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Guo Weiming,Jin Peng,Li Ruomei,Huang Lu,Liu Zhen,Li Hairui,Zhou Ting,Fang Bing,Xia Lunguo 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
The identification of predictive markers to determine the triggering phase prior to the onset of osteoporosis is essential to mitigate further irrevocable deterioration. To determine the early warning signs before osteoporosis, we used the dynamic network biomarker (DNB) approach to analyze time-series gene expression data in a zebrafish osteoporosis model, which revealed that cyclin-dependent kinase inhibitor 1 A (cdkn1a) is a core DNB. We found that cdkn1a negatively regulates osteogenesis, as evidenced by loss-of-function and gain-of-function studies. Specifically, CRISPR/Cas9-mediated cdkn1a knockout in zebrafish significantly altered skeletal development and increased bone mineralization, whereas inducible cdkn1a expression significantly contributed to osteoclast differentiation. We also found several mechanistic clues that cdkn1a participates in osteoclast differentiation by regulating its upstream signaling cascades. To summarize, in this study, we provided new insights into the dynamic nature of osteoporosis and identified cdkn1a as an early-warning signal of osteoporosis onset.
Measurement of the radon and thoron exhalation rates from the water surface of Yixin lake
Jiulin Wu,Shuaibin Liu,Tao Hu,Fen Lin,Ruomei Xie,Shuai Yuan,Haibo Yi,Yixiang Mo,Jiale Sun,Linquan Cheng,Huiying Li,Zhipeng Liu,Zhongkai Fan,Yanliang Tan Korean Nuclear Society 2024 Nuclear Engineering and Technology Vol.56 No.4
The importance of determining the radon exhalation rate from water surface is emphasized by the increased use of radon and its daughter products as tracers in large-scale circulation studies of the atmosphere. There were many methods to measure radon exhalation from water surface. With the development of radon exhalation rate measurement methods and instruments on the surface of the soil, the rock and building materials, so the radon exhalation rate from water surface can be more accurately measured by applying these improved methods and instruments. In this paper, a cuboid accumulation chamber surrounded by foam boards and a RAD7 were used to measure the radon exhalation rate on the water surface at three different positions by Yixin lake. Each measurement was performed 2 h. The radon exhalation rate from the water surface was about 6 × 10<sup>-3</sup> Bq m<sup>-2</sup>s<sup>-1</sup>. The thoron exhalation rate from the water surface also can be estimated, it is about 0.16 Bq m<sup>-2</sup>s<sup>-1</sup>. These results hint that the radon transmission from the lake bottom soil to water and then into the atmosphere.