cell Carcinoma Syndrome

Ryu, Hyun-Ho,Shin, Dong-Yoon,Ryu, Seok-Hwan,Kim, Taek-Woo,Lee, Jong-Bum,Kim, Bok-Joo,Kim, Chul-Hoon Korean Association of Maxillofacial Plastic and Re 2014 Maxillofacial Plastic Reconstructive Surgery Vol.36 No.1

Nevoid basal cell carcinoma syndrome (NBCCS) is inherited as an autosomal dominant trait with variable conditions, including multiple basal cell carcinoma, numerous keratocystic odontogenic tumors (KOTs) in the jaws, ectopic calcification of the falx cerebri, bifid ribs, macrocephaly, kyphoscoliosis, cleft palate, frontal and temporal bossing, mild ocular hypertelorism, mild mandibular prognathism, vertebral fusion, and so on. A 16-year-old boy visited the Dong-A University Medical Center, requiring diagnosis and treatment of multiple cystic lesions. He presented with many conditions related to NBCCS, including multiple KOTs, bifid rib, cleft lip, frontal bossing, mild ocular hypertelorism, and mild mandibular prognathism. No characteristic cutaneous manifestations (nevoid basal cell carcinoma) were observed in this patient. We report on a case of multiple KOTs associated with NBCCS with a review of the literature.

유방암 환자에서 bcl-2 단백 발현의 예후 인자로서의 의의

류진우,박종권,정민,박동국,김정택,이두선,이찬영,전호진 단국대학교 1998 論文集 Vol.32 No.-

Breast cancer in women pose a problem, and it can be difficult at times to evaluate the possibility of the cancer recurrence in node negative early cancer. The reliable prognostic markers are needed in breast cancer management to help clinicians identify the patient with the high risk of recurrence and arrive at more rational decisions for proper treatment. In order to investigate the prognostic significance of bcl-2, an immunohis-tochemical staining was performed in 35 tissue sections from paraffin blocks of primary breast cancer. Bcl-2 positivity was 43%. No relation could be observed between bcl-2 expression and known prognostic factors(tumor size, lymph node metastasis state, histologic grade, and nuclear grade), There was strong relation between bcl-2 expression and estrogen receptor positivity (ER) (P〈0.05). No relation is found between bcl-2 expression and c - erbB - 2 expression. These results suggest that bcl-2 expression is associated with a favorable prognostic factor(ER) but it is of no value as independent prognostic factor to the clinician in identifying the patients with high risk of recurrence.

Ki-67이 Luminal B형 유방암 환자의 예후에 미치는 영향

류동원,최우식,이충한 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

배경: Ki-67는 세포의 분열지수로서 특히 세포분열초기 나타나는 것으로 알려져 있다. 그래서 Ki-67의 분열지수가 높은 경우 조기 재발 및 예후와 관련되어 있다는 보고가 있다. 본 연구에서는 본원의 자료를 토대로 Ki-67의 분열지수가 예후에 영향을 미치는지를 알아보고자 한다 방법: 2001년 1월부터 2005년 12월까지 본원에서 유방암으로 수술을 받은 679명의 환자를 대상으로 후향적으로 조사를 하였다. 술후 조직병리학적 보고서를 토대로 조사하였다. Ki-67의 수치를 기준으로 10%이하군, 10%에서 20%군, 20%이상군으로 나누었다. 세군사이의 임상병리학적 요소의 분포를 비교하였으며 Kaplan-Meier를 이용하여서 생존율을 분석하였다. 결과: 환자들의 평균나이는 46세였으며, 평균종양의 크기는 3.2cm였다. 20%이상군에서 진행성 유방암환자의 비율이 높았다.(p=0.007) 특히 림프절의 전이정도와도 관련이 있었다.( p=0.003) 그러나 Ki-67과 생존율과는 의미있는 관련성을 없었다.( p=0.6112). 결론: 본원의 조사에 따르면 Ki-67은 진행성 유방암과 호르몬 수용체 음성과는 밀접한 관계를 가지고 있었으나 생존율에는 영향을 미치지 않았다. 그러나 본조사는 추적기간이 짧고 조사 규모가 크지 않아서 향후 계속적으로 추적 관찰한다면 더 의미있는 결과과 나올것이다. Background: Ki-67 expression has been considered to be a reliable marker for assessing tumor cell proliferation. The aims of the ourstudy were to assess the correlationbetween Ki-67 expression and clinocopathologic factors and to analyze the effect of Ki-67 expression on survival rate. Methods:The study subjects, 679 women with breast cancer, were a subset of patients operated at OOO hospital from Jun 2001 to Dec 2005.Patients are grouped into 3 categories according to Ki-67 determined in surgical specimens. Clincopathologic factors were compared with 3 categories of Ki-67. Chi-squared tests were used for statistical analysis. Kaplan–Meier estimates are presented for thesurvival function, and differences in survival were analyzed usingthe log rank test. Results: The median age was 46yrs, and median tumor size was 3.2cm. The strong correlation was observed between tumor staging and Ki-67 staining(p=0.007) and Group III(more than 20% staing) showed more advanced N-staging(p=0.003). The number of patients with estrogen receptor negative was higher in Group III(p=0.001) and that with HER-2 receptor positive was also higher in Group III(p =0.001) comparing with other groups. The univariate analysis for prognostic factors associated with DFS revealed that both the tumor groupas T1, T2, T3 or T4 and lymph node as N0, N1, N2 or N3 were statistically significant(p=0.0003 and p=0.0015 respectively) but the Ki-67 staining as <10%, 10~20%, >20% was statistically not significant(p=0.6112). The univariate analysis for prognostic factors associated with OS revealed that Tumor staging and N-staging was statically significant(p=0.003 and p=0.0015 respectively). Conclusions: According to our study, Ki-67 positive groups was associated with more advanced staging, ER-negative, PR-negative and HER-positive respectively. But there is no significant association between Ki-67 staining and 5-year disease free survival rate including overall survival rate.

