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Detection of Human Anti-Trypanosoma cruzi Antibody with Recombinant Fragmented Ribosomal P Protein
김영훈,Zhaoshou Yang,Jihoo Lee,안혜진,Chom-Kyu Chong,Wagner Maricondi,Ronaldo F. Dias,남호우 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.4
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is endemic in many Latin Ameri- can countries. Diagnosis is based on serologic testing and the WHO recommends two or more serological tests for confir- mation. Acidic ribosomal P protein of T. cruzi showed strong reactivity against positive sera of patients, and we cloned the protein after fragmenting it to enhance its antigenicity and solubility. Twelve positive sera of Chagas disease patients were reacted with the fragmented ribosomal P protein using western blot. Detection rate and density for each fragment were determined. Fragments F1R1, F1R2, and F2R1 showed 100% rate of detection, and average density scoring of 2.00, 1.67, and 2.42 from a maximum of 3.0, respectively. Therefore, the F2R1 fragment of the ribosomal P protein of T. cruzi could be a promising antigen to use in the diagnosis of Chagas disease in endemic regions with high specificity and sensitivity.