충수주위 농양의 임상적 고찰

김동환,정우식,류성열,장태수 대한대장항문학회 1997 Annals of Coloproctolgy Vol.13 No.2

생리 활성 세라믹 분말이 첨가된 포장용 LDPE 필름의 새로운 에틸렌 평형 용해 모델

류동완,정재철,심승우,박찬영 전남대학교 촉매연구소 2000 觸媒硏究 論文集 Vol.21 No.-

This work investigates a new model that predicts the equilibrium solubility of gaseous component with polymer film. The new model regards the gas concentration in fluid phase as depressing factor in desorption from the surface of the film. The final mathematical form describes actual observation well with its second order form. The over all figure of the equilibrium solubility is sigmoid that one sees frequently in experiments. The only disadvantage of this model is the bulk concentration appears in denominator that induces the expression becomes infinite if the concentration is none. Insertion of one constant added to the concentration term in the denominator defeats this shortcoming. The following is the mathmatical form of the net rate of dissolution and the equilibrium solubility, respectively. □ Also, this paper presents the logical method obtaining the parameters from the experimental equilibrium data for the ethylene dissolution in LDPE film that had incorporated a ceramic powder with selective gas permeability. Finally, the dependency of the equilibrium parameters, KA, Cmax, the others to the weight fraction of the powder and appears to be linear and presented to follow : The parameters were calculated by soluble equilibrium constant, KA, maximum soluble concentration, Cmax and soluble rate constant, k+ for ethylene gas permeated through LDPE packaging films containing the ceramic powders 0∼6wt% at 20℃, the above model being applied. The values showed 1.45×106∼3.70×106[(㎤/mol)2], 2.30×10-3~2.92×10-3 [mo1/㎠sec]and 0.273∼0.405[㎤/mol sec], respectively.

수증기 활성화법으로 제조된 영월 석탄계 활성탄의 특성 연구

이송우,권태훈,나영수,최동훈,류동춘,송승구 한국환경과학회 2000 한국환경과학회지 Vol.9 No.4

Activated carbons were prepared from Youngwall coal by steam activation in this study. The feasibility of the Youngwall coal to commercial activated carbon was examined. The variation of pore structures and the development of porosity in activated carbons were investigated by changing activation conditions in batch type apparatus. The values of BET surface area and adsorption capacity of iodine and methylene blue of the resulting activated carbons were obtained as high as 1,000㎡/g, 900㎎/g, 150㎖/g, respectively. Youngwall activated carbon prepared in this study showed much higher pore volume in pore diameter over l0Å than that of commercial reference activated carbon(Ningxia Taihua ZJ-15C) produced from China anthracite.

15세기 조선온실건축의 기능 및 실내환경 특성에 관한 연구

조동우,유기형,유수훈 대한건축학회 2004 대한건축학회논문집 Vol.20 No.12

Choson Greenhouse consisted of three sidewalls using yellow soil except the south side, the window with oiled Hanji to transmit sunlight that is sloped to the south And Goodle was raised on the floor level, the soil of 40cm thickness was stored up, and the soil of 45cm thickness was finally spread to set vegetables in Choson Greenhouse A kitchen range that was attached in the internal wall between the greenhouse and the kitchen was installed to control the temperature & humidity The heated-air flow goes through fire passageway under Doodle, and exhausts through the smokestack When the water in the kettle boils up on the kitchen range, steam flows to the inside of greenhouse through a pipeline The latent heat of steam can make the temperature and humidity control in the greenhouse To find whether Choson Greenhouse provides functions and thermal environment for planting or not, the thermal performance was measured and analyzed in the greenhouse As measurement results, sunlight entered in the greenhouse, passing through the oiled Hanji cover As it reached the soli of floor and wall surfaces, and it absorbed the sunlight's energy Once absorbed, some of the energy passed back into the atmosphere, but much of it remained trapped in indoor space by the greenhouse effect We found that Choson Greenhouse keeps warm to grow plants with the rise in temperature, and the oiled Hanji is distinctly suitable for a role of thermal insulation, sunlight transmittance Also, the thermal performance was compared a Hangi-covered greenhouse model with a vinyl-covered greenhouse model The Hangi-covered greenhouse model was better for ventilation, thermal insulation and humidity control than the vinyl-covered greenhouse model Therefore, Greenhouse m early Choson dynasty can be fairly evaluated as the extraordinary farming facility compared to nowadays greenhouses

수증기 활성화법으로 제조된 활성탄의 탄화온도에 따른 세공구조 고찰

이송우,나영수,김도한,최동훈,류동춘,송승군 한국환경과학회 2000 한국환경과학회지 Vol.9 No.4

Activated carbons were prepared from Korean coal by steam activation in this study. The variation of pore structure of the activated carbons were investigated according to different carbonization temperatures. Yield, surface area, pore volume and pore structure of this activated carbon were compared with those of activated carbon prepared without carbonization. The investigated carbonization temperature ranged from 700℃ to 1,000℃. Carbonization was carried out in nitrogen atmosphere for 70 minutes and activation was performed by steam at 950℃ for 210 minutes. Surface area and pore volume of the resulting activated carbons increased with carbonization temperature. Also pore volume increased by 20% compared to the activated carbon without carbonization. Especially, in mesopore region, the activated carbon carbonized at 900℃ had more pores by 60% than that of activated carbon carbonized at other temperature.

표정인식을 위한 PCA와 템플릿 정합을 사용한 얼굴 요소 추출

우효정, 이슬기, 김동우, 류성필, 안재형 충북대학교 산업과학기술연구소 2013 산업과학기술연구 논문집 Vol.27 No.2

This paper proposed an extracting algorithm of human facial components for the recognition of facial expressions. First face image is acquired using the Haar-like feature mask from an input image. The face image is divided into two images. One is the upper image including eye and eyebrow. The other is the lower image including mouth and jaw. The extraction of facial components, such as eye and mouth, begins getting eye image and mouth image. Then eigenfaces are produced by the PCA training process with learning images. An eigeneye and an eigenmouth are produced from eigenfaces. Result eye image is obtained by template matching the upper image with the eigeneye, and the mouth image is obtained by template matching the lower image with the eigenmouth. The simulation results show that the proposed method has superior extraction ratio than previous method.

주물공장 근로자에서 발생한 국한성 석면폐증 1예

김태우,고동희,김민기,유승원,류향우,한정희,정순희 大韓産業醫學會 2009 대한직업환경의학회지 Vol.21 No.2

배경: 주물공장 근로자에서 발생한 석면폐증의 작업 관련성을 평가하고 그 증례를 보고하고자 한다. 증례: 30년간 주물공장에서 근무한 환자로 인후통, 기침, 노란 가래가 있어 검사한 결과 결핵이 의심되어 치료 하였으며, 치료 중 석면폐증으로 진단되었다. 작업 관련성 평가를 위해 실시한 폐 조직의 조직학적 검사에서 1 cm^(2)당 3개의 석면소체가 발견되었고, 투과전자현미경으로 분석한 석면 함유량은 23.26x10^(6) fibers/g이었다. 결론: 작업환경조사, 폐 조직의 석면 분석 등을 통해 작업 관련성이 높다고 판단하였다. Background: Foundry workers are known to be exposed to silica and have an increased risk of Silicosis. There are also reports that state these foundry workers were associated with asbestos-related change in the X-ray results of the lungs. This report discusses a case of localized asbestosis developed in a foundry worker who worked in 12 Korean foundries. Case report: A 49-year-o1d man who worked at molding and melting for 30 years, Presented with sore throat, cough and yellow sputum for 1 month. From physical and clinical examination, Pulmonary tuberculosis was highly suspicious; therefore, he was medicated for 6 months. After tuberculosis medication, the radiological finding was reactivation of tuberculosis, and an asbestos body was detected at a trans-bronchial lung biopsy. During an operation, operators found multiple palpable masses and bullae 10calized in the right upper lobe (RUL) and performed right upper lobectomy and right middle lobe wedge resection. Using hematoxylin-eosin stain and iron stain, we could detect asbestos bodies by light microscopy. We analyzed the asbestos fiber burden in dry lung tissue by transmission electron microscopy with energy dispersive X-ray spectrometer (TEM-EDX). The fiber type was chrysotile and the fiber burden was 23.26 x 10^(6) fiber/g dry lung. Discussion: This case study of a foundry worker with localized asbestosis is uncommon in Korea. We found an occupational relationship between the foundry worker and localized asbestosis through various investigative techniques such as measurements taken at his working environment, clinical, radiological and pathological examination of the foundry worker and mineralogical examination of the asbestos fiber.